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  1. Rapid Bone Formation and Remodeling via Vascular Infiltration of a Hydroxyapatite/Collagen Nanocomposite beneath the Calvarial Periosteum

    Article • Biomaterials and Biosystems, January 2026, Elsevier

    Dr KAZUHIRO AOKI

  2. Effect of Calcination Temperature and Strontium Addition on the Properties of Sol-Gelled Bioactive Glass Powder

    Article • Gels, May 2025, MDPI AG

    Dr KAZUHIRO AOKI

  3. Effects of tensile and compressive stress on bone resorption and formation parameters surrounding dental implants

    Article • Journal of the Mechanical Behavior of Biomedical Materials, May 2025, Elsevier

    Dr KAZUHIRO AOKI

  4. The genetic basis of micro-structural fragility in murine dentin: Insights from type 2 diabetes mellitus

    Article • Journal of Oral Biosciences, March 2025, Elsevier

    Dr KAZUHIRO AOKI

  5. Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model

    Article • International Journal of Molecular Sciences, June 2023, MDPI AG

    Dr KAZUHIRO AOKI

  6. Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model

    Article • Regenerative Therapy, March 2023, Elsevier

    Dr KAZUHIRO AOKI

  7. Effect of tension and compression on dynamic alveolar histomorphometry

    Article • Journal of the Mechanical Behavior of Biomedical Materials, January 2023, Elsevier

    Dr KAZUHIRO AOKI

  8. Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2

    Article • International Journal of Molecular Sciences, July 2022, MDPI AG

    Dr KAZUHIRO AOKI

  9. Tetracycline, an Appropriate Reagent for Measuring Bone-Formation Activity in the Murine Model of the Streptococcus mutans-Induced Bone Loss

    Article • Frontiers in Cellular and Infection Microbiology, September 2021, Frontiers

    Dr KAZUHIRO AOKI

  10. The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation

    Article • Frontiers in Cell and Developmental Biology, July 2021, Frontiers

    Dr KAZUHIRO AOKI

  11. Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions

    Article • Journal of the Mechanical Behavior of Biomedical Materials, April 2021, Elsevier

    Dr KAZUHIRO AOKI

  12. A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice

    Article • Bone, June 2020, Elsevier

    Dr KAZUHIRO AOKI

  13. A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in regenerated bone induced by anabolic reagents

    Article • European Journal of Orthodontics, March 2020, Oxford University Press (OUP)

    Dr KAZUHIRO AOKI

  14. Bif‐1/Endophilin B1/SH3GLB1 regulates bone homeostasis

    Article • Journal of Cellular Biochemistry, June 2019, Wiley

    Dr KAZUHIRO AOKI

  15. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation

    Article • Biochemical and Biophysical Research Communications, February 2019, Elsevier

    Dr KAZUHIRO AOKI

  16. Coupling of bone resorption and formation by RANKL reverse signalling

    Article • Nature, September 2018, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  17. Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA-r-Phosmer) Coating

    Article • ACS Applied Materials & Interfaces, June 2018, American Chemical Society (ACS)

    Dr KAZUHIRO AOKI, Professor Yu Hoshino

  18. A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis

    Article • Journal of Cellular Physiology, April 2018, Wiley

    Dr KAZUHIRO AOKI, Chiaki Kitamura

  19. Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  20. Effect of doxycycline-treated hydroxyapatite surface on bone apposition: A histomophometric study in murine maxillae

    Article • Dental Materials Journal, January 2018, Japanese Society for Dental Materials and Devices

    Dr KAZUHIRO AOKI

  21. Low-level ultrahigh-frequency and ultrashort-pulse blue laser irradiation enhances osteoblast extracellular calcification by upregulating proliferation and differentiation via transient receptor potential vanilloid 1

