All Stories

  1. Offset nail fixation for intertrochanteric fractures improves reduction and lag screw position
  2. Disease activity affects the recurrent deformities of the lesser toes after resection arthroplasty for rheumatoid forefoot deformity
  3. Sustained anti-osteoporotic action of risedronate compared to anti-RANKL antibody following discontinuation in ovariectomized mice
  4. Type 2 innate lymphoid cells inhibit the differentiation of osteoclasts and protect from ovariectomy-induced bone loss
  5. Relationship Between Pain Reduction and Improvement in Health-Related Quality of Life in Patients with Knee Pain Due to Osteoarthritis Receiving Duloxetine: Exploratory Post Hoc Analysis of a Japanese Phase 3 Randomized Study
  6. Prevalence of Facet Effusion and Its Relationship with Lumbar Spondylolisthesis and Low Back Pain: The Wakayama Spine Study
  7. Reconstruction Using Frozen Autograft for Disseminated Phosphaturic Mesenchymal Tumor of the Humerus after a Pathological Fracture
  8. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity
  9. Phase II/III, randomized, double-blind, parallel-group study of monthly delayed-release versus daily immediate-release risedronate tablets in Japanese patients with involutional osteoporosis
  10. Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds
  11. Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)
  12. Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan
  13. Factors related to the quality of life in patients with bone metastases
  14. Development of nomograms for prognostication of patients with primary soft tissue sarcomas of the trunk and extremity: report from the Bone and Soft Tissue Tumor Registry in Japan
  15. A sliding scale to predict postoperative complications undergoing posterior spine surgery
  16. Hypermobile Medial Meniscus
  17. Factors affecting bone union after distal shortening oblique osteotomy of the lesser metatarsals
  18. Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis
  19. Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study
  20. Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway
  21. Spinal cord swelling in patients with cervical compression myelopathy
  22. Gorham-Stout Syndrome of the Shoulder Girdle Successfully Controlled by Antiresorptive Agents
  23. Intraoperative Tibial Anteroposterior Axis Could Not Be Replicated After Tibial Osteotomy in Total Knee Arthroplasty
  24. Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations
  25. Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation
  26. CTLA4‐Ig directly inhibits osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages
  27. Complications of implant removal in ankle fractures
  28. Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled ph...
  29. RANKL is a therapeutic target of bone destruction in rheumatoid arthritis
  30. Predictive factors for complications after surgical treatment for schwannomas of the extremities
  31. Bicruciate-stabilised total knee arthroplasty provides good functional stability during high-flexion weight-bearing activities
  32. Molecular understanding of pharmacological treatment of osteoporosis
  33. Influence of incidental dural tears and their primary microendoscopic repairs on surgical outcomes in patients undergoing microendoscopic lumbar surgery
  34. Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma
  35. Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
  36. Minimum clinically important difference in outcome scores among patients undergoing cervical laminoplasty
  37. Association Between Normothermia at the End of Surgery and Postoperative Complications Following Orthopedic Surgery
  38. Hypoglossal Nerve Palsy as a Cause of Severe Dysphagia along with the Oropharyngeal Stenosis due to Occipitocervical Kyphosis
  39. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens
  40. Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner
  41. Multi-layered PLLA-nanosheets loaded with FGF-2 induce robust bone regeneration with controlled release in critical-sized mouse femoral defects
  42. Successful Treatment of Atlantoaxial Subluxation in an Adolescent Patient with BrachytelephalangicChondrodysplasia Punctata
  43. Bilateral Stress Fractures of the Talus Associated with Adult-Acquired Flatfoot Deformities
  44. Mental State Can Influence the Degree of Postoperative Axial Neck Pain Following Cervical Laminoplasty
  45. Validation study of a diagnostic scoring system for sacroiliac joint-related pain
  46. Heterotopic Ossification of the Peroneus Longus Tendon in the Retromalleolar Portion with the Peroneus Quartus Muscle: A Case Report
  47. Wrist Arthrodesis in Rheumatoid Arthritis Using an LCP Metaphyseal Locking Plate versus an AO Wrist Fusion Plate
  48. The utility of 25-question Geriatric Locomotive Function Scale for evaluating functional ability and disease activity in Japanese rheumatoid arthritis patients: A cross-sectional study using NinJa database
  49. The effect of switching from teriparatide to anti-RANKL antibody on cancellous and cortical bone in ovariectomized mice
  50. Secondary Chondrosarcoma Presenting with Symptoms Similar to Thoracic Outlet Syndrome
  51. Total Hip Arthroplasty in a Patient with Oto-Spondylo-Megaepiphyseal Dysplasia Planned by Three-Dimensional Motion Analyses and Full-Scale Three-Dimensional Plaster Model of Bones
  52. RANKL: A therapeutic target for bone destruction in rheumatoid arthritis
  53. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in t...
