All Stories

  1. Hepatitis B virus proteome analysis identifies apolipoprotein C1 facilitating particle production and virus entry

    Article • April 2026, openRxiv

    Ralf Bartenschlager

  2. Front Cover: Effect of Substituents on the Tautomerism of Pyridone Nucleoside Analogs (Eur. J. Org. Chem. 14/2025)

    Article • European Journal of Organic Chemistry, April 2025, Wiley

    Ralf Bartenschlager

  3. Effect of Substituents on the Tautomerism of Pyridone Nucleoside Analogs

    Article • European Journal of Organic Chemistry, February 2025, Wiley

    Ralf Bartenschlager

  4. Durability of Humoral Responses after an Adapted SARS-CoV-2 mRNA Vaccine Dose in Hemodialysis Patients

    Article • Vaccines, July 2024, MDPI AG

    Ralf Bartenschlager

  5. Multi-detector fusion and Bayesian smoothing for tracking viral and chromatin structures

    Article • Medical Image Analysis, June 2024, Elsevier

    Ralf Bartenschlager

  6. Cutting edges in the hepatitis B virus genome: How RNA splicing is involved in modulating virus ultrastructure to promote infection

    Article • Journal of Hepatology, March 2024, Elsevier

    Ralf Bartenschlager

  7. Cell‐Penetrating Peptide‐Bismuth Bicycles**

    Article • Angewandte Chemie, January 2024, Wiley

    Ralf Bartenschlager

  8. Cell‐Penetrating Peptide‐Bismuth Bicycles**

    Article • Angewandte Chemie, January 2024, Wiley

    Ralf Bartenschlager

  9. Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

    Article • Nature Communications, December 2023, Springer Science + Business Media

    Ralf Bartenschlager

  10. SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle

    Article • Nature Communications, November 2023, Springer Science + Business Media

    Ralf Bartenschlager

  11. BA.1/BA.5 Immunogenicity, Reactogenicity, and Disease Activity after COVID-19 Vaccination in Patients with ANCA-Associated Vasculitis: A Prospective Observational Cohort Study

    Article • Viruses, August 2023, MDPI AG

    Ralf Bartenschlager

  12. Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

    Article • PLoS Pathogens, July 2023, PLOS

    Ralf Bartenschlager

  13. Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style

    Article • Nature Communications, March 2023, Springer Science + Business Media

    Ralf Bartenschlager

  14. Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication

    Article • Journal of Hepatology, January 2023, Elsevier

    Ralf Bartenschlager

  15. Multi-Channel Colocalization Analysis and Visualization of Viral Proteins in Fluorescence Microscopy Images

    Article • IEEE Access, January 2023, Institute of Electrical & Electronics Engineers (IEEE)

    Ralf Bartenschlager

  16. Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  17. A snapshot of protein trafficking in SARS‐CoV‐2 infection

    Article • Biology of the Cell, November 2022, Wiley

    Ralf Bartenschlager

  18. SARS-CoV-2 nsp3-4 suffice to form a pore shaping replication organelles

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  19. Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen

    Article • JHEP Reports, October 2022, Elsevier

    Ralf Bartenschlager

  20. Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread

    Article • Journal of Hepatology, October 2022, Elsevier

    Ralf Bartenschlager

  21. Impaired Neutralizing Antibody Activity against B.1.617.2 (Delta) after Anti-SARS-CoV-2 Vaccination in Patients Receiving Anti-CD20 Therapy

    Article • Journal of Clinical Medicine, March 2022, MDPI AG

    Ralf Bartenschlager

  22. Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier

    Article • European Journal of Medicinal Chemistry, February 2022, Elsevier

    Ralf Bartenschlager

  23. Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

    Article • Journal of Virology, November 2021, ASM Journals

    Ralf Bartenschlager

  24. The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein

    Article • Viruses, October 2021, MDPI AG

    Ralf Bartenschlager

  25. Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis

    Article • Journal of Virology, October 2021, ASM Journals

    Ralf Bartenschlager

  26. Dengue virus is sensitive to inhibition prior to productive replication

    Article • Cell Reports, October 2021, Elsevier

    Ralf Bartenschlager

  27. TLR3 Activation by Zika Virus Stimulates Inflammatory Cytokine Production Which Dampens the Antiviral Response Induced by RIG-I-Like Receptors

    Article • Journal of Virology, April 2021, ASM Journals

    Ralf Bartenschlager

  28. Can we predict antibody responses in SARS-CoV-2? A cohort analysis

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  29. A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application to Dengue Virus and SARS-CoV-2

    Article • Journal of Virology, January 2021, ASM Journals

    Ralf Bartenschlager

  30. Dimer Organization of Membrane‐Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H‐Detected Solid‐State NMR

    Article • Angewandte Chemie, January 2021, Wiley

    Ralf Bartenschlager

  31. Dimer Organization of Membrane‐Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H‐Detected Solid‐State NMR

    Article • Angewandte Chemie, January 2021, Wiley

    Ralf Bartenschlager

  32. SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

    Article • Nature Communications, November 2020, Springer Science + Business Media

    Ralf Bartenschlager

  33. A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Ralf Bartenschlager

  34. A versatile reporter system to monitor virus infected cells and its application to dengue virus and SARS-CoV-2

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  35. SARS-CoV-2 structure and replication characterized byin situcryo-electron tomography

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  36. Proton‐Detected Solid‐State NMR of the Cell‐Free Synthesized α‐Helical Transmembrane Protein NS4B from Hepatitis C Virus

    Article • ChemBioChem, February 2020, Wiley

    Ralf Bartenschlager

  37. Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation

    Article • PLoS Computational Biology, February 2020, PLOS

    Ralf Bartenschlager

  38. A Recurrent Neural Network for Particle Tracking in Microscopy Images Using Future Information, Track Hypotheses, and Multiple Detections

    Article • IEEE Transactions on Image Processing, January 2020, Institute of Electrical & Electronics Engineers (IEEE)

