All Stories

  1. Dual prodrugs of N4-hydroxycytidine with ProTide and ester modifications as anti-SARS-CoV-2 agents

    Article • European Journal of Medicinal Chemistry, November 2026, Elsevier

    Johan Neyts

  2. Design and anti-rhinovirus activity of novel derivatives based on the pleconaril core

    Article • European Journal of Medicinal Chemistry, November 2026, Elsevier

    Johan Neyts

  3. Antiviral sugar baits to reduce arbovirus transmission: a proof-of-concept study

    Article • September 2026, openRxiv

    Johan Neyts

  4. Accelerating the clinical development of treatments for dengue: WHO dengue therapeutics landscape analysis and target product profiles

    Article • The Lancet Microbe, September 2026, Elsevier

    Johan Neyts

  5. Oropouche virus causes severe congenital disease in embryonic mice

    Article • Nature Communications, August 2026, Springer Science + Business Media

    Johan Neyts

  6. The 5′-Isobutyryl Ester Prodrug of 4′-Thiouridine Inhibits SARS-CoV-2 Replication in Culture and in a Syrian Hamster Infection Model

    Article • ACS Omega, July 2026, American Chemical Society (ACS)

    Johan Neyts

  7. Discovery of orally bioavailable N-acylated remdesivir derivatives with potent broad-spectrum antiviral activity

    Article • Bioorganic Chemistry, July 2026, Elsevier

    Johan Neyts

  8. Cross-protection against Bundibugyo by Ebola and Sudan vaccines

    Article • June 2026, openRxiv

    Johan Neyts

  9. Estimating the in vivo prophylactic effect of mosnodenvir, a novel dengue antiviral, on DENV-2 infection

    Article • Journal of The Royal Society Interface, June 2026, Royal Society Publishing

    Johan Neyts

  10. Rat hepatitis E virus infection has multiphasic viral replication kinetics in vivo

    Article • June 2026, openRxiv

    Johan Neyts

  11. A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery

    Article • npj Viruses, May 2026, Springer Science + Business Media

    Johan Neyts

  12. An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target

    Article • PLoS Pathogens, May 2026, PLOS

    Johan Neyts

  13. 2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

    Article • ChemMedChem, April 2026, Wiley

    Johan Neyts

  14. Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells

    Article • Heliyon, April 2026, Elsevier

    Johan Neyts

  15. CD4+ T cell-mediated immunity protects from VSV-SUD lethal challenge in a mouse model of Sudan virus infection

    Article • Nature Immunology, March 2026, Springer Science + Business Media

    Johan Neyts

  16. A clinical SARS-CoV-2 Mpro inhibitor blocks replication of multiple enteroviruses and confers oral in vivo protection in animal models

    Article • PLoS Pathogens, March 2026, PLOS

    Johan Neyts

  17. A High-Throughput Antiviral Assay Based on a Sindbis Virus-GFP for the Discovery of Inhibitors of Alphavirus Replication

    Article • Viruses, February 2026, MDPI AG

    Johan Neyts

  18. COVID-19-related inflammation of the placenta impedes fetal development in pregnant hamsters

    Article • Nature Communications, February 2026, Springer Science + Business Media

    Johan Neyts

  19. New 1,2,3-triazole-α-aminophosphonate acyclic nucleosides scaffold: Design, synthesis, docking studies and biological evaluation as potential S. aureus agents

    Article • Journal of Molecular Structure, February 2026, Elsevier

    Johan Neyts

  20. Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor

    Article • European Journal of Medicinal Chemistry, February 2026, Elsevier

    Johan Neyts

  21. Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

    Article • Stem Cell Reviews and Reports, January 2026, Springer Science + Business Media

    Johan Neyts

  22. Proliferative Cell Targeting and Epithelial Cell Turnover Fuels Hepatitis E Virus Replication in Human Intestinal Enteroids

    Article • Gastro Hep Advances, January 2026, Elsevier

    Johan Neyts

  23. 2-amido-3-aryl-4-methyl-thiazole derivatives as broad-spectrum anti-rhinoviral agents

    Article • European Journal of Medicinal Chemistry, January 2026, Elsevier

    Johan Neyts

  24. Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection

    Article • eGastroenterology, January 2026, BMJ

    Johan Neyts

  25. Design, Synthesis, and Evaluation of Anti-Orthoflavivirus Anchimerically HINT1‑Activatable (AHA) ProTides

    Article • January 2026, Elsevier

    Johan Neyts

  26. Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates

    Article • Nature Communications, December 2025, Springer Science + Business Media

    Johan Neyts

  27. Antiviral activities of phenylalanine derivatives carrying carboxylic acid bioisosteres against chikungunya and parainfluenza virus type 3

    Article • Bioorganic & Medicinal Chemistry, December 2025, Elsevier

    Johan Neyts

  28. Oropouche virus causes severe congenital disease in embryonic mice

    Article • November 2025, Springer Science + Business Media

    Johan Neyts

  29. 1′-Cyanocytidine-5′-isobutyryl is a potent SARS-CoV-2 inhibitor in culture and infected Syrian hamsters

    Article • Science Advances, October 2025, American Association for the Advancement of Science

    Johan Neyts

  30. Synthesis and antiviral activity of thiazolyl hydrazones against dengue virus

    Article • Bioorganic & Medicinal Chemistry Letters, October 2025, Elsevier

    Johan Neyts

  31. Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group

    Article • ACS Medicinal Chemistry Letters, September 2025, American Chemical Society (ACS)

    Johan Neyts

  32. Correction to “Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity”

    Article • Journal of Medicinal Chemistry, September 2025, American Chemical Society (ACS)

    Johan Neyts, Dr Peng Ling

  33. Meeting report: 38th international conference on antiviral research in Las Vegas, United States of America, March 17–21, 2025

    Article • Antiviral Research, September 2025, Elsevier

    Johan Neyts

  34. High-throughput split-GFP antiviral screening assay against fusogenic paramyxoviruses

    Article • Antiviral Research, September 2025, Elsevier

    Johan Neyts

  35. The Indispensable Value of Small-Molecule Antivirals in Epidemic and Pandemic Preparedness

    Article • Clinical Infectious Diseases, September 2025, Oxford University Press (OUP)

    Johan Neyts

  36. New spirooxindole-benzothiazole hybrids incorporating a trifluoromethyl moiety as antiviral agents: Design, synthesis, crystal structure analysis, and in silico studies

    Article • Journal of Molecular Structure, September 2025, Elsevier

    Johan Neyts

  37. The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses

    Article • PLoS Pathogens, August 2025, PLOS

    Johan Neyts

  38. PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

    Article • Nature Communications, July 2025, Springer Science + Business Media

    Johan Neyts

  39. Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo

    Article • Antiviral Research, July 2025, Elsevier

    Johan Neyts

  40. Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor

    Article • Journal of Medicinal Chemistry, June 2025, American Chemical Society (ACS)

    Johan Neyts

  41. Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Johan Neyts

  42. Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Johan Neyts

  43. Discovery of Small Molecules Targeting Norovirus 3CL Protease by Multi-Stage Virtual Screening

    Article • International Journal of Molecular Sciences, June 2025, MDPI AG

    Johan Neyts

  44. Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

    Article • Nature Communications, May 2025, Springer Science + Business Media

    Johan Neyts

  45. Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Johan Neyts

  46. Functional Humoral Response During Intranasal Convalescent Plasma Prophylaxis for Severe Acute Respiratory Syndrome Coronavirus 2

    Article • The Journal of Infectious Diseases, May 2025, Oxford University Press (OUP)

    Johan Neyts

  47. 6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents

    Article • Molecules, April 2025, MDPI AG

    Johan Neyts

  48. A coronavirus assembly inhibitor that targets the viral membrane protein

    Article • Nature, March 2025, Springer Science + Business Media

    Johan Neyts

  49. A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein

    Article • Nature, March 2025, Springer Science + Business Media

    Johan Neyts

  50. The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model

    Article • Viruses, January 2025, MDPI AG

    Johan Neyts

  51. Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo

    Article • January 2025, Cold Spring Harbor Laboratory Press

    Johan Neyts

  52. Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease

    Article • Journal of Medicinal Chemistry, January 2025, American Chemical Society (ACS)

    Johan Neyts

  53. Optimization of SARS-CoV-2 Mpro Inhibitors by a Structure-Based Multilevel Virtual Screening Method

    Article • International Journal of Molecular Sciences, January 2025, MDPI AG

    Johan Neyts

  54. The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent

    Article • Viruses, January 2025, MDPI AG

    Johan Neyts

  55. The combination of GS-441524 (remdesivir) and ribavirin results in a potent antiviral effect against human parainfluenza virus 3 infection in human airway epithelial cell cultures and in a mouse infection model

    Article • January 2025, Cold Spring Harbor Laboratory Press

    Johan Neyts

  56. Design, synthesis and evaluation of arylpurine-based sinefungin mimetics as zika virus methyltransferase inhibitors

    Article • RSC Advances, January 2025, Royal Society of Chemistry

    Johan Neyts

  57. Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity

    Article • Nature Communications, December 2024, Springer Science + Business Media

    Johan Neyts

  58. Antigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19

    Article • Microorganisms, December 2024, MDPI AG

    Johan Neyts

  59. Human norovirus disturbs intestinal motility and transit time through its capsid proteins

    Article • PLoS Pathogens, November 2024, PLOS

    Johan Neyts

  60. Transcriptional profiling of zebrafish intestines identifies macrophages as host cells for human norovirus infection

    Article • Gut Microbes, November 2024, Taylor & Francis

    Johan Neyts

  61. Protecting Group Control of Hydroxyketone-Hemiketal Tautomeric Equilibrium Enables the Stereoselective Synthesis of a 1′-Azido C-Nucleoside

    Article • The Journal of Organic Chemistry, November 2024, American Chemical Society (ACS)

    Johan Neyts

  62. The effects of Remdesivir’s functional groups on its antiviral potency and resistance against the SARS-CoV-2 polymerase

    Article • Antiviral Research, November 2024, Elsevier

    Johan Neyts

  63. The triple combination of Remdesivir (GS-441524), Molnupiravir and Ribavirin is highly efficient in inhibiting coronavirus replication in human nasal airway epithelial cell cultures and in a hamster infection model

    Article • Antiviral Research, November 2024, Elsevier

    Johan Neyts

  64. A Pangenotypic Hepatitis E Virus Replication Inhibitor With High Potency in a Rat Infection Model

    Article • Gastroenterology, November 2024, Elsevier

    Johan Neyts

  65. Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Johan Neyts

  66. Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Johan Neyts

  67. The tyrosine kinase Yes1 is a druggable host factor of HEV

    Article • Hepatology Communications, October 2024, Wolters Kluwer Health

    Johan Neyts

  68. Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

    Article • Viruses, October 2024, MDPI AG

    Johan Neyts

  69. A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

    Article • Nature Communications, September 2024, Springer Science + Business Media

    Johan Neyts

  70. A Hepatitis E Virus Infection Model in the Mongolian Gerbil: Ready for Antiviral and Vaccine Studies

    Article • Gastroenterology, September 2024, Elsevier

    Johan Neyts

  71. Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation

    Article • Nature Communications, July 2024, Springer Science + Business Media

    Johan Neyts

  72. New Schiff bases and their vanadium complexes: Synthesis, characterization, and biological assessment for antibacterial and antiviral action

    Article • Applied Organometallic Chemistry, May 2024, Wiley

    Johan Neyts

  73. Standing the test of COVID-19: charting the new frontiers of medicine

    Article • Frontiers in Science, May 2024, Frontiers

    Johan Neyts

  74. The triple combination of Remdesivir (GS-441524), Molnupiravir and Ribavirin is highly efficient in inhibiting coronavirus replication in human nasal airway epithelial cell cultures and in a hamster infection model

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Johan Neyts

  75. A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology

    Article • April 2024, Springer Science + Business Media

    Johan Neyts

  76. Challenges in combating arboviral infections

    Article • Nature Communications, April 2024, Springer Science + Business Media

    Johan Neyts

  77. Mechanism of action of phthalazinone derivatives against rabies virus

    Article • Antiviral Research, April 2024, Elsevier

    Johan Neyts

  78. Hepatitis E virus replication is facilitated by epithelial cell turnover and targets enteroendocrine cells in human intestinal organoids

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Johan Neyts

  79. Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents

    Article • European Journal of Medicinal Chemistry, March 2024, Elsevier

    Johan Neyts

  80. Beware of drug resistance: Let’s not lose tecovirimat against mpox

    Article • Clinical Microbiology and Infection, March 2024, Elsevier

    Johan Neyts

  81. Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study

    Article • The Lancet Microbe, March 2024, Elsevier

    Johan Neyts

  82. Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids

    Article • Antiviral Research, March 2024, Elsevier

    Johan Neyts

  83. Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor

    Article • Journal of Medicinal Chemistry, February 2024, American Chemical Society (ACS)

    Johan Neyts

  84. Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted

    Article • EBioMedicine, February 2024, Elsevier

    Johan Neyts, Han Remaut

  85. Comparing the Infectivity of Recent SARS-CoV-2 Omicron Sub-Variants in Syrian Hamsters

    Article • Viruses, January 2024, MDPI AG

    Johan Neyts

  86. Multiplexed multicolor antiviral assay amenable for high-throughput research

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Johan Neyts

  87. Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

    Article • Virus Evolution, January 2024, Oxford University Press (OUP)

    Johan Neyts

  88. Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus

    Article • European Journal of Medicinal Chemistry, January 2024, Elsevier

    Johan Neyts

  89. Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

    Article • Acta Pharmaceutica Sinica B, January 2024, Elsevier

    Johan Neyts

  90. A new alkaloid from Pancratium maritimum - Structure elucidation using computer-assisted structure elucidation (CASE) and evaluation of cytotoxicity and anti-SARS-CoV-2 activity

    Article • Phytochemistry Letters, December 2023, Elsevier

    Johan Neyts

  91. Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters

    Article • Journal of Antimicrobial Chemotherapy, November 2023, Oxford University Press (OUP)

    Johan Neyts

  92. A Robust Phenotypic High-Throughput Antiviral Assay for the Discovery of Rabies Virus Inhibitors

    Article • Viruses, November 2023, MDPI AG

    Johan Neyts

  93. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

    Article • Science, November 2023, American Association for the Advancement of Science

    Johan Neyts

  94. Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

    Article • Antiviral Research, November 2023, Elsevier

    Johan Neyts

  95. Optimized vaccine candidate MVA-S(3P) fully protects against SARS-CoV-2 infection in hamsters

    Article • Frontiers in Immunology, October 2023, Frontiers

    Johan Neyts

  96. Comprehensive study of alkaloids from Scadoxus multiflorus by HPLC-PDA-SPE-NMR and evaluation of their anti-SARS-CoV-2 activity

    Article • Phytochemistry Letters, October 2023, Elsevier

    Johan Neyts

  97. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

    Article • Journal of Clinical Investigation, August 2023, American Society for Clinical Investigation

    Johan Neyts

  98. Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies

    Article • Antiviral Research, August 2023, Elsevier

    Johan Neyts

  99. YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge

    Article • npj Vaccines, July 2023, Springer Science + Business Media

    Johan Neyts

  100. Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors

    Article • Journal of Medicinal Chemistry, June 2023, American Chemical Society (ACS)