    Article • Lasers in Surgery and Medicine, December 2017, Wiley

    Dr KAZUHIRO AOKI

  22. The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis

    Article • Journal of Pharmacological Sciences, June 2017, Elsevier

    Dr KAZUHIRO AOKI

  23. Decontamination of Anodized Implant Surface With Different Modalities for Peri-Implantitis Treatment: Lasers and Mechanical Debridement With Citric Acid

    Article • The Journal of Periodontology, August 2016, Wiley

    Dr KAZUHIRO AOKI

  24. Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model

    Article • European Journal of Pharmacology, July 2016, Elsevier

    Dr KAZUHIRO AOKI

  25. Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling

    Article • BioEssays, June 2016, Wiley

    Dr KAZUHIRO AOKI

  26. Delivery of RANKL-Binding Peptide OP3-4 Promotes BMP-2–Induced Maxillary Bone Regeneration

    Article • Journal of Dental Research, March 2016, SAGE Publications

    Dr KAZUHIRO AOKI

  27. Ligature induced peri-implantitis: tissue destruction and inflammatory progression in a murine model

    Article • Clinical Oral Implants Research, January 2016, Wiley

    Dr KAZUHIRO AOKI

  28. A threshold of mechanical strain intensity for the direct activation of osteoblast function exists in a murine maxilla loading model

    Article • Biomechanics and Modeling in Mechanobiology, November 2015, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  29. Microgravity promotes osteoclast activity in medaka fish reared at the international space station

    Article • Scientific Reports, September 2015, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  30. The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

    Article • Arthritis Research & Therapy, September 2015, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  31. Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model

    Article • International Journal of Nanomedicine, May 2015, Dove Medical Press

    Dr KAZUHIRO AOKI

  32. Phytic Acid: An Alternative Root Canal Chelating Agent

    Article • Journal of Endodontics, February 2015, Elsevier

    Dr KAZUHIRO AOKI

  33. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma

    Article • Oncotarget, October 2014, Impact Journals, LLC

    Dr KAZUHIRO AOKI

  34. A disulfide bond replacement strategy enables the efficient design of artificial therapeutic peptides

    Article • Tetrahedron, October 2014, Elsevier

    Dr KAZUHIRO AOKI

  35. Gelatin Hydrogel as a Carrier of Recombinant Human Fibroblast Growth Factor-2 During Rat Mandibular Distraction

    Article • Journal of Oral and Maxillofacial Surgery, October 2014, Elsevier

    Dr KAZUHIRO AOKI

  36. Inhibition of BMP2-Induced Bone Formation by the p65 Subunit of NF-κB via an Interaction With Smad4

    Article • Molecular Endocrinology, September 2014, Endocrine Society

    Dr KAZUHIRO AOKI

  37. NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation

    Article • International Immunology, June 2014, Oxford University Press (OUP)

    Dr KAZUHIRO AOKI

  38. Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1

    Article • Experimental Hematology, June 2014, Elsevier

    Naoko Negishi, Dr KAZUHIRO AOKI

  39. TGF-β in dentin matrix extract induces osteoclastogenesis in vitro

    Article • Odontology, December 2013, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  40. p130Cas, Crk-Associated Substrate, Plays Important Roles in Osteoclastic Bone Resorption

    Article • Journal of Bone and Mineral Research, November 2013, Wiley

    Dr KAZUHIRO AOKI

  41. Disruption of NF-κB1 prevents bone loss caused by mechanical unloading

    Article • Journal of Bone and Mineral Research, May 2013, Wiley

    Dr KAZUHIRO AOKI

  42. The local administration of TNF-α and RANKL antagonist peptide promotes BMP-2-induced bone formation

    Article • Journal of Oral Biosciences, February 2013, Elsevier

    Dr KAZUHIRO AOKI

  43. Stimulation of Bone Formation in Cortical Bone of Mice Treated with a Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-binding Peptide That Possesses Osteoclastogenesis Inhibitory Activity

    Article • Journal of Biological Chemistry, January 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr KAZUHIRO AOKI

