All Stories

  1. Natural product-derived compounds in clinical trials and drug approvals

    Article • Natural Product Reports, January 2025, Royal Society of Chemistry

    Dr Mark S Butler

  2. A Review of Antibacterial Candidates with New Modes of Action

    Article • ACS Infectious Diseases, July 2024, American Chemical Society (ACS)

    Dr Mark S Butler

  3. Correction: Antibiotics in the clinical pipeline as of December 2022

    Article • The Journal of Antibiotics, November 2023, Springer Science + Business Media

    Dr Mark S Butler

  4. Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp.

    Article • Journal of Natural Products, August 2023, American Chemical Society (ACS)

    Dr Mark S Butler

  5. Nanoscaled Discovery of a Shunt Rifamycin from Salinispora arenicola Using a Three-Color GFP-Tagged Staphylococcus aureus Macrophage Infection Assay

    Article • ACS Infectious Diseases, July 2023, American Chemical Society (ACS)

    Dr Mark S Butler

  6. Antibiotics in the clinical pipeline as of December 2022

    Article • The Journal of Antibiotics, June 2023, Springer Science + Business Media

    Dr Mark S Butler

  7. Natural products as anthelmintics: safeguarding animal health

    Article • Natural Product Reports, January 2023, Royal Society of Chemistry

    Dr Mark S Butler

  8. Nanoscaled discovery of a shunt rifamycin fromSalinispora arenicolausing a three-colour GFP-taggedStaphylococcus aureusmacrophage infection assay

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Dr Mark S Butler

  9. A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

    Article • Science Translational Medicine, September 2022, American Association for the Advancement of Science

    Dr Mark S Butler

  10. Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

    Article • Plants, May 2022, MDPI AG

    Dr Mark S Butler

  11. Reply to Kaye and Belley, “Third-Generation Cephalosporin-Resistant Enterobacterales Are Critical Priority Pathogens, Too!”

    Article • Antimicrobial Agents and Chemotherapy, March 2022, ASM Journals

    Dr Mark S Butler

  12. Analysis of the clinical pipeline of treatments for drug resistant bacterial infections: despite progress, more action is needed

    Article • Antimicrobial Agents and Chemotherapy, January 2022, ASM Journals

    Dr Mark S Butler

  13. Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi

    Article • Chemical Communications, January 2022, Royal Society of Chemistry

    Dr Mark S Butler

  14. Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol

    Article • ACS Infectious Diseases, April 2021, American Chemical Society (ACS)

    Dr Mark S Butler

  15. Antibiotics in the clinical pipeline in October 2019

    Article • The Journal of Antibiotics, March 2020, Springer Science + Business Media

    Dr Mark S Butler

  16. Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16

    Article • Journal of Natural Products, October 2019, American Chemical Society (ACS)

    Dr Mark S Butler

  17. Structure-Function Studies of Polymyxin B Lipononapeptides

    Article • Molecules, February 2019, MDPI AG

    Dr Mark S Butler

  18. Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity

    Article • Journal of Medicinal Chemistry, December 2018, American Chemical Society (ACS)

    Dr Mark S Butler, Professor Nicholas West

  19. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

    Article • Science Translational Medicine, October 2018, American Association for the Advancement of Science

    Dr Mark S Butler

  20. Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing Klebsiella pneumoniae ST258 Clinical Isolate Compared to Polymyxins

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Dr Mark S Butler

  21. 5,6,7,3′,4′,5′-Hexamethoxyflavone from the Australian plant Eremophila debilis (Myoporaceae)

    Article • Fitoterapia, April 2018, Elsevier

    Dr Mark S Butler

  22. Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

    Article • Bioorganic & Medicinal Chemistry Letters, February 2018, Elsevier

    Dr Mark S Butler

  23. Developments in Glycopeptide Antibiotics

    Article • ACS Infectious Diseases, January 2018, American Chemical Society (ACS)

    Dr Mark S Butler

  24. Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Dr Mark S Butler

  25. Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

    Article • Bioorganic & Medicinal Chemistry Letters, June 2017, Elsevier

    Dr Mark S Butler

  26. Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia

    Article • Journal of Natural Products, March 2017, American Chemical Society (ACS)