  54. Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study
  55. Association of Lumbar Spondylolisthesis With Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort
  56. Capturing microscopic features of bone remodeling into a macroscopic model based on biological rationales of bone adaptation
  57. Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
  58. Wear resistance of poly(2‐methacryloyloxyethyl phosphorylcholine)‐grafted carbon fiber reinforced poly(ether ether ketone) liners against metal and ceramic femoral heads
  59. C7 sagittal vertical axis is the determinant of the C5–C7 angle in cervical sagittal alignment
  60. Prognostic factors associated with the surgical indication for lumbar spinal stenosis patients less responsive to conservative treatments
  61. Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1
  62. The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study
  63. Mortality and morbidity after spinal surgery in patients with Parkinson's disease: a retrospective matched-pair cohort study
  64. Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study
  65. Different regulation of limb development by p63 transcript variants
  66. The effects of presence of a backside screw hole on biotribological behavior of phospholipid polymer-grafted crosslinked polyethylene
  67. The Japanese version of the STarT Back Tool predicts 6-month clinical outcomes of low back pain
  68. The role of medial meniscus posterior root tear and proximal tibial morphology in the development of spontaneous osteonecrosis and osteoarthritis of the knee
  69. Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63
  70. RANKL-Independent Osteoclastogenesis: A Long-Standing Controversy
  71. Estimated risk for chronic pain determined using the generic STarT Back 5-item screening tool
  72. Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability study 2005–2015
  73. Skeletal-related events and prognosis in urothelial cancer patients with bone metastasis
  74. Multiple Acrometastases in a Patient with Renal Pelvic Urothelial Cancer
  75. Recalcitrant Lateral Premalleolar Bursitis of the Ankle Associated with Lateral Ankle Instability
  76. Anterior Impingement Syndrome of the Ankle Caused by Osteoid Osteoma in the Talar Neck Treated with Arthroscopy and 3D C-Arm-Based Imaging
  77. A hydrated phospholipid polymer-grafted layer prevents lipid-related oxidative degradation of cross-linked polyethylene
  78. Stenosing Tenosynovitis of the Flexor Hallucis Longus Tendon Associated with the Plantar Capsular Accessory Ossicle at the Interphalangeal Joint of the Great Toe
  79. Real-world evidence of raloxifene versus alendronate in preventing non-vertebral fractures in Japanese women with osteoporosis: retrospective analysis of a hospital claims database
  80. The relationship between findings on magnetic resonance imaging and previous history of low back pain
  81. Patient Satisfaction with Posterior Decompression Surgery for Cervical Ossification of the Posterior Longitudinal Ligament: Prognostic Radiographic Factors and Patient-Reported Outcomes for the Effectiveness of Surgical Treatment
  82. Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids
  83. Is osteoporosis a predictor for future sarcopenia or vice versa? Four-year observations between the second and third ROAD study surveys
  84. Clinical safety and wear resistance of the phospholipid polymer-grafted highly cross-linked polyethylene liner
  85. Relationship between roentgenographic joint destruction in the hands and functional disorders among patients with rheumatoid arthritis
  86. A Patient-Specific Instrument for Femoral Stem Placement During Total Hip Arthroplasty
  87. Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
  88. Diagnosing Discogenic Low Back Pain Associated with Degenerative Disc Disease Using a Medical Interview
  89. Effect of Preoperative Sagittal Balance on Cervical Laminoplasty Outcomes
  90. Total Talar Replacement for Idiopathic Necrosis of the Talus: A Case Report
  91. Time trends and risk factors for perioperative complications in total ankle arthroplasty: retrospective analysis using a national database in Japan
  92. The Serum Phosphorylated Neurofilament Heavy Subunit as a Predictive Marker for Outcome in Adult Patients after Traumatic Brain Injury
  93. Smad4 is required to inhibit osteoclastogenesis and maintain bone mass
  94. Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study
  95. The crucial role of Erk2 in demyelinating inflammation in the central nervous system
  96. Evaluation of wear suppression for phospholipid polymer-grafted ultra-high molecular weight polyethylene at concentrated contact
  97. Postoperative outcomes of major lower extremity amputations in patients with diabetes and peripheral artery disease: analysis using the Diagnosis Procedure Combination database in Japan
  98. The Association between the Cross-Sectional Area of the Dural Sac and Low Back Pain in a Large Population: The Wakayama Spine Study
  99. Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2
