All Stories

  1. Parainfluenza Fusion Peptide Promotes Membrane Fusion by Assembling into Oligomeric Porelike Structures

    Article • ACS Chemical Biology, May 2022, American Chemical Society (ACS)

    Miguel Castanho

  2. The antimetastatic breast cancer activity of the viral protein‐derived peptide vCPP2319 as revealed by cellular biomechanics

    Article • European Journal of Biochemistry, November 2021, Wiley

    Miguel Castanho, Marco Cavaco

  3. Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide

    Article • Pharmaceutics, November 2021, MDPI AG

    Miguel Castanho, Marco Cavaco

  4. Exosomes and Brain Metastases: A Review on Their Role and Potential Applications

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Miguel Castanho

  5. Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

    Article • Pharmaceutics, October 2021, MDPI AG

    Miguel Castanho, Marco Cavaco, Maria Manuela Gaspar

  6. Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules

    Article • ACS Medicinal Chemistry Letters, September 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco

  7. Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity

    Article • Bioconjugate Chemistry, May 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco, Dr Christine Cruz-Oliveira

  8. Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

    Article • Journal of Medicinal Chemistry, April 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco

  9. Integrative Human Biochemistry

    Article • January 2021, Springer Science + Business Media

    Miguel Castanho

  10. Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein

    Article • ACS Infectious Diseases, December 2020, American Chemical Society (ACS)

    Miguel Castanho

  11. Effects of Diabetes on Microcirculation and Leukostasis in Retinal and Non-Ocular Tissues: Implications for Diabetic Retinopathy

    Article • Biomolecules, November 2020, MDPI AG

    Miguel Castanho

  12. The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization

    Article • Angewandte Chemie, November 2020, Wiley

    Miguel Castanho, Marco Cavaco

  13. DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport Across the Blood-Brain Barrier

    Article • Current Pharmaceutical Design, May 2020, Bentham Science Publishers

    Miguel Castanho, Vera Neves, Marco Cavaco

  14. Antifungal and anti-biofilm activity of designed derivatives from kyotorphin

    Article • Fungal Biology, May 2020, Elsevier

    Miguel Castanho, Dr Montserrat Heras

  15. Can citation metrics predict the true impact of scientific papers?

    Article • European Journal of Biochemistry, March 2020, Wiley

    Miguel Castanho

  16. Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?

    Article • Pharmaceutics, January 2020, MDPI AG

    Miguel Castanho, Marco Cavaco

  17. Pharmaceutical Innovations: The Grand Challenges Ahead

    Article • Frontiers in Medical Technology, January 2020, Frontiers

    Miguel Castanho

  18. Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells

    Article • ACS Infectious Diseases, December 2019, American Chemical Society (ACS)

    Miguel Castanho

  19. Lidocaine turns the surface charge of biological membranes more positive and changes the permeability of blood-brain barrier culture models

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 2019, Elsevier

    Dr Maria A Deli, Miguel Castanho

  20. Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix–Loop–Helix Peptides with Cell Penetrating and Tumor Suppressor Properties

    Article • ACS Chemical Biology, August 2019, American Chemical Society (ACS)

    Miguel Castanho

  21. Structural determinants conferring unusual long life in human serum to rattlesnake‐derived antimicrobial peptide Ctn[15‐34]

    Article • Journal of Peptide Science, July 2019, Wiley

    Miguel Castanho

  22. Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy

    Article • Eye, July 2019, Springer Science + Business Media

    Miguel Castanho

  23. Synthesis and Characterization of Peptide–Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity

    Article • Biomacromolecules, June 2019, American Chemical Society (ACS)

    Miguel Castanho

  24. A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography

    Article • Frontiers in Neuroscience, June 2019, Frontiers

    Miguel Castanho

  25. The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

    Article • Journal of Antimicrobial Chemotherapy, May 2019, Oxford University Press (OUP)

    Miguel Castanho

  26. Bacteriocins as Anticancer Peptides: A Biophysical Approach

    Article • February 2019, Taylor & Francis

    Miguel Castanho

  27. Fast NMR method to probe solvent accessibility and disordered regions in proteins

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Miguel Castanho

  28. Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes

    Article • Nanoscale, January 2019, Royal Society of Chemistry

    Miguel Castanho

  29. Designing of Artificial Peptides for an Improved Antiviral Activity

    Article • Current Proteomics, September 2018, Bentham Science Publishers

    Cristina Borcan, Florin Borcan, Miguel Castanho

  30. Structure–Stability–Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

    Article • ACS Nano, September 2018, American Chemical Society (ACS)

    Miguel Castanho

  31. Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane

    Article • Bioconjugate Chemistry, August 2018, American Chemical Society (ACS)

