All Stories

  1. Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9
  2. Inhibition of human histone lysine methyltransferases by a redox-labile S-adenosyl-L-homocysteine analog
  3. Top-down Sequencing of Intact Proteoforms using the timsOmni mass spectrometer: Accurate Determination of Co-occurring Histone Modifications
  4. Substrate selectivity of human histidine methyltransferase METTL9
  5. Probing Attractive OH−π Interactions and Repulsive n−π Interactions in a Phenol Molecular Balance
  6. Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs
  7. Ion Mobility Separation of Isomeric Acyl-lysine Marks in Peptides
  8. Ion Mobility Separation of Isomeric Acyl-lysine Marks in Peptides
  9. Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7
  10. Histidine methylation via an enzymatic cascade with in situ generation of nucleoside-modified AdoMet analogues
  11. Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana Plant Cysteine Oxidase 4 induced by binding of substrate or substrate-mimics
  12. Dynamic Combinatorial Chemistry of Ditellurides
  13. Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment
  14. Selenalysine as a Chemical Tool for Probing Histone Post-Translational Modifications
  15. Chemical tools for probing histidine modifications
  16. Distinguishing isomeric N-methylhistidine peptidoforms by ion mobility mass spectrometry
  17. Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
  18. Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases
  19. Peptide-based inhibitors of epigenetic proteins
  20. Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3
  21. Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
  22. Top‐down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms
  23. (R)‐PFI‐2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7
  24. Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase
  25. The Role of Trp79 in β‐Actin on Histidine Methyltransferase SETD3 Catalysis
  26. Synthetic cysteine-based tools for probing protein posttranslational modifications
  27. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
  28. Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings**
  29. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
  30. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
  31. Investigation of in vitro histone H3 glycosylation using H3 tail peptides
  32. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
  33. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings
  34. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes
  35. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
  36. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
  37. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
  38. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents
  39. Probing lysine posttranslational modifications by unnatural amino acids
  40. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
  41. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases
  42. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins
  43. Substrate Specificity for Human Histidine Methyltransferase SETD3
  44. Characterization of Cyclic N ‐Acyliminium Ions by Infrared Ion Spectroscopy
  45. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy
  46. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy
  47. β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3
  48. Do Sulfonamides Interact with Aromatic Rings?
  49. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
  50. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
  51. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases
  52. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics
  53. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
  54. Probing Halogen−π versus CH−π Interactions in Molecular Balance
  55. Effect of lysine side chain length on histone lysine acetyltransferase catalysis
  56. Front Cover: Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols (ChemPhysChem 11/2020)
  57. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  58. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
  59. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  60. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
  61. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
  62. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails
  63. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
  64. Lysine Ethylation by Histone Lysine Methyltransferases
  65. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
  66. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2
  67. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
  68. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
  69. Catalytic Staudinger Reduction at Room Temperature
  70. Investigating the active site of human trimethyllysine hydroxylase
  71. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
  72. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols
  73. Mechanistic Insight into the Catalytic Staudinger Ligation
  74. Catalytic transport of molecular cargo using diffusive binding along a polymer track
  75. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
  76. Importance of the main chain of lysine for histone lysine methyltransferase catalysis
  77. Biomolecular Recognition of Methylated Histones
  78. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2
  79. Structure-Activity Relationship Studies on (R )-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
  80. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
  81. 2OG regulates binding of hydroxylated HIF to PHD2
  82. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
  83. Sustainable organophosphorus-catalysed Staudinger reduction
  84. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
  85. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation−π Interactions
  86. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine
  87. Fluorinated trimethyllysine as a19F NMR probe for trimethyllysine hydroxylase catalysis
  88. Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
  89. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition
  90. Multicolor Photoluminescence Including White-Light Emission by a Single Host–Guest Complex
  91. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  92. Natural supramolecular protein assemblies
  93. Substrate scope for trimethyllysine hydroxylase catalysis
  94. ChemInform Abstract: Chemoselective Calcium-Catalyzed Direct Amidation of Carboxylic Esters.
  95. ChemInform Abstract: Natural Supramolecular Protein Assemblies
  96. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  97. ChemInform Abstract: Zirconium-Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
  98. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
  99. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
  100. Zirconium-catalyzed direct amide bond formation between carboxylic esters and amines
  101. Chemoselective calcium-catalysed direct amidation of carboxylic esters
  102. ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.
  103. Thermodynamic investigation of Z33-antibody interaction leads to selective purification of human antibodies
  104. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions
  105. Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
  106. Catenane versus ring: do both assemblies of CS2 hydrolase exhibit the same stability and catalytic activity?
  107. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase
  108. The Effect of the Length of Histone H3K4me3 on Recognition by Reader Proteins
  109. Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides
  110. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
  111. Evidence that the catenane form of CS2 hydrolase is not an artefact
  112. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
  113. Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
  114. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase
  115. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
  116. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
  117. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model
  118. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL
  119. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
  120. Therapeutic Manipulation of the HIF Hydroxylases
  121. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
  122. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals
  123. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
  124. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
  125. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
  126. Direct Analysis of Enzyme-Catalyzed DNA Demethylation
  127. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
  128. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
  129. ChemInform Abstract: Triflic Anhydride Mediated Synthesis of Oxazoles.
  130. Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
  131. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  132. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  133. Triflic anhydride-mediated synthesis of oxazoles
  134. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
  135. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline
  136. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
  137. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥
  138. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site
  139. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
  140. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
  141. 3-(Dimethylamino)propenoate-based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-pyrazoles