All Stories

  1. In vitro safety and in vivo proof of concept of bacterial lysate-loaded inhalable locust bean gum microparticles aimed at respiratory infection prevention

    Article • Carbohydrate Polymers, November 2026, Elsevier

    Maria Manuela Gaspar

  2. Localized gold nanoparticles–mediated photothermal therapy for head and neck cancer: in vivo proof-of-concept

    Article • International Journal of Pharmaceutics, August 2026, Elsevier

    Maria Manuela Gaspar

  3. Correction: Ribeiro et al. Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model. Int. J. Mol. Sci. 2022, 23, 6728

    Article • International Journal of Molecular Sciences, May 2026, MDPI AG

    Maria Manuela Gaspar

  4. Organic nanoplatforms for metallodrugs delivery: Current advances in colorectal cancer

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, April 2026, Elsevier

    Maria Manuela Gaspar

  5. Targeting Triple-Negative Breast Cancer: A Special Focus on Phototherapy and Nanomaterials

    Article • Molecules, February 2026, MDPI AG

    Maria Manuela Gaspar, João MP Coelho

  6. Liposomal formulations of novel metal-based complexes exhibiting high antitumor activity against melanoma

    Article • International Journal of Pharmaceutics, December 2025, Elsevier

    Maria Manuela Gaspar

  7. Valorization of Thyme Combined with Phytocannabinoids as Anti-Inflammatory Agents for Skin Diseases

    Article • Pharmaceutics, October 2025, MDPI AG

    Maria Manuela Gaspar

  8. Towards a Less Invasive Treatment for Head and Neck Cancer: Initial Evaluation of Gold Nanoparticle-Mediated Photothermal Therapy

    Article • Pharmaceutics, October 2025, MDPI AG

    Maria Manuela Gaspar, João MP Coelho

  9. Gold nanoparticle-mediated photothermal therapy: Expanding the frontiers of cancer treatment and theragnostics

    Article • Biomedicine & Pharmacotherapy, September 2025, Elsevier

    Maria Manuela Gaspar

  10. Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach using lactate functionalized and selenium-chrysin loaded nanoparticles (SeChry@PUREG4-LA24)

    Article • Biomedicine & Pharmacotherapy, September 2025, Elsevier

    Maria Manuela Gaspar, Dr. Fatima Baltazar

  11. Locust bean gum (LBG) – A potential excipient for inhalation purposes: Excipient characterisation and in vitro and in vivo toxicological evaluation

    Article • Carbohydrate Polymers, September 2025, Elsevier

    Maria Manuela Gaspar

  12. Phytosomal delivery enhances bioactivity of Hylocereus costaricensis phenolic extract

    Article • Frontiers in Nutrition, August 2025, Frontiers

    Dr. Rosa Direito, Maria Manuela Gaspar

  13. Novel 8-Hydroxyquinoline-Derived V(IV)O, Ni(II), and Fe(III) Complexes: Synthesis, Characterization, and In Vitro Cytotoxicity Against Tumor Cells

    Article • Inorganics, May 2025, MDPI AG

    Maria Manuela Gaspar

  14. Liposomal nanoformulations of novel copper-based complexes exhibiting antimelanoma activity – In vitro and in vivo validation

    Article • International Journal of Pharmaceutics, May 2025, Elsevier

    Maria Manuela Gaspar

  15. A step forward on the in vitro and in vivo validation of rifabutin-loaded liposomes for the management of highly virulent MRSA infections

    Article • Journal of Controlled Release, April 2025, Elsevier

    Maria Manuela Gaspar

  16. Correction: Oliveira et al. Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice. Int. J. Mol. Sci. 2021, 22, 5289

    Article • International Journal of Molecular Sciences, February 2025, MDPI AG

    Maria Manuela Gaspar

  17. Combination of gold nanoparticles with near-infrared light as an alternative approach for melanoma management

    Article • International Journal of Pharmaceutics, January 2025, Elsevier

    João MP Coelho, Maria Manuela Gaspar

  18. Exploring the Biological Activity of Phytocannabinoid Formulations for Skin Health Care: A Special Focus on Molecular Pathways

    Article • International Journal of Molecular Sciences, December 2024, MDPI AG

    Maria Manuela Gaspar

  19. Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent—In Vitro and In Vivo Studies