    Johan Neyts

  101. Author Correction: Reverse engineering synthetic antiviral amyloids

    Article • Nature Communications, June 2023, Springer Science + Business Media

    Johan Neyts, Guy Bormans

  102. Towards antivirals against hepatitis E: In the steps of hepatitis C

    Article • Hepatology, June 2023, Wolters Kluwer Health

    Johan Neyts

  103. Antiviral strategies for epidemic and pandemic preparedness

    Article • Cell Host & Microbe, June 2023, Elsevier

    Johan Neyts

  104. Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters

    Article • EBioMedicine, June 2023, Elsevier

    Johan Neyts

  105. Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks

    Article • Nature Aging, May 2023, Springer Science + Business Media

    Johan Neyts, Hideo Imamura

  106. Urtica dioica Agglutinin Prevents Rabies Virus Infection in a Muscle Explant Model

    Article • Pharmaceutics, April 2023, MDPI AG

    Johan Neyts, Prof dr Els J.M. Van Damme

  107. Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment

    Article • Nature Communications, April 2023, Springer Science + Business Media

    Johan Neyts

  108. Validation of a Reporter Cell Line for Flavivirus Inhibition Assays

    Article • Microbiology Spectrum, April 2023, ASM Journals

    Johan Neyts

  109. Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

    Article • Molecules, April 2023, MDPI AG

    Johan Neyts

  110. Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

    Article • Nature, March 2023, Springer Science + Business Media

    Johan Neyts

  111. Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

    Article • Microorganisms, March 2023, MDPI AG

    Johan Neyts

  112. The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

    Article • mBio, February 2023, ASM Journals

    Johan Neyts

  113. Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

    Article • Scientific Reports, February 2023, Springer Science + Business Media

    Johan Neyts

  114. Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Johan Neyts

  115. A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships

    Article • Antiviral Research, February 2023, Elsevier

    Johan Neyts

  116. Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery

    Article • Antiviral Research, February 2023, Elsevier

    Johan Neyts

  117. Single-dose YF17D-vectored Ebola vaccine candidate protects mice against both lethal surrogate Ebola and yellow fever virus challenge

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Johan Neyts

  118. Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

    Article • Chemical Science, January 2023, Royal Society of Chemistry

    Johan Neyts

  119. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71

    Article • European Journal of Medicinal Chemistry, January 2023, Elsevier

    Johan Neyts

  120. Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives

    Article • Journal of Molecular Structure, January 2023, Elsevier

    Johan Neyts

  121. Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

    Article • Viruses, December 2022, MDPI AG

    Johan Neyts

  122. Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

    Article • Molecules, December 2022, MDPI AG

    Johan Neyts

  123. The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae

    Article • Microbiology Spectrum, December 2022, ASM Journals

    Johan Neyts

  124. Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters

    Article • Frontiers in Pharmacology, December 2022, Frontiers

    Johan Neyts

  125. Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

    Article • Neuron, December 2022, Elsevier

    Johan Neyts

  126. Human Norovirus Efficiently Replicates in Differentiated 3D-Human Intestinal Enteroids

    Article • Journal of Virology, November 2022, ASM Journals

    Johan Neyts

  127. Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

    Article • Science, November 2022, American Association for the Advancement of Science

    Johan Neyts

  128. Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Johan Neyts

  129. Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

    Article • Frontiers in Chemistry, October 2022, Frontiers

    Johan Neyts

  130. Bis(Benzofuran–1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Johan Neyts

  131. SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

    Article • Frontiers in Cardiovascular Medicine, October 2022, Frontiers

    Johan Neyts

  132. Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents

    Article • Molecular Diversity, October 2022, Springer Science + Business Media

    Johan Neyts

  133. Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

    Article • Research and Practice in Thrombosis and Haemostasis, October 2022, Elsevier

    Johan Neyts

  134. Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease

    Article • Journal of Medicinal Chemistry, September 2022, American Chemical Society (ACS)

    Johan Neyts

  135. A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

    Article • Molecular Therapy, September 2022, Elsevier

    Johan Neyts

  136. Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

    Article • EBioMedicine, September 2022, Elsevier

    Johan Neyts

  137. Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models

    Article • EBioMedicine, September 2022, Elsevier

    Johan Neyts

  138. A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection

    Article • Journal of Virology, August 2022, ASM Journals

    Johan Neyts

  139. The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution

    Article • Cardiovascular Research, August 2022, Oxford University Press (OUP)

    Johan Neyts

  140. Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

    Article • Scientific Reports, August 2022, Springer Science + Business Media

    Johan Neyts

  141. ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

    Article • Science, August 2022, American Association for the Advancement of Science

    Johan Neyts

  142. The dissemination of Rift Valley fever virus to the eye and sensory neurons of zebrafish larvae is stat1 dependent

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Johan Neyts

  143. Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19

    Article • Microorganisms, August 2022, MDPI AG

    Johan Neyts

  144. Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model

    Article • iScience, August 2022, Elsevier

    Johan Neyts

  145. Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

    Article • Nature Microbiology, July 2022, Springer Science + Business Media

    Johan Neyts

  146. Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

    Article • Scientific Data, July 2022, Springer Science + Business Media

    Johan Neyts

  147. Computer-Aided Design and Synthesis of (Functionalized quinazoline)–(α-substituted coumarin)–arylsulfonate Conjugates against Chikungunya Virus

    Article • International Journal of Molecular Sciences, July 2022, MDPI AG

    Johan Neyts

  148. Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors

    Article • European Journal of Medicinal Chemistry, July 2022, Elsevier

    Johan Neyts

  149. A High-Throughput Yellow Fever Neutralization Assay

    Article • Microbiology Spectrum, June 2022, ASM Journals

    Johan Neyts

  150. Biodistribution and environmental safety of a live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

    Article • Molecular Therapy — Methods & Clinical Development, June 2022, Elsevier

    Johan Neyts

  151. HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

    Article • Antiviral Research, June 2022, Elsevier

    Johan Neyts

  152. Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Johan Neyts

  153. Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

    Article • ACS Medicinal Chemistry Letters, May 2022, American Chemical Society (ACS)

    Johan Neyts

  154. SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells

    Article • Viruses, May 2022, MDPI AG

    Johan Neyts

  155. Restriction of viral replication, rather than T cell immunopathology, drives lethality in MNV CR6-infected STAT1-deficient mice

    Article • The Journal of Immunology, May 2022, The American Association of Immunologists

    Johan Neyts

  156. Cytidine nucleoside analog is an effective antiviral drug against Trichomonasvirus

    Article • Journal of Microbiology Immunology and Infection, April 2022, Elsevier

    Johan Neyts

  157. Development and optimization of a high‐throughput screening assay for in vitro anti‐SARS‐CoV‐2 activity: Evaluation of 5676 Phase 1 Passed Structures

    Article • Journal of Medical Virology, March 2022, Wiley

    Johan Neyts

  158. Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice

    Article • Journal of Virology, March 2022, ASM Journals

    Johan Neyts

  159. Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model

    Article • Microorganisms, March 2022, MDPI AG

    Johan Neyts

  160. MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters

    Article • Frontiers in Immunology, March 2022, Frontiers

    Johan Neyts

  161. The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model

    Article • Communications Biology, March 2022, Springer Science + Business Media

    Johan Neyts

  162. Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines

    Article • Journal of Molecular Structure, March 2022, Elsevier

    Johan Neyts

  163. Synthesis and antiviral activities of quinazolinamine–coumarin conjugates toward chikungunya and hepatitis C viruses

    Article • European Journal of Medicinal Chemistry, March 2022, Elsevier

    Johan Neyts

  164. Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Johan Neyts

  165. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

    Article • Nature Communications, February 2022, Springer Science + Business Media

    Johan Neyts

  166. Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

    Article • Journal of the American Chemical Society, February 2022, American Chemical Society (ACS)

    Johan Neyts

  167. Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

    Article • Molecules, February 2022, MDPI AG

    Johan Neyts

  168. Development and optimisation of a high-throughput screening assay for in vitro anti–SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Johan Neyts

  169. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

    Article • Cell Stem Cell, February 2022, Elsevier

    Johan Neyts

  170. Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

    Article • Antiviral Research, February 2022, Elsevier

    Johan Neyts

  171. The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters

    Article • Antiviral Research, February 2022, Elsevier

    Johan Neyts

  172. Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

    Article • Science, January 2022, American Association for the Advancement of Science

    Johan Neyts

  173. Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings

    Article • Biomedicines, January 2022, MDPI AG

    Johan Neyts

  174. Advances and gaps in SARS-CoV-2 infection models

    Article • PLoS Pathogens, January 2022, PLOS

    Dr Randy A Albrecht, Johan Neyts

  175. Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

    Article • Cell, January 2022, Elsevier

    Johan Neyts

  176. Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Johan Neyts

  177. Antiviral Strategies Against (Non‐polio) Picornaviruses

    Article • December 2021, Wiley

    Johan Neyts

  178. Antiviral Targets and Strategies to Treat and Prevent Human Norovirus Infections

    Article • December 2021, Wiley

    Johan Neyts

  179. An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

    Article • Science Translational Medicine, November 2021, American Association for the Advancement of Science

    Johan Neyts

  180. Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts.

    Article • November 2021, Research Square

    Johan Neyts

  181. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Johan Neyts

  182. Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species

    Article • Antiviral Research, November 2021, Elsevier

    Johan Neyts

  183. Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Johan Neyts

  184. The legacy of ZikaPLAN: a transnational research consortium addressing Zika

    Article • Global Health Action, October 2021, Taylor & Francis

    Johan Neyts

  185. Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

    Article • Nature, October 2021, Springer Science + Business Media

    Johan Neyts

  186. A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

    Article • Nature, October 2021, Springer Science + Business Media

    Johan Neyts

  187. A highly potent antibody effective against SARS-CoV-2 variants of concern

    Article • Cell Reports, October 2021, Elsevier

    Johan Neyts

  188. The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

    Article • EBioMedicine, October 2021, Elsevier

    Johan Neyts

  189. 1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors

    Article • European Journal of Medicinal Chemistry, October 2021, Elsevier

    Johan Neyts

  190. Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

    Article • Pharmaceuticals, September 2021, MDPI AG

    Johan Neyts

  191. Assessing In Vitro Resistance Development in Enterovirus A71 in the Context of Combination Antiviral Treatment

    Article • ACS Infectious Diseases, September 2021, American Chemical Society (ACS)

    Johan Neyts

  192. A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

    Article • Viruses, September 2021, MDPI AG

    Johan Neyts

  193. Broad betacoronavirus neutralization by a stem helix–specific human antibody

    Article • Science, September 2021, American Association for the Advancement of Science

    Johan Neyts

  194. Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development?

    Article • Biologicals, September 2021, Elsevier

    Johan Neyts

  195. Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

    Article • Antiviral Research, September 2021, Elsevier

    Johan Neyts

  196. Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

    Article • Antiviral Research, September 2021, Elsevier

    Johan Neyts

  197. Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

    Article • Microorganisms, August 2021, MDPI AG

    Johan Neyts

  198. A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

    Article • Antiviral Research, August 2021, Elsevier

    Johan Neyts

  199. A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice

    Article • JHEP Reports, August 2021, Elsevier

    Johan Neyts

  200. Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

    Article • Microorganisms, July 2021, MDPI AG

    Johan Neyts

  201. Broad sarbecovirus neutralization by a human monoclonal antibody

    Article • Nature, July 2021, Springer Science + Business Media

    Johan Neyts

  202. SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

    Article • Nature, July 2021, Springer Science + Business Media

    Johan Neyts, Tristan Croll

  203. Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model

    Article • The Journal of Infectious Diseases, July 2021, Oxford University Press (OUP)

    Johan Neyts

  204. Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors

    Article • Journal of Medicinal Chemistry, July 2021, American Chemical Society (ACS)

    Dr Ernesto Quesada, Johan Neyts

  205. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

    Article • Nature Communications, July 2021, Springer Science + Business Media

    Johan Neyts, Erwin Dreesen

  206. Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”

    Article • EBioMedicine, July 2021, Elsevier

    Johan Neyts, Erwin Dreesen

  207. Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, June 2021, ASM Journals

    Johan Neyts

  208. Discovery of novel furo[2,3‐ d ]pyrimidin‐2‐one–1,3,4‐oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis

    Article • Archiv der Pharmazie, June 2021, Wiley

    Az-eddine EL Mansouri, Johan Neyts

  209. Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

    Article • EBioMedicine, June 2021, Elsevier

    Johan Neyts

  210. Multivalent Tryptophan‐ and Tyrosine‐Containing [60]Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

    Article • Chemistry - A European Journal, June 2021, Wiley

    Johan Neyts

  211. COVID-19 and the intensive care unit: vaccines to the rescue

    Article • Intensive Care Medicine, May 2021, Springer Science + Business Media

    Johan Neyts

  212. In vitro activity of itraconazole against SARS‐CoV‐2

    Article • Journal of Medical Virology, May 2021, Wiley

    Johan Neyts

  213. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Johan Neyts

  214. Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions

    Article • Angewandte Chemie, May 2021, Wiley

    Johan Neyts

  215. ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

    Article • Biochemical and Biophysical Research Communications, May 2021, Elsevier

    Johan Neyts

  216. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

    Article • Journal of Medicinal Chemistry, April 2021, American Chemical Society (ACS)

    Johan Neyts

  217. Alpha variant versus D614G strain in the Syrian hamster model

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Johan Neyts

  218. N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

    Article • Cell, April 2021, Elsevier

    Johan Neyts, Dr. Louis-Marie Bloyet

  219. Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors

    Article • Nature Protocols, April 2021, Springer Science + Business Media

    Johan Neyts

  220. Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

    Article • EBioMedicine, April 2021, Elsevier

    Johan Neyts, Erwin Dreesen

  221. Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors

    Article • Microorganisms, March 2021, MDPI AG

    Johan Neyts

  222. A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Johan Neyts

  223. High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients

    Article • Cellular and Molecular Life Sciences, March 2021, Springer Science + Business Media

    Johan Neyts

  224. Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

    Article • ACS Pharmacology & Translational Science, March 2021, American Chemical Society (ACS)

    Johan Neyts

  225. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2

    Article • Nature Genetics, March 2021, Springer Science + Business Media

    Vincent geudens, Johan Neyts

  226. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19

    Article • The Journal of Physical Chemistry Letters, February 2021, American Chemical Society (ACS)

    Johan Neyts

  227. Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Johan Neyts

  228. Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

    Article • BDJ, January 2021, Springer Science + Business Media

    Johan Neyts

  229. Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome

    Article • RNA Biology, January 2021, Taylor & Francis

    Johan Neyts

  230. Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice

    Article • Emerging Microbes & Infections, January 2021, Taylor & Francis

    Johan Neyts

  231. Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Early mechanistic studies

    Article • Antiviral Chemistry and Chemotherapy, January 2021, SAGE Publications

    Johan Neyts

  232. Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Identification of active compounds

    Article • Antiviral Chemistry and Chemotherapy, January 2021, SAGE Publications

    Johan Neyts

  233. Screening and in vitro antiviral assessment of small molecules against fluorescent protein-expressing Bunyamwera virus in a cell-based assay using high-content imaging

    Article • Antiviral Chemistry and Chemotherapy, January 2021, SAGE Publications

    Johan Neyts

  234. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

    Article • Nature, December 2020, Springer Science + Business Media

    Johan Neyts

  235. Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

    Article • Science, November 2020, American Association for the Advancement of Science

    Johan Neyts

  236. STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

    Article • Nature Communications, November 2020, Springer Science + Business Media

    Johan Neyts

  237. Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

    Article • PLoS Biology, November 2020, PLOS

    Johan Neyts

  238. A dengue type 2 reporter virus assay amenable to high-throughput screening

    Article • Antiviral Research, November 2020, Elsevier

    Johan Neyts

  239. Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales

    Article • Antiviral Research, November 2020, Elsevier

    Johan Neyts

  240. SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

    Article • Nature Chemical Biology, October 2020, Springer Science + Business Media

    Johan Neyts

  241. Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

    Article • Proceedings of the National Academy of Sciences, October 2020, Proceedings of the National Academy of Sciences

    Johan Neyts

  242. Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

    Article • Antiviral Research, October 2020, Elsevier

    Johan Neyts

  243. Identification of TMEM106B as proviral host factor for SARS-CoV-2

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Johan Neyts

  244. Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

    Article • Nature Communications, August 2020, Springer Science + Business Media

    Johan Neyts, Matthew Frieman

  245. Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

    Article • Molecules, August 2020, MDPI AG

    Johan Neyts

  246. Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin

    Article • Journal of Antimicrobial Chemotherapy, August 2020, Oxford University Press (OUP)

    Johan Neyts

  247. A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Johan Neyts

  248. Establishing a Unified COVID-19 “Immunome”: Integrating Coronavirus Pathogenesis and Host Immunopathology

    Article • Frontiers in Immunology, July 2020, Frontiers

    Johan Neyts

  249. A prospect on the use of antiviral drugs to control local outbreaks of COVID-19

    Article • BMC Medicine, June 2020, Springer Science + Business Media

    Johan Neyts

  250. Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

    Article • Human Vaccines & Immunotherapeutics, June 2020, Taylor & Francis

    Johan Neyts

  251. Reverse engineering synthetic antiviral amyloids

    Article • Nature Communications, June 2020, Springer Science + Business Media

    Johan Neyts, Guy Bormans

  252. Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.)