  100. A population approach to analyze the effectiveness of a back extension exercise “One Stretch” in patients with low back pain: A replication study
  101. Impingement of the Mobile Bearing on the Lateral Wall of the Tibial Tray in Unicompartmental Knee Arthroplasty
  102. Identification of Nedd9 as a TGF-β-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis
  103. Myositis ossificans after navigated knee surgery: A report of two cases and literature review
  104. A modified technique to reduce tibial keel cutting errors during an Oxford unicompartmental knee arthroplasty
  105. Thoracic intradural extramedullary lesions causing progressive myelopathy as an initial manifestation of granulomatosis with polyangiitis: a case report and review of literature
  106. Cervical Anterolisthesis
  107. Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability
  108. Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study
  109. Predictive Factors for Subjective Improvement in Lumbar Spinal Stenosis Patients with Nonsurgical Treatment: A 3-Year Prospective Cohort Study
  110. Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study
  111. Does the microendoscopic technique reduce mortality and major complications in patients undergoing lumbar discectomy? A propensity score–matched analysis using a nationwide administrative database
  112. Foreword
  113. Extensive ossification of the paraspinal ligaments in a patient with vitamin D-resistant rickets: Case report with literature review
  114. Interdigital Neuroma in the Second Intermetatarsal Space Associated with Metatarsophalangeal Joint Instability
  115. Missed Medial Malleolar Fracture Associated With Achilles Tendon Rupture: A Case Report and Literature Review
  116. Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: the ROAD study
  117. Risk of infectious complications associated with blood transfusion in elective spinal surgery—a propensity score matched analysis
  118. Twice cutting method reduces tibial cutting error in unicompartmental knee arthroplasty
  119. Concurrent spinal schwannoma and meningioma mimicking a single cervical dumbbell-shaped tumor: case report
  120. Evaluation of Comorbidity Indices for a Study of Patient Outcomes Following Cervical Decompression Surgery
  121. Hand-Held Bone Cutting Tool With Autonomous Penetration Detection for Spinal Surgery
  122. Psychometric Validation of the Japanese Version of the Neuropathic Pain Symptom Inventory
  123. The impact of joint disease on the Modified Health Assessment Questionnaire scores in rheumatoid arthritis patients: A cross-sectional study using the National Database of Rheumatic Diseases by iR-net in Japan
  124. The effect of cartilage degeneration on ultrasound speed in human articular cartilage
  125. Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study
  126. Complications and Postoperative Mortality Rate After Surgery for Pathological Femur Fracture Related to Bone Metastasis: Analysis of a Nationwide Database
  127. Perioperative stroke in patients undergoing elective spinal surgery: a retrospective analysis using the Japanese diagnosis procedure combination database
  128. Phosphorylated neurofilament subunit levels in the serum of cervical compressive myelopathy patients
  129. Association between dementia and postoperative complications after hip fracture surgery in the elderly: analysis of 87,654 patients using a national administrative database
  130. Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer
  131. Quantitative and qualitative characterization of expanded CD4+ T cell clones in rheumatoid arthritis patients
  132. Effects of extra irradiation on surface and bulk properties of PMPC-grafted cross-linked polyethylene
  133. Risk Factors for Prolonged Treatment of Whiplash-Associated Disorders
  134. Elevated levels of phosphorylated neurofilament heavy subunit in the cerebrospinal fluid of patients with lumbar spinal stenosis: preliminary findings
  135. Repeated total en bloc spondylectomy for spinal metastases at different sites in one patient
  136. Secure fixation of femoral bone plug with a suspensory button in anatomical anterior cruciate ligament reconstruction with bone-patellar tendon-bone graft
  137. Disappearance of lung adenocarcinoma after total en bloc spondylectomy using frozen tumor-bearing vertebra for reconstruction
  138. Factors affecting changes in the serum levels of 25-hydroxyvitamin D: a 3-year follow-up of the ROAD study
  139. Prediction of proximal femur strength by a quantitative computed tomography-based finite element method—Creation of predicted strength data of the proximal femur according to age range in a normal population
  140. Prevalence of total knee arthroplasty and its predictive factors in Japanese patients with rheumatoid arthritis: Analysis using the NinJa cohort
  141. 8-Iso-Prostaglandin F2α and Metabolic Syndrome
  142. Influences of dehydration and rehydration on the lubrication properties of phospholipid polymer-grafted cross-linked polyethylene