    Miguel Castanho

  32. Biologically active peptides linked to antibody fragments

    Article • Peptide Science, December 2017, Wiley

    Vera Neves, Miguel Castanho, Marco Cavaco

  33. Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

    Article • Journal of Biological Chemistry, December 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Miguel Castanho

  34. A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

    Article • Molecules, October 2017, MDPI AG

    Miguel Castanho

  35. Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action

    Article • ACS Chemical Neuroscience, May 2017, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  36. New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

    Article • Frontiers in Microbiology, May 2017, Frontiers

    Miguel Castanho

  37. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

    Article • Scientific Reports, March 2017, Nature

    Miguel Castanho, Dr Montserrat Heras

  38. Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX

    Article • Antimicrobial Agents and Chemotherapy, March 2017, ASM Journals

    Dr Christine Cruz-Oliveira, Miguel Castanho

  39. Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism

    Article • ACS Chemical Biology, March 2017, American Chemical Society (ACS)

    Miguel Castanho

  40. Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Miguel Castanho

  41. Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives

    Article • Frontiers in Pharmacology, January 2017, Frontiers

    Miguel Castanho

  42. siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model

    Article • Journal of Controlled Release, January 2017, Elsevier

    Miguel Castanho

  43. Challenging metastatic breast cancer with the natural defensinPvD1

    Article • Nanoscale, January 2017, Royal Society of Chemistry

    Miguel Castanho

  44. Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates

    Article • Journal of Medical Microbiology, October 2016, Society for General Microbiology

    Miguel Castanho

  45. In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence

    Article • Journal of Virology, October 2016, ASM Journals

    Miguel Castanho

  46. Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

    Article • Bioconjugate Chemistry, October 2016, American Chemical Society (ACS)

    Miguel Castanho

  47. Bacterial Biofilms in Diabetic Foot Ulcers: Potential Alternative Therapeutics

    Article • July 2016, IntechOpen

    Miguel Castanho

  48. Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

    Article • AIDS, July 2016, Wolters Kluwer Health

    Miguel Castanho

  49. Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide

    Article • Scientific Reports, June 2016, Nature

    Miguel Castanho

  50. Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

    Article • ACS Chemical Neuroscience, June 2016, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  51. Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Miguel Castanho

  52. A Rapid and Quantitative Flow Cytometry Method for the Analysis of Membrane Disruptive Antimicrobial Activity

    Article • PLOS One, March 2016, PLOS

    Miguel Castanho

  53. Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

    Article • Frontiers in Aging Neuroscience, January 2016, Frontiers

    Miguel Castanho, Dr Montserrat Heras

  54. Anticancer Peptides: Prospective Innovation in Cancer Therapy

    Article • January 2016, Springer Science + Business Media

    Miguel Castanho

  55. Antibody Approaches To Treat Brain Diseases

    Article • Trends in Biotechnology, January 2016, Elsevier

    Miguel Castanho

  56. Improvement of the pharmacological properties of amidated kyotorphin by means of iodination

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Miguel Castanho, Dr Montserrat Heras

  57. Dps fromDeinococcus radiodurans: oligomeric forms of Dps1 with distinct cellular functions and Dps2 involved in metal storage

    Article • European Journal of Biochemistry, September 2015, Wiley

    Miguel Castanho

  58. The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism

    Article • Amino Acids, September 2015, Springer Science + Business Media

    Miguel Castanho, Dr Montserrat Heras

  59. Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets

    Article • Scientific Reports, July 2015, Nature

    Miguel Castanho

  60. Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture

    Article • Nanomedicine Nanotechnology Biology and Medicine, July 2015, Elsevier

    Miguel Castanho

  61. Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

    Article • European Journal of Biochemistry, April 2015, Wiley

    Miguel Castanho

  62. Mining viral proteins for antimicrobial and cell-penetrating drug delivery peptides

    Article • Bioinformatics, February 2015, Oxford University Press (OUP)

    Miguel Castanho

  63. Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

    Article • Journal of Peptide Science, February 2015, Wiley

    Miguel Castanho

  64. Monitoring antibacterial permeabilization in real time using time-resolved flow cytometry

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2015, Elsevier

    Miguel Castanho

  65. Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2015, Elsevier

    Miguel Castanho

  66. Integrative Human Biochemistry

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  67. Introduction to Metabolism

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  68. The Regulation of Metabolisms

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  69. Regulation and Integration of Metabolism During Physical Activity

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  70. The Families of Biological Molecules

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  71. The Chemistry and Physics of Life

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  72. Catabolism of the Major Biomolecules

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  73. Introduction: Life Is Made of Molecules!