    Article • Viruses, May 2020, MDPI AG

    Johan Neyts

  253. Medical treatment options for COVID-19

    Article • European Heart Journal Acute Cardiovascular Care, May 2020, SAGE Publications

    Johan Neyts

  254. Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

    Article • Antimicrobial Agents and Chemotherapy, April 2020, ASM Journals

    Johan Neyts

  255. STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Johan Neyts

  256. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence

    Article • Evidence-based Complementary and Alternative Medicine, April 2020, Hindawi Publishing Corporation

    Johan Neyts

  257. A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies

    Article • mBio, April 2020, ASM Journals

    Johan Neyts

  258. The Development of RNA-KISS, a Mammalian Three-Hybrid Method to Detect RNA–Protein Interactions in Living Mammalian Cells

    Article • Journal of Proteome Research, April 2020, American Chemical Society (ACS)

    Johan Neyts

  259. Antiviral drug discovery against arthritogenic alphaviruses: Tools and molecular targets

    Article • Biochemical Pharmacology, April 2020, Elsevier

    Johan Neyts

  260. Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein

    Article • Bioorganic & Medicinal Chemistry, April 2020, Elsevier

    Johan Neyts

  261. Mycophenolic Acid Has Intrinsic Antiviral Properties and Potentiates the Antiviral Effect of Ribavirin on Parainfluenza Virus

    Article • The Journal of Heart and Lung Transplantation, April 2020, Elsevier

    Johan Neyts

  262. Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

    Article • Molecules, March 2020, MDPI AG

    Johan Neyts

  263. Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus

    Article • ACS Medicinal Chemistry Letters, March 2020, American Chemical Society (ACS)

    Johan Neyts

  264. Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides

    Article • European Journal of Medicinal Chemistry, March 2020, Elsevier

    Johan Neyts

  265. Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment

    Article • Journal of Medicinal Chemistry, February 2020, American Chemical Society (ACS)

    Johan Neyts

  266. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

    Article • Antiviral Research, February 2020, Elsevier

    Johan Neyts, Professor Marc Lecuit

  267. Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site

    Article • Science Translational Medicine, January 2020, American Association for the Advancement of Science

    Johan Neyts

  268. Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents

    Article • RSC Advances, January 2020, Royal Society of Chemistry

    Johan Neyts

  269. A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

    Article • Emerging Microbes & Infections, January 2020, Taylor & Francis

    Johan Neyts

  270. Increased IL‐10‐producing regulatory T cells are characteristic of severe cases of COVID‐19

    Article • Clinical & Translational Immunology, January 2020, Wiley

    Johan Neyts

  271. Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease Severity

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Johan Neyts, Erwin Dreesen

  272. Itraconazole for COVID-19: Preclinical Studies and a Proof-of-Concept Pilot Clinical Study

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Johan Neyts, Erwin Dreesen

  273. A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Johan Neyts, Dr Ernesto Quesada

  274. Design, synthesis and discovery of novel N,N’‐carbazoyl‐aryl‐urea inhibitors of Zika NS5 methyltransferase and virus replication

    Article • ChemMedChem, December 2019, Wiley

    Johan Neyts

  275. Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Johan Neyts, Dr Paola Vergani

  276. 2019 meeting of the global virus network

    Article • Antiviral Research, December 2019, Elsevier

    Johan Neyts

  277. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

    Article • Antiviral Research, December 2019, Elsevier

    Johan Neyts, Professor Marc Lecuit

  278. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

    Article • Antiviral Research, December 2019, Elsevier

    Johan Neyts, Professor Marc Lecuit

  279. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Johan Neyts

  280. Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa

    Article • Phytochemistry, November 2019, Elsevier

    Johan Neyts

  281. A robust human norovirus replication model in zebrafish larvae

    Article • PLoS Pathogens, September 2019, PLOS

    Johan Neyts

  282. Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum

    Article • Antiviral Research, August 2019, Elsevier

    Johan Neyts

  283. A chimeric Japanese encephalitis vaccine protects against lethal yellow fever virus infection without inducing neutralizing antibodies

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Johan Neyts

  284. Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

    Article • Journal of Experimental Medicine, July 2019, Rockefeller University Press

    Johan Neyts

  285. New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

    Article • Molecules, July 2019, MDPI AG

    Johan Neyts

  286. A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

    Article • PLoS Biology, June 2019, PLOS

    Johan Neyts, Dr Sarah Jane Butcher

  287. Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

    Article • PLoS Pathogens, May 2019, PLOS

    Johan Neyts

  288. A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice

    Article • International Journal of Molecular Sciences, April 2019, MDPI AG

    Johan Neyts

  289. F-102 Antivirals, a lot has been achieved, yet a long way to go

    Article • JAIDS Journal of Acquired Immune Deficiency Syndromes, April 2019, Wolters Kluwer Health

    Johan Neyts

  290. Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Johan Neyts

  291. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

    Article • Antiviral Research, March 2019, Elsevier

    Professor Marc Lecuit, Johan Neyts

  292. Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

    Article • Viruses, February 2019, MDPI AG

    Johan Neyts

  293. Structural and functional similarities in bunyaviruses: Perspectives for pan-bunya antivirals

    Article • Reviews in Medical Virology, February 2019, Wiley

    Johan Neyts

  294. Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3

    Article • Antiviral Research, February 2019, Elsevier

    Johan Neyts

  295. Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

    Article • Journal of Natural Products, January 2019, American Chemical Society (ACS)

    Johan Neyts

  296. A robust human norovirus replication model in zebrafish larvae: Supplementary data file

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Johan Neyts

  297. Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication

    Article • ACS Medicinal Chemistry Letters, January 2019, American Chemical Society (ACS)

    Johan Neyts

  298. Progress in human picornavirus research: New findings from the AIROPico consortium

    Article • Antiviral Research, January 2019, Elsevier

    Mr., Dr. Petri Susi, Johan Neyts

  299. Pyrimethamine inhibits rabies virus replication in vitro

    Article • Antiviral Research, January 2019, Elsevier

    Johan Neyts

  300. Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

    Article • Emerging Microbes & Infections, January 2019, Taylor & Francis

    Johan Neyts, Carmen Mirabelli

  301. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

    Article • Global Health Action, January 2019, Taylor & Francis

    Johan Neyts, Professor sue C Barnett, Eduardo Massad, Rosanna Peeling

  302. Limited evolution of the yellow fever virus 17d in a mouse infection model

    Article • Emerging Microbes & Infections, January 2019, Taylor & Francis

    Johan Neyts

  303. Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals

    Article • PLOS One, December 2018, PLOS

    Johan Neyts

  304. A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

    Article • npj Vaccines, December 2018, Springer Science + Business Media

    Johan Neyts

  305. Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice

    Article • Antiviral Research, December 2018, Elsevier

    Johan Neyts

  306. CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer

    Article • Experimental Cell Research, November 2018, Elsevier

    Johan Neyts

  307. Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ

    Article • Journal of Interferon & Cytokine Research, November 2018, Mary Ann Liebert Inc

    Johan Neyts

  308. Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity

    Article • Journal of Ethnopharmacology, October 2018, Elsevier

    Johan Neyts

  309. A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

    Article • Cell Host & Microbe, October 2018, Elsevier

    Johan Neyts

  310. PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases

    Article • Journal of Antimicrobial Chemotherapy, September 2018, Oxford University Press (OUP)

    Johan Neyts

  311. Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors

    Article • Journal of Medicinal Chemistry, September 2018, American Chemical Society (ACS)

    Johan Neyts

  312. Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication

    Article • Journal of Medicinal Chemistry, September 2018, American Chemical Society (ACS)

    Johan Neyts

  313. HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis

    Article • Biochemical Pharmacology, September 2018, Elsevier

    Johan Neyts

  314. A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea

    Article • The Journal of Infectious Diseases, July 2018, Oxford University Press (OUP)

    Johan Neyts

  315. Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

    Article • International Journal of Antimicrobial Agents, July 2018, Elsevier

    Johan Neyts

  316. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection

    Article • International Journal of Antimicrobial Agents, July 2018, Elsevier

    Johan Neyts, Professor Wim M De Borggraeve

  317. Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds

    Article • ChemMedChem, June 2018, Wiley

    Johan Neyts

  318. Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice

    Article • Journal of Antimicrobial Chemotherapy, May 2018, Oxford University Press (OUP)

    Johan Neyts

  319. Favipiravir as a potential countermeasure against neglected and emerging RNA viruses

    Article • Antiviral Research, May 2018, Elsevier

    Johan Neyts

  320. Synthesis of Enantiomerically Pure 1′,2′-cis-dideoxy, -dideoxydi­dehydro, -ribo and -deoxy Carbocyclic Nucleoside Analogues

    Article • Synthesis, April 2018, Thieme Publishing Group

    Johan Neyts

  321. Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

    Article • European Journal of Medicinal Chemistry, April 2018, Elsevier

    Johan Neyts

  322. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe

    Article • Journal of Clinical Virology, April 2018, Elsevier

    Johan Neyts

  323. Hepatitis E virus replication and interferonresponse in human placental-derived cells

    Article • Journal of Hepatology, April 2018, Elsevier

    Johan Neyts

  324. Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium

    Article • Journal of Antimicrobial Chemotherapy, March 2018, Oxford University Press (OUP)

    Johan Neyts

  325. A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

    Article • Tetrahedron, March 2018, Elsevier

    Johan Neyts

  326. Pan-NS3 protease inhibitors of hepatitis C virus based on an R 3 -elongated pyrazinone scaffold

    Article • European Journal of Medicinal Chemistry, March 2018, Elsevier

    Johan Neyts

  327. Structurally Diverse Diterpenoids from Sandwithia guyanensis

    Article • Journal of Natural Products, March 2018, American Chemical Society (ACS)

    Johan Neyts

  328. Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones

    Article • ACS Infectious Diseases, February 2018, American Chemical Society (ACS)

    Johan Neyts

  329. Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

    Article • Bioorganic & Medicinal Chemistry, February 2018, Elsevier

    Johan Neyts

  330. Differential Antiviral Activities of RSV Inhibitors in Human Airway Epithelium

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Johan Neyts

  331. Hepatitis E virus replication and interferon responses in human placental cells

    Article • Hepatology Communications, January 2018, Wiley

    Johan Neyts

  332. Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection

    Article • Antiviral Research, January 2018, Elsevier

    Johan Neyts

  333. Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model

    Article • Antiviral Research, January 2018, Elsevier

    Johan Neyts, Thomas Michiels

  334. New Models to Study Hepatitis E Virus Replication and Particular Characteristics of Infection: The Needle Hides in the Hay Stack

    Article • Gastroenterology, January 2018, Elsevier

    Johan Neyts

  335. Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model

    Article • Antiviral Research, January 2018, Elsevier

    Johan Neyts

  336. Assessing the Efficacy of Small Molecule Inhibitors in a Mouse Model of Persistent Norovirus Infection

    Article • BIO-PROTOCOL, January 2018, Bio-Protocol, LLC

    Johan Neyts

  337. The path towards effective antivirals against rabies

    Article • Vaccine, December 2017, Elsevier

    Johan Neyts

  338. Mannitol treatment is not effective in therapy of rabies virus infection in mice

    Article • Vaccine, December 2017, Elsevier

    Johan Neyts

  339. Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study

    Article • European Journal of Medicinal Chemistry, November 2017, Elsevier

    Johan Neyts

  340. New class of early-stage enterovirus inhibitors with a novel mechanism of action

    Article • Antiviral Research, November 2017, Elsevier

    Johan Neyts

  341. Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India

    Article • Frontiers in Pharmacology, October 2017, Frontiers

    Johan Neyts

  342. Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

    Article • F1000Research, October 2017, Faculty of 1000, Ltd.

    Johan Neyts, Carmen Mirabelli

  343. Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry

    Article • Stem Cell Research & Therapy, September 2017, Springer Science + Business Media

    Johan Neyts

  344. Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks

    Article • ACS Chemical Biology, September 2017, American Chemical Society (ACS)

    Johan Neyts

  345. Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals

    Article • Antiviral Research, September 2017, Elsevier

    Johan Neyts

  346. In silico development of a novel putative inhibitor of the 3C protease of Coxsackievirus B3 with a benzene sulfonamide skeleton

    Article • JOURNAL OF PHARMACEUTICAL CHEMISTRY, August 2017, Vensel Publications

    Johan Neyts

  347. Antiviral activity of [1,2,3]triazolo[4,5- d ]pyrimidin-7(6 H )-ones against chikungunya virus targeting the viral capping nsP1

    Article • Antiviral Research, August 2017, Elsevier

    Johan Neyts

  348. Fluorination of Naturally Occurring N6-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity

    Article • Molecules, July 2017, MDPI AG

    Prof Sergey N Mikhailov, Johan Neyts

  349. Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

    Article • Journal of Natural Products, July 2017, American Chemical Society (ACS)

    Johan Neyts

  350. A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

    Article • Journal of Medicinal Chemistry, June 2017, American Chemical Society (ACS)

    Johan Neyts

  351. A novel kindred with inherited STAT2 deficiency and severe viral illness

    Article • Journal of Allergy and Clinical Immunology, June 2017, Elsevier

    Johan Neyts

  352. Chikungunya virus infections: time to act, time to treat

    Article • Current Opinion in Virology, June 2017, Elsevier

    Johan Neyts

  353. Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

    Article • Journal of Virology, April 2017, ASM Journals

    Johan Neyts

  354. Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication

    Article • Antiviral Research, April 2017, Elsevier

    Johan Neyts, Wenshi Wang

  355. Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

    Article • Marmara Pharmaceutical Journal, April 2017, Marmara Pharmaceutical Journal

    Johan Neyts

  356. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307

    Article • Antiviral Research, April 2017, Elsevier

    Johan Neyts

  357. Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery

    Article • Biochemical Pharmacology, March 2017, Elsevier

    Johan Neyts

  358. Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains

    Article • Vaccine, March 2017, Elsevier

    Johan Neyts

  359. Protein kinases C as potential host targets for the inhibition of chikungunya virus replication

    Article • Antiviral Research, March 2017, Elsevier

    Johan Neyts

  360. Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid

    Article • Antiviral Research, March 2017, Elsevier

    Johan Neyts, Dr Ernesto Quesada

  361. Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

    Article • Journal of Medicinal Chemistry, February 2017, American Chemical Society (ACS)

    Dr Emily Langron, Dr Paola Vergani, Johan Neyts

  362. Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

    Article • Bioorganic & Medicinal Chemistry Letters, February 2017, Elsevier

    Johan Neyts

  363. ZikaPLAN: Zika Preparedness Latin American Network

    Article • Global Health Action, January 2017, Taylor & Francis

    Johan Neyts

  364. Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    Johan Neyts

  365. Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

    Article • Bioorganic & Medicinal Chemistry, January 2017, Elsevier

    Johan Neyts

  366. In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    Johan Neyts

  367. Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones

    Article • Bioorganic & Medicinal Chemistry Letters, January 2017, Elsevier

    Johan Neyts

  368. In vitro Assay to Assess Efficacy of Potential Antiviral Compounds against Enterovirus D68

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Johan Neyts

  369. Antiviral Agents Towards Chikungunya Virus: Structures, Syntheses, and Isolation from Natural Sources

    Article • January 2017, Springer Science + Business Media

    Johan Neyts

  370. Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

    Article • Journal of Hepatology, January 2017, Elsevier

    Johan Neyts

  371. Biosafety standards for working with Crimean-Congo hemorrhagic fever virus

    Article • Journal of General Virology, November 2016, Society for General Microbiology

