All Stories

  1. Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
  2. Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer
  3. Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins
  4. Likelihood-based interactive local docking into cryo-EM maps in ChimeraX
  5. Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants
  6. AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination
  7. AlphaFold predictions are valuable hypotheses, and accelerate but do not replace experimental structure determination
  8. Accelerating crystal structure determination with iterative AlphaFold prediction
  9. Improved AlphaFold modeling with implicit experimental information
  10. Cryo-EM structures of light-harvesting 2 complexes fromRhodopseudomonas palustrisreveal the molecular origin of absorption tuning
  11. The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
  12. 2.4-Å structure of the double-ring Gemmatimonas phototrophica photosystem
  13. Improved AlphaFold modeling with implicit experimental information
  14. Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation
  15. Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å
  16. Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å
  17. A structural biology community assessment of AlphaFold 2 applications
  18. Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
  19. Structures of full-length glycoprotein hormone receptor signalling complexes
  20. Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å
  21. Structure and ion-release mechanism of PIB-4-type ATPases
  22. Structures of full-length glycoprotein hormone receptor signaling complexes
  23. SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
  24. MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
  25. Making the invisible enemy visible
  26. Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape
  27. Adaptive Cartesian and torsional restraints for interactive model rebuilding
  28. Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
  29. Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane
  30. Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
  31. Improving SARS-CoV-2 structures: Peer review by early coordinate release
  32. Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
  33. Phasertng: directed acyclic graphs for crystallographic phasing
  34. UCSF ChimeraX: Structure visualization for researchers, educators, and developers
  35. Structure, Dynamics, Receptor Binding, and Antibody Binding of Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane
  36. Making the invisible enemy visible
  37. Adaptive conformational restraints for interactive model rebuilding in Cartesian and torsion space
  38. Structures of fungal and plant acetohydroxyacid synthases
  39. How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor
  40. Developing a Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein Model in a Viral Membrane
  41. Lig v 1 structure and the inflammatory response to the Ole e 1 protein family
  42. Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane
  43. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
  44. Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
  45. Evaluation of model refinement in CASP13
  46. Evaluation of template‐based modeling in CASP13
  47. Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin
  48. Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55
  49. Molecular basis of Cul3 ubiquitin ligase subversion by vaccinia virus protein A55
  50. Bringing macromolecular model building to life with ISOLDE
  51. Xanthine Oxidoreductase: A Novel Therapeutic Target for the Treatment of Chronic Wounds?
  52. Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics
  53. Automating tasks in protein structure determination with the clipper python module
  54. Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
  55. Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases
  56. Multiple functional self-association interfaces in plant TIR domains
  57. The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins
  58. Re-evaluation of low-resolution crystal structuresviainteractive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4
  59. A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution
  60. Prediction of a novel internal rearrangement of the insulin receptor
  61. Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
  62. Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
  63. The rate ofcis–transconformation errors is increasing in low-resolution crystal structures
  64. Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling
  65. Vitronectin-Master controller or micromanager?
  66. A pre-clinical functional assessment of an acellular scaffold intended for the treatment of hard-to-heal wounds
  67. Transglutaminases and receptor tyrosine kinases
  68. A peptidomimetic inhibitor of matrix metalloproteinases containing a tetherable linker group
  69. Controlled presentation of recombinant proteins via a zinc-binding peptide-linker in two and three dimensional formats
  70. Nanoscale presentation of cell adhesive molecules via block copolymer self-assembly
  71. Modeling the adhesion of human embryonic stem cells to poly(lactic-co-glycolic acid) surfaces in a 3D environment
  72. Engineering tissue tubes using novel multilayered scaffolds in the rat peritoneal cavity
  73. Analysis of the Phase Behavior of the Aqueous Poly(ethylene glycol)-Ficoll System
  74. Transplantation of 3D scaffolds seeded with human embryonic stem cells: biological features of surrogate tissue and teratoma-forming potential
  75. A Blank Slate? Layer-by-Layer Deposition of Hyaluronic Acid and Chitosan onto Various Surfaces
  76. Systematic selection of solvents for the fabrication of 3D combined macro- and microporous polymeric scaffolds for soft tissue engineering
  77. Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications
  78. Scaffolds, Stem Cells, and Tissue Engineering: A Potent Combination!
  79. Controllable Surface Modification of Poly(lactic-co-glycolic acid) (PLGA) by Hydrolysis or Aminolysis I:  Physical, Chemical, and Theoretical Aspects
  80. Quantitative prediction of phase diagrams for polymer partitioning in aqueous two-phase systems