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  74. Energy Conservation in Metabolism: The Mechanisms of ATP Synthesis

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  75. Regulation and Integration of Metabolism During Hypoglycemia

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  76. Metabolic Responses to Hyperglycemia: Regulation and Integration of Metabolism in the Absorptive State

    Article • January 2015, Springer Science + Business Media

    Miguel Castanho

  77. Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives

    Article • Biopolymers, January 2015, Wiley

    Miguel Castanho, Dr Montserrat Heras

  78. Enhanced HIV Fusion Inhibitors Efficacy Requires Membrane Affinity and Exposure of the Pocket Binding Domain of C34 Derivatives

    Article • Biophysical Journal, January 2015, Elsevier

    Miguel Castanho

  79. Receptors and routes of dengue virus entry into the host cells

    Article • FEMS Microbiology Reviews, December 2014, Oxford University Press (OUP)

    Dr Christine Cruz-Oliveira, Miguel Castanho

  80. The interaction of antibodies with lipid membranes unraveled by fluorescence methodologies

    Article • Journal of Molecular Structure, December 2014, Elsevier

    Miguel Castanho

  81. Understanding Dengue Virus Capsid Protein Disordered N-Terminus and pep14-23-Based Inhibition

    Article • ACS Chemical Biology, November 2014, American Chemical Society (ACS)

    Miguel Castanho

  82. The Use of Visual Analog Scales to Compare Pain Between Patients With Alzheimer’s Disease and Patients Without Any Known Neurodegenerative Disease and Their Caregivers

    Article • American Journal of Alzheimer s Disease & Other Dementias®, June 2014, SAGE Publications

    Miguel Castanho

  83. Antimicrobial protein rBPI21-induced surface changes on Gram-negative and Gram-positive bacteria

    Article • Nanomedicine Nanotechnology Biology and Medicine, April 2014, Elsevier

    Miguel Castanho

  84. Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors

    Article • Biochemical Journal, April 2014, Portland Press Ltd.

    Miguel Castanho

  85. Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies

    Article • IUBMB Life, March 2014, Wiley

    Miguel Castanho

  86. The Mechanisms and Quantification of the Selective Permeability in Transport Across Biological Barriers: the Example of Kyotorphin

    Article • Mini-Reviews in Medicinal Chemistry, February 2014, Bentham Science Publishers

    Miguel Castanho

  87. Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure

    Article • Journal of Antimicrobial Chemotherapy, January 2014, Oxford University Press (OUP)

    Miguel Castanho

  88. Dengue virus capsid protein interacts specifically with very low-density lipoproteins

    Article • Nanomedicine Nanotechnology Biology and Medicine, January 2014, Elsevier

    Ivo Martins, Miguel Castanho

  89. Dengue Virus Capsid Protein Delivers Nucleic Acids Intracellularly

    Article • Biophysical Journal, January 2014, Elsevier

    Miguel Castanho

  90. Dengue Virus Capsid Protein Interacts Specifically with Very Low-Density Lipoproteins

    Article • Biophysical Journal, January 2014, Elsevier

    Miguel Castanho

  91. New Broad-Spectrum Viral Fusion Inhibitors Act by Deleterious Effect on the Viral Membrane through the Production Singlet Oxygen Molecules

    Article • Biophysical Journal, January 2014, Elsevier

    Miguel Castanho

  92. Intracellular Nucleic Acid Delivery by the Supercharged Dengue Virus Capsid Protein

    Article • PLOS One, December 2013, PLOS

    Miguel Castanho

  93. Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action

    Article • European Journal of Biochemistry, November 2013, Wiley

    Miguel Castanho

  94. rBPI21 interacts with negative membranes endothermically promoting the formation of rigid multilamellar structures

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 2013, Elsevier

    Miguel Castanho

  95. The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability

    Article • ChemBioChem, August 2013, Wiley

    Miguel Castanho

  96. N-Terminal AH2 segment of protein NS4B from hepatitis C virus. Binding to and interaction with model biomembranes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2013, Elsevier

    Miguel Castanho

  97. Decoding distinct membrane interactions of HIV-1 fusion inhibitors using a combined atomic force and fluorescence microscopy approach

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2013, Elsevier

    Miguel Castanho

  98. Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid

    Article • Biopolymers, July 2013, Wiley

    Miguel Castanho

  99. A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

    Article • PLoS Pathogens, April 2013, PLOS

    Miguel Castanho, Dr Alexander N Freiberg

  100. Conjugation of Cholesterol to HIV-1 Fusion Inhibitor C34 Increases Peptide-Membrane Interactions Potentiating Its Action