  44. Peptide-based delivery to bone

    Article • Advanced Drug Delivery Reviews, September 2012, Elsevier

    Dr KAZUHIRO AOKI

  45. CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction

    Article • Biochemical and Biophysical Research Communications, August 2012, Elsevier

    Dr KAZUHIRO AOKI

  46. The influence of mechanical stimulation on osteoclast localization in the mouse maxilla: bone histomorphometry and finite element analysis

    Article • Biomechanics and Modeling in Mechanobiology, May 2012, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  47. A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model

    Article • European Journal of Pharmacology, March 2012, Elsevier

    Dr KAZUHIRO AOKI

  48. Accumulation of p100, a Precursor of NF-κB2, Enhances Osteoblastic Differentiationin Vitroand Bone Formationin Vivoinaly/alyMice

    Article • Molecular Endocrinology, March 2012, Endocrine Society

    Dr KAZUHIRO AOKI

  49. Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo

    Article • International Journal of Cancer, February 2012, Wiley

    Dr KAZUHIRO AOKI

  50. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae

    Article • Journal of Bone and Mineral Metabolism, June 2011, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  51. Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide

    Article • Journal of Periodontal Research, December 2010, Wiley

    Dr KAZUHIRO AOKI

  52. A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats

    Article • Journal of Bone and Mineral Metabolism, December 2010, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  53. Suppression of NF-κB Increases Bone Formation and Ameliorates Osteopenia in Ovariectomized Mice

    Article • Endocrinology, October 2010, Endocrine Society

    Dr KAZUHIRO AOKI

  54. The Effects of Hyperbaric Oxygen on Tooth Movement into the Regenerated Area after Distraction Osteogenesis

    Article • The Cleft Palate-Craniofacial Journal, July 2010, SAGE Publications

    Dr KAZUHIRO AOKI

  55. Amount of Bone Lengthening Affects Blood Flow Recovery and Bone Mineralization after Distraction Osteogenesis in a Canine Cleft Palate Model

    Article • The Cleft Palate-Craniofacial Journal, May 2010, SAGE Publications

    Dr KAZUHIRO AOKI

  56. IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

    Article • Nature, April 2010, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  57. Effect of recombinant human fibroblast growth factor-2 on bone formation in rabbit mandibular distraction models using β-tricalcium phosphate

    Article • Congenital Anomalies, February 2010, Wiley

    Dr KAZUHIRO AOKI

  58. The Effects of NF-κB Inhibitors on Bone Formation

    Article • Journal of Oral Biosciences, January 2010, Japanese Association for Oral Biology

    Dr KAZUHIRO AOKI

  59. Increased bone mass in adult prostacyclin-deficient mice

    Article • Journal of Endocrinology, November 2009, Bioscientifica

    Dr KAZUHIRO AOKI

  60. Processing of the NF-κB2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation

    Article • Journal of Bone and Mineral Research, October 2009, Wiley

    Dr KAZUHIRO AOKI

  61. The Pivotal Role of the Alternative NF-κB Pathway in Maintenance of Basal Bone Homeostasis and Osteoclastogenesis

    Article • Journal of Bone and Mineral Research, October 2009, Wiley

    Dr KAZUHIRO AOKI

  62. LPS-Induced Inhibition of Osteogenesis Is TNF-α Dependent in a Murine Tooth Extraction Model

    Article • Journal of Bone and Mineral Research, October 2009, Wiley

    Dr KAZUHIRO AOKI

  63. Polysaccharide nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss

    Article • European Journal of Pharmaceutical Sciences, May 2009, Elsevier

    Dr KAZUHIRO AOKI

  64. Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

    Article • AJP Gastrointestinal and Liver Physiology, April 2009, American Physiological Society

    Dr KAZUHIRO AOKI

  65. Bovine dentine organic matrix down-regulates osteoclast activity

    Article • Journal of Bone and Mineral Metabolism, March 2009, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  66. Multiwalled Carbon Nanotubes Specifically Inhibit Osteoclast Differentiation and Function

    Article • Nano Letters, March 2009, American Chemical Society (ACS)