    Johan Neyts, Aykut Ozkul

  372. Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism

    Article • Biochemical Pharmacology, November 2016, Elsevier

    Johan Neyts

  373. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

    Article • European Journal of Medicinal Chemistry, November 2016, Elsevier

    Johan Neyts

  374. Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Johan Neyts

  375. Norovirus genetic diversity and evolution: implications for antiviral therapy

    Article • Current Opinion in Virology, October 2016, Elsevier

    Johan Neyts

  376. Towards antiviral therapies for treating dengue virus infections

    Article • Current Opinion in Pharmacology, October 2016, Elsevier

    Johan Neyts

  377. Zika Virus Replicons for Drug Discovery

    Article • EBioMedicine, October 2016, Elsevier

    Johan Neyts

  378. Zika and Other Emerging Viruses: Aiming at the Right Target

    Article • Cell Host & Microbe, October 2016, Elsevier

    Johan Neyts

  379. Hydantoin: The mechanism of its in vitro anti-enterovirus activity revisited

    Article • Antiviral Research, September 2016, Elsevier

    Johan Neyts

  380. Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity

    Article • Journal of Hepatology, September 2016, Elsevier

    Johan Neyts

  381. The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    Johan Neyts

  382. 9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction

    Article • Free Radical Biology and Medicine, August 2016, Elsevier

    Johan Neyts

  383. Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model

    Article • Antiviral Research, August 2016, Elsevier

    Johan Neyts

  384. Post-exposure antiviral treatment of norovirus infections effectively protects against diarrhea and reduces virus shedding in the stool in a mortality mouse model

    Article • Antiviral Research, August 2016, Elsevier

    Johan Neyts

  385. Viral Macro Domains Reverse Protein ADP-Ribosylation

    Article • Journal of Virology, July 2016, ASM Journals

    Johan Neyts

  386. A rat model for hepatitis E virus

    Article • Disease Models & Mechanisms, July 2016, The Company of Biologists

    Johan Neyts

  387. Update on hepatitis E virology: Implications for clinical practice

    Article • Journal of Hepatology, July 2016, Elsevier

    Johan Neyts

  388. Cover Image

    Article • Journal of Viral Hepatitis, June 2016, Wiley

    Johan Neyts

  389. Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease

    Article • Bioorganic & Medicinal Chemistry, June 2016, Elsevier

    Johan Neyts

  390. Reply

    Article • Gastroenterology, June 2016, Elsevier

    Johan Neyts

  391. VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

    Article • European Journal of Medicinal Chemistry, June 2016, Elsevier

    Johan Neyts

  392. Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

    Article • Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals

    Dr. ANA SAN-FELIX, Johan Neyts, Dr Ernesto Quesada

  393. Antiviral Activity of Favipiravir (T-705) against a Broad Range of ParamyxovirusesIn Vitroand against Human Metapneumovirus in Hamsters

    Article • Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals

    Johan Neyts

  394. The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

    Article • PLoS Neglected Tropical Diseases, May 2016, PLOS

    Rafael Elias Marques, Johan Neyts

  395. 3-(imidazo[1,2- a :5,4- b ′]dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

    Article • Antiviral Research, May 2016, Elsevier

    Johan Neyts

  396. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

    Article • Gut, March 2016, BMJ

    Lander Foquet, Johan Neyts, Thomas Michiels

  397. Modification of the length and structure of the linker of N6-benzyladenosine modulates its selective antiviral activity against enterovirus 71

    Article • European Journal of Medicinal Chemistry, March 2016, Elsevier

    Prof Sergey N Mikhailov, Johan Neyts

  398. The viral polymerase inhibitor 7-deaza-2'-C-methyladenosine is a potent inhibitor of in 1 vitro Zika virus replication and delays disease progression in a robust mouse infection model

    Article • March 2016, Cold Spring Harbor Laboratory Press

    Johan Neyts

  399. Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication

    Article • Journal of Hepatology, March 2016, Elsevier

    Johan Neyts

  400. Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

    Article • Journal of Natural Products, February 2016, American Chemical Society (ACS)

    Johan Neyts

  401. Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

    Article • Journal of Natural Products, February 2016, American Chemical Society (ACS)

    Johan Neyts

  402. Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells

    Article • Journal of Viral Hepatitis, February 2016, Wiley

    Johan Neyts

  403. Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

    Article • Molecules, February 2016, MDPI AG

    Johan Neyts

  404. The Medicinal Chemistry of Dengue Virus

    Article • Journal of Medicinal Chemistry, February 2016, American Chemical Society (ACS)

    Johan Neyts

  405. Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, February 2016, Elsevier

    Johan Neyts

  406. Antiviral Strategies Against Chikungunya Virus

    Article • January 2016, Springer Science + Business Media

    Johan Neyts

  407. Assessment of the activity of directly acting antivirals and other products against different genotypes of hepatitis C virus prevalent in resource-poor countries

    Article • Antiviral Research, January 2016, Elsevier

    Johan Neyts

  408. Identification and Analysis of Antiviral Compounds Against Poliovirus

    Article • January 2016, Springer Science + Business Media

    Johan Neyts

  409. Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin

    Article • Gastroenterology, January 2016, Elsevier

    Johan Neyts

  410. PKCA/AP-1 Drives Transcription of Interferon-Stimulated Genes and Mediates Cell-Autonomous Defense against Hepatitis E Virus

    Article • Journal of Hepatology, January 2016, Elsevier

    Johan Neyts

  411. Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants

    Article • Antimicrobial Agents and Chemotherapy, December 2015, ASM Journals

    Johan Neyts

  412. Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents

    Article • Antiviral Chemistry and Chemotherapy, December 2015, SAGE Publications

    Johan Neyts

  413. The future of antivirals

    Article • Current Opinion in Infectious Diseases, December 2015, Wolters Kluwer Health

    Johan Neyts

  414. ID: 146

    Article • Cytokine, November 2015, Elsevier

    Johan Neyts

  415. Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

    Article • PLoS Pathogens, October 2015, PLOS

    Johan Neyts

  416. Toward antiviral therapy/prophylaxis for rhinovirus-induced exacerbations of chronic obstructive pulmonary disease: challenges, opportunities, and strategies

    Article • Reviews in Medical Virology, September 2015, Wiley

    Johan Neyts

  417. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68

    Article • Antimicrobial Agents and Chemotherapy, September 2015, ASM Journals

    Johan Neyts

  418. Structure of Coxsackievirus A16 in complex with GPP3

    Article • September 2015, Protein Data Bank, Rutgers University

    Johan Neyts

  419. Towards antivirals against chikungunya virus

    Article • Antiviral Research, September 2015, Elsevier

    Johan Neyts

  420. LC-MS2-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

    Article • Fitoterapia, September 2015, Elsevier

    Johan Neyts

  421. NMR-based conformational analysis of 2′,6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

    Article • Bioorganic & Medicinal Chemistry, September 2015, Elsevier

    Johan Neyts

  422. Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Johan Neyts

  423. In vitro combinations containing Tegobuvir are highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance

    Article • Antiviral Research, August 2015, Elsevier

    Johan Neyts

  424. Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells

    Article • Biochemical Pharmacology, August 2015, Elsevier

    Johan Neyts

  425. The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis

    Article • European Heart Journal, July 2015, European Society of Cardiology

    Johan Neyts

  426. In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

    Article • Virology Journal, July 2015, Springer Science + Business Media

    Johan Neyts

  427. Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

    Article • Journal of Medicinal Chemistry, June 2015, American Chemical Society (ACS)

    Johan Neyts

  428. Bicyclic and Tricyclic “Expanded” Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies

    Article • ACS Infectious Diseases, June 2015, American Chemical Society (ACS)

    Johan Neyts

  429. The Enterovirus 3C Protease Inhibitor SG85 Efficiently Blocks Rhinovirus Replication and Is Not Cross-Resistant with Rupintrivir

    Article • Antimicrobial Agents and Chemotherapy, June 2015, ASM Journals

    Johan Neyts

  430. Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus

    Article • Antiviral Research, June 2015, Elsevier

    Johan Neyts

  431. P200: Extrahepatic replication of hepatitis E virus in neuronal and placental cell lines

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Johan Neyts

  432. HEV4 O-22: Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Johan Neyts

  433. P209: Near full-length hepatitis E virus genome sequencing analysis in a chronically infected patient following ribavirin treatment failure

    Article • Journal of Viral Hepatitis, June 2015, Wiley

    Johan Neyts

  434. Tonantzitlolones from Stillingia lineata ssp. lineata as potential inhibitors of chikungunya virus

    Article • Phytochemistry Letters, June 2015, Elsevier

    Johan Neyts

  435. Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

    Article • Journal of Natural Products, May 2015, American Chemical Society (ACS)

    Johan Neyts

  436. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

    Article • Journal of Natural Products, May 2015, American Chemical Society (ACS)

    Johan Neyts

  437. Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

    Article • Antiviral Research, May 2015, Elsevier

    Johan Neyts

  438. Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses

    Article • Journal of Virology, April 2015, ASM Journals

    Dr Surender Vashist, Johan Neyts

  439. Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

    Article • Reviews in Medical Virology, April 2015, Wiley

    Johan Neyts

  440. Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2015, Elsevier

    Johan Neyts, Dr Vishnu Nayak Badavath

  441. Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor

    Article • April 2015, Protein Data Bank, Rutgers University

    Johan Neyts

  442. Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143

    Article • April 2015, Protein Data Bank, Rutgers University

    Johan Neyts

  443. Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

    Article • Antiviral Chemistry and Chemotherapy, April 2015, SAGE Publications

    Johan Neyts

  444. I304V 3D polymerase mutant of EMCV

    Article • April 2015, Protein Data Bank, Rutgers University

    Johan Neyts

  445. M300V 3D polymerase mutant of EMCV

    Article • April 2015, Protein Data Bank, Rutgers University

    Johan Neyts

  446. P0488 : Dissecting the complexity of interferon response that cross talks with 4E-BP1 in hepatitis E virus infection

    Article • Journal of Hepatology, April 2015, Elsevier

    Johan Neyts

  447. P0692 : PKC/AP-1 signaling drives transcription of interferon-stimulated genes and exerts potent antiviral activity against hepatitis C and E viruses

    Article • Journal of Hepatology, April 2015, Elsevier

    Johan Neyts

  448. The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

    Article • PLoS Pathogens, March 2015, PLOS

    Johan Neyts

  449. Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

    Article • European Journal of Medicinal Chemistry, March 2015, Elsevier

    Johan Neyts, Dr Ernesto Quesada

  450. Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

    Article • Cell Reports, February 2015, Elsevier

    Dr Minetaro Arita, Johan Neyts

  451. Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection

    Article • Chemistry & Biology, February 2015, Elsevier

    Johan Neyts

  452. Antiviral activity of cytokinin-like adenosine derivatives

    Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

    Mr Vladimir Evgenievich Oslovsky, Prof Sergey N Mikhailov, Johan Neyts

  453. Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Johan Neyts, Venkatesan Jayaprakash

  454. New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2

    Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

    Johan Neyts

  455. Norbornane-based nucleoside and nucleotide analogues locked in North conformation

    Article • Bioorganic & Medicinal Chemistry, January 2015, Elsevier

    Johan Neyts

  456. A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus

    Article • Biochemical and Biophysical Research Communications, December 2014, Elsevier

    Johan Neyts

  457. Complete Genome Sequence of a Rat Hepatitis E Virus Strain Isolated in the United States

    Article • Genome Announcements, November 2014, ASM Journals

    Johan Neyts

  458. A Mutation in the Hepatitis E Virus RNA Polymerase Promotes Its Replication and Associates With Ribavirin Treatment Failure in Organ Transplant Recipients

    Article • Gastroenterology, November 2014, Elsevier

    Johan Neyts

  459. Structure–activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

    Article • Bioorganic & Medicinal Chemistry, November 2014, Elsevier

    Johan Neyts

  460. Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

    Article • European Journal of Medicinal Chemistry, November 2014, Elsevier

    Johan Neyts

  461. H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1

    Article • Antiviral Research, October 2014, Elsevier

    Johan Neyts

  462. Rapamycin and everolimus facilitate hepatitis E virus replication: Revealing a basal defense mechanism of PI3K-PKB-mTOR pathway

    Article • Journal of Hepatology, October 2014, Elsevier

    Johan Neyts

  463. Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus

    Article • Journal of Antimicrobial Chemotherapy, September 2014, Oxford University Press (OUP)

    Johan Neyts

  464. The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

    Article • Antimicrobial Agents and Chemotherapy, September 2014, ASM Journals

    Johan Neyts

  465. Norovirus: Targets and tools in antiviral drug discovery

    Article • Biochemical Pharmacology, September 2014, Elsevier

    Johan Neyts

  466. Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

    Article • Fitoterapia, September 2014, Elsevier

    Johan Neyts

  467. A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds

    Article • Transboundary and Emerging Diseases, August 2014, Wiley

    Johan Neyts

  468. A benzonitrile analogue inhibits rhinovirus replication

    Article • July 2014, Protein Data Bank, Rutgers University

    Johan Neyts

  469. Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

    Article • Journal of Antimicrobial Chemotherapy, June 2014, Oxford University Press (OUP)

    Professor Eric J. Snijder, Johan Neyts

  470. A novel benzonitrile analogue inhibits rhinovirus replication

    Article • Journal of Antimicrobial Chemotherapy, June 2014, Oxford University Press (OUP)

    Johan Neyts

  471. Jatrophane Diterpenes as Inhibitors of Chikungunya Virus Replication: Structure–Activity Relationship and Discovery of a Potent Lead

    Article • Journal of Natural Products, June 2014, American Chemical Society (ACS)

    Johan Neyts

  472. The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus Replicon

    Article • Antimicrobial Agents and Chemotherapy, June 2014, ASM Journals

    Johan Neyts

  473. Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus

    Article • Gastroenterology, June 2014, Elsevier

    Johan Neyts

  474. From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

    Article • Bioorganic & Medicinal Chemistry, June 2014, Elsevier

    Johan Neyts

  475. Substituted 2,6-bis(benzimidazol-2-yl)pyridines: A novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase

    Article • Antiviral Research, June 2014, Elsevier

    Johan Neyts

  476. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C

    Article • Gut, May 2014, BMJ

    Johan Neyts

  477. Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

    Article • Antimicrobial Agents and Chemotherapy, May 2014, ASM Journals

    Professor Eric J. Snijder, Johan Neyts

  478. Identification of [1,2,3]Triazolo[4,5-d]pyrimidin-7(6H)-ones as Novel Inhibitors of Chikungunya Virus Replication

    Article • Journal of Medicinal Chemistry, May 2014, American Chemical Society (ACS)

    Johan Neyts

  479. Are statins a viable option for the treatment of infections with the hepatitis C virus?

    Article • Antiviral Research, May 2014, Elsevier

    Johan Neyts

  480. In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks

    Article • Antiviral Research, May 2014, Elsevier

    Johan Neyts

  481. Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine

    Article • Journal of Feline Medicine and Surgery, April 2014, SAGE Publications

    Johan Neyts

  482. Binding of Glutathione to Enterovirus Capsids Is Essential for Virion Morphogenesis

    Article • PLoS Pathogens, April 2014, PLOS

    Johan Neyts

  483. New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors

    Article • Journal of Medicinal Chemistry, April 2014, American Chemical Society (ACS)