    Ralf Bartenschlager

  39. ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

    Article • Nature Microbiology, October 2019, Springer Science + Business Media

    Ralf Bartenschlager

  40. RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection

    Article • PLoS Pathogens, September 2019, PLOS

    Ralf Bartenschlager, Dr. Md Shafiqur Rahman

  41. Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells

    Article • ACS Medicinal Chemistry Letters, July 2019, American Chemical Society (ACS)

    Ralf Bartenschlager

  42. A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

    Article • PLoS Pathogens, May 2019, PLOS

    Ralf Bartenschlager

  43. Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1‐Activated Prodrugs as Antiviral Agents

    Article • ChemMedChem, January 2019, Wiley

    Ralf Bartenschlager

  44. Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses

    Article • Virus Research, January 2019, Elsevier

    Ralf Bartenschlager

  45. The Role of Tissue Oxygen Tension in Dengue Virus Replication

    Article • Cells, December 2018, MDPI AG

    Ralf Bartenschlager

  46. mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, November 2018, Royal Society Publishing

    Ralf Bartenschlager

  47. Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro

    Article • Antiviral Research, October 2018, Elsevier

    Ralf Bartenschlager

  48. A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy

    Article • Viruses, July 2018, MDPI AG

    Ralf Bartenschlager

  49. HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon

    Article • Gastroenterology, May 2018, Elsevier

    Ralf Bartenschlager, Thomas Tu

  50. Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis

    Article • Journal of Hepatology, March 2018, Elsevier

    Ralf Bartenschlager

  51. Glycine-zipper motifs in hepatitis C virus nonstructural protein 4B are required for the establishment of viral replication organelles

    Article • Journal of Virology, November 2017, ASM Journals

    David Paul, Ralf Bartenschlager

  52. Optimization of Substrate-Analogue Furin Inhibitors

    Article • ChemMedChem, November 2017, Wiley

    Ralf Bartenschlager

  53. Membrane alterations induced by nonstructural proteins of human norovirus

    Article • PLoS Pathogens, October 2017, PLOS

    Ralf Bartenschlager

  54. Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis

    Article • Journal of Virology, October 2017, ASM Journals

    David Paul, Ralf Bartenschlager

  55. Host-directed therapies for bacterial and viral infections

    Article • Nature Reviews Drug Discovery, September 2017, Springer Science + Business Media

    Ralf Bartenschlager

  56. Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses

    Article • Cell Host & Microbe, September 2017, Elsevier

    Ralf Bartenschlager

  57. Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network

    Article • Cellular Microbiology, July 2017, Wiley

    Ralf Bartenschlager

  58. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model

    Article • Gut, June 2017, BMJ

    Ralf Bartenschlager

  59. Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A

    Article • Biochemistry, June 2017, American Chemical Society (ACS)

    Ralf Bartenschlager

  60. Erratum for Roth et al., “Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses”

    Article • mBio, April 2017, ASM Journals

    Ralf Bartenschlager

  61. Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity

    Article • Journal of Hepatology, April 2017, Elsevier

    Ralf Bartenschlager

  62. Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism

    Article • Chemical Biology & Drug Design, March 2017, Wiley

    Ralf Bartenschlager

  63. Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

    Article • Molecular Cell, February 2017, Elsevier

    Ralf Bartenschlager

  64. Ultrastructural Characterization of Zika Virus Replication Factories

    Article • Cell Reports, February 2017, Elsevier

    Ralf Bartenschlager

  65. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

    Article • mBio, January 2017, ASM Journals

    Ralf Bartenschlager

  66. Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2017, Taylor & Francis

    Ralf Bartenschlager

  67. Chronic viral hepatitis and its association with liver cancer

    Article • Biological Chemistry, January 2017, De Gruyter

    Thomas Tu, Ralf Bartenschlager

  68. Editorial: An expanded view of viruses

    Article • FEMS Microbiology Reviews, January 2017, Oxford University Press (OUP)

    Ralf Bartenschlager

  69. Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

    Article • Journal of Medicinal Chemistry, December 2016, American Chemical Society (ACS)

    Ralf Bartenschlager

  70. The quest for host targets to combat dengue virus infections

    Article • Current Opinion in Virology, October 2016, Elsevier

    Ralf Bartenschlager

  71. Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

    Article • Hepatology, September 2016, Wiley

    Ralf Bartenschlager

  72. Hepatitis C Virus—From Discovery to Cure

    Article • JAMA, September 2016, American Medical Association (AMA)

    Ralf Bartenschlager

  73. Corrigendum: Conserved RNA secondary structures and long-range interactions in hepatitis C viruses

    Article • RNA, September 2016, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  74. Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

    Article • Cell Host & Microbe, September 2016, Elsevier

    Ralf Bartenschlager

  75. Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling

    Article • Cellular Microbiology, July 2016, Hindawi Publishing Corporation

    Ralf Bartenschlager

  76. A Slow Maturation Process Renders Hepatitis B Virus Infectious

    Article • Cell Host & Microbe, July 2016, Elsevier

    Ralf Bartenschlager

  77. Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

    Article • Viruses, June 2016, MDPI AG

    Ralf Bartenschlager

  78. Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus

    Article • Journal of Biomolecular NMR, May 2016, Springer Science + Business Media

    David Paul, Ralf Bartenschlager

  79. Correlative light and electron microscopy methods for the study of virus-cell interactions

    Article • FEBS Letters, April 2016, Wiley

    Ralf Bartenschlager

  80. Type I and type II interferon responses in two human liver cell lines (Huh-7 and HuH6)

    Article • Genomics Data, March 2016, Elsevier

    Ralf Bartenschlager

  81. Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

    Article • Hepatology, July 2015, Wolters Kluwer Health

    Ralf Bartenschlager

  82. Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

    Article • Proceedings of the National Academy of Sciences, July 2015, Proceedings of the National Academy of Sciences

    Ralf Bartenschlager

  83. A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

    Article • Journal of Biological Chemistry, July 2015, Elsevier

    Ralf Bartenschlager

  84. P147: A phenotypic NS3-protease inhibitor resistance assay to characterize resistance-associated mutations in patients

