All Stories

  1. TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Associate Professor Nicholas West

  2. Mycobacterium tuberculosis Deficient in PdtaS Cytosolic Histidine Kinase Displays Attenuated Growth and Affords Protective Efficacy against Aerosol M. tuberculosis Infection in Mice

    Article • Vaccines, January 2024, MDPI AG

    Associate Professor Nicholas West

  3. seco-1-Azacubane-2-carboxylic Acid: Derivative Scope and Comparative Biological Evaluation

    Article • The Journal of Organic Chemistry, December 2023, American Chemical Society (ACS)

    Associate Professor Nicholas West

  4. Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin

    Article • Australian Journal of Chemistry, November 2023, CSIRO Publishing

    Associate Professor Nicholas West

  5. TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy

    Article • April 2023, Research Square

    Associate Professor Nicholas West

  6. Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

    Article • Nature Communications, March 2023, Springer Science + Business Media

    Associate Professor Nicholas West

  7. Discovery of Anti‐tubercular Analogues of Bedaquiline with Modified A‐, B‐ and C‐Ring Subunits

    Article • ChemMedChem, November 2022, Wiley

    Associate Professor Nicholas West

  8. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection

    Article • Journal of Medicinal Chemistry, September 2022, American Chemical Society (ACS)

    Associate Professor Nicholas West

  9. Two‐component sensor histidine kinases of Mycobacterium tuberculosis : Beacons for niche navigation

    Article • Molecular Microbiology, April 2022, Wiley

    Associate Professor Nicholas West

  10. Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles

    Article • ACS Biomaterials Science & Engineering, August 2021, American Chemical Society (ACS)

    Associate Professor Nicholas West

  11. Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

    Article • Immunity, August 2021, Elsevier

    Associate Professor Nicholas West

  12. Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads

    Article • Journal of Medicinal Chemistry, January 2021, American Chemical Society (ACS)

    Associate Professor Nicholas West

  13. The antimicrobial potential of cannabidiol

    Article • Communications Biology, January 2021, Springer Science + Business Media

    Associate Professor Nicholas West

  14. Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol–Acid Reductoisomerase

    Article • Chemistry - A European Journal, January 2021, Wiley

    Associate Professor Nicholas West

  15. Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit

    Article • RSC Medicinal Chemistry, January 2021, Royal Society of Chemistry

    Associate Professor Nicholas West

  16. GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

    Article • Frontiers in Immunology, November 2020, Frontiers

    Associate Professor Nicholas West

  17. Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

    Article • Journal of Medicinal Chemistry, November 2020, American Chemical Society (ACS)

    Associate Professor Nicholas West

  18. Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface

    Article • Gastroenterology, October 2020, Elsevier

    Associate Professor Nicholas West

  19. Structures of fungal and plant acetohydroxyacid synthases

    Article • Nature, July 2020, Springer Science + Business Media

    Associate Professor Nicholas West

  20. Discovery, Synthesis and Evaluation of a Ketol‐Acid Reductoisomerase Inhibitor

    Article • Chemistry - A European Journal, July 2020, Wiley

    Associate Professor Nicholas West

  21. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

    Article • The FASEB Journal, April 2020, Wiley

    Associate Professor Nicholas West

  22. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

    Article • PLoS Pathogens, February 2020, PLOS

    Dr Colin Jackson, Hafna Ahmed, Associate Professor Nicholas West

  23. Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

    Article • Molecular Microbiology, August 2019, Wiley

    Associate Professor Nicholas West

  24. Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone

    Article • Organic Letters, July 2019, American Chemical Society (ACS)

    Associate Professor Matthew J Piggott, Associate Professor Nicholas West

  25. Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity

    Article • Journal of Medicinal Chemistry, December 2018, American Chemical Society (ACS)

    Dr Mark S Butler, Associate Professor Nicholas West

  26. Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

    Article • European Journal of Medicinal Chemistry, November 2018, Elsevier

    Associate Professor Nicholas West

  27. Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method

    Article • PeerJ, June 2018, PeerJ

    Associate Professor Nicholas West

  28. Use of Soluble Extracellular Regions of MmpL (SERoM) as Vaccines for Tuberculosis

    Article • Scientific Reports, April 2018, Springer Science + Business Media

    Associate Professor Nicholas West

  29. PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection

    Article • PLoS ONE, March 2018, PLOS

    Associate Professor Nicholas West

  30. Endopeptidase PepO Regulates the SpeB Cysteine Protease and Is Essential for the Virulence of Invasive M1T1 Streptococcus pyogenes

    Article • Journal of Bacteriology, January 2018, ASM Journals

    Mark Walker, Associate Professor Nicholas West

  31. Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent

    Article • Australian Journal of Chemistry, January 2018, CSIRO Publishing

    Associate Professor Nicholas West

  32. Isothermal Point Mutation Detection: Toward a First-Pass Screening Strategy for Multidrug-Resistant Tuberculosis

    Article • Analytical Chemistry, August 2017, American Chemical Society (ACS)

    Associate Professor Nicholas West

  33. Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli

    Article • Journal of Antimicrobial Chemotherapy, July 2017, Oxford University Press (OUP)