    Johan Neyts

  484. In search of Flavivirus inhibitors part 2: Tritylated, diphenylmethylated and other alkylated nucleoside analogues

    Article • European Journal of Medicinal Chemistry, April 2014, Elsevier

    Johan Neyts

  485. Synthesis, biological activity and structure–activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection

    Article • European Journal of Medicinal Chemistry, April 2014, Elsevier

    Johan Neyts

  486. O118 A MUTATION IN THE HEPATITIS E VIRUS POLYMERASE ASSOCIATED WITH RIBAVIRIN TREATMENT FAILURE HAS A REPLICATION ADVANTAGE IN VITRO

    Article • Journal of Hepatology, April 2014, Elsevier

    Johan Neyts

  487. P212 STEM CELL-DERIVED HEPATOCYTES AS A NOVEL IN VITRO MODEL TO STUDY HEPATOTROPIC VIRUSES

    Article • Journal of Hepatology, April 2014, Elsevier

    Johan Neyts

  488. Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

    Article • Molecules, March 2014, MDPI AG

    Johan Neyts

  489. Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position

    Article • Archiv der Pharmazie, March 2014, Wiley

    Johan Neyts

  490. Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

    Article • Antiviral Research, March 2014, Elsevier

    Johan Neyts

  491. Antiviral strategies for hepatitis E virus

    Article • Antiviral Research, February 2014, Elsevier

    Johan Neyts

  492. Luminescence-based Antiviral Assay for Hepatitis E Virus

    Article • BIO-PROTOCOL, January 2014, Bio-Protocol, LLC

    Johan Neyts

  493. Fitness and Virulence of a Coxsackievirus Mutant That Can Circumnavigate the Need for Phosphatidylinositol 4-Kinase Class III Beta

    Article • Journal of Virology, December 2013, ASM Journals

    Johan Neyts

  494. Artemisinin Analogues as Potent Inhibitors of In Vitro Hepatitis C Virus Replication

    Article • PLOS One, December 2013, PLOS

    Johan Neyts

  495. The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

    Article • Journal of Medicinal Chemistry, November 2013, American Chemical Society (ACS)

    Johan Neyts

  496. Laboratory validation of a lateral flow device for the detection of CyHV-3 antigens in gill swabs

    Article • Journal of Virological Methods, November 2013, Elsevier

    Johan Neyts

  497. Ribavirin InhibitsIn VitroHepatitis E Virus Replication through Depletion of Cellular GTP Pools and Is Moderately Synergistic with Alpha Interferon

    Article • Antimicrobial Agents and Chemotherapy, October 2013, ASM Journals

    Johan Neyts

  498. Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative

    Article • Antiviral Research, October 2013, Elsevier

    Johan Neyts

  499. Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication

    Article • Antiviral Research, October 2013, Elsevier

    Johan Neyts

  500. The potential of antiviral agents to control classical swine fever: A modelling study

    Article • Antiviral Research, September 2013, Elsevier

    Johan Neyts

  501. The Viral Polymerase Inhibitor 2'-C-Methylcytidine Inhibits Norwalk Virus Replication and Protects against Norovirus-Induced Diarrhea and Mortality in a Mouse Model

    Article • Journal of Virology, August 2013, ASM Journals

    Johan Neyts

  502. Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication

    Article • Antiviral Research, August 2013, Elsevier

    Johan Neyts

  503. A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

    Article • Antimicrobial Agents and Chemotherapy, July 2013, ASM Journals

    Johan Neyts

  504. In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

    Article • European Journal of Medicinal Chemistry, July 2013, Elsevier

    Johan Neyts

  505. 3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

    Article • European Journal of Medicinal Chemistry, June 2013, Elsevier

    Johan Neyts

  506. Exploration of the in vitro Antiviral Activity of a Series of New Pyrimidine Analogues on the Replication of HIV and HCV

    Article • Antiviral Chemistry and Chemotherapy, June 2013, SAGE Publications

    Johan Neyts

  507. Molecular Biology and Inhibitors of Hepatitis A Virus

    Article • Medicinal Research Reviews, May 2013, Wiley

    Johan Neyts

  508. Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

    Article • ACS Medicinal Chemistry Letters, May 2013, American Chemical Society (ACS)

    Johan Neyts

  509. Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal PhenotypeIn Vivo

    Article • Antimicrobial Agents and Chemotherapy, May 2013, ASM Journals

    Johan Neyts

  510. Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication

    Article • Antiviral Research, May 2013, Elsevier

    Johan Neyts

  511. 3′,5′Di-O-trityluridine inhibits in vitro flavivirus replication

    Article • Antiviral Research, May 2013, Elsevier

    Johan Neyts

  512. Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus

    Article • European Journal of Medicinal Chemistry, May 2013, Elsevier

    Johan Neyts

  513. Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy

    Article • Antiviral Research, May 2013, Elsevier

    Johan Neyts

  514. Intervention strategies for emerging viruses: use of antivirals

    Article • Current Opinion in Virology, April 2013, Elsevier

    Johan Neyts

  515. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

    Article • Antiviral Research, April 2013, Elsevier

    Johan Neyts

  516. 1194 SYNERGISTIC COMBINATIONS OF ENTRY INHIBITORS WITH DACLATASVIR OR SOFOSBUVIR FOR PREVENTION AND TREATMENT OF CHRONIC HEPATITIS C

    Article • Journal of Hepatology, April 2013, Elsevier

    Johan Neyts

  517. Proof of Concept for the Inhibition of Foot-and-Mouth Disease Virus Replication by the Anti-Viral Drug 2′-C-Methylcytidine in Severe Combined Immunodeficient Mice

    Article • Transboundary and Emerging Diseases, March 2013, Wiley

    Johan Neyts

  518. Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

    Article • Journal of Medicinal Chemistry, March 2013, American Chemical Society (ACS)

    Johan Neyts

  519. Simple and inexpensive three-step rapid amplification of cDNA 5′ ends using 5′ phosphorylated primers

    Article • Analytical Biochemistry, March 2013, Elsevier

    Johan Neyts

  520. 9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro

    Article • Bioorganic & Medicinal Chemistry, March 2013, Elsevier

    Johan Neyts

  521. 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

    Article • Journal of Virology, February 2013, ASM Journals

    Rolf Hilgenfeld, Johan Neyts

  522. Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C

    Article • Antimicrobial Agents and Chemotherapy, January 2013, ASM Journals

    Johan Neyts

  523. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon

    Article • January 2013, Springer Science + Business Media

    Johan Neyts

  524. Differentiated umbilical cord matrix stem cells as a newin vitromodel to study early events during hepatitis B virus infection

    Article • Hepatology, January 2013, Wiley

    Johan Neyts

  525. Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

    Article • January 2013, Springer Science + Business Media

    Johan Neyts, Ralf Bartenschlager

  526. Erratum to “Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus” [J Hepatol 2012;57:246–251]

    Article • Journal of Hepatology, January 2013, Elsevier

    Johan Neyts

  527. Safety Assessment in Pigs of an Experimental Molecule with In-Vitro Antiviral Activity Against African Swine Fever

    Article • Journal of Comparative Pathology, January 2013, Elsevier

    Johan Neyts

  528. The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination

    Article • Hepatology, December 2012, Wiley

    Johan Neyts

  529. Prostratin and 12-O-Tetradecanoylphorbol 13-Acetate Are Potent and Selective Inhibitors of Chikungunya Virus Replication

    Article • Journal of Natural Products, December 2012, American Chemical Society (ACS)

    Johan Neyts

  530. Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection

    Article • Antiviral Research, December 2012, Elsevier

    Johan Neyts

  531. The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

    Article • Biochemical Pharmacology, December 2012, Elsevier

    Johan Neyts

  532. Inhibition of norovirus replication by the nucleoside analogue 2′-C-methylcytidine

    Article • Biochemical and Biophysical Research Communications, November 2012, Elsevier

    Johan Neyts

  533. Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication

    Article • BDJ, September 2012, Springer Science + Business Media

    Johan Neyts

  534. Classical swine fever outbreak containment using antiviral supplementation: A potential alternative to emergency vaccination and stamping-out

    Article • Preventive Veterinary Medicine, September 2012, Elsevier

    Johan Neyts

  535. A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

    Article • Journal of Virological Methods, August 2012, Elsevier

    Johan Neyts

  536. Favipiravir (T-705) inhibits in vitro norovirus replication

    Article • Biochemical and Biophysical Research Communications, August 2012, Elsevier

    Johan Neyts

  537. Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus

    Article • Journal of Hepatology, August 2012, Elsevier

    Johan Neyts

  538. 705 Stimulation of Angiogenesis by Hepatitis C Virus (HCV) Non-structural Proteins

    Article • European Journal of Cancer, July 2012, Elsevier

    Johan Neyts

  539. Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays

    Article • Journal of Antimicrobial Chemotherapy, June 2012, Oxford University Press (OUP)

    Dr Thierry Verbinnen, Johan Neyts

  540. The HCV Non-Nucleoside Inhibitor Tegobuvir Utilizes a Novel Mechanism of Action to Inhibit NS5B Polymerase Function

    Article • PLOS One, June 2012, PLOS

    Johan Neyts

  541. Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations

    Article • Bioorganic & Medicinal Chemistry, June 2012, Elsevier

    Johan Neyts

  542. An Analogue of the Antibiotic Teicoplanin Prevents Flavivirus Entry In Vitro

    Article • PLOS One, May 2012, PLOS

    Johan Neyts

  543. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

    Article • Journal of Antimicrobial Chemotherapy, April 2012, Oxford University Press (OUP)

    Professor Martino Bolognesi, Johan Neyts

  544. Synthesis of novel thienonorbornylpurine derivatives

    Article • Tetrahedron, April 2012, Elsevier

    Dr Michal Šála, Johan Neyts

  545. 841 BC556, A POTENT, PAN-GENOTYPIC, HIGH BARRIER TO RESISTANCE, SECOND GENERATION CYCLOPHILIN INHIBITOR FOR TREATMENT OF CHRONIC HCV INFECTION

    Article • Journal of Hepatology, April 2012, Elsevier

    Johan Neyts

  546. 124 HEPATOCYTES DERIVED FROM HUMAN PLURIPOTENT STEM CELLS PERMIT COMPLETE REPLICATION OF THE HEPATITIS C VIRUS

    Article • Journal of Hepatology, April 2012, Elsevier

    Johan Neyts

  547. Efficient synthesis and anti-enteroviral activity of 9-arylpurines

    Article • European Journal of Medicinal Chemistry, March 2012, Elsevier

    Johan Neyts

  548. Novel substituted 9-norbornylpurines and their activities against RNA viruses

    Article • Bioorganic & Medicinal Chemistry Letters, March 2012, Elsevier

    Johan Neyts

  549. Evaluation of the antiviral activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl]guanine (A-5021) against equine herpesvirus type 1 in cell monolayers and equine nasal mucosal explants

    Article • Antiviral Research, February 2012, Elsevier

    Professor Hans Jan Nauwynck, Johan Neyts

  550. Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Johan Neyts

  551. Synthesis of novel azanorbornylpurine derivatives

    Article • Tetrahedron, January 2012, Elsevier

    Dr Michal Šála, Johan Neyts

  552. Combating enterovirus replication: State-of-the-art on antiviral research

    Article • Biochemical Pharmacology, January 2012, Elsevier

    Johan Neyts

  553. In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors

    Article • Journal of Hepatology, January 2012, Elsevier

    Johan Neyts

  554. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

    Article • Bioorganic & Medicinal Chemistry, January 2012, Elsevier

    Johan Neyts

  555. Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge

    Article • Antiviral Research, January 2012, Elsevier

    Johan Neyts

  556. Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    Johan Neyts

  557. Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice

    Article • PLOS One, December 2011, PLOS

    Johan Neyts

  558. Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action

    Article • Current Opinion in Virology, December 2011, Elsevier

    Johan Neyts

  559. Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors

    Article • November 2011, Wiley

    Johan Neyts

  560. The main Hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication

    Article • Antiviral Research, November 2011, Elsevier

    Johan Neyts

  561. Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Johan Neyts

  562. Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus

    Article • Antiviral Research, August 2011, Elsevier

    Johan Neyts

  563. Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

    Article • Journal of Medicinal Chemistry, July 2011, American Chemical Society (ACS)

    Johan Neyts

  564. Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

    Article • Antimicrobial Agents and Chemotherapy, July 2011, ASM Journals

    Johan Neyts

  565. SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, July 2011, Elsevier

    Johan Neyts

  566. Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells

    Article • PLOS One, June 2011, PLOS

    Johan Neyts

  567. Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication

    Article • Antimicrobial Agents and Chemotherapy, June 2011, ASM Journals

    Johan Neyts

  568. Towards the design of combination therapy for the treatment of enterovirus infections

    Article • Antiviral Research, June 2011, Elsevier

    Johan Neyts

  569. European Training Network on (+)RNA Virus Replication and Antiviral Drug Development

    Article • Antiviral Research, May 2011, Elsevier

    Professor Eric J. Snijder, Johan Neyts

  570. 3′,5′di-O-Trityluridine Inhibits Flavivirus (Dengue and Yellow Fever Virus) Replication and Targets the Viral RNA Dependent RNA Polymerase

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  571. Classical Swine Fever Outbreak Containment – Antivirals as an Epidemiologically and Economically Viable Alternative to Emergency Vaccination and Culling

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  572. Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents

    Article • Phosphorus Sulfur and Silicon and the Related Elements, May 2011, Taylor & Francis

    Johan Neyts

  573. Phosphoramidate Dinucleosides as Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts, Helene Dutartre

  574. Viral Genome Dynamics During Antiviral Resistance Selection: A First Glimpse into Viral Evolution

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  575. A Novel Method—Amenable for High-throughput Screening Purposes—to Quantify Antiviral Activity Against Viruses that Induce Limited CPE

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  576. An Analogue of the Antibiotic Teicoplanin Inhibits Dengue Virus Entry In Vitro

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  577. An Antiviral Assay to Identify Inhibitors of the Human Metapneumovirus that is Amenable for High-throughput Screening Purposes

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  578. Computer-aided Design and Evaluation of Novel Anti-CHIKV Compounds

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  579. Coumarins Hybridized with Heterocycles or Ribonucleosides for Eradication of Hepatitis C Virus

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  580. In Vitro Combination Therapy with Tegobuvir (GS-9190) is Highly Efficient in Curing Cells from HCV Replicon and in Delaying/Preventing the Development of Antiviral Resistance

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  581. Targeting the Flavivirus Helicase

    Article • Antiviral Research, May 2011, Elsevier

    Johan Neyts

  582. Coumarin−Purine Ribofuranoside Conjugates as New Agents against Hepatitis C Virus

    Article • Journal of Medicinal Chemistry, April 2011, American Chemical Society (ACS)

    Johan Neyts

  583. Diagnostic performance and application of two commercial cell viability assays in foot-and-mouth disease research

    Article • Journal of Virological Methods, April 2011, Elsevier

    Johan Neyts

  584. Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics

    Article • Journal of Antimicrobial Chemotherapy, March 2011, Oxford University Press (OUP)

    Johan Neyts

  585. Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

    Article • Antimicrobial Agents and Chemotherapy, March 2011, ASM Journals

    Johan Neyts

  586. Picornavirus non-structural proteins as targets for new anti-virals with broad activity

    Article • Antiviral Research, March 2011, Elsevier

    Nicolas Papageorgiou, Johan Neyts

  587. 482 IN VITRO COMBINATION THERAPY WITH TEGOBUVIR (GS-9190) IS HIGHLY EFFICIENT IN CURING CELLS FROM HCV REPLICON AND IN DELAYING/PREVENTING THE DEVELOPMENT OF ANTIVIRAL RESISTANCE