    Dr KAZUHIRO AOKI

  67. Inhibition of the classical NF-κB pathway prevents osteoclast bone-resorbing activity

    Article • Journal of Bone and Mineral Metabolism, January 2009, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  68. Applications and the Future of Peptide Drugs for Inflammatory Bone Resorption

    Article • Journal of Oral Biosciences, January 2009, Japanese Association for Oral Biology

    Dr KAZUHIRO AOKI

  69. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo

    Article • Journal of Bone and Mineral Metabolism, August 2008, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  70. Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

    Article • Science, February 2008, American Association for the Advancement of Science

    Dr KAZUHIRO AOKI

  71. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density inPyk2−/−mice

    Article • Journal of Cell Biology, September 2007, Rockefeller University Press

    Dr KAZUHIRO AOKI

  72. A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti–tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Dr KAZUHIRO AOKI

  73. NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor

    Article • Arthritis Research & Therapy, January 2007, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  74. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

    Article • Nature Medicine, November 2006, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  75. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody

    Article • Biochemical and Biophysical Research Communications, August 2006, Elsevier

    Dr KAZUHIRO AOKI

  76. A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss

    Article • Journal of Clinical Investigation, June 2006, American Society for Clinical Investigation

    Dr KAZUHIRO AOKI

  77. Bovine deciduous dentine is more susceptible to osteoclastic resorption than permanent dentine: results of quantitative analyses

    Article • Journal of Bone and Mineral Metabolism, April 2006, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  78. A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice

    Article • Journal of Periodontal Research, April 2006, Wiley

    Dr KAZUHIRO AOKI

  79. Regional distinctions in cortical bone mineral density measured by pQCT can predict alterations in material property at the tibial diaphysis of the Cynomolgus monkey

    Article • Bone, February 2006, Elsevier

    Dr KAZUHIRO AOKI

  80. Inhibition of RANKL-Induced Osteoclastogenesis by (−)-DHMEQ, a Novel NF-κB Inhibitor, Through Downregulation of NFATc1

    Article • Journal of Bone and Mineral Research, December 2004, Wiley

    Dr KAZUHIRO AOKI

  81. The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis

    Article • Bone, November 2004, Elsevier

    Dr KAZUHIRO AOKI

  82. Appearance of electron-dense segments: indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones

    Article • Journal of Electron Microscopy, August 2004, Oxford University Press (OUP)

    Dr KAZUHIRO AOKI

  83. Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

    Article • Nature Medicine, May 2004, Springer Science + Business Media

    Professor Fulvio D'Acquisto, Dr KAZUHIRO AOKI

  84. Bone mineral density of the mandible in ovariectomized rats: analyses using dual energy X-ray absorptiometry and peripheral quantitative computed tomography

    Article • Oral Diseases, January 2003, Wiley

    Dr KAZUHIRO AOKI

  85. A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders

    Article • Journal of Bone and Mineral Metabolism, September 2002, Springer Science + Business Media

    Dr KAZUHIRO AOKI, Dr. Sakae Tanaka

  86. Effects of neurectomy and tenotomy on the bone mineral density and strength of tibiae

    Article • Acta Astronautica, August 2001, Elsevier

    Dr KAZUHIRO AOKI

  87. Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis

    Article • Nature Medicine, September 2000, Springer Science + Business Media

    Dr KAZUHIRO AOKI

  88. Trabecular bone turnover, bone marrow cell development, and gene expression of bone matrix proteins after low calcium feeding in rats

    Article • Bone, December 1999, Elsevier

    Dr KAZUHIRO AOKI

  89. The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in mev/mev mutant mice

    Article • Bone, September 1999, Elsevier

    Dr KAZUHIRO AOKI

  90. Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits

    Article • Bone, December 1997, Elsevier

    Dr KAZUHIRO AOKI

  91. Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ods rats

    Article • Archives of Oral Biology, October 1997, Elsevier

    Dr KAZUHIRO AOKI