    Dr Mark S Butler

  27. Old dogs and new tricks in antimicrobial discovery

    Article • Current Opinion in Microbiology, October 2016, Elsevier

    Dr Mark S Butler

  28. Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

    Article • ACS Medicinal Chemistry Letters, September 2016, American Chemical Society (ACS)

    Dr Mark S Butler

  29. Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence inCryptococcus neoformans

    Article • ACS Infectious Diseases, September 2016, American Chemical Society (ACS)

    Dr Mark S Butler, Professor Bostjan Kobe, Ulrike Kappler

  30. Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

    Article • European Journal of Medicinal Chemistry, September 2016, Elsevier

    Dr Mark S Butler

  31. Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and MutantEscherichia coli

    Article • ACS Infectious Diseases, August 2016, American Chemical Society (ACS)

    Dr Mark S Butler

  32. Antibiotics in the clinical pipeline at the end of 2015

    Article • The Journal of Antibiotics, June 2016, Nature

    Dr Mark S Butler

  33. A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

    Article • Scientific Reports, March 2016, Nature

    Dr Mark S Butler

  34. Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

    Article • Journal of Medicinal Chemistry, February 2016, American Chemical Society (ACS)

    Dr Mark S Butler

  35. Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum

    Article • Journal of Natural Products, August 2015, American Chemical Society (ACS)

    Dr Mark S Butler

  36. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

    Article • Nature Communications, July 2015, Nature

    Dr Mark S Butler

  37. Mucin Binding Reduces Colistin Antimicrobial Activity

    Article • Antimicrobial Agents and Chemotherapy, July 2015, ASM Journals

    Matthew Cooper, Dr Mark S Butler

  38. Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two ‘old’ antibiotics—polymyxin B and chloramphenicol

    Article • Journal of Antimicrobial Chemotherapy, May 2015, Oxford University Press (OUP)

    Dr Mark S Butler

  39. Evaluation of biomarkers for in vitro prediction of drug‐induced nephrotoxicity: comparison of HK ‐2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells

    Article • Pharmacology Research & Perspectives, May 2015, Wiley

    Matthew Cooper, Dr Mark S Butler

  40. Gargantulide A, a Complex 52-Membered Macrolactone Showing Antibacterial Activity from Streptomyces sp.

    Article • Organic Letters, March 2015, American Chemical Society (ACS)

    Dr Mark S Butler

  41. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    Article • Nature Reports Stem Cells, February 2015, Nature

    Professor Eicke Latz, Dr Mark S Butler

  42. Synthesis of norbornane bisether antibiotics via silver-mediated alkylation

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Dr Frederick Matthew Pfeffer, Dr Mark S Butler

  43. Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Frederick Matthew Pfeffer, Dr Mark S Butler

  44. Ramoplanin at Bactericidal Concentrations Induces Bacterial Membrane Depolarization in Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, September 2014, ASM Journals

    Matthew Cooper, Dr Mark S Butler

  45. Glycopeptide antibiotics: Back to the future

    Article • The Journal of Antibiotics, August 2014, Springer Science + Business Media

    Dr Mark S Butler

  46. An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

    Article • Bioorganic & Medicinal Chemistry, August 2014, Elsevier

    Dr Mark S Butler

  47. Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads

    Article • Tetrahedron Letters, March 2014, Elsevier

    Dr Mark S Butler

  48. Cardenolide Glycosides from Elaeodendron australe var. integrifolium

    Article • Phytochemistry, February 2014, Elsevier

    Dr Mark S Butler

  49. Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Matthew Cooper, Dr Mark S Butler

  50. Natural product and natural product derived drugs in clinical trials

    Article • Natural Product Reports, January 2014, Royal Society of Chemistry

    Dr Mark S Butler

  51. Natural Product Libraries: Assembly, Maintenance, and Screening.

    Article • Planta Medica, December 2013, Thieme Publishing Group

    Dr Mark S Butler

  52. Remediating Cancer via Splicing Modulation

    Article • Journal of Medicinal Chemistry, September 2013, American Chemical Society (ACS)

    Dr Mark S Butler

  53. Antibiotics in the clinical pipeline in 2013

    Article • The Journal of Antibiotics, September 2013, Springer Science + Business Media

