All Stories

  1. Substrate selectivity of human histidine methyltransferase METTL9
  2. Probing Attractive OH−π Interactions and Repulsive n−π Interactions in a Phenol Molecular Balance
  3. Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs
  4. Ion Mobility Separation of Isomeric Acyl-lysine Marks in Peptides
  5. Ion Mobility Separation of Isomeric Acyl-lysine Marks in Peptides
  6. Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7
  7. Histidine methylation via an enzymatic cascade with in situ generation of nucleoside-modified AdoMet analogues
  8. Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana Plant Cysteine Oxidase 4 induced by binding of substrate or substrate-mimics
  9. Dynamic Combinatorial Chemistry of Ditellurides
  10. Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment
  11. Selenalysine as a Chemical Tool for Probing Histone Post-Translational Modifications
  12. Chemical tools for probing histidine modifications
  13. Distinguishing isomeric N-methylhistidine peptidoforms by ion mobility mass spectrometry
  14. Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
  15. Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases
  16. Peptide-based inhibitors of epigenetic proteins
  17. Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3
  18. Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
  19. Top‐down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms
  20. (R)‐PFI‐2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7
  21. Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase
  22. The Role of Trp79 in β‐Actin on Histidine Methyltransferase SETD3 Catalysis
  23. Synthetic cysteine-based tools for probing protein posttranslational modifications
  24. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
  25. Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings**
  26. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
  27. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
  28. Investigation of in vitro histone H3 glycosylation using H3 tail peptides
  29. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
  30. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings
  31. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes
  32. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
  33. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
  34. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
  35. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents
  36. Probing lysine posttranslational modifications by unnatural amino acids
  37. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
  38. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases
  39. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins
  40. Substrate Specificity for Human Histidine Methyltransferase SETD3
  41. Characterization of Cyclic N ‐Acyliminium Ions by Infrared Ion Spectroscopy
  42. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy
  43. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy
  44. β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3
  45. Do Sulfonamides Interact with Aromatic Rings?
  46. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
  47. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
  48. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases
  49. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics
  50. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
  51. Probing Halogen−π versus CH−π Interactions in Molecular Balance
  52. Effect of lysine side chain length on histone lysine acetyltransferase catalysis
  53. Front Cover: Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols (ChemPhysChem 11/2020)
  54. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  55. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
  56. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  57. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
  58. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
  59. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails
  60. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
  61. Lysine Ethylation by Histone Lysine Methyltransferases
  62. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
  63. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2
  64. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
  65. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
  66. Catalytic Staudinger Reduction at Room Temperature
  67. Investigating the active site of human trimethyllysine hydroxylase
  68. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
  69. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols
  70. Mechanistic Insight into the Catalytic Staudinger Ligation
  71. Catalytic transport of molecular cargo using diffusive binding along a polymer track
  72. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
  73. Importance of the main chain of lysine for histone lysine methyltransferase catalysis
  74. Biomolecular Recognition of Methylated Histones
  75. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2
  76. Structure-Activity Relationship Studies on (R )-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
  77. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
  78. 2OG regulates binding of hydroxylated HIF to PHD2
  79. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
  80. Sustainable organophosphorus-catalysed Staudinger reduction
  81. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
  82. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation−π Interactions
  83. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine
  84. Fluorinated trimethyllysine as a19F NMR probe for trimethyllysine hydroxylase catalysis
  85. Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
  86. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition
  87. Multicolor Photoluminescence Including White-Light Emission by a Single Host–Guest Complex
  88. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  89. Natural supramolecular protein assemblies
  90. Substrate scope for trimethyllysine hydroxylase catalysis
  91. ChemInform Abstract: Chemoselective Calcium-Catalyzed Direct Amidation of Carboxylic Esters.
  92. ChemInform Abstract: Natural Supramolecular Protein Assemblies
  93. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  94. ChemInform Abstract: Zirconium-Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
  95. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
  96. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
  97. Zirconium-catalyzed direct amide bond formation between carboxylic esters and amines
  98. Chemoselective calcium-catalysed direct amidation of carboxylic esters
  99. ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.
  100. Thermodynamic investigation of Z33-antibody interaction leads to selective purification of human antibodies
  101. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions
  102. Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
  103. Catenane versus ring: do both assemblies of CS2 hydrolase exhibit the same stability and catalytic activity?
  104. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase
  105. The Effect of the Length of Histone H3K4me3 on Recognition by Reader Proteins
  106. Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides
  107. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
  108. Evidence that the catenane form of CS2 hydrolase is not an artefact
  109. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
  110. Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
  111. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase
  112. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
  113. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
  114. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model
  115. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL
  116. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
  117. Therapeutic Manipulation of the HIF Hydroxylases
  118. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
  119. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals
  120. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
  121. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
  122. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
  123. Direct Analysis of Enzyme-Catalyzed DNA Demethylation
  124. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
  125. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
  126. ChemInform Abstract: Triflic Anhydride Mediated Synthesis of Oxazoles.
  127. Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
  128. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  129. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  130. Triflic anhydride-mediated synthesis of oxazoles
  131. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
  132. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline
  133. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
  134. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥
  135. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site
  136. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
  137. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
  138. 3-(Dimethylamino)propenoate-based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-pyrazoles