  143. Individual and combining effects of anti-RANKL monoclonal antibody and teriparatide in ovariectomized mice
  144. Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1)
  145. Genomewide Comprehensive Analysis Reveals Critical Cooperation Between Smad and c-Fos in RANKL-Induced Osteoclastogenesis
  146. Wear resistance of the biocompatible phospholipid polymer-grafted highly cross-linked polyethylene liner against larger femoral head
  147. Comparison of the Japanese Orthopaedic Association (JOA) Score and Modified JOA (mJOA) Score for the Assessment of Cervical Myelopathy: A Multicenter Observational Study
  148. Risks of In-Hospital Death and Complications After Fusion Surgery in Patients with Atlantoaxial Subluxation: Analysis of 1090 Patients Using the Japanese Diagnosis Procedure Combination Database
  149. The association of combination of disc degeneration, end plate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study
  150. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2
  151. Total Hip Arthroplasty After Rotational Acetabular Osteotomy
  152. Prophylactic effect of fondaparinux and enoxaparin for preventing pulmonary embolism after total hip or knee arthroplasty: A retrospective observational study using the Japanese Diagnosis Procedure Combination database
  153. Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study
  154. Effects of Surface Modification and Bulk Geometry on the Biotribological Behavior of Cross-Linked Polyethylene: Wear Testing and Finite Element Analysis
  155. Erratum to: Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study
  156. Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury
  157. Long-Term Outcomes of Cervical Laminoplasty in the Elderly
  158. Patient satisfaction with double-door laminoplasty for cervical compression myelopathy
  159. Prospective multicenter surveillance and risk factor analysis of deep surgical site infection after posterior thoracic and/or lumbar spinal surgery in adults
  160. Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding proteins
  161. Temporal Trends in Characteristics of Newly Diagnosed Nontraumatic Osteonecrosis of the Femoral Head From 1997 to 2011: A Hospital-Based Sentinel Monitoring System in Japan
  162. Identification of SCAN Domain Zinc-Finger Gene ZNF449 as a Novel Factor of Chondrogenesis
  163. SOX10 Transactivates S100B to Suppress Schwann Cell Proliferation and to Promote Myelination
  164. New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide
  165. Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell–cell fusion
  166. Mutual associations among musculoskeletal diseases and metabolic syndrome components: A 3-year follow-up of the ROAD study
  167. Necrotising soft-tissue infections of the upper limb: risk factors for amputation and death
  168. Effects of fondaparinux on pulmonary embolism following hemiarthroplasty for femoral neck fracture: a retrospective observational study using the Japanese Diagnosis Procedure Combination database
  169. Progression of ossification of the posterior longitudinal ligament of the thoracic spine following posterior decompression and stabilization
  170. Multidirectional Wear and Impact-to-wear Tests of Phospholipid-polymer-grafted and Vitamin E-blended Crosslinked Polyethylene: A Pilot Study
  171. Ischemic stroke after cervical spine injury: analysis of 11,005 patients using the Japanese Diagnosis Procedure Combination database
  172. Serum levels of 25-hydroxyvitamin D and the occurrence of musculoskeletal diseases: a 3-year follow-up to the road study
  173. Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: Three-year results of a prospective consecutive series
  174. Development of femoral bone fracture model simulating muscular contraction force by pneumatic rubber actuator
  175. Poly(2-methacryloyloxyethyl phosphorylcholine) grafting and vitamin E blending for high wear resistance and oxidative stability of orthopedic bearings
  176. Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury
  177. Clinical Trials Express:Fracture Risk Reduction With Denosumab in Japanese Postmenopausal Women and Men With Osteoporosis: Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)
  178. Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan
  179. Eccentric Femoral Tunnel Widening in Anatomic Anterior Cruciate Ligament Reconstruction
  180. Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study
  181. Cervical Microendoscopic Interlaminar Decompression through a Midline Approach in Patients with Cervical Myelopathy: A Technical Note
  182. Nomogram Predicting Severe Adverse Events After Musculoskeletal Tumor Surgery: Analysis of a National Administrative Database
  183. Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan: the ROAD study
  184. Autonomous penetration detection for bone cutting tool using demonstration-based learning
  185. A review of denosumab for the treatment of osteoporosis
  186. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study
  187. Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD study