    Article • Pharmaceutics, December 2024, MDPI AG

    Maria Manuela Gaspar

  20. In Vivo Measurements of Murine Melanoma's Complex Permittivity Between 500 MHz and 8.5 GHz

    Article • IEEE Antennas and Wireless Propagation Letters, December 2024, Institute of Electrical & Electronics Engineers (IEEE)

    Maria Manuela Gaspar

  21. Gold nanoparticles for photothermal therapy – Influence of experimental conditions on the properties of resulting AuNPs

    Article • Journal of Drug Delivery Science and Technology, November 2024, Elsevier

    João MP Coelho, Maria Manuela Gaspar

  22. 3D-printed aerogels as theranostic implants monitored by fluorescence bioimaging

    Article • Bioactive Materials, November 2024, Elsevier

    Maria Manuela Gaspar

  23. Combining Phototherapy and Gold-Based Nanomaterials: A Breakthrough in Basal Cell Carcinoma Treatment

    Article • International Journal of Molecular Sciences, October 2024, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  24. Rifabutin: a repurposed antibiotic with high potential against planktonic and biofilm staphylococcal clinical isolates

    Article • Frontiers in Microbiology, October 2024, Frontiers

    Maria Manuela Gaspar

  25. Targeting superficial cancers with gold nanoparticles: a review of current research

    Article • Therapeutic Delivery, September 2024, Taylor & Francis

    João MP Coelho, Maria Manuela Gaspar

  26. Selenium Nanoparticles Synergize with a KRAS Nanovaccine against Breast Cancer

    Article • Advanced Healthcare Materials, August 2024, Wiley

    Prof. Hélder Santos, Maria Manuela Gaspar

  27. Enhanced Cytotoxicity against a Pancreatic Cancer Cell Line Combining Radiation and Gold Nanoparticles

    Article • Pharmaceutics, July 2024, MDPI AG

    Maria Manuela Gaspar

  28. Role of ionic liquids in ibuprofen-based eutectic systems: Aqueous solubility, permeability, human cytotoxicity, hemolytic activity and anti-inflammatory activity

    Article • Journal of Molecular Liquids, June 2024, Elsevier

    Maria Manuela Gaspar

  29. Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors

    Article • Cell Death Discovery, May 2024, Springer Science + Business Media

    Maria Manuela Gaspar

  30. An alternative hybrid lipid nanosystem combining cytotoxic and magnetic properties as a tool to potentiate antitumor effect of 5-fluorouracil

    Article • Life Sciences, May 2024, Elsevier

    Maria Manuela Gaspar

  31. A Step Forward for the Treatment of Localized Prostate Cancer Using Gold Nanoparticles Combined with Laser Irradiation

    Article • International Journal of Molecular Sciences, April 2024, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  32. Liposomal Rifabutin—A Promising Antibiotic Repurposing Strategy against Methicillin-Resistant Staphylococcus aureus Infections

    Article • Pharmaceuticals, April 2024, MDPI AG

    Maria Manuela Gaspar

  33. Liposomal Rifabutin – A Promising Antibiotic Repurposing Strategy against Methicillin-Resistant <em>Staphylococcus aureus </em>Infections

    Article • February 2024, MDPI AG

    Maria Manuela Gaspar

  34. Antimicrobial activity of prophage endolysins against critical Enterobacteriaceae antibiotic-resistant bacteria

    Article • International Journal of Pharmaceutics, February 2024, Elsevier

    Dr Vera Manageiro, Maria Manuela Gaspar

  35. Rational approach to design gold nanoparticles for photothermal therapy: the effect of gold salt on physicochemical, optical and biological properties

    Article • International Journal of Pharmaceutics, January 2024, Elsevier

    João MP Coelho, Maria Manuela Gaspar

  36. Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability

    Article • ChemMedChem, November 2023, Wiley

    Maria Manuela Gaspar

  37. The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential

    Article • Life Sciences, September 2023, Elsevier

    Maria Manuela Gaspar

  38. Respirable konjac glucomannan microparticles as antitubercular drug carriers: Effects of in vitro and in vivo interactions

    Article • International Journal of Biological Macromolecules, September 2023, Elsevier