    Article • PLOS One, April 2013, PLOS

    Miguel Castanho

  101. Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs

    Article • Amino Acids, March 2013, Springer Science + Business Media

    Miguel Castanho, Dr Montserrat Heras

  102. Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2013, Elsevier

    Miguel Castanho

  103. Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems

    Article • Journal of Peptide Science, January 2013, Wiley

    Miguel Castanho

  104. The Dengue Virus Capsid Protein Inhibitor Peptide Pep14-23 becomes Alpha-Helical upon Binding to Negative Lipids

    Article • Biophysical Journal, January 2013, Elsevier

    Ivo Martins, Miguel Castanho

  105. Dengue Virus Capsid Protein Binding to Lipid Droplets and its Inhibition. towards a New Drug Target

    Article • Biophysical Journal, January 2013, Elsevier

    Ivo Martins, Miguel Castanho

  106. From antimicrobial to anticancer peptides. A review

    Article • Frontiers in Microbiology, January 2013, Frontiers

    Miguel Castanho

  107. Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer’s Disease Patients: Potential Diagnostic and Pharmacological Implications

    Article • Frontiers in Aging Neuroscience, January 2013, Frontiers

    Miguel Castanho

  108. The application of biophysical techniques to study antimicrobial peptides

    Article • January 2013, IOS Press

    Miguel Castanho

  109. Arginine-rich self-assembling peptides as potent antibacterial gels

    Article • Biomaterials, December 2012, Elsevier

    Miguel Castanho

  110. Antimicrobial Peptide rBPI21: A Translational Overview from Bench to Clinical Studies

    Article • Current Protein and Peptide Science, November 2012, Bentham Science Publishers

    Miguel Castanho

  111. Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

    Article • Journal of Neuroscience, August 2012, Society for Neuroscience

    Miguel Castanho

  112. Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization

    Article • Biochemistry, August 2012, American Chemical Society (ACS)

    Miguel Castanho

  113. Phosphatidylethanolamine Binding Is a Conserved Feature of Cyclotide-Membrane Interactions

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Miguel Castanho

  114. The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif

    Article • Biochemical Journal, June 2012, Portland Press Ltd.

    Ivo Martins, Miguel Castanho

  115. A Focus on Glucose-Mediated Drug Delivery to the Central Nervous System

    Article • Mini-Reviews in Medicinal Chemistry, April 2012, Bentham Science Publishers

    Miguel Castanho

  116. Peptide Drug Discovery and Development: Translational Research in Academia and Industry. Edited by Miguel Castanho and Nuno C. Santos.

    Article • ChemMedChem, April 2012, Wiley

    Miguel Castanho

  117. Antimicrobial properties of analgesic kyotorphin peptides unraveled through atomic force microscopy

    Article • Biochemical and Biophysical Research Communications, April 2012, Elsevier

    Miguel Castanho, Dr Montserrat Heras

  118. Electron/proton coupling in biological energy transduction

    Article • FEBS Letters, February 2012, Wiley

    Miguel Castanho

  119. Short Stories - on Antimicrobial Peptides that are Too Short to Span the Membrane

    Article • Biophysical Journal, January 2012, Elsevier

    Maria Luisa Mangoni, Miguel Castanho

  120. Biomedical applications of dipeptides and tripeptides

    Article • Biopolymers, January 2012, Wiley

    Miguel Castanho

  121. Interaction of antimicrobial peptides, BP100 and pepR, with model membrane systems as explored by brownian dynamics simulations on a coarse-grained model

    Article • Biopolymers, January 2012, Wiley

    Visvaldas Kairys, Miguel Castanho

  122. The Researching, Teaching, and Learning Triangle

    Article • January 2012, Springer Science + Business Media

    Miguel Castanho

  123. The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria

    Article • Frontiers in Immunology, January 2012, Frontiers

    Miguel Castanho

  124. Conjugation of Cholesterol to HIV-1 Fusion Inhibitor C34 Synergistically Potentiates Peptide-Membrane Interaction

    Article • Biophysical Journal, January 2012, Elsevier

    Miguel Castanho

  125. Relating Molecular-Level Events with Bacterial Killing by Antimicrobial Peptides

    Article • Biophysical Journal, January 2012, Elsevier

    Miguel Castanho

  126. Translocating the blood-brain barrier using electrostatics

    Article • Frontiers in Cellular Neuroscience, January 2012, Frontiers

    Miguel Castanho

  127. Biophysical characterization of polymyxin b interaction with LPS aggregates and membrane model systems

    Article • Biopolymers, January 2012, Wiley

    Miguel Castanho

  128. The Application of Biophysical Techniques to Study Antimicrobial Peptides

    Article • Spectroscopy An International Journal, January 2012, Hindawi Publishing Corporation