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Ralf Bartenschlager

  85. P117: Hepatitis C Virus mediates NRG1-dependent down-regulation of ErbB3, thereby modifies ErbB receptor family composition at the cell surface

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Ralf Bartenschlager

  86. P119: Hepatitis C virus inhibits IL-1 β -induced Iк Bζ expression and thereby antagonizes mechanisms which may affect cell proliferation

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Ralf Bartenschlager

  87. P096: Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Ralf Bartenschlager

  88. P118: The Hepatitis C Virus (HCV) facilitates CXCR2 ligand expression in response to the Epidermal Growth Factor (EGF) and is able to induce the EGF production by an autocrine circuit in its host cell

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Ralf Bartenschlager

  89. Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62

    Article • Journal of Virology, May 2015, ASM Journals

    Ralf Bartenschlager

  90. Conserved RNA secondary structures and long-range interactions in hepatitis C viruses

    Article • RNA, May 2015, Cold Spring Harbor Laboratory Press

    Ralf Bartenschlager

  91. A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication

    Article • Journal of Virology, April 2015, ASM Journals

    Professor Ralf Bartenschlager, Ralf Bartenschlager

  92. Hepatitis C virus infection inhibits P-body granule formation in human livers

    Article • Journal of Hepatology, April 2015, Elsevier

    Ralf Bartenschlager

  93. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

    Article • Nature Biotechnology, March 2015, Nature

    Dr Sebastien Pfeffer, Ralf Bartenschlager

  94. A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication

    Article • PLoS Pathogens, March 2015, PLOS

    Dr Brett D Lindenbach, Ralf Bartenschlager

  95. A monocytic detour to replicate patient‐derived hepatitis C virus in hepatoma cells and its use for phenotypic analyses

    Article • Hepatology, March 2015, Wolters Kluwer Health

    Ralf Bartenschlager

  96. Expression of the Novel Hepatitis C Virus Core+1/ARF Protein in the Context of JFH1-Based Replicons

    Article • Journal of Virology, February 2015, ASM Journals

    Ralf Bartenschlager

  97. A sensor at the lipid‐protein interface: Lipid peroxidation controls hepatitis C virus replication

    Article • Hepatology, January 2015, Wolters Kluwer Health

    David Paul, Ralf Bartenschlager

  98. Identification of HNRNPK as Regulator of Hepatitis C Virus Particle Production

    Article • PLoS Pathogens, January 2015, PLOS

    Ralf Bartenschlager

  99. Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins

    Article • Protein Expression and Purification, January 2015, Elsevier

    David Paul, Ralf Bartenschlager

  100. Novel Dengue Virus NS2B/NS3 Protease Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, December 2014, ASM Journals

    Prof Dr Jochen Bodem, Ralf Bartenschlager

  101. Aminoterminal Amphipathic α-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production

    Article • PLoS Pathogens, November 2014, PLOS

    David Paul, Ralf Bartenschlager

  102. Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication

    Article • Gastroenterology, November 2014, Elsevier

    David Paul, Ralf Bartenschlager

  103. Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land

    Article • Cell Host & Microbe, November 2014, Elsevier

    David Paul, Ralf Bartenschlager

  104. Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region

    Article • Antiviral Research, October 2014, Elsevier

    Ralf Bartenschlager, Dr Richard Brown

  105. Apolipoprotein E Likely Contributes to a Maturation Step of Infectious Hepatitis C Virus Particles and Interacts with Viral Envelope Glycoproteins

    Article • Journal of Virology, August 2014, ASM Journals

    Professor Ralf Bartenschlager, Ralf Bartenschlager

  106. The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production

    Article • Virology, August 2014, Elsevier

    Ralf Bartenschlager

  107. Characterization of the Mode of Action of a Potent Dengue Virus Capsid Inhibitor

    Article • Journal of Virology, July 2014, ASM Journals

    David Paul, Ralf Bartenschlager

  108. Membranous Replication Factories Induced by Plus-Strand RNA Viruses

    Article • Viruses, July 2014, MDPI AG

    Ralf Bartenschlager

  109. Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes

    Article • Gastroenterology, July 2014, Elsevier

    Ralf Bartenschlager

  110. Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin

    Article • PLOS One, May 2014, PLOS

    Ralf Bartenschlager

  111. Inhibition of HCV Replication by Cyclophilin Antagonists Is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation

    Article • Gastroenterology, May 2014, Elsevier

    David Paul, Ralf Bartenschlager

  112. Heterologous Src Homology 4 Domains Support Membrane Anchoring and Biological Activity of HIV-1 Nef

    Article • Journal of Biological Chemistry, May 2014, Elsevier

    Ralf Bartenschlager

  113. Targets for Antiviral Therapy of Hepatitis C

    Article • Seminars in Liver Disease, April 2014, Thieme Publishing Group

    Professor Ralf Bartenschlager, Ralf Bartenschlager

  114. Dengue Virus- and Hepatitis C Virus-Induced Replication and Assembly Compartments: the Enemy Inside--Caught in the Web

    Article • Journal of Virology, March 2014, ASM Journals

    Professor Ralf Bartenschlager, Ralf Bartenschlager

  115. Perilipin discerns chronic from acute hepatocellular steatosis

    Article • Journal of Hepatology, March 2014, Elsevier

    Ralf Bartenschlager

  116. Revisiting Dengue Virus–Host Cell Interaction

    Article • January 2014, Elsevier

    Ralf Bartenschlager

  117. On the History of Hepatitis C Virus Cell Culture Systems

    Article • Journal of Medicinal Chemistry, November 2013, American Chemical Society (ACS)

    Ralf Bartenschlager

  118. Thiazolidinone–Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture

    Article • Journal of Medicinal Chemistry, October 2013, American Chemical Society (ACS)

    Ralf Bartenschlager

  119. Hepatitis C: A mouse at the end of the tunnel

    Article • BDJ, September 2013, Springer Science + Business Media

    Ralf Bartenschlager

  120. Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

    Article • Nucleic Acids Research, September 2013, Oxford University Press (OUP)

