Click chemistry with DNA

Afaf H. El-Sagheer, Tom Brown
  • Chemical Society Reviews, January 2010, Royal Society of Chemistry
  • DOI: 10.1039/b901971p

Click Chemistry on DNA

What is it about?

A review of publications on DNA click chemistry; methods to join together nucleic acids chemically and to label them with reporter groups such as fluorescent dyes.

Why is it important?

A new paradigm in nucleic acid chemistry enabling the synthesis of modified nucleic acids and DNA and RNA analogues that could not previously be made.

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