All Stories

  1. Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana Plant Cysteine Oxidase 4 induced by binding of substrate or substrate-mimics
  2. Dynamic Combinatorial Chemistry of Ditellurides
  3. Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment
  4. Selenalysine as a Chemical Tool for Probing Histone Post-Translational Modifications
  5. Chemical tools for probing histidine modifications
  6. Distinguishing isomeric N-methylhistidine peptidoforms by ion mobility mass spectrometry
  7. Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
  8. Investigating the N-terminal linker histone H1 subtypes as substrates for JmjC lysine demethylases
  9. Peptide-based inhibitors of epigenetic proteins
  10. Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3
  11. Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
  12. Top‐down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms
  13. (R)‐PFI‐2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7
  14. Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase
  15. The Role of Trp79 in β‐Actin on Histidine Methyltransferase SETD3 Catalysis
  16. Synthetic cysteine-based tools for probing protein posttranslational modifications
  17. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
  18. Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings**
  19. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
  20. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
  21. Investigation of in vitro histone H3 glycosylation using H3 tail peptides
  22. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
  23. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings
  24. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes
  25. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
  26. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
  27. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
  28. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents
  29. Probing lysine posttranslational modifications by unnatural amino acids
  30. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
  31. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases
  32. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins
  33. Substrate Specificity for Human Histidine Methyltransferase SETD3
  34. Characterization of Cyclic N ‐Acyliminium Ions by Infrared Ion Spectroscopy
  35. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy
  36. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy
  37. β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3
  38. Do Sulfonamides Interact with Aromatic Rings?
  39. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
  40. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
  41. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases
  42. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics
  43. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
  44. Probing Halogen−π versus CH−π Interactions in Molecular Balance
  45. Effect of lysine side chain length on histone lysine acetyltransferase catalysis
  46. Front Cover: Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols (ChemPhysChem 11/2020)
  47. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  48. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
  49. Through‐Space Polar‐π Interactions in 2,6‐Diarylthiophenols
  50. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
  51. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
  52. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails
  53. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
  54. Lysine Ethylation by Histone Lysine Methyltransferases
  55. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
  56. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2
  57. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
  58. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
  59. Catalytic Staudinger Reduction at Room Temperature
  60. Investigating the active site of human trimethyllysine hydroxylase
  61. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
  62. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols
  63. Mechanistic Insight into the Catalytic Staudinger Ligation
  64. Catalytic transport of molecular cargo using diffusive binding along a polymer track
  65. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
  66. Importance of the main chain of lysine for histone lysine methyltransferase catalysis
  67. Biomolecular Recognition of Methylated Histones
  68. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2
  69. Structure-Activity Relationship Studies on (R )-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
  70. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
  71. 2OG regulates binding of hydroxylated HIF to PHD2
  72. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
  73. Sustainable organophosphorus-catalysed Staudinger reduction
  74. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
  75. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation−π Interactions
  76. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine
  77. Fluorinated trimethyllysine as a19F NMR probe for trimethyllysine hydroxylase catalysis
  78. Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
  79. Investigatingd-lysine stereochemistry for epigenetic methylation, demethylation and recognition
  80. Multicolor Photoluminescence Including White-Light Emission by a Single Host–Guest Complex
  81. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  82. Natural supramolecular protein assemblies
  83. Substrate scope for trimethyllysine hydroxylase catalysis
  84. ChemInform Abstract: Chemoselective Calcium-Catalyzed Direct Amidation of Carboxylic Esters.
  85. ChemInform Abstract: Natural Supramolecular Protein Assemblies
  86. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis
  87. ChemInform Abstract: Zirconium-Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
  88. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
  89. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
  90. Zirconium-catalyzed direct amide bond formation between carboxylic esters and amines
  91. Chemoselective calcium-catalysed direct amidation of carboxylic esters
  92. ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.
  93. Thermodynamic investigation of Z33-antibody interaction leads to selective purification of human antibodies
  94. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions
  95. Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
  96. Catenane versus ring: do both assemblies of CS2 hydrolase exhibit the same stability and catalytic activity?
  97. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase
  98. The Effect of the Length of Histone H3K4me3 on Recognition by Reader Proteins
  99. Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides
  100. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
  101. Evidence that the catenane form of CS2 hydrolase is not an artefact
  102. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
  103. Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
  104. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase
  105. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
  106. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
  107. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model
  108. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL
  109. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
  110. Therapeutic Manipulation of the HIF Hydroxylases
  111. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
  112. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals
  113. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
  114. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
  115. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
  116. Direct Analysis of Enzyme-Catalyzed DNA Demethylation
  117. Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
  118. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
  119. ChemInform Abstract: Triflic Anhydride Mediated Synthesis of Oxazoles.
  120. Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
  121. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  122. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water
  123. Triflic anhydride-mediated synthesis of oxazoles
  124. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
  125. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline
  126. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
  127. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥
  128. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site
  129. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
  130. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
  131. 3-(Dimethylamino)propenoate-based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-pyrazoles