    Ralf Bartenschlager

  121. Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study

    Article • Journal of Biomolecular Structure and Dynamics, August 2013, Taylor & Francis

    Ralf Bartenschlager

  122. Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle

    Article • PLoS Pathogens, August 2013, PLOS

    Ralf Bartenschlager

  123. Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment

    Article • Journal of Virology, July 2013, ASM Journals

    David Paul, Professor Ralf Bartenschlager, Ralf Bartenschlager

  124. The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

    Article • PLoS Pathogens, July 2013, PLOS

    Ralf Bartenschlager

  125. Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site

    Article • Journal of General Virology, July 2013, Society for General Microbiology

    Ralf Bartenschlager, Dr Latifa Bakiri

  126. Evidence for Novel Hepaciviruses in Rodents

    Article • PLoS Pathogens, June 2013, PLOS

    Dr Augustina Annan, Ralf Bartenschlager

  127. The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

    Article • Nature Reviews Microbiology, June 2013, Springer Science + Business Media

    Ralf Bartenschlager

  128. The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A

    Article • PLoS Pathogens, May 2013, PLOS

    Ralf Bartenschlager

  129. Three-Dimensional Architecture of Tick-Borne Encephalitis Virus Replication Sites and Trafficking of the Replicated RNA

    Article • Journal of Virology, April 2013, ASM Journals

    Alessandro Marcello, Ralf Bartenschlager

  130. Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

    Article • Journal of Virology, February 2013, ASM Journals

    Professor Ralf Bartenschlager, Ralf Bartenschlager

  131. Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B

    Article • Hepatology, February 2013, Wolters Kluwer Health

    Ralf Bartenschlager

  132. Factors That Determine the Antiviral Efficacy of HCV-Specific CD8+ T Cells Ex Vivo

    Article • Gastroenterology, February 2013, Elsevier

    Ralf Bartenschlager

  133. Virion Assembly and Release

    Article • January 2013, Springer Science + Business Media

    Dr Brett D Lindenbach, Ralf Bartenschlager

  134. Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

    Article • January 2013, Springer Science + Business Media

    Dr David Robert McGivern, Ralf Bartenschlager

  135. Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

    Article • January 2013, Springer Science + Business Media

    Johan Neyts, Ralf Bartenschlager

  136. Adaptive Immune Responses in Hepatitis C Virus Infection

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  137. Animal Models for Hepatitis C

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  138. Cell Culture Systems for Hepatitis C Virus

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  139. Hepatitis C Virus Proteins: From Structure to Function

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  140. Hepatitis C Virus RNA Replication

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  141. Hepatitis C Virus RNA Translation

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  142. Hepatitis C Virus Replicons Volume 3 and 4

    Article • Gastroenterology, January 2013, Elsevier

    Ralf Bartenschlager

  143. Inhibition of hepatitis C virus RNA translation by antisense bile acid conjugated phosphorothioate modified oligodeoxynucleotides (ODN)

    Article • Antiviral Research, January 2013, Elsevier

    Ralf Bartenschlager

  144. Innate Immune Responses to Hepatitis C Virus

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  145. The Origin of Hepatitis C Virus

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  146. Treatment of Chronic Hepatitis C: Current and Future

    Article • January 2013, Springer Science + Business Media

    Ralf Bartenschlager

  147. Low Oxygen Tension Enhances Hepatitis C Virus Replication

    Article • Journal of Virology, December 2012, ASM Journals

    Ralf Bartenschlager

  148. Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

    Article • PLoS Pathogens, December 2012, PLOS

    Ralf Bartenschlager

  149. A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

    Article • Antimicrobial Agents and Chemotherapy, October 2012, ASM Journals

    Ralf Bartenschlager

  150. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication

    Article • Hepatology, October 2012, Wolters Kluwer Health

    Ralf Bartenschlager

  151. TCR-Redirected Human T Cells Inhibit Hepatitis C Virus Replication: Hepatotoxic Potential Is Linked to Antigen Specificity and Functional Avidity

    Article • The Journal of Immunology, September 2012, The American Association of Immunologists

    Associate Professor Margaret Chen, Ralf Bartenschlager

  152. Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps

    Article • Journal of Biological Chemistry, September 2012, Elsevier

    Ralf Bartenschlager

  153. Reconstitution of the Entire Hepatitis C Virus Life Cycle in Nonhepatic Cells

    Article • Journal of Virology, August 2012, ASM Journals

    Ralf Bartenschlager

  154. Persistence of HCV in Quiescent Hepatic Cells Under Conditions of an Interferon-Induced Antiviral Response

    Article • Gastroenterology, August 2012, Elsevier

    Ralf Bartenschlager

  155. MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles

    Article • PLoS Pathogens, July 2012, PLOS

    Ralf Bartenschlager

  156. Viral immune modulators perturb the human molecular network by common and unique strategies

    Article • Nature, July 2012, Nature

    Friedemann Weber, Ralf Bartenschlager

  157. A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes

    Article • Gastroenterology, July 2012, Elsevier

    Elisabeth Davioud-Charvet, Ralf Bartenschlager

  158. Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape From Neutralizing Antibodies

    Article • Gastroenterology, July 2012, Elsevier

    Ralf Bartenschlager

  159. Failure of innate and adaptive immune responses in controlling hepatitis C virus infection

    Article • FEMS Microbiology Reviews, May 2012, Oxford University Press (OUP)

    Ralf Bartenschlager

  160. Persistent intracellular pathogens

    Article • FEMS Microbiology Reviews, May 2012, Oxford University Press (OUP)