  188. Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study
  189. Grafting of poly(2-methacryloyloxyethyl phosphorylcholine) on polyethylene liner in artificial hip joints reduces production of wear particles
  190. Recurrent hemarthrosis after total knee arthroplasty caused by the impingement of a remnant lateral meniscus: A case report
  191. Usefulness of QuickDASH in patients with cervical laminoplasty
  192. Anti-apoptotic Bcl-2 family member Mcl-1 regulates cell viability and bone-resorbing activity of osteoclasts
  193. Determination of differential gene expression profiles in superficial and deeper zones of mature rat articular cartilage using RNA sequencing of laser microdissected tissue specimens
  194. Midterm Results of Resection Arthroplasty for Forefoot Deformities in Patients with Rheumatoid Arthritis and the Risk Factors Associated with Patient Dissatisfaction
  195. S100A1 and S100B are dispensable for endochondral ossification during skeletal development
  196. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast
  197. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
  198. Vertebral fractures affect functional status in postmenopausal rheumatoid arthritis patients
  199. Prevalence, incidence and progression of lumbar spondylosis by gender and age strata
  200. Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study
  201. Clinical outcome of anatomic double-bundle ACL reconstruction and 3D CT model-based validation of femoral socket aperture position
  202. Validity and Reliability of the Japanese Version of the painDETECT Questionnaire: A Multicenter Observational Study
  203. Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation
  204. Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study
  205. Impact of Hospital Volume on Postoperative Complications and In-Hospital Mortality After Musculoskeletal Tumor Surgery
  206. Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study
  207. Iliotibial band irritation caused by the EndoButton after anatomic double-bundle anterior cruciate ligament reconstruction: Report of two cases
  208. Cervical canal stenosis caused by progressive fusion and enlargement of cervical vertebrae with features of Proteus syndrome and Klippel–Feil syndrome
  209. Impact of age and comorbidity burden on mortality and major complications in older adults undergoing orthopaedic surgery: an analysis using the Japanese diagnosis procedure combination database
  210. Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study
  211. Influence of navigation system updates on total knee arthroplasty
  212. An Additional Reference Axis Improves Femoral Rotation Alignment in Image-Free Computer Navigation Assisted Total Knee Arthroplasty
  213. Economic Impact of Venous Thromboembolism Following Major Orthopaedic Surgery in Japan
  214. Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b-mediated microtubule stabilization
  215. Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study
  216. Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database
  217. Associations between neck and shoulder discomfort (Katakori) and job demand, job control, and worksite support
  218. Patellar Fracture After Total Knee Arthroplasty for Rheumatoid Arthritis
  219. Pyogenic discitis due to Abiotrophia adiacens
  220. Regulation of bone destruction in rheumatoid arthritis through RANKL-RANK pathways
  221. Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study
  222. Ultrasonographic Evaluation of Displaced Neurovascular Bundle in Dupuytren Disease
  223. Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport
  224. Regulation of RANKL-Induced Osteoclastogenesis by TGF-β
  225. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study
  226. Natural Course and Prognostic Factors in Patients With Mild Cervical Spondylotic Myelopathy With Increased Signal Intensity on T2-Weighted Magnetic Resonance Imaging
  227. Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption
  228. Three-Dimensional Fluoroscopic Navigation Guidance for Femoral Tunnel Creation in Revision Anterior Cruciate Ligament Reconstruction
  229. The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure: a nested case control study
  230. Recent Advance in Epigenetics - Application to The Regulation of Osteoclast Differentiation
  231. Analysis of the affected joints in rheumatoid arthritis patients in a large Japanese cohort
  232. Fungal arthritis of the wrist caused by Candida parapsilosis during infliximab therapy for rheumatoid arthritis
  233. Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study
  234. Risk factors affecting inhospital mortality after hip fracture: retrospective analysis using the Japanese Diagnosis Procedure Combination Database
  235. Risk Factors for Pulmonary Embolism and the Effects of Fondaparinux After Total Hip and Knee Arthroplasty: A Retrospective Observational Study with Use of a National Database in Japan
  236. Epigenetic regulation of osteoclast differentiation
  237. Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the Akt pathway and the ERK/Bim axis