    Miguel Castanho

  129. Decoding Distinct Membrane Interactions of HIV-1 Inhibitors Enfuvirtide and T-1249 using Atomic Force Microscopy Combined with Fluorescence Methodologies

    Article • Biophysical Journal, January 2012, Elsevier

    Miguel Castanho

  130. Prediction of Antibacterial Activity from Physicochemical Properties of Antimicrobial Peptides

    Article • PLOS One, December 2011, PLOS

    Miguel Castanho

  131. Dengue Virus Capsid Protein Binding to Hepatic Lipid Droplets (LD) Is Potassium Ion Dependent and Is Mediated by LD Surface Proteins

    Article • Journal of Virology, November 2011, ASM Journals

    Ivo Martins, Miguel Castanho

  132. Peptide Drug Discovery and Development

    Article • October 2011, Wiley

    Miguel Castanho

  133. Chemical Conjugation of the Neuropeptide Kyotorphin and Ibuprofen Enhances Brain Targeting and Analgesia

    Article • Molecular Pharmaceutics, October 2011, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  134. Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

    Article • Bone Marrow Transplantation, June 2011, Wiley

    Miguel Castanho, Dr Montserrat Heras

  135. Decoding the Membrane Activity of the Cyclotide Kalata B1

    Article • Journal of Biological Chemistry, May 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Miguel Castanho

  136. Characterization of the Interaction of the Dengue Virus Capsid Protein with Lipid Droplets

    Article • Biophysical Journal, February 2011, Elsevier

    Ivo Martins, Miguel Castanho

  137. rBPI21 Causes (HEMI)Fusion and Leakage of Membranes and Promotes Massive Lipopolysaccharide Aggregation

    Article • Biophysical Journal, February 2011, Elsevier

    Miguel Castanho

  138. Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes

    Article • AIDS, February 2011, Wolters Kluwer Health

    Miguel Castanho

  139. Using zeta-potential measurements to quantify peptide partition to lipid membranes

    Article • European Biophysics Journal, January 2011, Springer Science + Business Media

    Miguel Castanho

  140. Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

    Article • Soft Matter, January 2011, Royal Society of Chemistry

    Miguel Castanho

  141. The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide

    Article • Biochemical and Biophysical Research Communications, December 2010, Elsevier

    Miguel Castanho

  142. Quantitative assessment of peptide–lipid interactions.

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 2010, Elsevier

    Miguel Castanho

  143. Drug–lipid interaction evaluation: why a 19th century solution?

    Article • Trends in Pharmacological Sciences, October 2010, Elsevier

    Miguel Castanho

  144. Is PrP(106-126) Fragment Involved in the Membrane Activity of the Prion Protein?

    Article • Current Protein and Peptide Science, August 2010, Bentham Science Publishers

    Miguel Castanho

  145. Escherichia coliCell Surface Perturbation and Disruption Induced by Antimicrobial Peptides BP100 and pepR

    Article • Journal of Biological Chemistry, June 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Miguel Castanho

  146. Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, June 2010, Elsevier

    Miguel Castanho

  147. Is PrP(106-126) Fragment Involved in the Membrane Activity of the Prion Protein?

    Article • Current Protein and Peptide Science, May 2010, Bentham Science Publishers

    Miguel Castanho

  148. HIV-1 Fusion Inhibitor Peptides Enfuvirtide and T-1249 Interact with Erythrocyte and Lymphocyte Membranes

    Article • PLOS One, March 2010, PLOS

    Miguel Castanho

  149. In Vitro Blood-Brain Barrier Models – Latest Advances and Therapeutic Applications in a Chronological Perspective

    Article • Mini-Reviews in Medicinal Chemistry, March 2010, Bentham Science Publishers

    Miguel Castanho

  150. Membrane-Active Peptides: Methods and Results on Structure and Function

    Article • January 2010, International University Line

    Miguel Castanho

  151. Fast membrane association is a crucial factor in the peptide pep-1 translocation mechanism: A kinetic study followed by surface plasmon resonance

    Article • Biopolymers, January 2010, Wiley

    Miguel Castanho

  152. Unraveling the Molecular Basis of the Selectivity of the HIV-1 Fusion Inhibitor Sifuvirtide Towards Phosphatidylcholine-Rich Rigid Membranes

    Article • Biophysical Journal, January 2010, Elsevier

    Miguel Castanho

  153. rBPI21 Promotes Lipopolysaccharide Aggregation and Exerts Its Antimicrobial Effects by (Hemi)fusion of PG-Containing Membranes

    Article • PLOS One, December 2009, PLOS

    Miguel Castanho

  154. Interaction of the Dengue Virus Fusion Peptide with Membranes Assessed by NMR: The Essential Role of the Envelope Protein Trp101 for Membrane Fusion