    Ralf Bartenschlager

  161. High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients

    Article • Hepatology, April 2012, Wolters Kluwer Health

    Ralf Bartenschlager

  162. miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Ralf Bartenschlager

  163. Promotion of Hepatocellular Carcinoma by Hepatitis C Virus

    Article • Digestive Diseases, January 2012, Karger Publishers

    Ralf Bartenschlager

  164. New targets for antiviral therapy of chronic hepatitis C

    Article • Liver International, December 2011, Wiley

    Ralf Bartenschlager

  165. Normalizing for individual cell population context in the analysis of high-content cellular screens

    Article • BMC Bioinformatics, December 2011, Springer Science + Business Media

    Ralf Bartenschlager

  166. Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3

    Article • Journal of General Virology, November 2011, Society for General Microbiology

    Associate Professor Margaret Chen, Ralf Bartenschlager

  167. Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles

    Article • Gastroenterology, September 2011, Elsevier

    Ralf Bartenschlager

  168. Exploitation of cellular pathways by Dengue virus

    Article • Current Opinion in Microbiology, August 2011, Elsevier

    Ralf Bartenschlager

  169. Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

    Article • Journal of Biological Chemistry, August 2011, Elsevier

    Ralf Bartenschlager

  170. A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly

    Article • PLoS Pathogens, July 2011, PLOS

    Ralf Bartenschlager

  171. Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo

    Article • Journal of Hepatology, July 2011, Elsevier

    Ralf Bartenschlager

  172. Die molekularen Mechanismen der Replikation des Hepatitis C Virus – Implikationen für die Entwicklung antiviraler Wirkstoffe

    Article • Zeitschrift für Gastroenterologie, July 2011, Thieme Publishing Group

    Ralf Bartenschlager

  173. Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

    Article • Bioorganic & Medicinal Chemistry, July 2011, Elsevier

    Ralf Bartenschlager

  174. Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

    Article • Journal of Biological Chemistry, June 2011, Elsevier

    Ralf Bartenschlager

  175. Interleukin‐32: A new proinflammatory cytokine involved in hepatitis C virus‐related liver inflammation and fibrosis

    Article • Hepatology, May 2011, Wolters Kluwer Health

    Ralf Bartenschlager

  176. NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes

    Article • Journal of Virology, May 2011, ASM Journals

    David Paul, Dr jerome Gouttenoire, Ralf Bartenschlager

  177. C-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: A prerequisite for replication

    Article • Hepatology, April 2011, Wolters Kluwer Health

    Ralf Bartenschlager

  178. Hepatitis c virus and host cell lipids: An intimate connection

    Article • RNA Biology, March 2011, Taylor & Francis

    Gualtiero Alvisi, Ralf Bartenschlager

  179. Assembly of infectious hepatitis C virus particles

    Article • Trends in Microbiology, February 2011, Elsevier

    Professor Patrice André, Ralf Bartenschlager

  180. A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

    Article • Journal of Virology, January 2011, ASM Journals

    Ralf Bartenschlager

  181. Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome

    Article • Journal of Biological Chemistry, January 2011, Elsevier

    Ralf Bartenschlager

  182. Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

    Article • Cell Host & Microbe, January 2011, Elsevier

    Ralf Bartenschlager

  183. Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

    Article • PLoS Pathogens, December 2010, PLOS

    Dr jerome Gouttenoire, Ralf Bartenschlager

  184. Experimental models to study the immunobiology of hepatitis C virus

    Article • Journal of General Virology, December 2010, Society for General Microbiology

    Ralf Bartenschlager

  185. Comparative Analysis of the Lambda-Interferons IL-28A and IL-29 regarding Their Transcriptome and Their Antiviral Properties against Hepatitis C Virus

    Article • PLOS One, December 2010, PLOS

    Ralf Bartenschlager

  186. DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

    Article • PLOS One, October 2010, PLOS

    Johan Neyts, Ralf Bartenschlager

  187. New Insights into Structure and Replication of the Hepatitis C Virus and Clinical Implications

    Article • Seminars in Liver Disease, October 2010, Thieme Publishing Group

    Ralf Bartenschlager

  188. Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes

    Article • Gastroenterology, October 2010, Elsevier

    Ralf Bartenschlager

  189. A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

    Article • PLoS Pathogens, September 2010, PLOS

    Ralf Bartenschlager

  190. Detecting host factors involved in virus infection by observing the clustering of infected cells in siRNA screening images

    Article • Bioinformatics, September 2010, Oxford University Press (OUP)

    Ralf Bartenschlager

  191. Hepatitis C virus replication cycle

    Article • Journal of Hepatology, September 2010, Elsevier

    Ralf Bartenschlager

  192. Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development

    Article • Pathology International, April 2010, Wiley

    Ralf Bartenschlager

  193. Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles

    Article • Journal of Virology, March 2010, ASM Journals

    Ralf Bartenschlager

  194. Mouse-Specific Residues of Claudin-1 Limit Hepatitis C Virus Genotype 2a Infection in a Human Hepatocyte Cell Line

    Article • Journal of Virology, November 2009, ASM Journals

    Ralf Bartenschlager

  195. The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response

    Article • Hepatology, September 2009, Wolters Kluwer Health

    Ralf Bartenschlager

  196. Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly

    Article • Journal of Virology, September 2009, ASM Journals

    Ralf Bartenschlager

  197. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A

    Article • Hepatology, September 2009, Wiley

    Johan Neyts, Ralf Bartenschlager

  198. Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation

    Article • Journal of Virology, September 2009, ASM Journals

    Ralf Bartenschlager

  199. Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

    Article • PLoS Pathogens, August 2009, PLOS

    Ralf Bartenschlager

  200. A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication

    Article • Antiviral Research, August 2009, Elsevier

    Ralf Bartenschlager

  201. Hepatitis B and C virus coinfection: A novel model system reveals the absence of direct viral interference #

    Article • Hepatology, July 2009, Wolters Kluwer Health

    Dr jerome Gouttenoire, Ralf Bartenschlager

  202. Reconstructing signaling pathways from RNAi data using probabilistic Boolean threshold networks

    Article • Bioinformatics, June 2009, Oxford University Press (OUP)