  238. Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1
  239. Are Bone and Serum Cefazolin Concentrations Adequate for Antimicrobial Prophylaxis?
  240. Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody
  241. Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6
  242. Bim: Guardian of Tissue Homeostasis and Critical Regulator of the Immune System, Tumorigenesis and Bone Biology
  243. Hes1 functions downstream of growth factors to maintain oligodendrocyte lineage cells in the early progenitor stage
  244. Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis
  245. tPA Activates LDL Receptor-Related Protein 1-Mediated Mitogenic Signaling Involving the p90RSK and GSK3β Pathway
  246. Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone
  247. Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury
  248. The usefulness of neutrophil CD64 expression in the diagnosis of local infection in patients with rheumatoid arthritis in daily practice
  249. Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis
  250. Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone
  251. Statistics for orthopedic surgery 2006–2007: data from the Japanese Diagnosis Procedure Combination database
  252. Impact of biologics on the prevalence of orthopedic surgery in the National Database of Rheumatic Diseases in Japan
  253. PEDF regulates osteoclasts via osteoprotegerin and RANKL
  254. New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro
  255. Preparation and characterization of a mouse osteoclast-like multinucleated cell population
  256. NF-κB2 (p100) emerges as a negative regulator of TNFα-induced osteoclastogenesis
  257. Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts
  258. NF-κB2 (p100) limits TNF-α–induced osteoclastogenesis
  259. The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice
  260. Over-expression of integrin β3 can partially overcome the defect of integrin β3 signaling in transglutaminase 2 null macrophages
  261. Neutrophil CD64 expression in the diagnosis of local musculoskeletal infection and the impact of antibiotics
  262. Rheumatoid arthritis associated with osteopetrosis
  263. Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α
  264. Prevalence of joint replacement surgery in rheumatoid arthritis patients: cross-sectional analysis in a large observational cohort in Japan
  265. Regulation of Osteoclast Apoptosis by Bcl-2 Family Protein Bim and Caspase-3
  266. Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis
  267. A Novel Function of RING Finger Protein 10 in Transcriptional Regulation of the Myelin-Associated Glycoprotein Gene and Myelin Formation in Schwann Cells
  268. Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption
  269. Pivotal Role of Bcl-2 Family Proteins in the Regulation of Chondrocyte Apoptosis
  270. Tumor necrosis factor-α inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways
  271. Osteoporotic bone formation in mice lackingtob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation
  272. MKK6–p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts
  273. Posttranslational Regulation of Bim by Caspase-3
  274. Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling
  275. Negative Feedback Loop in the Bim-Caspase-3 Axis Regulating Apoptosis and Activity of Osteoclasts
  276. Overexpression of γ-Glutamyltransferase in Transgenic Mice Accelerates Bone Resorption and Causes Osteoporosis
  277. Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis
  278. Molecular mechanism of bone destruction in rheumatoid arthritis
  279. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2
  280. Ectodomain Shedding of Receptor Activator of NF-κB Ligand
  281. Erk pathways negatively regulate matrix mineralization
  282. Signaling Axis in Osteoclast Biology and Therapeutic Targeting in the RANKL/RANK/OPG System
  283. Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas
  284. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
  285. Negative Regulation of Osteoclastogenesis by Ectodomain Shedding of Receptor Activator of NF-κB Ligand
  286. Pro-inflammatory Cytokine Tumor Necrosis Factor-α Induces Bone Morphogenetic Protein-2 in Chondrocytes via mRNA Stabilization and Transcriptional Up-regulation
  287. Molecular Mechanism of the Life and Death of the Osteoclast
  288. The role of c-Src kinase in the regulation of osteoclast function