    Article • Journal of Hepatology, March 2011, Elsevier

    Johan Neyts

  588. 789 PRECLINICAL CHARACTERIZATION OF NOVEL CYCLOPHILIN INHIBITORS BASED ON THE POLYKETIDE, SANGLIFEHRIN

    Article • Journal of Hepatology, March 2011, Elsevier

    Johan Neyts

  589. Adefovir serum levels do not differ between responders and nonresponders

    Article • Journal of Viral Hepatitis, January 2011, Wiley

    Johan Neyts

  590. Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

    Article • Collection of Czechoslovak Chemical Communications, January 2011, Institute of Organic Chemistry & Biochemistry

    Johan Neyts

  591. Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives

    Article • Antiviral Research, December 2010, Elsevier

    Johan Neyts

  592. Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2010, Elsevier

    Johan Neyts

  593. Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

    Article • Tetrahedron Letters, November 2010, Elsevier

    Johan Neyts

  594. DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

    Article • PLOS One, October 2010, PLOS

    Johan Neyts, Ralf Bartenschlager

  595. Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

    Article • Journal of Medicinal Chemistry, October 2010, American Chemical Society (ACS)

    Johan Neyts

  596. Development of a Foot-and-Mouth Disease Infection Model in Severe Combined Immunodeficient Mice for the Preliminary Evaluation of Antiviral Drugs

    Article • Transboundary and Emerging Diseases, October 2010, Wiley

    Johan Neyts

  597. Hepatitis C Virus Infection of Neuroepithelioma Cell Lines

    Article • Gastroenterology, October 2010, Elsevier

    Dr Stuart C. Ray, Johan Neyts

  598. 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

    Article • Journal of Medicinal Chemistry, September 2010, American Chemical Society (ACS)

    Johan Neyts, Helene Dutartre

  599. A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

    Article • Antimicrobial Agents and Chemotherapy, September 2010, ASM Journals

    Johan Neyts

  600. Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

    Article • Journal of Virology, August 2010, ASM Journals

    Dr Thierry Verbinnen, Johan Neyts

  601. Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

    Article • Antiviral Research, August 2010, Elsevier

    Professor Martino Bolognesi, Johan Neyts

  602. Antiviral strategies to control calicivirus infections

    Article • Antiviral Research, August 2010, Elsevier

    Johan Neyts

  603. Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription

    Article • Antiviral Research, August 2010, Elsevier

    Johan Neyts

  604. Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

    Article • Bioorganic & Medicinal Chemistry, June 2010, Elsevier

    Dr Michal Šála, Johan Neyts

  605. S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus

    Article • Bioorganic & Medicinal Chemistry Letters, June 2010, Elsevier

    Johan Neyts, Dr Peng Ling

  606. Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections

    Article • Viruses, May 2010, MDPI AG

    Johan Neyts

  607. Differential Effects of the Putative GBF1 Inhibitors Golgicide A and AG1478 on Enterovirus Replication

    Article • Journal of Virology, May 2010, ASM Journals

    Johan Neyts

  608. Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

    Article • European Journal of Medicinal Chemistry, May 2010, Elsevier

    Johan Neyts

  609. A Novel 9-Arylpurine Acts as a Selective Inhibitor of In Vitro Enterovirus Replication Possibly by Targeting Virus Encapsidation

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  610. Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

    Article • Bioorganic & Medicinal Chemistry, April 2010, Elsevier

    Johan Neyts

  611. In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  612. γ-Carboline Derivatives as Potent and Selective Inhibitors of Bovine Viral Diarrhea Virus (BVDV) Replication

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  613. Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  614. Eradication of Persistent Bovine Viral Diarrhea Virus Infection in Cell Culture by Antiviral Treatment: How to Get Ahead of the Viral Evasion Strategy

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  615. Inhibition of Hepatitis C Virus Replication by Semisynthetic Derivatives of Glycopeptide Antibiotics

    Article • Antiviral Research, April 2010, Elsevier

    Johan Neyts

  616. Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care

    Article • Viruses, March 2010, MDPI AG

    Johan Neyts

  617. Replication of not-known-vector flaviviruses in mosquito cells is restricted by intracellular host factors rather than by the viral envelope proteins

    Article • Journal of General Virology, March 2010, Society for General Microbiology

    Johan Neyts

  618. Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

    Article • European Journal of Medicinal Chemistry, February 2010, Elsevier

    Johan Neyts

  619. 9-Arylpurines as a Novel Class of Enterovirus Inhibitors

    Article • Journal of Medicinal Chemistry, January 2010, American Chemical Society (ACS)

    Johan Neyts

  620. Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene

    Article • Collection of Czechoslovak Chemical Communications, November 2009, Institute of Organic Chemistry & Biochemistry

    Johan Neyts

  621. Reply:

    Article • Hepatology, November 2009, Wiley

    Johan Neyts

  622. Norbornane as the novel pseudoglycone moiety in nucleosides

    Article • Tetrahedron, November 2009, Elsevier

    Dr Michal Šála, Johan Neyts

  623. The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: A proof of concept

    Article • Veterinary Microbiology, November 2009, Elsevier

    Johan Neyts

  624. Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

    Article • Antiviral Research, October 2009, Elsevier

    Johan Neyts, Helene Dutartre

  625. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A

    Article • Hepatology, September 2009, Wiley

    Johan Neyts, Ralf Bartenschlager

  626. The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

    Article • Bioorganic & Medicinal Chemistry Letters, August 2009, Elsevier

    Johan Neyts

  627. Cu-Mediated SelectiveN-Arylation of Aminotriazole Acyclonucleosides

    Article • Helvetica Chimica Acta, August 2009, Wiley

    Johan Neyts, Dr Peng Ling

  628. Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides

    Article • Nucleosides Nucleotides & Nucleic Acids, July 2009, Taylor & Francis

    Johan Neyts

  629. A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

    Article • Antiviral Research, June 2009, Elsevier

    Johan Neyts, Helene Dutartre

  630. Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

    Article • Bioorganic & Medicinal Chemistry Letters, June 2009, Elsevier

    Johan Neyts

  631. Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor

    Article • Journal of Medicinal Chemistry, May 2009, American Chemical Society (ACS)

    Johan Neyts

  632. Antiviral Activity of Carbohydrate Binding Agents (CBAS) and the Role of DC-SIGN in Dengue Virus and HIV Infection

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  633. Comparative Study of the Genetic Barrier and Pathways Towards Resistance of Selective Inhibitors of HCV Replication

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  634. In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  635. Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  636. Phosphoramidate Protides Greatly Enhance the Anti-HCV Activity of 2′-Methylguanosine

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  637. Substituted imidazopyridines as potent inhibitors of HCV replication

    Article • Journal of Hepatology, May 2009, Elsevier

    Johan Neyts

  638. Synthesis and SAR of 9-Arylpurines as Novel Inhibitors of Enterovirus Replication

    Article • Antiviral Research, May 2009, Elsevier

    Johan Neyts

  639. Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection

    Article • Virology, April 2009, Elsevier

    Johan Neyts

  640. Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis

    Article • The Journal of Pathology, April 2009, Wiley

    Johan Neyts

  641. 88 PARTICULAR IN VITRO ANTI-HCV ACTIVITIES AND RESISTANCE PROFILE OF THE CYCLOPHILIN INHIBITOR DEBIO 025

    Article • Journal of Hepatology, April 2009, Elsevier

    Johan Neyts

  642. Structure−Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle−Coumarin Conjugates

    Article • Journal of Medicinal Chemistry, March 2009, American Chemical Society (ACS)

    Johan Neyts

  643. Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor

    Article • Journal of General Virology, March 2009, Society for General Microbiology

    Johan Neyts

  644. Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Johan Neyts, Dr Peng Ling

  645. Mutations in the Nonstructural Protein 3A Confer Resistance to the Novel Enterovirus Replication Inhibitor TTP-8307

    Article • Antimicrobial Agents and Chemotherapy, February 2009, ASM Journals

    Johan Neyts

  646. Statins potentiate thein vitroanti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

    Article • Hepatology, February 2009, Wiley

    Johan Neyts

  647. ChemInform Abstract: Selective Inhibitors of Picornavirus Replication

    Article • ChemInform, February 2009, Wiley

    Johan Neyts

  648. Antiviral Agents Acting as DNA or RNA Chain Terminators

    Article • January 2009, Springer Science + Business Media

    Johan Neyts

  649. Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol

    Article • Collection of Czechoslovak Chemical Communications, January 2009, Institute of Organic Chemistry & Biochemistry

    Johan Neyts

  650. Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses

    Article • Collection of Czechoslovak Chemical Communications, January 2009, Institute of Organic Chemistry & Biochemistry

    Johan Neyts

  651. Studies of antiviral activity and cytotoxicity ofWrightia tinctoriaandMorinda citrifolia

    Article • Indian Journal of Pharmaceutical Sciences, January 2009, OMICS Publishing Group

    Johan Neyts

  652. Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, December 2008, ASM Journals

    Johan Neyts

  653. Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis

    Article • Virology, December 2008, Elsevier

    Johan Neyts

  654. Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues

    Article • Bioorganic & Medicinal Chemistry Letters, December 2008, Elsevier

    Johan Neyts

  655. Selective inhibitors of picornavirus replication

    Article • Medicinal Research Reviews, November 2008, Wiley

    Johan Neyts

  656. Mouse and Hamster Models for the Study of Therapy against Flavivirus Infections

    Article • October 2008, Wiley

    Johan Neyts

  657. Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

    Article • Biochemical Pharmacology, October 2008, Elsevier

    Johan Neyts

  658. Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

    Article • Journal of Medicinal Chemistry, September 2008, American Chemical Society (ACS)

    Johan Neyts, Helene Dutartre

  659. Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens

    Article • Antimicrobial Agents and Chemotherapy, September 2008, ASM Journals

    Johan Neyts

  660. A case for developing antiviral drugs against polio

    Article • Antiviral Research, September 2008, Elsevier

    Johan Neyts

  661. Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles

    Article • Bioorganic & Medicinal Chemistry Letters, September 2008, Elsevier

    Johan Neyts

  662. Synthesis and antiviral activity of novel derivatives of 2'- -C-methylcytidine

    Article • Nucleic Acids Symposium Series, September 2008, Oxford University Press (OUP)

    Johan Neyts

  663. The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases

    Article • Journal of Virology, July 2008, ASM Journals

    Johan Neyts

  664. Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

    Article • Antimicrobial Agents and Chemotherapy, July 2008, ASM Journals

    Johan Neyts, Ralf Bartenschlager

  665. Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication

    Article • Bioorganic & Medicinal Chemistry Letters, June 2008, Elsevier

    Johan Neyts, Dr Peng Ling

  666. R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond

    Article • Antiviral Research, June 2008, Elsevier

    Johan Neyts

  667. A Derivate of the Antibiotic Doxorubicin Inhibits Dengue and Yellow Fever Virus Replication In Vitro

    Article • Antiviral Research, May 2008, Elsevier

    Johan Neyts

  668. Application of the Phosphoramidate Protide Approach to the Antiviral Drug Ribavirin

    Article • Antiviral Research, May 2008, Elsevier

    Johan Neyts

  669. Discovery of a Novel HCV Helicase Inhibitor by a De Novo Drug Design Approach

    Article • Antiviral Research, May 2008, Elsevier

    Johan Neyts

  670. Mevastatin Markedly Potentiates the Anti-HCV Activity of Selective Inhibitors of HCV Replication and Delays or Prevents the Emergence of Antiviral Resistance

    Article • Antiviral Research, May 2008, Elsevier

    Johan Neyts

  671. Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

    Article • Antiviral Research, May 2008, Elsevier

    Johan Neyts

  672. Treatment of yellow fever

    Article • Antiviral Research, April 2008, Elsevier

    Dr Thomas P. Monath, Johan Neyts

  673. The VIZIER project: Preparedness against pathogenic RNA viruses

    Article • Antiviral Research, April 2008, Elsevier

    Professor Martino Bolognesi, Johan Neyts

  674. Animal models of highly pathogenic RNA viral infections: Encephalitis viruses

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  675. Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  676. Current and future antiviral therapy of severe seasonal and avian influenza

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  677. Does antiviral therapy have a role in the control of Japanese encephalitis?

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  678. FDA perspective on antivirals against biothreats: Communicate early and often

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  679. Highly pathogenic RNA viral infections: Challenges for antiviral research

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  680. International research networks in viral structural proteomics: Again, lessons from SARS

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  681. Molecular strategies to inhibit the replication of RNA viruses

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  682. NIAID resources for developing new therapies for severe viral infections

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  683. New opportunities for field research on the pathogenesis and treatment of Lassa fever

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  684. Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  685. Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  686. The Southeast Asian Influenza Clinical Research Network: Development and challenges for a new multilateral research endeavor

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  687. Treatment of Argentine hemorrhagic fever

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  688. Treatment of Crimean-Congo hemorrhagic fever

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  689. Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  690. Treatment of hantavirus pulmonary syndrome

    Article • Antiviral Research, April 2008, Elsevier

    Johan Neyts

  691. Potential Use of Antiviral Agents in Polio Eradication

    Article • Emerging Infectious Diseases, April 2008, Centers for Disease Control and Prevention (CDC)

    Johan Neyts

  692. Suboptimal Response to Adefovir Dipivoxil Therapy for Chronic Hepatitis B in Nucleoside-Naive Patients is not due to Pre-Existing Drug-Resistant Mutants

    Article • Antiviral Therapy, April 2008, SAGE Publications

    Johan Neyts

  693. The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C

    Article • Journal of Virology, March 2008, ASM Journals

    Johan Neyts

  694. Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase

    Article • Antiviral Research, February 2008, Elsevier

    Johan Neyts

  695. Synthesis of new benzimidazole–coumarin conjugates as anti-hepatitis C virus agents

    Article • Antiviral Research, February 2008, Elsevier

    Johan Neyts

  696. Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent

    Article • Antimicrobial Agents and Chemotherapy, January 2008, ASM Journals

    Johan Neyts

  697. In vitro antiviral activity of some novel isatin derivatives against HCV and SARS-CoV viruses

    Article • Indian Journal of Pharmaceutical Sciences, January 2008, OMICS Publishing Group

    Johan Neyts

  698. Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

    Article • Antimicrobial Agents and Chemotherapy, December 2007, ASM Journals

    Johan Neyts

  699. Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Johan Neyts

  700. Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Johan Neyts

  701. New Analogs of Acyclovir Substituted at the Side Chain

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Johan Neyts

  702. Ester Prodrugs of Cyclic 1-(S)- [3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine:  Synthesis and Antiviral Activity

    Article • Journal of Medicinal Chemistry, November 2007, American Chemical Society (ACS)

    Johan Neyts

  703. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: Further optimization of anti-hepatitis C virus activity

    Article • Bioorganic & Medicinal Chemistry Letters, September 2007, Elsevier

    Johan Neyts

  704. The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

    Article • Journal of Virology, August 2007, ASM Journals

    Johan Neyts, Helene Dutartre

  705. Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication

    Article • Journal of General Virology, August 2007, Society for General Microbiology

    Johan Neyts

  706. Potent Inhibition of Genital Herpesvirus Infection in Goats by Cidofovir

    Article • Antiviral Therapy, August 2007, SAGE Publications

    Johan Neyts

  707. Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

    Article • Antimicrobial Agents and Chemotherapy, July 2007, ASM Journals

    Johan Neyts

  708. Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention

    Article • Trends in Pharmacological Sciences, June 2007, Elsevier

    Johan Neyts

  709. Comparative Activity of Anti-Enteroviral Agents Against Poliovirus Replication In VitroImplications For the End Phase of the Polio Eradication Initiative

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  710. Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication

    Article • Journal of General Virology, June 2007, Society for General Microbiology

    Johan Neyts

  711. Enhanced Antiviral Activity of Hexadecyloxypropyl-PME-N6-Cyclopropyl-diaminopurine Against Herpesviruses, Hepatitis B Virus and Vaccinia Virus, In Vitro

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  712. In Vivo Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Cyclic Form

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  713. Substituted Imidazopyridines as Potent Inhibitors of Hepatitis C Virus Replication that Target the Viral Polymerase