    Article • Journal of Molecular Biology, September 2009, Elsevier

    Professor Ana Paula Valente, Miguel Castanho

  155. The Toxicity of Prion Protein Fragment PrP(106−126) is Not Mediated by Membrane Permeabilization as Shown by a M112W Substitution

    Article • Biochemistry, May 2009, American Chemical Society (ACS)

    Miguel Castanho

  156. Interactions of HIV-1 Antibodies 2F5 and 4E10 with a gp41 Epitope Prebound to Host and Viral Membrane Model Systems

    Article • ChemBioChem, April 2009, Wiley

    Miguel Castanho

  157. Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

    Article • Nature Reviews Microbiology, March 2009, Nature

    Miguel Castanho

  158. Synergistic Effects of the Membrane Actions of Cecropin-Melittin Antimicrobial Hybrid Peptide BP100

    Article • Biophysical Journal, March 2009, Elsevier

    Miguel Castanho

  159. Human Erythrocytes And Mononuclear Leukocytes Are Capable Of Concentrating HIV-1 Fusion Inhibitor Peptides In Their Membranes

    Article • Biophysical Journal, February 2009, Elsevier

    Miguel Castanho

  160. Fold-Unfold Transitions in the Selectivity and Mechanism of Action of the N-Terminal Fragment of the Bactericidal/Permeability-Increasing Protein (rBPI21)

    Article • Biophysical Journal, February 2009, Elsevier

    Miguel Castanho

  161. PrP(106-126) Does Not Interact with Membranes under Physiological Conditions

    Article • Biophysical Journal, August 2008, Elsevier

    Miguel Castanho

  162. Sifuvirtide Screens Rigid Membrane Surfaces. Establishment of a Correlation between Efficacy and Membrane Domain Selectivity among HIV Fusion Inhibitor Peptides

    Article • Journal of the American Chemical Society, May 2008, American Chemical Society (ACS)

    Miguel Castanho

  163. Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2

    Article • Journal of Viral Hepatitis, May 2008, Wiley

    Miguel Castanho

  164. Translocation or membrane disintegration? Implication of peptide–membrane interactions in pep-1 activity

    Article • Journal of Peptide Science, January 2008, Wiley

    Miguel Castanho

  165. Enfuvirtide effects on human erythrocytes and lymphocytes functional properties

    Article • Journal of Peptide Science, January 2008, Wiley

    Miguel Castanho

  166. Biophysics meets membrane-active peptides

    Article • Journal of Peptide Science, January 2008, Wiley

    Miguel Castanho

  167. Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering

    Article • Molecular Membrane Biology, January 2008, Taylor & Francis

    Miguel Castanho

  168. What can light scattering spectroscopy do for membrane-active peptide studies?

    Article • Journal of Peptide Science, January 2008, Wiley

    Miguel Castanho

  169. Molecular interaction studies of peptides using steady-state fluorescence intensity. Static (de)quenching revisited

    Article • Journal of Peptide Science, January 2008, Wiley

    Miguel Castanho

  170. The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers

    Article • European Journal of Biochemistry, September 2007, Wiley

    Miguel Castanho

  171. Omiganan interaction with bacterial membranes and cell wall models. Assigning a biological role to saturation

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2007, Elsevier

    Miguel Castanho

  172. Shiga toxin B-subunit sequential binding to its natural receptor in lipid membranes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2007, Elsevier

    Miguel Castanho

  173. How to address CPP and AMP translocation? Methods to detect and quantify peptide internalizationin vitroandin vivo(Review)

    Article • Molecular Membrane Biology, January 2007, Taylor & Francis

    Miguel Castanho

  174. Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1

    Article • Molecular Membrane Biology, January 2007, Taylor & Francis

    Miguel Castanho

  175. Cell-penetrating peptides and antimicrobial peptides: how different are they?

    Article • Biochemical Journal, October 2006, Portland Press Ltd.

    Miguel Castanho

  176. The membranes’ role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation

    Article • Antiviral Research, August 2006, Elsevier

    Miguel Castanho

  177. Chiral Recognition ofD-Kyotorphin by Lipidic Membranes: Relevance Toward Improved Analgesic Efficiency

    Article • ChemMedChem, July 2006, Wiley

    Miguel Castanho

  178. Omiganan Pentahydrochloride in the Front Line of Clinical Applications of Antimicrobial Peptides

    Article • Recent Patents on Anti-Infective Drug Discovery, June 2006, Bentham Science Publishers

    Miguel Castanho

  179. Conformational and Orientational Guidance of the Analgesic Dipeptide Kyotorphin Induced by Lipidic Membranes:  Putative Correlation toward Receptor Docking

