All Stories

  1. The ABC toxin complex from Yersinia entomophaga can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo

    Article • IUCrJ, May 2024, International Union of Crystallography

    Shaun Lott

  2. RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria

    Article • Antimicrobial Agents and Chemotherapy, October 2022, ASM Journals

    Shaun Lott

  3. Structural characterization of human peptidyl-arginine deiminase type III by X-ray crystallography

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2021, International Union of Crystallography

    Shaun Lott

  4. Structural characterization of a PCP–R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Shaun Lott

  5. The tryptophan biosynthetic pathway is essential forMycobacterium tuberculosisto cause disease

    Article • Biochemical Society Transactions, September 2020, Portland Press Ltd.

    Shaun Lott

  6. Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand

    Article • PeerJ, September 2020, PeerJ

    Shaun Lott

  7. Membrane trafficking pathways regulating the epithelial Na+channel

    Article • AJP Renal Physiology, January 2020, American Physiological Society

    Shaun Lott

  8. Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Shaun Lott

  9. Teneurin Structures Are Composed of Ancient Bacterial Protein Domains

    Article • Frontiers in Neuroscience, March 2019, Frontiers

    Shaun Lott

  10. Mechanism of Fluorinated Anthranilate-Induced Growth Inhibition in Mycobacterium tuberculosis

    Article • ACS Infectious Diseases, November 2018, American Chemical Society (ACS)

    Shaun Lott

  11. Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

    Article • ACS Chemical Biology, August 2018, American Chemical Society (ACS)

    Shaun Lott

  12. Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

    Article • eLife, August 2018, eLife

    Shaun Lott

  13. Expression and purification of high sulfur and high glycine-tyrosine keratin-associated proteins (KAPs) for biochemical and biophysical characterization

    Article • Protein Expression and Purification, June 2018, Elsevier

    Shaun Lott

  14. Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha- d -ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, February 2018, Elsevier

    Shaun Lott

  15. Datasets, processing and refinement details for Mtb -AnPRT: inhibitor structures with various space groups

    Article • Data in Brief, December 2017, Elsevier

    Shaun Lott

  16. Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

    Article • Structure, May 2017, Elsevier

    Shaun Lott

  17. Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas

    Article • Proteins Structure Function and Bioinformatics, April 2017, Wiley

    Dr Xue-Xian Zhang, Shaun Lott

  18. The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, April 2016, Elsevier

    Shaun Lott

  19. Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure

    Article • Acta Crystallographica Section D Structural Biology, January 2016, International Union of Crystallography

    Jason Busby, Shaun Lott

  20. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

    Article • Acta Crystallographica Section D Biological Crystallography, October 2015, International Union of Crystallography

    Dr Ghader Bashiri, Shaun Lott

  21. Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening

    Article • Proteins Structure Function and Bioinformatics, September 2015, Wiley

    Shaun Lott

  22. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

    Article • Biochemistry, September 2015, American Chemical Society (ACS)

    Shaun Lott

  23. Synthesis of DOHNAA, a Mycobacterium tuberculosis Cholesterol CD Ring Catabolite and FadD3 Substrate

    Article • European Journal of Organic Chemistry, August 2015, Wiley

    Shaun Lott

  24. A covalent adduct of MbtN, an acyl-ACP dehydrogenase fromMycobacterium tuberculosis, reveals an unusual acyl-binding pocket

    Article • Acta Crystallographica Section D Biological Crystallography, March 2015, International Union of Crystallography

    Edward Baker, Shaun Lott

  25. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Dr Ghader Bashiri, Shaun Lott

  26. Corrigendum: Repurposing the Chemical Scaffold of the Anti‐Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis

    Article • ChemBioChem, March 2015, Wiley

    Shaun Lott

  27. Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (ketosteroid regulatory protein) fromMycobacterium tuberculosis

    Article • Acta Crystallographica Section F Structural Biology Communications, November 2014, International Union of Crystallography

    Dr Stephanie S Dawes, Shaun Lott

  28. Crystal Structure of PhnF, a GntR-Family Transcriptional Regulator of Phosphate Transport in Mycobacterium smegmatis

    Article • Journal of Bacteriology, July 2014, ASM Journals

    Shaun Lott

  29. Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

    Article • Biochemical Journal, June 2014, Portland Press Ltd.

    Shaun Lott

  30. Repurposing the Chemical Scaffold of the Anti‐Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis

    Article • ChemBioChem, March 2014, Wiley

    Shaun Lott

  31. The 3D structure of a bacterial enzyme important for energy generation for many organisms.

    Article • Molecular Microbiology, January 2014, Wiley

    Shaun Lott

  32. Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) fromMycobacterium tuberculosis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2013, International Union of Crystallography

    Shaun Lott

  33. The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

    Article • Nature, August 2013, Springer Science + Business Media

    Shaun Lott

  34. Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, August 2013, Elsevier

    Shaun Lott

  35. The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition

    Article • Biochemistry, February 2013, American Chemical Society (ACS)

    Shaun Lott

  36. Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

    Article • Biochemistry, June 2012, American Chemical Society (ACS)

    Shaun Lott

  37. Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne

    Article • Phytochemistry, March 2012, Elsevier

    Dr Albert Koulman, Shaun Lott

  38. Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Associate Professor Nicholas West, Shaun Lott