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts, Helene Dutartre

  714. Synthesis and antiviral activities of new acyclic and “double-headed” nucleoside analogues

    Article • Bioorganic Chemistry, June 2007, Elsevier

    Johan Neyts

  715. Synthesis and Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Ester Prodrugs

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  716. Synthesis of Novel Types of Anti-Coxsackie Virus Compounds

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  717. The Cyclophilin Inhibitor Debio-025 is a Potent Inhibitor of Hepatitis C Virus Replication in vitro With a Unique Resistance Profile

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts, Ralf Bartenschlager

  718. The Imidazopyrrolopyridine Analogue AG110 is a Novel, Highly Selective Inhibitor of Pestivirus Replication and Targets the viral RNA-dependent RNA Polymerase

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts, Helene Dutartre

  719. Thiazolobenzimidazoles, a Novel Class of Enterovirus Inhibitors, Target the 2C Protein

    Article • Antiviral Research, June 2007, Elsevier

    Johan Neyts

  720. In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet

    Article • Veterinary Microbiology, May 2007, Elsevier

    Professor Hans Jan Nauwynck, Johan Neyts

  721. Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, May 2007, International Union of Crystallography

    Johan Neyts

  722. Cidofovir is effective against caprine herpesvirus 1 infection in goats

    Article • Antiviral Research, May 2007, Elsevier

    Johan Neyts

  723. In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants

    Article • Antimicrobial Agents and Chemotherapy, March 2007, ASM Journals

    Johan Neyts

  724. 2′-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus

    Article • Antiviral Research, March 2007, Elsevier

    Johan Neyts

  725. Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir

    Article • Antiviral Research, March 2007, Elsevier

    Johan Neyts

  726. Antiviral Activity of Triazine Analogues of 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) and Related Compounds

    Article • Journal of Medicinal Chemistry, February 2007, American Chemical Society (ACS)

    Johan Neyts

  727. Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

    Article • Biochemical and Biophysical Research Communications, February 2007, Elsevier

    Johan Neyts

  728. Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A

    Article • Bioorganic & Medicinal Chemistry Letters, February 2007, Elsevier

    Johan Neyts

  729. Substituted 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A New Class of Pestivirus Inhibitors.

    Article • ChemInform, January 2007, Wiley

    Johan Neyts

  730. Synthesis of 5-Aryltriazole Ribonucleosides via Suzuki Coupling and Promoted by Microwave Irradiation.

    Article • ChemInform, January 2007, Wiley

    Johan Neyts

  731. 239 EMBRYOTOXICITY ASSAY FOR ANTIVIRAL COMPOUND BPIP (5-[(4-BROMOPHENYL)METHYL]-2-PHENYL-5H-IMIDAZO[4,5-c]PYRIDINE) IN BOVINE IN VITRO -PRODUCED EMBRYOS

    Article • Reproduction Fertility and Development, January 2007, CSIRO Publishing

    Professor Hans Jan Nauwynck, Johan Neyts

  732. Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future

    Article • Reviews in Medical Virology, January 2007, Wiley

    Johan Neyts

  733. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity

    Article • Bioorganic & Medicinal Chemistry Letters, January 2007, Elsevier

    Johan Neyts

  734. Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenine

    Article • Journal of Medicinal Chemistry, December 2006, American Chemical Society (ACS)

    Johan Neyts

  735. Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′-C-Methylcytidine, the Active Component of Valopicitabine

    Article • Antimicrobial Agents and Chemotherapy, October 2006, ASM Journals

    Johan Neyts, Ralf Bartenschlager

  736. Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A new class of pestivirus inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2006, Elsevier

    Johan Neyts

  737. Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles

    Article • Bioorganic Chemistry, October 2006, Elsevier

    Johan Neyts

  738. Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells

    Article • Molecular and Cellular Biochemistry, September 2006, Springer Science + Business Media

    Johan Neyts

  739. Selective inhibitors of hepatitis C virus replication

    Article • Antiviral Research, September 2006, Elsevier

    Johan Neyts

  740. Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin

    Article • Biochemical and Biophysical Research Communications, September 2006, Elsevier

    Johan Neyts

  741. Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

    Article • Antiviral Research, September 2006, Elsevier

    Johan Neyts

  742. Synthesis of 5-aryltriazole ribonucleosides via Suzuki coupling and promoted by microwave irradiation

    Article • Tetrahedron Letters, September 2006, Elsevier

    Johan Neyts

  743. Inhibition of Urokinase-Type Plasminogen Activator or Matrix Metalloproteinases Prevents Cardiac Injury and Dysfunction During Viral Myocarditis

    Article • Circulation, August 2006, Wolters Kluwer Health

    Johan Neyts

  744. Synthesis of 6-Arylthio Analogs of 2′,3′-Dideoxy-3′-Fluoroguanosine and Their Effect against Hepatitis B Virus Replication

    Article • Nucleosides Nucleotides & Nucleic Acids, June 2006, Taylor & Francis

    Johan Neyts

  745. Clinical effect of cidofovir and a diet supplemented with Spirulina platensis in white spot syndrome virus (WSSV) infected specific pathogen-free Litopenaeus vannamei juveniles

    Article • Aquaculture, May 2006, Elsevier

    Cesar Marcial Escobedo-Bonilla, Professor Hans Jan Nauwynck, Johan Neyts

  746. Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection

    Article • Antimicrobial Agents and Chemotherapy, May 2006, ASM Journals

    Johan Neyts

  747. Heterocyclic rimantadine analogues with antiviral activity

    Article • Bioorganic & Medicinal Chemistry, May 2006, Elsevier

    Ioannis P. Papanastasiou , Johan Neyts

  748. Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

    Article • Brain Pathology, April 2006, Wiley

    Johan Neyts

  749. Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents1

    Article • Journal of Medicinal Chemistry, April 2006, American Chemical Society (ACS)

    Johan Neyts, Helene Dutartre

  750. The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication

    Article • Molecular Pharmacology, January 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Johan Neyts

  751. A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

    Article • Journal of Virology, January 2006, ASM Journals

    Johan Neyts, Helene Dutartre

  752. Selective inhibitors of the replication of poxviruses

    Article • January 2006, Springer Science + Business Media

    Johan Neyts

  753. P.091 Selection and phenotypic characterization of multiple drug resistant variants in patients with chronic hepatitis B

    Article • Journal of Clinical Virology, January 2006, Elsevier

    Johan Neyts

  754. Synthesis and Antiviral Evaluation of Cyclic and Acyclic 2-Methyl-3-hydroxy-4-pyridinone Nucleoside Derivatives

    Article • Journal of Medicinal Chemistry, January 2006, American Chemical Society (ACS)

    Johan Neyts

  755. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replicationin vitro

    Article • Hepatology, January 2006, Wiley

    Johan Neyts, Ralf Bartenschlager

  756. Viral load quantitation of SARS-coronavirus RNA using a one-step real-time RT-PCR

    Article • International Journal of Infectious Diseases, January 2006, Elsevier

    Johan Neyts

  757. Preliminary report of anti-hepatitis C virus activity of chloroquine and hydroxychloroquine in huh-5-2 cell line

    Article • Indian Journal of Pharmaceutical Sciences, January 2006, OMICS Publishing Group

    Johan Neyts

  758. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

    Article • Nature, December 2005, Springer Science + Business Media

    Johan Neyts

  759. Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives

    Article • ARKIVOC, November 2005, ARKAT USA, Inc.

    Johan Neyts

  760. Corrigendum to “Selective inhibition of hepatitis B virus replication by RNA interference” [Biochem. Biophys. Res. Commun. 309 (2003) 482–484]

    Article • Biochemical and Biophysical Research Communications, November 2005, Elsevier

    Johan Neyts

  761. An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge

    Article • Journal of Virology, October 2005, ASM Journals

    Johan Neyts

  762. ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2005, Taylor & Francis

    Johan Neyts

  763. Growth kinetics of SARS-coronavirus in Vero E6 cells

    Article • Biochemical and Biophysical Research Communications, April 2005, Elsevier

    Johan Neyts

  764. Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

    Article • Antimicrobial Agents and Chemotherapy, March 2005, ASM Journals

    Johan Neyts

  765. The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

    Article • Journal of Virology, February 2005, ASM Journals

    Johan Neyts

  766. Synthesis and Antiviral Evaluation of Cis-Substituted Cyclohexenyl and Cyclohexanyl Nucleosides

    Article • Journal of Medicinal Chemistry, January 2005, American Chemical Society (ACS)

    Johan Neyts

  767. In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

    Article • Biochemical and Biophysical Research Communications, October 2004, Elsevier

    Johan Neyts

  768. Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections

    Article • Reviews in Medical Virology, August 2004, Wiley

    Johan Neyts

  769. Rodent models for the study of therapy against flavivirus infections

    Article • Antiviral Research, August 2004, Elsevier

    Johan Neyts

  770. Rodent models for the study of therapy against flavivirus infections

    Article • Antiviral Research, August 2004, Elsevier

    Johan Neyts

  771. Exchanging the Yellow Fever Virus Envelope Proteins with Modoc Virus prM and E Proteins Results in a Chimeric Virus That Is Neuroinvasive in SCID Mice

    Article • Journal of Virology, July 2004, ASM Journals

    Johan Neyts

  772. Efficacy of Cidofovir in a Murine Model of Disseminated Progressive Vaccinia

    Article • Antimicrobial Agents and Chemotherapy, June 2004, ASM Journals

    Johan Neyts

  773. Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein–Barr virus (EBV) by a quantitative real-time PCR assay

    Article • Antiviral Research, June 2004, Elsevier

    Johan Neyts

  774. Antiviral drugs in current clinical use

    Article • Journal of Clinical Virology, June 2004, Elsevier

    Johan Neyts

  775. The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis

    Article • Antimicrobial Agents and Chemotherapy, January 2004, ASM Journals

    Johan Neyts

  776. In vivomonitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging

    Article • Journal of NeuroVirology, January 2004, Springer Science + Business Media

    Johan Neyts

  777. Heterocyclic rimantadine analogues with antiviral activity

    Article • Bioorganic & Medicinal Chemistry, December 2003, Elsevier

    Johan Neyts

  778. Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, December 2003, Elsevier

    Johan Neyts

  779. Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Johan Neyts

  780. Selective Inhibitors of Hepatitis B Virus Replication

    Article • Current Medicinal Chemistry - Anti-Infective Agents, September 2003, Bentham Science Publishers

    Johan Neyts

  781. Selective inhibition of hepatitis B virus replication by RNA interference

    Article • Biochemical and Biophysical Research Communications, September 2003, Elsevier

    Johan Neyts

  782. The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.)

    Article • Antiviral Research, July 2003, Elsevier

    Johan Neyts

  783. Are the 2-Isomers of the Drug Rimantadine Active Anti-Influenza a Agents?

    Article • Antiviral Chemistry and Chemotherapy, June 2003, SAGE Publications

    Johan Neyts

  784. Spiro[pyrrolidine-2,2′-adamantanes]: synthesis, anti-influenza virus activity and conformational properties

    Article • Bioorganic & Medicinal Chemistry Letters, May 2003, Elsevier

    Johan Neyts

  785. A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses

    Article • Journal of Virological Methods, March 2003, Elsevier

    Johan Neyts

  786. Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice

    Article • Antimicrobial Agents and Chemotherapy, February 2003, ASM Journals

    Johan Neyts

  787. Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation

    Article • Antiviral Chemistry and Chemotherapy, February 2003, SAGE Publications

    Johan Neyts

  788. Inhibition of coxsackie B3 virus induced myocarditis in mice by 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile

    Article • Journal of Medical Virology, January 2003, Wiley

    Johan Neyts

  789. Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

    Article • Journal of NeuroVirology, January 2003, Springer Science + Business Media

    Johan Neyts

  790. Article • BMC Microbiology, January 2003, Springer Science + Business Media

    Johan Neyts

  791. Prospects for Antiviral Therapy

    Article • January 2003, Elsevier

    Johan Neyts

  792. Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives

    Article • Antiviral Research, January 2003, Elsevier

    Johan Neyts

  793. Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

    Article • Journal of NeuroVirology, January 2003, Springer Science + Business Media

    Johan Neyts

  794. Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase

    Article • Journal of Virology, October 2002, ASM Journals

    Johan Neyts

  795. Gammaherpesviruses encode functional dihydrofolate reductase activity

    Article • Biochemical and Biophysical Research Communications, October 2002, Elsevier

    Johan Neyts

  796. Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus

    Article • Journal of General Virology, October 2002, Society for General Microbiology

    Johan Neyts

  797. Effect of 5-Iodo-2′-Deoxyuridine on Vaccinia Virus (Orthopoxvirus) Infections in Mice

    Article • Antimicrobial Agents and Chemotherapy, September 2002, ASM Journals

    Johan Neyts

  798. 2-chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

    Article • Antiviral Research, September 2002, Elsevier

    Johan Neyts

  799. Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3′ untranslated region of flaviviruses with no known vector

    Article • Journal of General Virology, August 2002, Society for General Microbiology

    Johan Neyts

  800. Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

    Article • Journal of General Virology, August 2002, Society for General Microbiology

    Johan Neyts

  801. Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo

    Article • Antiviral Research, July 2002, Elsevier

    Johan Neyts

  802. Sulphated and Sulphonated Polymers Inhibit the Initial Interaction of Hepatitis B Virus with Hepatocytes

    Article • Antiviral Chemistry and Chemotherapy, June 2002, SAGE Publications

    Johan Neyts

  803. Complete Genome Sequence, Taxonomic Assignment, and Comparative Analysis of the Untranslated Regions of the Modoc Virus, a Flavivirus with No Known Vector

    Article • Virology, February 2002, Elsevier

    Johan Neyts

  804. Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

    Article • Blood, December 2001, American Society of Hematology

    Johan Neyts

  805. In vitro Activity of Polyhydroxycarboxylates against Herpesviruses and Hiv

    Article • Antiviral Chemistry and Chemotherapy, December 2001, SAGE Publications

    Johan Neyts

  806. Carrier-Mediated Delivery Improves the Efficacy of 9-(2-Phosphonylmethoxyethyl)Adenine against Hepatitis B Virus

    Article • Molecular Pharmacology, September 2001, Elsevier

    Johan Neyts

  807. Novel 3-(2-Adamantyl)pyrrolidines with potent activity against influenza A virus—identification of aminoadamantane derivatives bearing two pharmacophoric amine groups

    Article • Bioorganic & Medicinal Chemistry Letters, August 2001, Elsevier

    Johan Neyts

  808. A chemiluminescence detection method of hantaviral antigens in neutralisation assays and inhibitor studies

    Article • Journal of Virological Methods, July 2001, Elsevier

    Johan Neyts

  809. ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

    Article • Nucleosides Nucleotides & Nucleic Acids, March 2001, Taylor & Francis

    Johan Neyts

  810. Angiogenesis: regulators and clinical applications

    Article • Biochemical Pharmacology, February 2001, Elsevier

    Johan Neyts

  811. Anti-herpesvirus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)-cycloprop-1′-yl]methyl]guanine (A-5021) in vitro and in vivo

    Article • Antiviral Research, February 2001, Elsevier

    Johan Neyts

  812. The anti-herpesvirus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil

    Article • Antiviral Research, February 2001, Elsevier

    Johan Neyts

  813. Efficacy of 2-Amino-7-(1,3-Dihydroxy-2-Propoxymethyl)Purine for Treatment of Vaccinia Virus (Orthopoxvirus) Infections in Mice