    Maria Manuela Gaspar

  39. Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma

    Article • Frontiers in Veterinary Science, August 2023, Frontiers

    Marco Cavaco, Maria Manuela Gaspar

  40. Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery

    Article • Cells, August 2023, MDPI AG

    Maria Manuela Gaspar

  41. miR‐21‐5p promotes NASH‐related hepatocarcinogenesis

    Article • Liver International, August 2023, Wiley

    Maria Manuela Gaspar

  42. Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential

    Article • Inorganic Chemistry, July 2023, American Chemical Society (ACS)

    Maria Manuela Gaspar

  43. A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma

    Article • International Journal of Pharmaceutics, June 2023, Elsevier

    Ana Francisco, Maria Manuela Gaspar

  44. Experimental Murine Models for Colorectal Cancer Research

    Article • Cancers, April 2023, MDPI AG

    Maria Manuela Gaspar

  45. Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist

    Article • Pharmaceutics, March 2023, MDPI AG

    Professor Lia Ascensão, Maria Manuela Gaspar

  46. Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research

    Article • Gels, March 2023, MDPI AG

    Maria Manuela Gaspar

  47. Advancing Medicine with Lipid-Based Nanosystems—The Successful Case of Liposomes

    Article • Biomedicines, February 2023, MDPI AG

    Maria Manuela Gaspar

  48. Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by Mycobacterium tuberculosis and Helps Control the Phagosomal Replicative Niches

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Maria Manuela Gaspar

  49. Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management

    Article • Biomedicine & Pharmacotherapy, January 2023, Elsevier

    Ana Francisco, Maria Manuela Gaspar

  50. Challenges in delivery of plant actives

    Article • January 2023, Elsevier

    Maria Manuela Gaspar

  51. Current Insights and Progress in the Clinical Management of Head and Neck Cancer

    Article • Cancers, December 2022, MDPI AG

    Maria Manuela Gaspar

  52. Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole

    Article • Pharmaceutics, November 2022, MDPI AG

    Maria Manuela Gaspar

  53. 3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution

    Article • Journal of Advanced Research, November 2022, Elsevier

    Maria Manuela Gaspar

  54. Nanoformulation of Seaweed Eisenia bicyclis in Albumin Nanoparticles Targeting Cardiovascular Diseases: In Vitro and In Vivo Evaluation

    Article • Marine Drugs, September 2022, MDPI AG

    Professor Lia Ascensão, Maria Manuela Gaspar

  55. Melanoma Management: From Epidemiology to Treatment and Latest Advances

    Article • Cancers, September 2022, MDPI AG

    Maria Manuela Gaspar

  56. Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aeruginosa Model

    Article • International Journal of Molecular Sciences, September 2022, MDPI AG

    Maria Manuela Gaspar

  57. How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT

    Article • Pharmaceutics, August 2022, MDPI AG

    Maria Manuela Gaspar

  58. Human Cytotoxicity, Hemolytic Activity, Anti-Inflammatory Activity and Aqueous Solubility of Ibuprofen-Based Ionic Liquids

    Article • Sustainable Chemistry, August 2022, MDPI AG

    Maria Manuela Gaspar

  59. Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

    Article • Gels, August 2022, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  60. New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes

    Article • International Journal of Pharmaceutics, July 2022, Elsevier

    Maria Manuela Gaspar

  61. Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model

    Article • International Journal of Molecular Sciences, June 2022, MDPI AG

    Maria Manuela Gaspar

  62. Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature of drug interaction beyond bulk tumor cells

    Article • European Journal of Pharmaceutics and Biopharmaceutics, March 2022, Elsevier

    Maria Manuela Gaspar

  63. Liposomes as Tools to Improve Therapeutic Enzyme Performance

    Article • Pharmaceutics, February 2022, MDPI AG

    Maria Manuela Gaspar

  64. The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment

    Article • Biomolecules, January 2022, MDPI AG

    Professor Lia Ascensão, João MP Coelho, Maria Manuela Gaspar

  65. A Comprehensive Updated Review on Magnetic Nanoparticles in Diagnostics

    Article • Nanomaterials, December 2021, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  66. The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

    Article • Cells, November 2021, MDPI AG

    Maria Manuela Gaspar

  67. Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

    Article • Pharmaceutics, October 2021, MDPI AG

    Miguel Castanho, Marco Cavaco, Maria Manuela Gaspar

  68. Sulfur Analogues of Tyrosine in the Development of Triazene Hybrid Compounds: A New Strategy against Melanoma

    Article • ACS Medicinal Chemistry Letters, September 2021, American Chemical Society (ACS)