    Ralf Bartenschlager

  203. Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

    Article • PLoS Pathogens, June 2009, PLOS

    Professor Geert Leroux-Roels, Ralf Bartenschlager

  204. Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

    Article • Journal of Biological Chemistry, May 2009, Elsevier

    Ralf Bartenschlager

  205. Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly

    Article • Journal of General Virology, May 2009, Society for General Microbiology

    Ralf Bartenschlager

  206. Analysis of CD8+ T-Cell–Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model

    Article • Gastroenterology, April 2009, Elsevier

    Ralf Bartenschlager

  207. Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

    Article • Cell Host & Microbe, April 2009, Elsevier

    Ralf Bartenschlager

  208. Single-cell-based image analysis of high-throughput cell array screens for quantification of viral infection

    Article • Cytometry Part A, April 2009, Wiley

    Ralf Bartenschlager

  209. Moving closer to a mouse model for hepatitis C

    Article • Nature Reports Stem Cells, March 2009, Springer Science + Business Media

    Ralf Bartenschlager

  210. Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase

    Article • Hepatology, January 2009, Wolters Kluwer Health

    Ralf Bartenschlager

  211. Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins

    Article • PLOS One, January 2009, PLOS

    Professor Patrice André, Ralf Bartenschlager

  212. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

    Article • Journal of Clinical Investigation, January 2009, American Society for Clinical Investigation

    Ralf Bartenschlager

  213. Hepatitis C virus replicons: dinosaurs still in business?

    Article • Journal of Viral Hepatitis, January 2009, Wiley

    Ralf Bartenschlager

  214. Neutralizing Host Responses in Hepatitis C Virus Infection Target Viral Entry at Postbinding Steps and Membrane Fusion

    Article • Gastroenterology, November 2008, Elsevier

    Ralf Bartenschlager

  215. Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte films

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Ralf Bartenschlager

  216. Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

    Article • Journal of Biological Chemistry, October 2008, Elsevier

    Ralf Bartenschlager

  217. Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

    Article • Journal of Virology, September 2008, ASM Journals

    Professor Geert Leroux-Roels, Ralf Bartenschlager

  218. Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, July 2008, ASM Journals

    Johan Neyts, Ralf Bartenschlager

  219. Efficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like Particles

    Article • Journal of Virology, May 2008, ASM Journals

    Ralf Bartenschlager

  220. Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

    Article • Molecules, May 2008, MDPI AG

    Ralf Bartenschlager

  221. Molecular aspects of Dengue virus replication

    Article • Future Microbiology, April 2008, Future Medicine

    Ralf Bartenschlager

  222. Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

    Article • PLoS Pathogens, March 2008, PLOS

    Ralf Bartenschlager

  223. Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR

    Article • Journal of Hepatology, February 2008, Elsevier

    Professor Patrice André, Ralf Bartenschlager

  224. 18 BILE ACIDS ENHANCE GENOTYPE 1 HEPATITIS C VIRUS REPLICATION

    Article • Journal of Hepatology, January 2008, Elsevier

    Ralf Bartenschlager

  225. 607 NEUTRALIZING HOST RESPONSES IN HEPATITIS C VIRUS INFECTION TARGET VIRAL ENTRY AT POST-BINDING STEPS AND MEMBRANE FUSION

    Article • Journal of Hepatology, January 2008, Elsevier

    Ralf Bartenschlager

  226. Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81

    Article • Hepatology, December 2007, Wolters Kluwer Health

    Ralf Bartenschlager

  227. The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly

    Article • Journal of Biological Chemistry, December 2007, Elsevier

    Ralf Bartenschlager

  228. Erratum

    Article • Nature Cell Biology, October 2007, Springer Science + Business Media

    Ralf Bartenschlager

  229. Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

    Article • Journal of Virology, September 2007, ASM Journals

    Professor Geert Leroux-Roels, Ralf Bartenschlager

  230. The lipid droplet is an important organelle for hepatitis C virus production

    Article • Nature Cell Biology, August 2007, Springer Science + Business Media

    Ralf Bartenschlager

  231. A Tribute to a Colleague

    Article • Virus Research, August 2007, Elsevier

    Ralf Bartenschlager

  232. Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture

    Article • Virus Research, August 2007, Elsevier

    Ralf Bartenschlager

  233. Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

    Article • Hepatology, August 2007, Wolters Kluwer Health

    Ralf Bartenschlager

  234. Hepatitis viruses in the XXI century

    Article • Virus Research, August 2007, Elsevier

    Ralf Bartenschlager

  235. Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions

    Article • PLoS Pathogens, July 2007, PLOS

    Ralf Bartenschlager

  236. Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes

    Article • Journal of Virology, July 2007, ASM Journals

    Ralf Bartenschlager

  237. The Cyclophilin Inhibitor Debio-025 is a Potent Inhibitor of Hepatitis C Virus Replication in vitro With a Unique Resistance Profile

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts, Ralf Bartenschlager

  238. Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

    Article • Journal of Virology, March 2007, ASM Journals

    Ralf Bartenschlager

  239. The Non-structural Protein 4A of Dengue Virus Is an Integral Membrane Protein Inducing Membrane Alterations in a 2K-regulated Manner

    Article • Journal of Biological Chemistry, March 2007, Elsevier

    Ralf Bartenschlager

  240. Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes

    Article • Journal of Virology, February 2007, ASM Journals

    Ralf Bartenschlager

  241. euHCVdb: the European hepatitis C virus database

    Article • Nucleic Acids Research, January 2007, Oxford University Press (OUP)

    Ralf Bartenschlager

  242. Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus

    Article • Hepatology, January 2007, Wolters Kluwer Health

    Ralf Bartenschlager

  243. The Level of CD81 Cell Surface Expression Is a Key Determinant for Productive Entry of Hepatitis C Virus into Host Cells

    Article • Journal of Virology, November 2006, ASM Journals

    Ralf Bartenschlager

  244. Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′-C-Methylcytidine, the Active Component of Valopicitabine

    Article • Antimicrobial Agents and Chemotherapy, October 2006, ASM Journals

    Johan Neyts, Ralf Bartenschlager

  245. The Hepatitis C Virus RNA 3′-Untranslated Region Strongly Enhances Translation Directed by the Internal Ribosome Entry Site

