Contact

All Stories

  1. An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Tom Brown

  2. Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

    Article • ACS Nano, April 2019, American Chemical Society (ACS)

    Tom Brown

  3. DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

    Article • ACS Applied Materials & Interfaces, December 2018, American Chemical Society (ACS)

    Tom Brown

  4. Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Tom Brown

  5. Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

    Article • ACS Omega, June 2018, American Chemical Society (ACS)

    Tom Brown

  6. Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

    Article • ACS Nano, June 2018, American Chemical Society (ACS)

    Tom Brown

  7. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers

    Article • ACS Nano, March 2018, American Chemical Society (ACS)

    Tom Brown

  8. Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

    Article • ChemPhysChem, February 2018, Wiley

    Tom Brown

  9. Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

    Article • Analytical Chemistry, February 2018, American Chemical Society (ACS)

    Tom Brown

  10. Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Tom Brown

  11. Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Tom Brown

  12. Gene assemblyviaone-pot chemical ligation of DNA promoted by DNA nanostructures

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Tom Brown

  13. NMR analyses onN-hydroxymethylated nucleobases – implications for formaldehyde toxicity and nucleic acid demethylases

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Tom Brown

  14. Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Tom Brown

  15. CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

    Article • eLife, October 2017, eLife

    Tom Brown

  16. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

    Article • Nature Chemistry, September 2017, Springer Science + Business Media

    Tom Brown

  17. Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET

    Article • Journal of the American Chemical Society, June 2017, American Chemical Society (ACS)

    Tom Brown

  18. 5-Formylcytosine does not change the global structure of DNA

    Article • Nature Structural & Molecular Biology, May 2017, Springer Science + Business Media

    Tom Brown

  19. Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

    Article • Journal of the American Chemical Society, January 2017, American Chemical Society (ACS)

    Tom Brown

  20. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Tom Brown

  21. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Tom Brown, Prof. Dr. Jasmin Mecinovic

  22. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Tom Brown

  23. Single tube gene synthesis by phosphoramidate chemical ligation

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Tom Brown

  24. Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

    Article • Journal of Materials Chemistry C, January 2017, Royal Society of Chemistry

    Tom Brown

  25. Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer’s Disease and Prostate Cancer

    Article • ACS Sensors, December 2016, American Chemical Society (ACS)

    Tom Brown

  26. Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes

    Article • Angewandte Chemie International Edition, September 2016, Wiley

    Tom Brown

  27. An autonomous molecular assembler for programmable chemical synthesis

    Article • Nature Chemistry, April 2016, Springer Science + Business Media

    Tom Brown

  28. Stable end-sealed DNA as robust nano-rulers for in vivo single-molecule fluorescence

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Tom Brown

  29. Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling

    Article • The Analyst, January 2015, Royal Society of Chemistry

    Tom Brown

  30. Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA

    Article • Bioorganic & Medicinal Chemistry, August 2014, Elsevier

    Tom Brown

  31. Triplex-mediated analysis of cytosine methylation at CpA sites in DNA

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Tom Brown

  32. Structural insights into how 5-hydroxymethylation influences transcription factor binding

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Tom Brown, Christopher Schofield

  33. Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Tom Brown

  34. Enhanced H-bonding and π-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Tom Brown

  35. Solid phase click ligation for the synthesis of very long oligonucleotides

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Tom Brown

  36. Click DNA and RNA ligation for new biocompatible nucleic acid backbone mimics

    Article • January 2011, Institute of Organic Chemistry & Biochemistry

    Tom Brown

  37. Click Chemistry on DNA

    Article • Chemical Society Reviews, January 2010, Royal Society of Chemistry

    Tom Brown