    A/Prof Scott A Beatson, Associate Professor Nicholas West

  34. The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes

    Article • Infection and Immunity, April 2017, ASM Journals

    Mark Walker, Associate Professor Nicholas West

  35. Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

    Article • Nature Communications, March 2017, Springer Science + Business Media

    Associate Professor Nicholas West

  36. Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models

    Article • mBio, June 2016, ASM Journals

    Dr Peter Michael Moyle, Associate Professor Nicholas West

  37. Saccharomyces cerevisiae Acetohydroxyacid Synthase in complex with bensulfuron methyl

    Article • March 2016, Protein Data Bank, Rutgers University

    Associate Professor Nicholas West

  38. Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase

    Article • Angewandte Chemie International Edition, February 2016, Wiley

    Associate Professor Nicholas West

  39. Naked-Eye Colorimetric and Electrochemical Detection of Mycobacterium tuberculosis—toward Rapid Screening for Active Case Finding

    Article • ACS Sensors, December 2015, American Chemical Society (ACS)

    Associate Professor Nicholas West

  40. Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Associate Professor Nicholas West

  41. Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles

    Article • Analytical Chemistry, October 2015, American Chemical Society (ACS)

    Associate Professor Nicholas West

  42. Host–pathogen interaction during bacterial vaccination

    Article • Current Opinion in Immunology, October 2015, Elsevier

    Associate Professor Nicholas West

  43. Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

    Article • May 2015, Protein Data Bank, Rutgers University

    Associate Professor Nicholas West

  44. First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

    Article • Journal of Medicinal Chemistry, May 2015, American Chemical Society (ACS)

    Associate Professor Nicholas West

  45. Manganese Homeostasis in Group A Streptococcus Is Critical for Resistance to Oxidative Stress and Virulence

    Article • mBio, March 2015, ASM Journals

    Mark Walker, Associate Professor Nicholas West

  46. Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid

    Article • December 2014, Protein Data Bank, Rutgers University

    Associate Professor Nicholas West

  47. ZapE Is a Novel Cell Division Protein Interacting with FtsZ and Modulating the Z-Ring Dynamics

    Article • mBio, March 2014, ASM Journals

    Associate Professor Nicholas West

  48. TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines

    Article • Vaccine, September 2013, Elsevier

    Associate Professor Nicholas West

  49. Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

    Article • Journal of Medicinal Chemistry, August 2013, American Chemical Society (ACS)

    Associate Professor Nicholas West

  50. Plasmin(ogen) Acquisition by Group A <b><i>Streptococcus</i></b> Protects against C3b-Mediated Neutrophil Killing

    Article • Journal of Innate Immunity, August 2013, Karger Publishers

    Associate Professor Nicholas West

  51. Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Associate Professor Nicholas West

  52. Host Cell–Induced Components of the Sulfate Assimilation Pathway Are Major Protective Antigens of Mycobacterium tuberculosis

    Article • The Journal of Infectious Diseases, December 2012, Oxford University Press (OUP)

    Associate Professor Nicholas West

  53. The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice

    Article • PLoS ONE, May 2012, PLOS

    Associate Professor Nicholas West

  54. Elucidation ofMycobacterium tuberculosisType II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy

    Article • ChemMedChem, March 2012, Wiley

    Associate Professor Nicholas West

  55. Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Associate Professor Nicholas West, Shaun Lott

  56. Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis

    Article • Vaccine, October 2011, Elsevier

    Associate Professor Nicholas West

  57. Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Associate Professor Nicholas West

  58. Immunity toMycobacterium tuberculosis

    Article • Clinical and Developmental Immunology, January 2011, Hindawi Publishing Corporation

    Associate Professor Nicholas West

  59. Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads

    Article • ChemMedChem, November 2010, Wiley

    Associate Professor Nicholas West

  60. Tetrahydrolipstatin Inhibition, Functional Analyses, and Three-dimensional Structure of a Lipase Essential for Mycobacterial Viability

    Article • Journal of Biological Chemistry, September 2010, Elsevier

    Associate Professor Nicholas West

  61. Modulation of Shigella virulence in response to available oxygen in vivo

    Article • Nature, May 2010, Springer Science + Business Media

    Associate Professor Nicholas West

  62. Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine

    Article • Vaccine, February 2010, Elsevier

    Associate Professor Nicholas West

  63. Cutinase‐like proteins of Mycobacterium tuberculosis : characterization of their variable enzymatic functions and active site identification

    Article • The FASEB Journal, February 2009, Wiley

    Associate Professor Nicholas West

  64. Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis

    Article • Vaccine, July 2008, Elsevier

    Associate Professor Nicholas West

  65. Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells

    Article • FEMS Microbiology Letters, January 2006, Oxford University Press (OUP)

    Associate Professor Nicholas West

  66. Available carbon source influences the resistance of Neisseria meningitidis against complement

    Article • The Journal of Experimental Medicine, May 2005, Rockefeller University Press

    Associate Professor Nicholas West

  67. Optimization of Virulence Functions Through Glucosylation of Shigella LPS

    Article • Science, February 2005, American Association for the Advancement of Science

    Associate Professor Nicholas West

  68. Finding your niche: what has been learnt from STM studies on GI colonization

    Article • Trends in Microbiology, July 2003, Elsevier

    Associate Professor Nicholas West

  69. An aromatic amino acid auxotrophic mutant ofBordetella bronchisepticais attenuated and immunogenic in a mouse model of infection

    Article • FEMS Microbiology Letters, April 2003, Oxford University Press (OUP)

    Professor Steven P Djordjevic, Associate Professor Nicholas West

  70. Role of Phosphoglucomutase of Bordetella bronchiseptica in Lipopolysaccharide Biosynthesis and Virulence

    Article • Infection and Immunity, August 2000, ASM Journals

    Associate Professor Nicholas West

  71. Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells

    Article • FEMS Microbiology Letters, January 1997, Oxford University Press (OUP)

    Associate Professor Nicholas West