    Matthew Cooper, Dr Mark S Butler

  54. Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae

    Article • Innate Immunity, July 2013, SAGE Publications

    Dr Mark S Butler

  55. Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2

    Article • The Journal of Antibiotics, January 2013, Nature

    Dr Mark S Butler

  56. Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

    Article • Current Drug Targets, August 2012, Bentham Science Publishers

    Matthew Cooper, Dr Mark S Butler

  57. Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins

    Article • Tetrahedron Letters, May 2012, Elsevier

    Dr Mark S Butler

  58. Structure aided design of chimeric antibiotics

    Article • Bioorganic & Medicinal Chemistry Letters, April 2012, Elsevier

    Matthew Cooper, Dr Mark S Butler

  59. Absolute Configuration and Total Synthesis of a Novel Antimalarial Lipopeptide by the de Novo Preparation of Chiral Nonproteinogenic Amino Acids

    Article • Organic Letters, March 2012, American Chemical Society (ACS)

    Dr Mark S Butler

  60. Identification of aluminium dioxalate in fungal cultures grown on vermiculite

    Article • The Journal of Antibiotics, March 2012, Springer Science + Business Media

    Dr Mark S Butler

  61. Screening Strategies to Identify New Antibiotics

    Article • Current Drug Targets, March 2012, Bentham Science Publishers

    Matthew Cooper, Dr Mark S Butler

  62. Identification of a Naturally Occurring Quinazolin-4(3H)-one Firefly Luciferase Inhibitor

    Article • Journal of Natural Products, June 2011, American Chemical Society (ACS)

    Dr Mark S Butler

  63. Antibiotics in the clinical pipeline in 2011

    Article • The Journal of Antibiotics, May 2011, Springer Science + Business Media

    Matthew Cooper, Dr Mark S Butler

  64. Synthesis of Essramycin and Comparison of Its Antibacterial Activity

    Article • Journal of Natural Products, November 2010, American Chemical Society (ACS)

    Dr Mark S Butler

  65. A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents

    Article • Tetrahedron, November 2010, Elsevier

    Dr Mark S Butler

  66. ChemInform Abstract: Psammopemmins (A-C), Novel Brominated 4-Hydroxyindole Alkaloids from an Antarctic Sponge, Psammopemma sp.

    Article • ChemInform, August 2010, Wiley

    Dr Mark S Butler

  67. A Snapshot of Natural Product-Derived Compounds in Late Stage Clinical Development at the End of 2008

    Article • October 2009, Royal Society of Chemistry

    Dr Mark S Butler

  68. A benzopyrroloisoquinoline alkaloid from Ficus fistulosa

    Article • Phytochemistry Letters, April 2009, Elsevier

    Dr Mark S Butler

  69. Microsphaerins A–D, four novel benzophenone dimers with activity against MRSA from the fungus Microsphaeropsis sp.

    Article • Tetrahedron, October 2008, Elsevier

    Dr Srinivasulu Aitipamula, Dr Mark S Butler

  70. Natural products to drugs: natural product-derived compounds in clinical trials

    Article • Natural Product Reports, January 2008, Royal Society of Chemistry

    Dr Mark S Butler

  71. A Simple Method for High-Throughput Extract Prefractionation for Biological Screening

    Article • CHIMIA International Journal for Chemistry, June 2007, Swiss Chemical Society

    Dr Mark S Butler

  72. Natural products — The future scaffolds for novel antibiotics?

    Article • Biochemical Pharmacology, March 2006, Elsevier

    Dr Mark S Butler

  73. Sundaicumones A and B, Polyprenylated Acylphloroglucinol Derivatives from Calophyllum sundaicum with Weak Activity against the Glucocorticoid Receptor

    Article • Journal of Natural Products, February 2006, American Chemical Society (ACS)

    Dr Mark S Butler

  74. Pyrrole Carboxamidine Tryptase Inhibitors from Leptonychia pubescens

    Article • Planta Medica, September 2005, Thieme Publishing Group

    Dr Mark S Butler

  75. New Estrogenic Prenylflavone from Epimedium brevicornum Inhibits the Growth of Breast Cancer Cells

    Article • Planta Medica, February 2005, Thieme Publishing Group

    Dr Mark S Butler

  76. Natural products to drugs: natural product derived compounds in clinical trials

    Article • Natural Product Reports, January 2005, Royal Society of Chemistry

    Dr Mark S Butler

  77. NMR spectral assignments of three aspidofractinine alkaloids, kopsine, fruticosine and fruticosamine

    Article • Magnetic Resonance in Chemistry, January 2005, Wiley

    Dr Mark S Butler

  78. Isolation and total synthesis of gymnastatin N, a POLO-like kinase 1 active constituent from the fungus Arachniotus punctatus

