All Stories

  1. Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration

    Article • Chemical Science, January 2026, Royal Society of Chemistry

    Marco Cavaco

  2. Antimigratory and Antiproliferative Effects of the Brain‐Targeted Peptide Conjugate PepH3‐vCPP2319 on Triple Negative Breast Cancer Cell Cultures

    Article • Journal of Peptide Science, June 2025, Wiley

    Marco Cavaco

  3. PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier

    Article • Fluids and Barriers of the CNS, April 2025, Springer Science + Business Media

    Marco Cavaco

  4. The Potential of Peptide-Based Inhibitors in Disrupting Protein–Protein Interactions for Targeted Cancer Therapy

    Article • International Journal of Molecular Sciences, March 2025, MDPI AG

    Marco Cavaco

  5. Optimizing magnetic hyperthermia for melanoma: the role of nanoparticle uptake inhibition

    Article • Nano Express, March 2025, Institute of Physics Publishing

    Marco Cavaco

  6. vCPP2319 interacts with metastatic breast cancer extracellular vesicles (EVs) and transposes a human blood-brain barrier model

    Article • Heliyon, December 2024, Elsevier

    Marco Cavaco

  7. Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation

    Article • Fluids and Barriers of the CNS, May 2024, Springer Science + Business Media

    Marco Cavaco

  8. The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis

    Article • Biomedicine & Pharmacotherapy, May 2024, Elsevier

    Marco Cavaco

  9. Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use

    Article • International Journal of Peptide Research and Therapeutics, April 2024, Springer Science + Business Media

    Marco Cavaco

  10. Quantitative Imaging of the Action of vCPP2319, an Antimicrobial Peptide from a Viral Scaffold, against Staphylococcus aureus Biofilms of a Clinical Isolate

    Article • ACS Infectious Diseases, September 2023, American Chemical Society (ACS)

    Marco Cavaco

  11. Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma

    Article • Frontiers in Veterinary Science, August 2023, Frontiers

    Marco Cavaco, Maria Manuela Gaspar

  12. Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells

    Article • Toxicology, August 2023, Elsevier

    Marco Cavaco

  13. Structural and Biochemical Characterization of Three Antimicrobial Peptides from Capsicum annuum L. var. annuum Leaves for Anti-Candida Use

    Article • Probiotics and Antimicrobial Proteins, June 2023, Springer Science + Business Media

    Marco Cavaco

  14. Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates

    Article • Scientific Reports, March 2023, Springer Science + Business Media

    Marco Cavaco, Professor Berta Ferreira São Braz

  15. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors

    Article • ACS Pharmacology & Translational Science, November 2022, American Chemical Society (ACS)

    Marco Cavaco

  16. Posters

    Article • FEBS Open Bio, July 2022, Wiley

    Mr. Aleksandrs Petjukevics, Professor Volker F. Wendisch, Ricardo Ferraz, Marco Cavaco

  17. Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

    Article • Pharmaceutics, March 2022, MDPI AG

    Marco Cavaco, Dr Christine Cruz-Oliveira

  18. The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections

    Article • Frontiers in Microbiology, March 2022, Frontiers

    Marco Cavaco

  19. The antimetastatic breast cancer activity of the viral protein‐derived peptide vCPP2319 as revealed by cellular biomechanics

    Article • European Journal of Biochemistry, November 2021, Wiley

    Miguel Castanho, Marco Cavaco

  20. Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide

    Article • Pharmaceutics, November 2021, MDPI AG

    Miguel Castanho, Marco Cavaco

  21. Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

    Article • Pharmaceutics, October 2021, MDPI AG

    Miguel Castanho, Marco Cavaco, Maria Manuela Gaspar

  22. Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules

    Article • ACS Medicinal Chemistry Letters, September 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco

  23. Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity

    Article • Bioconjugate Chemistry, May 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco, Dr Christine Cruz-Oliveira

  24. Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

    Article • Journal of Medicinal Chemistry, April 2021, American Chemical Society (ACS)

    Miguel Castanho, Marco Cavaco

  25. Estimating peptide half‐life in serum from tunable, sequence‐related physicochemical properties

    Article • Clinical and Translational Science, February 2021, Wiley

    Marco Cavaco

  26. Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo

    Article • Bioconjugate Chemistry, January 2021, American Chemical Society (ACS)

    Marco Cavaco

  27. The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization

    Article • Angewandte Chemie International Edition, November 2020, Wiley

    Miguel Castanho, Marco Cavaco

  28. The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization

    Article • Angewandte Chemie International Edition, November 2020, Wiley

    Marco Cavaco, Miguel Castanho

  29. To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models

    Article • Frontiers in Bioengineering and Biotechnology, September 2020, Frontiers

    Marco Cavaco

  30. DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport Across the Blood-Brain Barrier

    Article • Current Pharmaceutical Design, May 2020, Bentham Science Publishers

    Miguel Castanho, Vera Neves, Marco Cavaco

  31. The Effect of Different Fluorophores on Fluorescence-Based Techniques

    Article • Biophysical Journal, February 2020, Elsevier

    Marco Cavaco

  32. Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?

    Article • Pharmaceutics, January 2020, MDPI AG

    Miguel Castanho, Marco Cavaco

  33. Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

    Article • Alimentary Pharmacology & Therapeutics, June 2018, Wiley

    Dr Isadora Rosa, Dr Luis F Gouveia, Marco Cavaco

  34. P545 Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition

    Article • Journal of Crohn s and Colitis, January 2018, Oxford University Press (OUP)

    Marco Cavaco

  35. Biologically active peptides linked to antibody fragments

    Article • Peptide Science, December 2017, Wiley

    Vera Neves, Miguel Castanho, Marco Cavaco

  36. Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

    Article • Clinical Pharmacology & Therapeutics, June 2017, Wiley

    Marco Cavaco

  37. SAT0046 TNF antagonist drug safety assessment by pharmacovigilance signaling and post-marketing adverse event reports

    Article • June 2017, BMJ

    Marco Cavaco

  38. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2017, Elsevier

    Dr Luis F Gouveia, Marco Cavaco

  39. Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies

    Article • Journal of Clinical Pharmacy and Therapeutics, November 2016, Hindawi Publishing Corporation

    Marco Cavaco