All Stories

  1. Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

    Article • Proceedings of the National Academy of Sciences, April 2022, Proceedings of the National Academy of Sciences

    Christopher Schofield

  2. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

    Article • Hypoxia, November 2018, Dove Medical Press

    Christopher Schofield

  3. Symmetry breaking by enzyme-catalyzed epoxide hydrolysis

    Article • IUCrJ, May 2018, International Union of Crystallography

    Christopher Schofield

  4. New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis

    Article • Antimicrobial Agents and Chemotherapy, October 2017, ASM Journals

    Christopher Schofield

  5. Cyclic Boronates Inhibit All Classes of β-Lactamases

    Article • Antimicrobial Agents and Chemotherapy, January 2017, ASM Journals

    Christopher Schofield

  6. Interaction of Avibactam with Class B Metallo-β-Lactamases

    Article • Antimicrobial Agents and Chemotherapy, July 2016, ASM Journals

    Martine I Abboud, Professor Jean-Marie A FRERE, Christopher Schofield

  7. On the pivotal role of PPAR  in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

    Article • The FASEB Journal, April 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Andrew J Murray, Prof. Kieran Clarke, Prof Peter A Robbins, Christopher Schofield

  8. Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

    Article • Antimicrobial Agents and Chemotherapy, December 2015, ASM Journals

    Professor CEMAL SANDALLI, Martine I Abboud, Christopher Schofield

  9. Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

    Article • Antimicrobial Agents and Chemotherapy, October 2015, ASM Journals

    Christopher Schofield

  10. Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Christopher Schofield

  11. Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy

    Article • New Journal of Chemistry, September 2014, Royal Society of Chemistry

    Christopher Schofield

  12. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Article • Hypoxia, July 2014, Taylor & Francis

    Christopher Schofield

  13. Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Christopher Schofield

  14. Structural insights into how 5-hydroxymethylation influences transcription factor binding

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Tom Brown, Christopher Schofield

  15. Modulating carnitine levels by targeting its biosynthesis – selective inhibition of γ-butyrobetaine hydroxylase

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Christopher Schofield

  16. Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Christopher Schofield

  17. The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

    Article • Chemical Science, January 2013, Royal Society of Chemistry

    Christopher Schofield

  18. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Refaat B Hamed, Christopher Schofield