    Article • Tetrahedron, December 2004, Elsevier

    Dr Mark S Butler

  79. The Role of Natural Product Chemistry in Drug Discovery

    Article • Journal of Natural Products, November 2004, American Chemical Society (ACS)

    Dr Mark S Butler

  80. Inhibition of the Human Chemokine Receptor CCR5 by Variecolin and Variecolol and Isolation of Four New Variecolin Analogues, Emericolins A−D, from Emericella aurantiobrunnea

    Article • Journal of Natural Products, September 2004, American Chemical Society (ACS)

    Dr Mark S Butler

  81. A new model for utilising chemical diversity from natural sources

    Article • Drug Development Research, August 2004, Wiley

    Dr Mark S Butler

  82. Cochlioquinones and Epi-Cochlioquinones: Antagonists of the Human Chemokine Receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum.

    Article • The Journal of Antibiotics, January 2004, Japan Antibiotics Research Association

    Dr Mark S Butler

  83. Phenolic derivatives from Wigandia urens with weak activity against the chemokine receptor CCR5

    Article • Phytochemistry, November 2003, Elsevier

    Dr Mark S Butler

  84. 10-Methoxydihydrofuscin, Fuscinarin, and Fuscin, Novel Antagonists of the Human CCR5 Receptor from Oidiodendron griseum

    Article • Journal of Natural Products, July 2003, American Chemical Society (ACS)

    Dr Mark S Butler

  85. Ancisheynine, a novel naphthylisoquinolinium alkaloid from Ancistrocladus heyneanus

    Article • Tetrahedron Letters, July 2003, Elsevier

    Dr Mark S Butler

  86. Identification of Chelerythrine as an Inhibitor of BclXL Function

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Mark S Butler

  87. Flavonoids from Artocarpus Lanceifolius

    Article • Natural Product Research, January 2003, Taylor & Francis

    Dr Mark S Butler

  88. Naturally Occurring Cembranes from an Australian Sarcophyton Species

    Article • Journal of Natural Products, July 2002, American Chemical Society (ACS)

    Dr Mark S Butler

  89. Three New Pyridoacridine Type Alkaloids from a Singaporean Ascidian

    Article • Journal of Natural Products, June 2002, American Chemical Society (ACS)

    Dr Mark S Butler

  90. Agonodepsides A and B:  Two New Depsides from a Filamentous Fungus F7524

    Article • Journal of Natural Products, June 2002, American Chemical Society (ACS)

    Dr Mark S Butler

  91. Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II

    Article • Phytochemistry, May 2002, Elsevier

    Dr Mark S Butler

  92. Ardisiaquinones from Ardisia teysmanniana

    Article • Phytochemistry, December 2001, Elsevier

    Dr Mark S Butler

  93. Actephilol A and epiactephilol A: two novel aromatic terpenoids isolated from Actephila excelsa

    Article • Tetrahedron Letters, October 2001, Elsevier

    Dr Mark S Butler

  94. Circumdatin G, a New Alkaloid from the Fungus Aspergillus ochraceus

    Article • Journal of Natural Products, December 2000, American Chemical Society (ACS)

    Dr Mark S Butler

  95. 10-Hydroxydarlingine, a New Tropane Alkaloid from the Australian Proteaceous Plant Triunia erythrocarpa

    Article • Journal of Natural Products, March 2000, American Chemical Society (ACS)

    Dr Mark S Butler

  96. Anthoptilides A−E, New Briarane Diterpenes from the Australian Sea Pen Anthoptilum cf. kukenthali

    Article • Journal of Natural Products, March 2000, American Chemical Society (ACS)

    Dr Mark S Butler

  97. Isolation of Psammaplin A 11‘-Sulfate and Bisaprasin 11‘-Sulfate from the Marine Sponge Aplysinella rhax

    Article • Journal of Natural Products, February 2000, American Chemical Society (ACS)