    Article • The Journal of Physical Chemistry B, February 2006, American Chemical Society (ACS)

    Miguel Castanho

  180. An Insight on the Leading HIV Entry Inhibitors

    Article • Recent Patents on Anti-Infective Drug Discovery, January 2006, Bentham Science Publishers

    Miguel Castanho

  181. Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2006, Elsevier

    Miguel Castanho

  182. Miguel A.R.B. Castanho

    Article • European Biophysics Journal, December 2005, Springer Science + Business Media

    Miguel Castanho

  183. Lipid membrane-induced optimization for ligand–receptor docking: recent tools and insights for the “membrane catalysis” model

    Article • European Biophysics Journal, October 2005, Springer Science + Business Media

    Miguel Castanho

  184. Translocation of β-Galactosidase Mediated by the Cell-Penetrating Peptide Pep-1 into Lipid Vesicles and Human HeLa Cells Is Driven by Membrane Electrostatic Potential†

    Article • Biochemistry, August 2005, American Chemical Society (ACS)

    Miguel Castanho

  185. Re-evaluating the role of strongly charged sequences in amphipathic cell-penetrating peptides

    Article • FEBS Letters, July 2005, Wiley

    Miguel Castanho

  186. Overview of Common Spectroscopic Methods to Determine the Orientation/Alignment of Membrane Probes and Drugs in Lipidic Bilayers

    Article • Current Organic Chemistry, June 2005, Bentham Science Publishers

    Miguel Castanho

  187. Environmental factors that enhance the action of the cell penetrating peptide pep-1

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2005, Elsevier

    Miguel Castanho

  188. Developing students' awareness of public understanding of science: A matter of survival?

    Article • Biochemistry and Molecular Biology Education, May 2005, Wiley

    Miguel Castanho

  189. Lipidic Membranes Are Potential “Catalysts” in the Ligand Activity of the Multifunctional Pentapeptide Neokyotorphin

    Article • ChemBioChem, March 2005, Wiley

    Miguel Castanho

  190. Cholesterol modulates maculosin's orientation in model systems of biological membranes

    Article • Steroids, December 2004, Elsevier

    Miguel Castanho

  191. HIV Fusion Inhibitor Peptide T-1249 Is Able To Insert or Adsorb to Lipidic Bilayers. Putative Correlation with Improved Efficiency

    Article • Journal of the American Chemical Society, November 2004, American Chemical Society (ACS)

    Miguel Castanho

  192. Consequences of Nonlytic Membrane Perturbation to the Translocation of the Cell Penetrating Peptide Pep-1 in Lipidic Vesicles†

    Article • Biochemistry, August 2004, American Chemical Society (ACS)

    Miguel Castanho

  193. Does Aliphatic Chain Length Influence Carbocyanines' Orientation in Supported Lipid Multilayers?

    Article • Journal of Fluorescence, May 2004, Springer Science + Business Media

    Miguel Castanho

  194. Filipin Orientation Revealed by Linear Dichroism. Implication for a Model of Action

    Article • Journal of the American Chemical Society, April 2004, American Chemical Society (ACS)

    Miguel Castanho

  195. What do college life sciences students need to know about knowledge management?

    Article • Journal of Biological Education, March 2004, Taylor & Francis

    Miguel Castanho

  196. An overview of the biophysical applications of atomic force microscopy

    Article • Biophysical Chemistry, February 2004, Elsevier

    Miguel Castanho

  197. Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level

    Article • Biochemical Journal, January 2004, Portland Press Ltd.

    Miguel Castanho

  198. Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, June 2003, Elsevier

    Miguel Castanho

  199. Evaluation of Lipopolysaccharide Aggregation by Light Scattering Spectroscopy

    Article • ChemBioChem, January 2003, Wiley

    Miguel Castanho

  200. Lipossomas: a bala mágica acertou?

    Article • Química Nova, December 2002, FapUNIFESP (SciELO)

    Miguel Castanho

  201. Teaching Molecular Applications of the Particle-in-a-Ring Model Using Azulene

    Article • Journal of Chemical Education, September 2002, American Chemical Society (ACS)

    Miguel Castanho

  202. Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 2002, Elsevier

    Miguel Castanho

  203. Joint determination by Brownian dynamics and fluorescence quenching of the in-depth location profile of biomolecules in membranes

    Article • Analytical Biochemistry, August 2002, Elsevier

    Miguel Castanho

  204. Revealing the Orientation of Nystatin and Amphotericin B in Lipidic Multilayers by UV−Vis Linear Dichroism

    Article • The Journal of Physical Chemistry B, July 2002, American Chemical Society (ACS)