  289. Tissue-type Plasminogen Activator Acts as a Cytokine That Triggers Intracellular Signal Transduction and Induces Matrix Metalloproteinase-9 Gene Expression
  290. Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src
  291. Identification of an Alternatively Spliced Variant of Ca2+-promoted Ras Inactivator as a Possible Regulator of RANKL Shedding
  292. Regulation of Osteoclast Apoptosis and Motility by Small GTPase Binding Protein Rac1
  293. Monokine induced by interferon-  is induced by receptor activator of nuclear factor  B ligand and is involved in osteoclast adhesion and migration
  294. Intracellular signal transduction pathways: good therapeutic targets for joint destruction in rheumatoid arthritis
  295. RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
  296. In vitro and in vivo assays for osteoclast apoptosis
  297. Essential Role of Synoviolin in Embryogenesis
  298. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
  299. Opposing Extracellular Signal-Regulated Kinase and Akt Pathways Control Schwann Cell Myelination
  300. Osteoclast Differentiation by RANKL Requires NF-κB-Mediated Downregulation of Cyclin-Dependent Kinase 6 (Cdk6)
  301. Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells
  302. Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts
  303. Fcγ receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction
  304. Src Kinase Activity Is Essential for Osteoclast Function
  305. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: Therapeutic potential in rheumatoid arthritis
  306. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
  307. Association of sustained ERK activity with integrin β3 induction during receptor activator of nuclear factor kappaB ligand (RANKL)-directed osteoclast differentiation
  308. Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts
  309. Signal transduction pathways regulating osteoclast differentiation and function
  310. Jun Dimerization Protein 2 (JDP2), a Member of the AP-1 Family of Transcription Factor, Mediates Osteoclast Differentiation Induced by RANKL
  311. Extracellular Signal-regulated Kinase Mediates Phosphorylation of Tropomyosin-1 to Promote Cytoskeleton Remodeling in Response to Oxidative Stress: Impact on Membrane Blebbing
  312. Regulation of cytochromecoxidase activity by c-Src in osteoclasts
  313. Traf6 is essential for murine tooth cusp morphogenesis
  314. A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders
  315. Usefulness of absorbable screws in the Sauvé-Kapandji procedure for rheumatoid wrist reconstruction
  316. Macrophage Migration Inhibitory Factor Up-regulates Matrix Metalloproteinase-9 and -13 in Rat Osteoblasts
  317. Akt Protein Kinase Inhibits Non-apoptotic Programmed Cell Death Induced by Ceramide
  318. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
  319. Negative Regulation of BMP/Smad Signaling by Tob in Osteoblasts
  320. Partial Functional Recovery of Paraplegic Rat by Adenovirus-Mediated Gene Delivery of Constitutively Active MEK1
  321. Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts
  322. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
  323. Giant trichoblastoma mimicking malignancy
  324. Adenovirus-mediated Overexpression of C-terminal Src Kinase (Csk) in Type I Astrocytes Interferes with Cell Spreading and Attachment to Fibronectin
  325. Modulation of Osteoclast Function by Adenovirus Vector-Induced Epidermal Growth Factor Receptor
  326. A New Mechanism of Bone Destruction in Rheumatoid Arthritis: Synovial Fibroblasts Induce Osteoclastogenesis
  327. Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts
  328. Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development
  329. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption
  330. A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders
  331. Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption
  332. Tyrosine Phosphorylation and Translocation of the c-Cbl Protein after Activation of Tyrosine Kinase Signaling Pathways
  333. Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption
  334. Postmitotic Osteoclast Precursors Are Mononuclear Cells Which Express Macrophage-Associated Phenotypes
  335. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
  336. Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors
  337. Osteoclasts express high levels of p60c-src , preferentially on ruffled border membranes
  338. Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells
  339. Generating Murine Osteoclasts from Bone Marrow