    Dr Mark S Butler

  98. Tropane alkaloids from Darlingia darlingiana

    Article • Phytochemistry, October 1999, Elsevier

    Dr Mark S Butler

  99. Isolation of Xestosterol Esters of Brominated Acetylenic Fatty Acids from the Marine Sponge Xestospongia testudinaria

    Article • Journal of Natural Products, September 1999, American Chemical Society (ACS)

    Dr Mark S Butler

  100. Adociasulfates 1−6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia ) sp.

    Article • The Journal of Organic Chemistry, July 1999, American Chemical Society (ACS)

    Dr Mark S Butler

  101. Adociasulfates 1, 7, and 8:  New Bioactive Hexaprenoid Hydroquinones from the Marine SpongeAdociasp.

    Article • The Journal of Organic Chemistry, July 1999, American Chemical Society (ACS)

    Dr Mark S Butler

  102. Two New Naphthoquinones from the Roots of Conospermum sphacelatum

    Article • Australian Journal of Chemistry, January 1999, CSIRO Publishing

    Dr Mark S Butler

  103. Dragmacidins:  New Protein Phosphatase Inhibitors from a Southern Australian Deep-Water Marine Sponge, Spongosorites sp.

    Article • Journal of Natural Products, May 1998, American Chemical Society (ACS)

    Dr Mark S Butler, Professor Anthony Carroll

  104. Isolation and Structure of Hemibastadinols 1−3 from the Papua New Guinea Marine Sponge Ianthella basta

    Article • Journal of Natural Products, January 1996, American Chemical Society (ACS)

    Dr Mark S Butler

  105. Antineoplastic Agents, 326. The Stereochemistry of Bastadins 8, 10, and 12 from the Bismarck Archipelago Marine Sponge lanthella basta

    Article • Journal of Natural Products, May 1995, American Chemical Society (ACS)

    Dr Mark S Butler

  106. Organic geochemical and geochemical studies of Inner Great Barrier Reef sediments—IV. Identification of terrigenous and marine sourced inputs

    Article • Organic Geochemistry, October 1994, Elsevier

    Dr Mark S Butler

  107. Lamellarins O and P: New Aromatic Metabolites From the Australian Marine Sponge Dendrilla cactos

    Article • Australian Journal of Chemistry, January 1994, CSIRO Publishing

    Dr Mark S Butler

  108. Extraordinary levels of cadmium and zinc in a marine sponge,Tedania charcoti Topsent: inorganic chemical defense agents

    Article • Cellular and Molecular Life Sciences, March 1993, Springer Science + Business Media

    Dr Mark S Butler

  109. Trunculin-F and Contrunculin-A and -B: Novel Oxygenated Norterpenes From a Southern Australian Marine Sponge, Latrunculia conulosa

    Article • Australian Journal of Chemistry, January 1993, CSIRO Publishing

    Dr Mark S Butler

  110. Beyond Polygodial: New Drimane Sesquiterpenes From a Southern Australian Marine Sponge, Dysidea sp.

    Article • Australian Journal of Chemistry, January 1993, CSIRO Publishing

    Dr Mark S Butler

  111. Conulosins (A and B): Novel Norsesterterpene Acids from an Australian Marine Sponge, Latrunculia Conulosa

    Article • Natural Product Letters, November 1992, Taylor & Francis

    Dr Mark S Butler

  112. The Luffarins (A-Z), Novel Terpenes From an Australian Marine Sponge, Luffariella geometrica

    Article • Australian Journal of Chemistry, January 1992, CSIRO Publishing

    Dr Mark S Butler

  113. Aromatic Disabolenes from an Australian Marine Sponge, Arenochalina sp.

    Article • Journal of Natural Products, March 1991, American Chemical Society (ACS)

    Dr Mark S Butler

  114. The Bastadins Revisited: New Chemistry From the Australian Marine Sponge Ianthella basta

    Article • Australian Journal of Chemistry, January 1991, CSIRO Publishing

    Dr Mark S Butler

  115. Norterpene Dienes From an Australian Marine Sponge Latrunculia brevis

    Article • Australian Journal of Chemistry, January 1991, CSIRO Publishing

    Dr Mark S Butler

  116. Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery

    Article • Springer Science + Business Media

    Dr Mark S Butler