    Article • Journal of Virology, September 2006, ASM Journals

    Ralf Bartenschlager

  246. Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b

    Article • Virology, August 2006, Elsevier

    Ralf Bartenschlager

  247. Hepatitis C virus molecular clones: from cDNA to infectious virus particles in cell culture

    Article • Current Opinion in Microbiology, August 2006, Elsevier

    Ralf Bartenschlager

  248. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells

    Article • Journal of Hepatology, July 2006, Elsevier

    Ralf Bartenschlager

  249. Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses

    Article • Journal of Virology, June 2006, ASM Journals

    Ralf Bartenschlager

  250. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Ralf Bartenschlager

  251. High Density Lipoprotein Inhibits Hepatitis C Virus-neutralizing Antibodies by Stimulating Cell Entry via Activation of the Scavenger Receptor BI

    Article • Journal of Biological Chemistry, May 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvie RICARD-BLUM, Ralf Bartenschlager

  252. From Structure to Function: New Insights into Hepatitis C Virus RNA Replication

    Article • Journal of Biological Chemistry, April 2006, Elsevier

    Ralf Bartenschlager

  253. 417 Subgenomic hepatitis C replicon deriving from a clinical isolate with virologic non-response to IFN-based therapy and IFN resistance in vitro

    Article • Journal of Hepatology, April 2006, Elsevier

    Ralf Bartenschlager

  254. Subcellular Localization and Membrane Topology of the Dengue Virus Type 2 Non-structural Protein 4B

    Article • Journal of Biological Chemistry, March 2006, Elsevier

    Ralf Bartenschlager

  255. Relation between viral fitness and immune escape within the hepatitis C virus protease

    Article • Gut, February 2006, BMJ

    Ralf Bartenschlager

  256. The face of future hepatitis C antiviral drug development: Recent biological and virologic advances and their translation to drug development and clinical practice

    Article • Journal of Hepatology, February 2006, Elsevier

    Ralf Bartenschlager

  257. O.137 HDL inhibits neutralisation by HCV antibodies via a ternary interaction with the scavenger receptor BI

    Article • Journal of Clinical Virology, January 2006, Elsevier

    Sylvie RICARD-BLUM, Ralf Bartenschlager

  258. O.171 HDL inhibits HCV neutralisation by CD81-NOB antibodies by stimulating cell entry through activation of the scavenger receptor BI

    Article • Journal of Clinical Virology, January 2006, Elsevier

    Sylvie RICARD-BLUM, Ralf Bartenschlager

  259. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replicationin vitro

    Article • Hepatology, January 2006, Wiley

    Johan Neyts, Ralf Bartenschlager

  260. Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33

    Article • Hepatology, January 2006, Wolters Kluwer Health

    Ralf Bartenschlager, Dr Richard Brown

  261. O.067 Hepatitis C virus: Virology, immunology, natural history, treatment

    Article • Journal of Clinical Virology, January 2006, Elsevier

    Ralf Bartenschlager

  262. Quantitative Analysis of the Hepatitis C Virus Replication Complex

    Article • Journal of Virology, November 2005, ASM Journals

    Ralf Bartenschlager

  263. Dissecting the Interferon-Induced Inhibition of Hepatitis C Virus Replication by Using a Novel Host Cell Line

    Article • Journal of Virology, November 2005, ASM Journals

    Ralf Bartenschlager

  264. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

    Article • Nature, September 2005, Springer Science + Business Media

    Ralf Bartenschlager

  265. Hepatitis C Virus NS2/3 Processing Is Required for NS3 Stability and Viral RNA Replication

    Article • Journal of Biological Chemistry, August 2005, Elsevier

    Ralf Bartenschlager

  266. Erratum: Corrigendum: Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

    Article • Nature Reports Stem Cells, August 2005, Springer Science + Business Media

    Ralf Bartenschlager

  267. The hepatitis C virus replicon system: From basic research to clinical application

    Article • Journal of Hepatology, August 2005, Elsevier

    Ralf Bartenschlager

  268. Efficient hepatitis C virus cell culture system: What a difference the host cell makes

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Ralf Bartenschlager

  269. Hepatitis C Virus-Replicating Hepatocytes Induce Fibrogenic Activation of Hepatic Stellate Cells

    Article • Gastroenterology, July 2005, Elsevier

    Ralf Bartenschlager

  270. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

    Article • Nature Reports Stem Cells, June 2005, Springer Science + Business Media

    Ralf Bartenschlager

  271. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

    Article • Oncogene, May 2005, Springer Science + Business Media

    Ralf Bartenschlager

  272. Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain

    Article • Journal of Virology, March 2005, ASM Journals

    Ralf Bartenschlager

  273. Efficient Rescue of Hepatitis C Virus RNA Replication by trans-Complementation with Nonstructural Protein 5A

    Article • Journal of Virology, January 2005, ASM Journals

    Ralf Bartenschlager

  274. Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication

    Article • Journal of Virology, January 2005, ASM Journals

    Ralf Bartenschlager

  275. Membrane Association of the RNA-Dependent RNA Polymerase Is Essential for Hepatitis C Virus RNA Replication

    Article • Journal of Virology, December 2004, ASM Journals

    Ralf Bartenschlager

  276. Interferon type I gene expression in chronic hepatitis C

    Article • Laboratory Investigation, September 2004, Elsevier

    Ralf Bartenschlager

  277. Structure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A

    Article • Journal of Biological Chemistry, September 2004, Elsevier

    Ralf Bartenschlager

  278. Targeting of Hepatitis C Virus Core Protein to Mitochondria through a Novel C-Terminal Localization Motif

    Article • Journal of Virology, August 2004, ASM Journals

    Ralf Bartenschlager

  279. Application of the trak-C? HCV core assay for monitoring antiviral activity in HCV replication systems

    Article • Journal of Virological Methods, June 2004, Elsevier

    Ralf Bartenschlager

  280. Alternative Approaches for Efficient Inhibition of Hepatitis C Virus RNA Replication by Small Interfering RNAs

    Article • Journal of Virology, April 2004, ASM Journals

    Ralf Bartenschlager

  281. Novel Insights into Hepatitis C Virus Replication and Persistence

    Article • January 2004, Elsevier

    Ralf Bartenschlager

  282. Replication of the hepatitis C virus in cell culture

    Article • Antiviral Research, October 2003, Elsevier

    Ralf Bartenschlager

  283. A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C

    Article • Journal of Virological Methods, June 2003, Elsevier

    Professor (Associate) Bart L. Haagmans, Ralf Bartenschlager

  284. Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

    Article • Journal of Virology, May 2003, ASM Journals

    Ralf Bartenschlager

  285. Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α

    Article • Journal of General Virology, May 2003, Society for General Microbiology