    Ana Francisco, Maria Manuela Gaspar

  69. Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery

    Article • Pharmaceutics, August 2021, MDPI AG

    Maria Manuela Gaspar

  70. miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease

    Article • Frontiers in Cell and Developmental Biology, June 2021, Frontiers

    Maria Manuela Gaspar

  71. Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice

    Article • International Journal of Molecular Sciences, May 2021, MDPI AG

    Maria Manuela Gaspar

  72. A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

    Article • Pharmaceuticals, May 2021, MDPI AG

    Professor Lia Ascensão, Professor Patrícia M Rijo, Maria Manuela Gaspar

  73. Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Professor Lia Ascensão, Maria Manuela Gaspar

  74. Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

    Article • Molecules, April 2021, MDPI AG

    Maria Manuela Gaspar

  75. GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

    Article • Nano Today, April 2021, Elsevier

    Maria Manuela Gaspar

  76. Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management

    Article • International Journal of Pharmaceutics, April 2021, Elsevier

    Maria Manuela Gaspar

  77. Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma

    Article • Biomolecules, March 2021, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  78. Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward

    Article • Cancers, March 2021, MDPI AG

    Professor Lia Ascensão, João MP Coelho, Maria Manuela Gaspar

  79. Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

    Article • Sustainable Chemistry, March 2021, MDPI AG

    Maria Manuela Gaspar

  80. Liposomes as a Nanoplatform to Improve the Delivery of Antibiotics into Staphylococcus aureus Biofilms

    Article • Pharmaceutics, March 2021, MDPI AG

    Maria Manuela Gaspar

  81. Nanomedicines in the treatment of colon cancer: a focus on metallodrugs

    Article • Drug Delivery and Translational Research, February 2021, Springer Science + Business Media

    Maria Manuela Gaspar

  82. Advances in nanotechnology-related strategies against melanoma

    Article • January 2021, Elsevier

    Maria Manuela Gaspar

  83. RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease

    Article • Gut, December 2020, BMJ

    Maria Manuela Gaspar

  84. Recent Advances in Ionic Liquids and Nanotechnology for Drug Delivery

    Article • Nanomedicine, December 2020, Taylor & Francis

    Maria Manuela Gaspar

  85. A Step Forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Professor Lia Ascensão, João MP Coelho, Maria Manuela Gaspar

  86. Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

    Article • Pharmaceutics, December 2020, MDPI AG

    Professor Lia Ascensão, Professor Patrícia M Rijo, Maria Manuela Gaspar

  87. Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses

    Article • Industrial Crops and Products, October 2020, Elsevier

    Maria Manuela Gaspar

  88. Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials

    Article • Nanomaterials, August 2020, MDPI AG

    João MP Coelho, Maria Manuela Gaspar

  89. mIR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD

    Article • Journal of Hepatology, August 2020, Elsevier

    Maria Manuela Gaspar

  90. The role of RIPK3 in non-alcoholic fatty liver disease: a multi-omics perspective

    Article • Journal of Hepatology, August 2020, Elsevier

    Maria Manuela Gaspar

  91. Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors

    Article • Drug Delivery and Translational Research, June 2020, Springer Science + Business Media

    Maria Manuela Gaspar

  92. How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models

    Article • Biomolecules, April 2020, MDPI AG

    Professor Lia Ascensão, Maria Manuela Gaspar

  93. A Novel Hybrid Nanosystem Integrating Cytotoxic and Magnetic Properties as a Tool to Potentiate Melanoma Therapy

    Article • Nanomaterials, April 2020, MDPI AG

    Professor Lia Ascensão, Maria Manuela Gaspar

  94. The Aquaporin-3-Inhibiting Potential of Polyoxotungstates

    Article • International Journal of Molecular Sciences, April 2020, MDPI AG

    Maria Manuela Gaspar

  95. If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products

    Article • Industrial Crops and Products, February 2020, Elsevier

    Maria Manuela Gaspar

  96. Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin: Therapeutic assessment in a murine model of tuberculosis infection

    Article • European Journal of Pharmaceutics and Biopharmaceutics, February 2020, Elsevier

    Maria Manuela Gaspar

  97. Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells

    Article • Cancers, November 2019, MDPI AG

    Professor Patrícia M Rijo, Professor Lia Ascensão, Maria Manuela Gaspar

  98. Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease

    Article • Cell Death and Disease, November 2019, Springer Science + Business Media