  39. Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal ABC Toxin Complex of Yersinia entomophaga

    Article • Journal of Molecular Biology, January 2012, Elsevier

    Shaun Lott

  40. 3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Shaun Lott

  41. The TB Structural Genomics Consortium: A decade of progress

    Article • Tuberculosis, March 2011, Elsevier

    Shaun Lott

  42. Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target

    Article • Protein Expression and Purification, December 2010, Elsevier

    Shaun Lott

  43. Interaction of Serum- and Glucocorticoid Regulated Kinase 1 (SGK1) with the WW-Domains of Nedd4-2 Is Required for Epithelial Sodium Channel Regulation

    Article • PLoS ONE, August 2010, PLOS

    Shaun Lott

  44. Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)

    Article • ChemMedChem, June 2010, Wiley

    Professor Peter Rutledge, Shaun Lott

  45. Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

    Article • Microbiology, May 2010, Society for General Microbiology

    Shaun Lott

  46. Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

    Article • Journal of Biological Chemistry, November 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Albert Koulman, Shaun Lott

  47. Making Sense of a Missense Mutation: Characterization of MutT2, a Nudix Hydrolase from Mycobacterium tuberculosis, and the G58R Mutant Encoded in W-Beijing Strains of M. tuberculosis

    Article • Biochemistry, December 2008, American Chemical Society (ACS)

    Shaun Lott

  48. The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis

    Article • Journal of Molecular Biology, November 2008, Elsevier

    Shaun Lott

  49. A new Gateway® vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

    Article • Protein Expression and Purification, January 2008, Elsevier

    Dr Ghader Bashiri, Shaun Lott

  50. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

    Article • Molecular Microbiology, July 2007, Wiley

    Shaun Lott

  51. High Throughput Crystallography of TB Drug Targets

    Article • Infectious Disorders - Drug Targets, June 2007, Bentham Science Publishers

    Shaun Lott

  52. The Structure of MbtI from Mycobacterium tuberculosis, the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate Synthase

    Article • Journal of Bacteriology, September 2006, ASM Journals

    Shaun Lott

  53. The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases

    Article • Journal of Biological Chemistry, August 2006, Elsevier

    Shaun Lott

  54. The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate

    Article • Journal of Molecular Biology, January 2006, Elsevier

    Shaun Lott

  55. The potential impact of structural genomics on tuberculosis drug discovery

    Article • Drug Discovery Today, January 2006, Elsevier

    Shaun Lott

  56. The Structure of 3-Deoxy-d-arabino-heptulosonate 7-phosphate Synthase from Mycobacterium tuberculosis Reveals a Common Catalytic Scaffold and Ancestry for Type I and Type II Enzymes

    Article • Journal of Molecular Biology, December 2005, Elsevier

    Shaun Lott

  57. A flexible and economical medium-throughput strategy for protein production and crystallization

    Article • Acta Crystallographica Section D Biological Crystallography, September 2005, International Union of Crystallography

    Shaun Lott

  58. Crystallization of a protein using dehydration without a precipitant

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2005, International Union of Crystallography

    Shaun Lott

  59. Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase fromMycobacterium tuberculosis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, March 2005, International Union of Crystallography

    Shaun Lott

  60. Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin

    Article • Journal of Molecular Biology, March 2005, Elsevier

    Shaun Lott

  61. Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis inMycobacterium tuberculosis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2004, International Union of Crystallography

    Shaun Lott

  62. Using Structural Genomics to Understand Mycobacterium Tuberculosis

    Article • IUBMB Life, March 2004, Wiley

    Shaun Lott

  63. Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing

    Article • Acta Crystallographica Section D Biological Crystallography, November 2003, International Union of Crystallography

    Shaun Lott

  64. The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology

    Article • Tuberculosis, August 2003, Elsevier

    Shaun Lott

  65. The TB Structural Genomics Consortium: Providing a Structural Foundation for Drug Discovery

    Article • Current Drug Targets - Infectious Disorders, June 2002, Bentham Science Publishers

    Shaun Lott

  66. A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

    Article • Biochemical Journal, February 2002, Portland Press Ltd.

    Shaun Lott

  67. Using Secretion to Solve a Solubility Problem: High-Yield Expression in Escherichia coli and Purification of the Bacterial Glycoamidase PNGase F

    Article • Protein Expression and Purification, February 2002, Elsevier

    Shaun Lott

  68. Structure of HisF, a histidine biosynthetic protein fromPyrobaculum aerophilum

    Article • Acta Crystallographica Section D Biological Crystallography, October 2001, International Union of Crystallography

    Shaun Lott

  69. Crystal Structure of a Truncated Mutant of Glucose-Fructose Oxidoreductase Shows that an N-terminal Arm Controls Tetramer Formation

    Article • Journal of Molecular Biology, December 2000, Elsevier

    Shaun Lott

  70. The cloning, expression and crystallisation of a thermostable arginase

    Article • FEBS Letters, May 1996, Wiley

    Shaun Lott

  71. The γ‐subunit of the principal G‐protein from squid (Loligo forbesi) photoreceptors contains a novel N‐terminal sequence

    Article • FEBS Letters, November 1992, Wiley

    Shaun Lott