    Article • Antimicrobial Agents and Chemotherapy, January 2001, ASM Journals

    Johan Neyts

  814. A Novel Model for the Study of the Therapy of Flavivirus Infections Using the Modoc Virus

    Article • Virology, January 2001, Elsevier

    Johan Neyts

  815. Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8

    Article • Reviews in Medical Virology, January 2001, Wiley

    Johan Neyts

  816. Effect of TNP-470 (AGM-1470) on the Growth of Rat Rhabdomyosarcoma Tumors of Different Sizes

    Article • Cancer Investigation, January 2001, Taylor & Francis

    Johan Neyts

  817. Potent inhibition of hemangiosarcoma development in mice by cidofovir

    Article • International Journal of Cancer, January 2001, Wiley

    Johan Neyts

  818. Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus

    Article • Antiviral Research, November 2000, Elsevier

    Johan Neyts

  819. Use of Cotton Rats to Evaluate the Efficacy of Antivirals in Treatment of Measles Virus Infections

    Article • Antimicrobial Agents and Chemotherapy, May 2000, ASM Journals

    Johan Neyts

  820. Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: Impact on the search for vaginal microbicides

    Article • Journal of Medical Virology, May 2000, Wiley

    Johan Neyts

  821. Antiviral activity of ganciclovir elaidic acid ester against herpesviruses

    Article • Antiviral Research, March 2000, Elsevier

    Johan Neyts

  822. Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir

    Article • Journal of Viral Hepatitis, March 2000, Wiley

    Johan Neyts

  823. Perspectives for the Treatment of Infections with Flaviviridae

    Article • Clinical Microbiology Reviews, January 2000, ASM Journals

    Johan Neyts

  824. Perspectives for the Treatment of Infections withFlaviviridae

    Article • Clinical Microbiology Reviews, January 2000, ASM Journals

    Johan Neyts

  825. Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture

    Article • Journal of Viral Hepatitis, January 2000, Wiley

    Johan Neyts

  826. Hydroxyurea Potentiates the Antiherpesvirus Activities of Purine and Pyrimidine Nucleoside and Nucleoside Phosphonate Analogs

    Article • Antimicrobial Agents and Chemotherapy, December 1999, ASM Journals

    Johan Neyts

  827. Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring

    Article • Archiv der Pharmazie, October 1999, Wiley

    Johan Neyts

  828. Budding Yeast as a Screening Tool for Discovery of Nucleoside Analogs for Use in HSV-1 TK Suicide-Gene Therapy

    Article • BioTechniques, October 1999, Future Science

    Johan Neyts

  829. Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation

    Article • Journal of Virological Methods, August 1999, Elsevier

    Johan Neyts

  830. Modulation of Fibroblast Growth Factor-2 Receptor Binding, Signaling, and Mitogenic Activity by Heparin-Mimicking Polysulfonated Compounds

    Article • Molecular Pharmacology, July 1999, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Johan Neyts

  831. Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro

    Article • Journal of Viral Hepatitis, May 1999, Wiley

    Johan Neyts

  832. Potent inhibition of human cytomegalovirus (HCMV) replication by alkenyl guanine analogs with a thiazole[4,5-d]pyrimidine ring

    Article • Journal of Clinical Virology, April 1999, Elsevier

    Johan Neyts

  833. Antitumor Potential of Acyclic Nucleoside Phosphonates

    Article • Nucleosides and Nucleotides, April 1999, Taylor & Francis

    Johan Neyts

  834. THE IMMUNOSUPPRESSIVE AGENT MYCOPHENOLATE MOFETIL MARKEDLY POTENTIATES THE ACTIVITY OF LOBUCAVIR [1R(1??,2??,3??)]-9-[2,3-BIS(HYDROXYMETHYL)-CYCLOBUTYL]GUANINE AGAINST DIFFERENT HERPES VIRUSES1

    Article • Transplantation, March 1999, Wolters Kluwer Health

    Johan Neyts

  835. Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir

    Article • Antiviral Research, December 1998, Elsevier

    Johan Neyts

  836. Polyanion Inhibitors of HIV and Other Viruses. 7. Polyanionic Compounds and Polyzwitterionic Compounds Derived from Cyclodextrins as Inhibitors of HIV Transmission

    Article • Journal of Medicinal Chemistry, December 1998, American Chemical Society (ACS)

    Johan Neyts

  837. The Antiherpesvirus Activity of H2G [(R)-9-[4-Hydroxy-2-(Hydroxymethyl)Butyl]Guanine] Is Markedly Enhanced by the Novel Immunosuppressive Agent Mycophenolate Mofetil

    Article • Antimicrobial Agents and Chemotherapy, December 1998, ASM Journals

    Johan Neyts

  838. 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

    Article • FEBS Letters, October 1998, Wiley

    Johan Neyts

  839. Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12

    Article • Antiviral Chemistry and Chemotherapy, October 1998, SAGE Publications

    Johan Neyts

  840. Synthesis, Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 2:1Adenosine and Uridine Analogues

    Article • Nucleosides and Nucleotides, July 1998, Taylor & Francis

    Johan Neyts

  841. Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication

    Article • Antiviral Chemistry and Chemotherapy, June 1998, SAGE Publications

    Johan Neyts

  842. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells

    Article • Gene Therapy, March 1998, Springer Science + Business Media

    Johan Neyts

  843. The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo

    Article • Antimicrobial Agents and Chemotherapy, February 1998, ASM Journals

    Johan Neyts

  844. Intracellular Metabolism of the N7-Substituted Acyclic Nucleoside Analog 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a Potent Inhibitor of Herpesvirus Replication

    Article • Molecular Pharmacology, January 1998, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Johan Neyts

  845. Differential anti-hepatitis B virus activity in vitro of three potent of inosine monophosphate dehydrogenase inhibitors: mycophenolic acid (MPA), 5-ethynyl-1-β-d-ribofuranosyli-midazole-4-carboxamide (EICAR) and ribavirin

    Article • Journal of Hepatology, January 1998, Elsevier

    Johan Neyts

  846. Inhibitory effect of 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) on hepatitis B virus replication in vitro

    Article • Journal of Hepatology, January 1998, Elsevier

    Johan Neyts

  847. The influences of immunosuppressive agents on HBV replication in vitro

    Article • Journal of Hepatology, January 1998, Elsevier

    Johan Neyts

  848. In Vitro and In Vivo Inhibition of Murine Gamma Herpesvirus 68 Replication by Selected Antiviral Agents

    Article • Antimicrobial Agents and Chemotherapy, January 1998, ASM Journals

    Johan Neyts

  849. Antiviral drug susceptibility of human herpesvirus 8.

    Article • Antimicrobial Agents and Chemotherapy, December 1997, ASM Journals

    Johan Neyts

  850. Phosphorylation of aciclovir, ganciclovir, penciclovir and S2242 by the cytomegalovirus UL97 protein: a quantitative analysis using recombinant vaccinia viruses

    Article • Antiviral Research, October 1997, Elsevier

    Johan Neyts

  851. Antiviral activity of a novel compound P-4018 against different strains of herpes simplex virus in vitro and in vivo

    Article • Antiviral Research, April 1997, Elsevier

    Johan Neyts

  852. Differential antiviral activity of several IMP dehydrogenase inhibitors

    Article • Antiviral Research, April 1997, Elsevier

    Johan Neyts

  853. Mycophenolate Mofetil markedly enhances the antiviral activity of acyclovir, ganciclovir and penciclovir against herpes simplex virus (wild type and TK− strains) and human cytomegalovirus

    Article • Antiviral Research, April 1997, Elsevier

    Johan Neyts

  854. Synthesis and antiviral evaluation of benzyl-substituted thiopurine and tiazofurin derivatives

    Article • Antiviral Research, April 1997, Elsevier

    Johan Neyts

  855. HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections

    Article • Antiviral Chemistry and Chemotherapy, February 1997, SAGE Publications

    Johan Neyts

  856. Nucleosides and Nucleotides. Part 154. New Neplanocin Analogues. VIII. Synthesis and Biological Activity of 6'-C-Ethyl, -Ethenyl, and -Ethynyl Derivatives of Neplanocin A.

    Article • Chemical and Pharmaceutical Bulletin, January 1997, Pharmaceutical Society of Japan

    Johan Neyts

  857. Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues

    Article • Antiviral Chemistry and Chemotherapy, June 1996, SAGE Publications

    Johan Neyts

  858. Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections

    Article • Antiviral Research, May 1996, Elsevier

    Johan Neyts

  859. Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. Part 2. Polymerized Anionic Surfactants Derived from Amino Acids and Dipeptides†

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Johan Neyts

  860. Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Johan Neyts

  861. Differential antiviral activity of derivatized dextrans

    Article • Biochemical Pharmacology, September 1995, Elsevier

    Johan Neyts

  862. Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures

    Article • Cell Calcium, August 1995, Elsevier

    Johan Neyts

  863. Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues

    Article • Antiviral Chemistry and Chemotherapy, June 1995, SAGE Publications

    Johan Neyts

  864. Human Cytomegalovirus Stimulates Thymidylate Synthase in Human Embryonic Lung Cells: A Possible Target for Anti-HCMV Therapy?

    Article • Nucleosides Nucleotides & Nucleic Acids, May 1995, Taylor & Francis

    Johan Neyts

  865. In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)

    Article • Nucleosides Nucleotides & Nucleic Acids, May 1995, Taylor & Francis

    Johan Neyts

  866. Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes

    Article • The Journal of Infectious Diseases, April 1995, Oxford University Press (OUP)

    Johan Neyts

  867. In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine

    Article • Antimicrobial Agents and Chemotherapy, January 1995, ASM Journals

    Johan Neyts

  868. The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication.

    Article • Antimicrobial Agents and Chemotherapy, December 1994, ASM Journals

    Johan Neyts

  869. Host Defense Mechanisms Against Murine Cytomegalovirus Infection Induced by Poly l:C in Severe Combined Immune Deficient (SCID) Mice

    Article • Experimental Biology and Medicine, November 1994, SAGE Publications

    Johan Neyts

  870. Calcineurin as a possible new target for treatment of Parkinson's disease

    Article • Medical Hypotheses, September 1994, Elsevier

    Johan Neyts

  871. Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata

    Article • Biochemical Pharmacology, June 1994, Elsevier

    Johan Neyts

  872. In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion.

    Article • Antimicrobial Agents and Chemotherapy, February 1994, ASM Journals

    Johan Neyts

  873. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication

    Article • Biochemical Pharmacology, January 1994, Elsevier

    Johan Neyts

  874. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice

    Article • Journal of Medical Virology, November 1993, Wiley

    Johan Neyts

  875. In vitro Activity of a Novel Series of Polyoxosilicotungstates against Human Myxo-, Herpes- and Retroviruses

    Article • Antiviral Chemistry and Chemotherapy, October 1993, SAGE Publications

    Johan Neyts

  876. Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication

    Article • Antiviral Research, July 1993, Elsevier

    Johan Neyts

  877. Protective activity of lipid A analogue GLA-60 against murine cytomegalovirus infection in mice

    Article • Journal of Medical Virology, July 1993, Wiley

    Johan Neyts

  878. Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice

    Article • Journal of General Virology, July 1993, Society for General Microbiology

    Johan Neyts

  879. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo

    Article • European Journal of Clinical Microbiology & Infectious Diseases, June 1993, Springer Science + Business Media

    Johan Neyts

  880. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine in the treatment of intracerebral murine cytomegalovirus infections in immunocompetent and immunodeficient mice

    Article • European Journal of Clinical Microbiology & Infectious Diseases, April 1993, Springer Science + Business Media

    Johan Neyts

  881. Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice

    Article • Journal of Medical Virology, February 1993, Wiley

    Johan Neyts

  882. Strategies for the treatment and prevention of cytomegalovirus infections

    Article • International Journal of Antimicrobial Agents, January 1993, Elsevier

    Johan Neyts

  883. Therapy for herpesvirus infections

    Article • Current Opinion in Infectious Diseases, December 1992, Wolters Kluwer Health

    Johan Neyts

  884. Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.

    Article • Molecular Pharmacology, December 1992, Elsevier

    Johan Neyts

  885. Poly(Hydroxy)Carboxylates as Selective Inhibitors of Cytomegalovirus and Herpes Simplex Virus Replication

    Article • Antiviral Chemistry and Chemotherapy, August 1992, SAGE Publications

    Johan Neyts

  886. Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate

    Article • Virology, July 1992, Elsevier

    Johan Neyts

  887. The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replicati...

    Article • Antiviral Research, June 1992, Elsevier

    Prof dr Els J.M. Van Damme, Johan Neyts

  888. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

    Article • Journal of Medical Virology, May 1992, Wiley

    Johan Neyts

  889. Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anticytomegalovirus agents

    Article • Journal of Virological Methods, November 1991, Elsevier

    Johan Neyts

  890. Inhibitory Effects of Polycations on the Replication of Enveloped Viruses (HIV, HSV, CMV, RSV, Influenza A Virus and Togaviruses) in vitro

    Article • Antiviral Chemistry and Chemotherapy, August 1991, SAGE Publications

    Johan Neyts

  891. Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique

    Article • Antiviral Research, July 1991, Elsevier

    Johan Neyts

  892. Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro

    Article • Antiviral Research, July 1991, Elsevier

    Johan Neyts

  893. Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro.

    Article • Antimicrobial Agents and Chemotherapy, March 1991, ASM Journals

    Johan Neyts

  894. Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG)

    Article • Virology, November 1990, Elsevier

    Johan Neyts

  895. Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses

    Article • Antiviral Chemistry and Chemotherapy, August 1990, SAGE Publications

    Johan Neyts

  896. Detection of substances recognized by antisera directed against vertebrate somatotropin, prolactin and placental lactogen, within the brain of the insect Locusta migratoria: A comparison of immunocytochemical localization patterns

    Article • Comparative Biochemistry and Physiology Part A Physiology, January 1990, Elsevier

    Johan Neyts

  897. Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry

    Article • Journal of Virological Methods, December 1989, Elsevier

    Johan Neyts

  898. Antiviral Drugs

    Article • ASM Journals

    Johan Neyts

  899. Antiviral Drugs

    Article • ASM Journals

    Johan Neyts

  900. Methods in Anti-HCMV Research

    Article • Springer Science + Business Media

    Johan Neyts

  901. Selective inhibitors of the replication of poxviruses

    Article • Springer Science + Business Media

    Johan Neyts

  902. Faculty of 1000 evaluation for Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease.

    Article • Faculty of 1000, Ltd.

    Johan Neyts

  903. Faculty of 1000 evaluation for Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.

    Article • Faculty of 1000, Ltd.

    Johan Neyts

  904. Article • PLOS

    Johan Neyts

  905. Article • PLOS

    Johan Neyts

  906. Article • PLOS

    Johan Neyts

  907. Article • PLOS

    Johan Neyts

  908. Article • PLOS

    Johan Neyts

  909. Article • PLOS

    Johan Neyts

  910. Article • PLOS

    Johan Neyts

  911. Article • PLOS

    Johan Neyts

  912. Article • PLOS

    Johan Neyts

  913. Article • PLOS

    Johan Neyts

  914. Article • PLOS

    Johan Neyts

  915. Article • PLOS

    Johan Neyts

  916. Article • PLOS

    Johan Neyts

  917. Article • PLOS

    Johan Neyts

  918. Article • PLOS

    Johan Neyts

  919. Article • PLOS

    Johan Neyts

  920. Article • PLOS

    Johan Neyts

  921. Article • PLOS

    Johan Neyts

  922. Article • PLOS

    Johan Neyts

  923. Article • PLOS

    Johan Neyts

  924. Article • PLOS

    Johan Neyts

  925. Article • PLOS

    Johan Neyts

  926. Article • PLOS

    Johan Neyts

  927. Article • PLOS

    Johan Neyts

  928. Article • PLOS

    Johan Neyts

  929. Article • PLOS

    Johan Neyts

  930. Article • PLOS

    Johan Neyts

  931. Article • PLOS

    Johan Neyts

  932. Article • PLOS

    Johan Neyts

  933. Article • PLOS

    Johan Neyts

  934. Article • PLOS

    Johan Neyts

  935. Article • PLOS

    Johan Neyts

  936. Article • PLOS

    Johan Neyts

  937. Article • PLOS

    Johan Neyts

  938. Article • PLOS

    Johan Neyts

  939. Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

    Article • American Chemical Society (ACS)

    Johan Neyts