    Maria Manuela Gaspar

  99. Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

    Article • Nanomaterials, October 2019, MDPI AG

    Maria Manuela Gaspar

  100. Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation

    Article • Pharmaceutics, October 2019, MDPI AG

    Maria Manuela Gaspar

  101. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies

    Article • October 2019, Frontiers

    Maria Manuela Gaspar

  102. Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS

    Article • Toxicology Letters, October 2019, Elsevier

    Maria Manuela Gaspar

  103. Demonstrating the Safety of Nanoparticles with Persimmon Extract

    Article • Pharmaceutics, June 2019, MDPI AG

    Dr. Rosa Direito, Maria Manuela Gaspar

  104. FRI-278-RIP3-dependent signalling exerts divergent effects on liver steatosis and carcinogenesis in experimental non-alcholic fatty liver disease

    Article • Journal of Hepatology, April 2019, Elsevier

    Maria Manuela Gaspar

  105. Copper Complex Nanoformulations Featuring Highly Promising Therapeutic Potential in Murine Melanoma Models

    Article • Nanomedicine, March 2019, Taylor & Francis

    Maria Manuela Gaspar

  106. New Hyaluronic Acid Particles for Longer-Lasting Osteoarthritis Relief

    Article • International Journal of Pharmaceutics, March 2019, Elsevier

    Professor Lia Ascensão, Dr. Rosa Direito, Professor Patrícia M Rijo, Maria Manuela Gaspar

  107. The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis

    Article • Frontiers in Immunology, February 2019, Frontiers

    Maria Manuela Gaspar

  108. Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

    Article • Pharmaceutics, January 2019, MDPI AG

    Maria Manuela Gaspar

  109. Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer

    Article • Pharmaceutics, November 2018, MDPI AG

    Professor Lia Ascensão, Professor Patrícia M Rijo, Maria Manuela Gaspar

  110. α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

    Article • Acta Biomaterialia, August 2018, Elsevier

    Maria Manuela Gaspar

  111. Track analysis of the passage of rhodamine-labeled liposomes across porcine jejunal mucus in a microchannel device

    Article • Therapeutic Delivery, May 2018, Future Science

    Maria Manuela Gaspar, Sourav Bhattacharjee

  112. The role of necroptosis in non-alcoholic fatty liver disease-related carcinogenesis

    Article • Free Radical Biology and Medicine, May 2018, Elsevier

    Maria Manuela Gaspar

  113. RIP3-dependent signalling contributes to non-alcoholic fatty liver disease-related hepatocarcinogenesis

    Article • Journal of Hepatology, April 2018, Elsevier

    Maria Manuela Gaspar

  114. miRNA-21 ablation protects against liver injury and necroptosis in cholestasis

    Article • Cell Death and Differentiation, December 2017, Springer Science + Business Media

    Maria Manuela Gaspar

  115. Lipid Vesicles for Skin Delivery: Evolution from First Generation

    Article • September 2017, Taylor & Francis

    Maria Manuela Gaspar

  116. Lipid-Based Nanocarriers for the Treatment of Infected Skin Lesions

    Article • September 2017, Taylor & Francis

    Maria Manuela Gaspar

  117. Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery

    Article • Molecular Pharmaceutics, August 2017, American Chemical Society (ACS)

    Maria Manuela Gaspar

  118. The selective cytotoxicity of new triazene compounds to human melanoma cells

    Article • Bioorganic & Medicinal Chemistry, August 2017, Elsevier

    Ana Francisco, Maria Manuela Gaspar

  119. Umbilical cord tissue–derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing

    Article • Cytotherapy, March 2017, Elsevier

    Maria Manuela Gaspar

  120. Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management

    Article • Current Pharmaceutical Design, January 2017, Bentham Science Publishers

    Maria Manuela Gaspar

  121. Activation of necroptosis in human and experimental cholestasis

    Article • Cell Death and Disease, September 2016, Springer Science + Business Media

    Maria Manuela Gaspar

  122. Nanoformulations of a Potent copper-based Aquaporin Inhibitor With Cytotoxic Effect Against Cancer Cells

    Article • Nanomedicine, July 2016, Taylor & Francis

    Maria Manuela Gaspar

  123. Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma

    Article • Journal of Nanoscience with Advanced Technology, March 2016, Verizona Publisher Limited