    Miguel Castanho

  205. Dealing with the challenges of teaching molecular biophysics to biochemistry majors through an heuristics-based approach

    Article • Biochemistry and Molecular Biology Education, May 2002, Wiley

    Miguel Castanho

  206. Crude tall-oil sodium salts micellization in aqueous solutions studied by static and dynamic light scattering

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, November 2001, Elsevier

    Miguel Castanho

  207. A photophysical study of the polyene antibiotic filipin

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2001, Elsevier

    Miguel Castanho

  208. Conference Report

    Article • Biochemistry and Molecular Biology Education, July 2000, Wiley

    Miguel Castanho

  209. Meeting Report — Biochemical Education at the University Level, Lisbon, Portugal, October 30−31, 1999

    Article • Biochemistry and Molecular Biology Education, July 2000, Elsevier

    Miguel Castanho

  210. Conformation and dynamic properties of a saturated hydrocarbon chain confined in a model membrane: a Brownian dynamics simulation

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, January 2000, Elsevier

    Miguel Castanho

  211. Overcoming Angular Dependency When Teaching Light Scattering Using a Spectrofluorometer: The Molecular Weight of Latex Beads

    Article • Journal of Chemical Education, September 1999, American Chemical Society (ACS)

    Miguel Castanho

  212. The pentaene macrolide antibiotic filipin prefers more rigid DPPC bilayers: a fluorescence pressure dependence study

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, June 1999, Elsevier

    Miguel Castanho

  213. Simulation of the distribution and diffusion of a rigid amphipathic particle embedded in a model membrane

    Article • Biophysical Chemistry, May 1999, Elsevier

    Miguel Castanho

  214. Reconstitution of Phospholipid Bilayer by an Atomic Force Microscope Tip

    Article • Biophysical Journal, October 1998, Elsevier

    Miguel Castanho

  215. Filipin-Induced Lesions in Planar Phospholipid Bilayers Imaged by Atomic Force Microscopy

    Article • Biophysical Journal, October 1998, Elsevier

    Miguel Castanho

  216. Fluorescence quenching data interpretation in biological systems

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 1998, Elsevier

    Miguel Castanho

  217. Continuous particle size distribution analysis with dynamic light scattering

    Article • Journal of Biochemical and Biophysical Methods, June 1998, Elsevier

    Miguel Castanho

  218. Interaction of the Major Epitope Region of HIV Protein gp41 with Membrane Model Systems. A Fluorescence Spectroscopy Study†

    Article • Biochemistry, June 1998, American Chemical Society (ACS)

    Miguel Castanho

  219. Separating the turbidity spectra of vesicles from the absorption spectra of membrane probes and other chromophores

    Article • European Biophysics Journal, August 1997, Springer Science + Business Media

    Miguel Castanho

  220. Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy

    Article • Carbohydrate Research, May 1997, Elsevier

    Miguel Castanho

  221. Structural characterization (shape and dimensions) and stability of polysaccharide/lipid nanoparticles

    Article • Biopolymers, April 1997, Wiley

    Miguel Castanho

  222. Snatos, Nuno C., and Miguel A. R. B. Castanho. 1996. Biophys. J. 71:1641–1650

    Article • Biophysical Journal, March 1997, Elsevier

    Miguel Castanho

  223. The Shape, Dimension and Organisation of Maltodextrins Gel Fragments with and without Associated Phospholipids

    Article • January 1997, Springer Science + Business Media

    Miguel Castanho

  224. Teaching light scattering spectroscopy: the dimension and shape of tobacco mosaic virus

    Article • Biophysical Journal, September 1996, Elsevier

    Miguel Castanho

  225. The transverse location of the fluorescent probe trans-parinaric acid in lipid bilayers

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 1996, Elsevier

    Miguel Castanho

  226. Filipin fluorescence quenching by spin-labeled probes: studies in aqueous solution and in a membrane model system

    Article • Biophysical Journal, July 1995, Elsevier

    Miguel Castanho

  227. Filipin and its interaction with cholesterol in aqueous media studied using static and dynamic light scattering

    Article • Biopolymers, April 1994, Wiley

    Miguel Castanho

  228. Fluorescence study of a derivatized diacylglycerol incorporated in model membranes

    Article • Chemistry and Physics of Lipids, January 1994, Elsevier

    Miguel Castanho

  229. Rod-like cholesterol micelles in aqueous solution studied using polarized and depolarized dynamic light scattering

    Article • Biophysical Journal, December 1992, Elsevier

    Miguel Castanho

  230. Fluorescence study of the macrolide pentaene antibiotic filipin in aqueous solution and in a model system of membranes

    Article • European Journal of Biochemistry, July 1992, Wiley

    Miguel Castanho