All Stories

  1. Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7
  2. Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana Plant Cysteine Oxidase 4 induced by binding of substrate or substrate-mimics
  3. Dynamic Combinatorial Chemistry of Ditellurides
  4. Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment
  5. Selenalysine as a Chemical Tool for Probing Histone Post-Translational Modifications
  6. Chemical tools for probing histidine modifications
  7. Distinguishing isomeric N-methylhistidine peptidoforms by ion mobility mass spectrometry
  8. Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
  9. Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases
  10. Peptide-based inhibitors of epigenetic proteins
  11. Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3
  12. Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
  13. Top‐down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms
  14. (R)‐PFI‐2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7
  15. Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase
  16. The Role of Trp79 in β‐Actin on Histidine Methyltransferase SETD3 Catalysis
  17. Synthetic cysteine-based tools for probing protein posttranslational modifications
  18. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
  19. Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings**
  20. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
  21. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
  22. Investigation of in vitro histone H3 glycosylation using H3 tail peptides
  23. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
  24. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings
  25. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes
  26. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
  27. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
  28. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
  29. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents
  30. Probing lysine posttranslational modifications by unnatural amino acids
  31. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
  32. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases
  33. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins
  34. Substrate Specificity for Human Histidine Methyltransferase SETD3
  35. Characterization of Cyclic N ‐Acyliminium Ions by Infrared Ion Spectroscopy
  36. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy
  37. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy
  38. β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3
  39. Do Sulfonamides Interact with Aromatic Rings?
  40. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
  41. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
  42. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases
  43. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics
  44. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
  45. Probing Halogen−π versus CH−π Interactions in Molecular Balance
  46. Effect of lysine side chain length on histone lysine acetyltransferase catalysis
  47. Front Cover: Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols (ChemPhysChem 11/2020)
  48. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  49. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
  50. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  51. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
  52. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
  53. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails
  54. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
  55. Lysine Ethylation by Histone Lysine Methyltransferases
  56. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
  57. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2
  58. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
  59. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
  60. Catalytic Staudinger Reduction at Room Temperature
  61. Investigating the active site of human trimethyllysine hydroxylase
  62. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
  63. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols
  64. Mechanistic Insight into the Catalytic Staudinger Ligation
  65. Catalytic transport of molecular cargo using diffusive binding along a polymer track
  66. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
  67. Importance of the main chain of lysine for histone lysine methyltransferase catalysis
  68. Biomolecular Recognition of Methylated Histones
  69. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2
  70. Structure-Activity Relationship Studies on (R )-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
  71. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
  72. 2OG regulates binding of hydroxylated HIF to PHD2
  73. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
  74. Sustainable organophosphorus-catalysed Staudinger reduction
  75. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
  76. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation−π Interactions
  77. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine
  78. Fluorinated trimethyllysine as a19F NMR probe for trimethyllysine hydroxylase catalysis
  79. Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
  80. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition
  81. Multicolor Photoluminescence Including White-Light Emission by a Single Host–Guest Complex
  82. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  83. Natural supramolecular protein assemblies
  84. Substrate scope for trimethyllysine hydroxylase catalysis
  85. ChemInform Abstract: Chemoselective Calcium-Catalyzed Direct Amidation of Carboxylic Esters.
  86. ChemInform Abstract: Natural Supramolecular Protein Assemblies
  87. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  88. ChemInform Abstract: Zirconium-Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
  89. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
  90. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
  91. Zirconium-catalyzed direct amide bond formation between carboxylic esters and amines
  92. Chemoselective calcium-catalysed direct amidation of carboxylic esters
  93. ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.
  94. Thermodynamic investigation of Z33-antibody interaction leads to selective purification of human antibodies
  95. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions
  96. Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
  97. Catenane versus ring: do both assemblies of CS2 hydrolase exhibit the same stability and catalytic activity?
  98. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase
  99. The Effect of the Length of Histone H3K4me3 on Recognition by Reader Proteins
  100. Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides
  101. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
  102. Evidence that the catenane form of CS2 hydrolase is not an artefact
  103. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
  104. Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
  105. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase
  106. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
  107. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
  108. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model
  109. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL
  110. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
  111. Therapeutic Manipulation of the HIF Hydroxylases
  112. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
  113. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals
  114. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
  115. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
  116. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
  117. Direct Analysis of Enzyme-Catalyzed DNA Demethylation
  118. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
  119. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
  120. ChemInform Abstract: Triflic Anhydride Mediated Synthesis of Oxazoles.
  121. Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
  122. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  123. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  124. Triflic anhydride-mediated synthesis of oxazoles
  125. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
  126. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline
  127. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
  128. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥
  129. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site
  130. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
  131. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
  132. 3-(Dimethylamino)propenoate-based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-pyrazoles