    Ana Francisco, Maria Manuela Gaspar

  124. Lipid-Based Nanoformulations of Trifluralin Analogs in the Management ofLeishmania InfantumInfections

    Article • Nanomedicine, December 2015, Taylor & Francis

    Maria Manuela Gaspar

  125. Human neonatal mesenchymal stem cell spheroids-conditioned medium accelerates skin regeneration

    Article • Toxicology Letters, October 2015, Elsevier

    Maria Manuela Gaspar

  126. Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems

    Article • Nanomedicine Nanotechnology Biology and Medicine, October 2015, Elsevier

    Maria Manuela Gaspar

  127. Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing

    Article • Stem Cell Research & Therapy, May 2015, Springer Science + Business Media

    Maria Manuela Gaspar

  128. In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

    Article • Journal of Controlled Release, January 2015, Elsevier

    Maria Manuela Gaspar

  129. What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

    Article • Stem Cells International, January 2015, Hindawi Publishing Corporation

    Maria Manuela Gaspar

  130. Liposomes versus Lipid Nanoparticles: Comparative Study of Lipid-Based Systems as Oryzalin Carriers for the Treatment of Leishmaniasis

    Article • Journal of Biomedical Nanotechnology, December 2014, American Scientific Publishers

    Maria Manuela Gaspar

  131. The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

    Article • Journal of Translational Medicine, January 2013, Springer Science + Business Media

    Maria Manuela Gaspar

  132. Targeted Delivery of Transferrin-Conjugated Liposomes to an Orthotopic Model of Lung Cancer in Nude Rats

    Article • Journal of Aerosol Medicine and Pulmonary Drug Delivery, December 2012, Mary Ann Liebert Inc

    Professor Marek W Radomski, Professor Marek W Radomski, Maria Manuela Gaspar

  133. Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, June 2010, Taylor & Francis

    Rui Moreira, Maria Manuela Gaspar

  134. Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulizers

    Article • Journal of Liposome Research, February 2010, Taylor & Francis

    Maria Manuela Gaspar

  135. Atomic Force Microscopy for the Characterization of Proteoliposomes

    Article • November 2009, Springer Science + Business Media

    Maria Manuela Gaspar

  136. Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H37Rv, MDR and NRP Mycobacterium tuberculosis

    Article • Bioorganic & Medicinal Chemistry, January 2009, Elsevier

    Maria Manuela Gaspar

  137. Inhaled Liposomes–Current Strategies and Future Challenges

    Article • Journal of Biomedical Nanotechnology, September 2008, American Scientific Publishers

    Maria Manuela Gaspar

  138. Developments on Drug Delivery Systems for the Treatment of Mycobacterial Infections

    Article • Current Topics in Medicinal Chemistry, April 2008, Bentham Science Publishers

    Maria Manuela Gaspar

  139. Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis

    Article • International Journal of Antimicrobial Agents, January 2008, Elsevier

    Maria Manuela Gaspar

  140. Radiation sterilization of antibiotic liposome formulations: A case study

    Article • Radiation Physics and Chemistry, August 2007, Elsevier

    Sandra Cabo Verde, Maria Manuela Gaspar

  141. Enzymosomes with surface-exposed superoxide dismutase: In vivo behaviour and therapeutic activity in a model of adjuvant arthritis

    Article • Journal of Controlled Release, February 2007, Elsevier

    Maria Manuela Gaspar

  142. Liposomal Superoxide Dismutases and Their Use in the Treatment of Experimental Arthritis

    Article • January 2005, Elsevier

    Maria Manuela Gaspar

  143. Design and characterization of enzymosomes with surface-exposed superoxide dismutase

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, January 2003, Elsevier

    Maria Manuela Gaspar

  144. Therapeutic Efficacy of Liposomal Rifabutin in a Mycobacterium avium Model of Infection

    Article • Antimicrobial Agents and Chemotherapy, September 2000, ASM Journals

    Maria Manuela Gaspar

  145. Formulation of l-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release

    Article • Journal of Controlled Release, March 1998, Elsevier

    Maria Manuela Gaspar

  146. Biological characterization of L -asparaginase liposomal formulations

    Article • Cancer Chemotherapy and Pharmacology, July 1996, Springer Science + Business Media

    Maria Manuela Gaspar

  147. Liposomal l-asparaginase: in vitro evaluation

    Article • International Journal of Pharmaceutics, July 1993, Elsevier

    Maria Manuela Gaspar