    Ralf Bartenschlager

  286. Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

    Article • Journal of Virology, March 2003, ASM Journals

    Ralf Bartenschlager

  287. Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein

    Article • Journal of General Virology, March 2003, Society for General Microbiology

    Ralf Bartenschlager

  288. The Hepatitis C Virus RNA-Dependent RNA Polymerase Membrane Insertion Sequence Is a Transmembrane Segment

    Article • Journal of Virology, December 2002, ASM Journals

    Ralf Bartenschlager

  289. Hepatitis C virus replicons: potential role for drug development

    Article • Nature Reviews Drug Discovery, November 2002, Springer Science + Business Media

    Ralf Bartenschlager

  290. Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

    Article • Proceedings of the National Academy of Sciences, October 2002, Proceedings of the National Academy of Sciences

    Ralf Bartenschlager

  291. Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication

    Article • Journal of Virology, June 2002, ASM Journals

    Ralf Bartenschlager

  292. Serum versus intrahepatic HCV RNA and liver histology

    Article • Hepatology, June 2002, Wolters Kluwer Health

    Ralf Bartenschlager

  293. Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture

    Article • Journal of Virology, April 2002, ASM Journals

    Ralf Bartenschlager

  294. Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs

    Article • Hepatology, March 2002, Wolters Kluwer Health

    Ralf Bartenschlager

  295. Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase

    Article • Journal of Biological Chemistry, January 2002, Elsevier

    Ralf Bartenschlager

  296. Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication

    Article • Journal of Virology, December 2001, ASM Journals

    Ralf Bartenschlager

  297. Oral immunization with HCV-NS3—transformed Salmonella: Induction of HCV-specific CTL in a transgenic mouse model

    Article • Gastroenterology, November 2001, Elsevier

    Ralf Bartenschlager

  298. Novel cell culture systems for the hepatitis C virus

    Article • Antiviral Research, October 2001, Elsevier

    Ralf Bartenschlager

  299. Enhancement of Hepatitis C Virus RNA Replication by Cell Culture-Adaptive Mutations

    Article • Journal of Virology, May 2001, ASM Journals

    Ralf Bartenschlager

  300. Characterization of Cell Lines Carrying Self-Replicating Hepatitis C Virus RNAs

    Article • Journal of Virology, February 2001, ASM Journals

    Ralf Bartenschlager

  301. Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

    Article • Journal of Virology, February 2001, ASM Journals

    Ralf Bartenschlager

  302. Replication of the hepatitis C virus

    Article • Best Practice & Research Clinical Gastroenterology, April 2000, Elsevier

    Ralf Bartenschlager

  303. Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

    Article • Science, July 1999, American Association for the Advancement of Science

    Ralf Bartenschlager

  304. The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

    Article • Journal of Viral Hepatitis, May 1999, Wiley

    Ralf Bartenschlager

  305. Selective Stimulation of Hepatitis C Virus and Pestivirus NS5B RNA Polymerase Activity by GTP

    Article • Journal of Biological Chemistry, April 1999, Elsevier

    Ralf Bartenschlager

  306. Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum

    Article • Hepatology, January 1999, Wolters Kluwer Health

    Ralf Bartenschlager

  307. Biochemical and Kinetic Analyses of NS5B RNA-Dependent RNA Polymerase of the Hepatitis C Virus

    Article • Virology, September 1998, Elsevier

    Ralf Bartenschlager

  308. Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation

    Article • Hepatology, January 1998, Wolters Kluwer Health

    Ralf Bartenschlager

  309. Determinants of Substrate Specificity in the NS3 Serine Proteinase of the Hepatitis C Virus

    Article • Virology, October 1997, Elsevier

    Ralf Bartenschlager

  310. Candidate Targets for Hepatitis C Virus-Specific Antiviral Therapy

    Article • Intervirology, January 1997, Karger Publishers

    Ralf Bartenschlager

  311. In VitroStudies on the Activation of the Hepatitis C Virus NS3 Proteinase by the NS4A Cofactor

    Article • Virology, July 1996, Elsevier

    Ralf Bartenschlager

  312. An in Vitro Assay for Hepatitis C Virus NS3 Serine Proteinase

    Article • Virology, May 1995, Elsevier

    Ralf Bartenschlager

  313. Mechanisms governing hepadnaviral nucleocapsid assembly

    Article • Journal of Hepatology, January 1993, Elsevier

    Ralf Bartenschlager

  314. Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites

    Article • Nucleic Acids Research, January 1992, Oxford University Press (OUP)

    Ralf Bartenschlager

  315. The duck hepatitis B virus P-gene codes for protein strongly associated with the 5′-end of the viral dna minus strand

    Article • Virology, October 1988, Elsevier

    Ralf Bartenschlager

  316. Adaptation of the Hepatitis C Virus to Cell Culture

    Article • Springer Science + Business Media

    Ralf Bartenschlager

  317. Chronic hepatitis C: Portrait of a silent epidemic and the etiologic agent

    Article • Springer Science + Business Media

    Ralf Bartenschlager

  318. In Vitro Replication Models

    Article • Wiley

    Ralf Bartenschlager