All Stories

  1. PTPN13 Contributes to Ebola Virus-Induced Immune Dysregulation via Dephosphorylation of IRF3 and PI3K-p85
  2. A cocktail of human mAbs targeting the henipavirus fusion and receptor binding proteins provides cross-species neutralization
  3. Repurposing Clinical Candidates for Nipah and Hendra Viruses
  4. Viral Disruption of Blood–Testis Barrier Precedes Testicular Infection
  5. Efficacy of Polyphenylene Carboxymethylene (PPCM) Gel at Protecting Type I Interferon Receptors Knockout Mice from Intravaginal Ebola Virus Challenge
  6. Efficacy and Immunogenicity of a Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine in Cynomolgus Macaques
  7. Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease
  8. Structure guided mutagenesis of Henipavirus Receptor Binding Proteins reveals molecular determinants of receptor usage and antibody binding epitopes
  9. Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-like Receptors
  10. The Susceptibility of BALB/c Mice to a Mouse-Adapted Ebola Virus Intravaginal Infection
  11. Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities
  12. Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption
  13. Hydrogen Sulfide Ameliorates SARS-CoV-2–Associated Lung Endothelial Barrier Disruption
  14. Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses
  15. Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo
  16. Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
  17. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
  18. Tilorone-Dihydrochloride Protects against Rift Valley Fever Virus Infection and Disease in the Mouse Model
  19. Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model
  20. Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-CoV-2. Proof of concept in primary human undifferentiated epithelial cells
  21. Recent advances in combating Nipah virus
  22. Rift Valley fever virus 78kDa envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice
  23. STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV)
  24. Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness
  25. Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors
  26. Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition
  27. Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells
  28. Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
  29. Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity
  30. SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
  31. Spike mutation D614G alters SARS-CoV-2 fitness
  32. Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig
  33. SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts
  34. Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
  35. VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection
  36. Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
  37. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors
  38. Polyphenylene carboxymethylene (PPCM) in vitro antiviral efficacy against Ebola virus in the context of a sexually transmitted infection
  39. Repurposing Quinacrine against Ebola Virus Infection In Vivo
  40. Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity
  41. Henipavirus infection of the central nervous system
  42. Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir
  43. A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice
  44. Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines
  45. Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing
  46. Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters
  47. Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription
  48. Experimental Infection of Syrian Hamsters With Aerosolized Nipah Virus
  49. Favipiravir (T-705) protects against Nipah virus infection in the hamster model
  50. Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model
  51. Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain
  52. Finding an old drug that works against ebola
  53. Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection
  54. Contribution of Human Lung Parenchyma and Leukocyte Influx to Oxidative Stress and Immune System-Mediated Pathology following Nipah Virus Infection
  55. The host ubiquitin system promotes Ebola virus replication
  56. Efficient and Robust Paramyxoviridae Reverse Genetics Systems
  57. Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
  58. Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses
  59. The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response
  60. Antiviral effect of ranpirnase against Ebola virus
  61. Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR
  62. N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN
  63. Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway
  64. ISG15 deficiency and increased viral resistance in humans but not mice
  65. Optimized P2A for reporter gene insertion into Nipah virus results in efficient ribosomal skipping and wild-type lethality
  66. Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine
  67. Cytokine response in mouse bone marrow derived macrophages after infection with pathogenic and non-pathogenic Rift Valley fever virus
  68. Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments
  69. Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins
  70. Timing of Galectin-1 Exposure Differentially Modulates Nipah Virus Entry and Syncytium Formation in Endothelial Cells
  71. Evidence for henipavirus spillover into human populations in Africa
  72. Efficient Reverse Genetics Reveals Genetic Determinants of Budding and Fusogenic Differences between Nipah and Hendra Viruses and Enables Real-Time Monitoring of Viral Spread in Small Animal Models of Henipavirus Infection
  73. Multiplexed Digital mRNA Profiling of the Inflammatory Response in the West Nile Swiss Webster Mouse Model
  74. Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names
  75. Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription
  76. Bunyaviruses: Hantavirus and Others
  77. Favipiravir (T-705) Inhibits Junín Virus Infection and Reduces Mortality in a Guinea Pig Model of Argentine Hemorrhagic Fever
  78. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
  79. Modeling Pre-Existing Immunity to Adenovirus in Rodents: Immunological Requirements for Successful Development of a Recombinant Adenovirus Serotype 5-Based Ebola Vaccine
  80. Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes
  81. Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice
  82. Rift Valley Fever Virus and Hemorrhagic Fever
  83. The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains
  84. Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus
  85. A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion
  86. Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae
  87. Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol
  88. Genetic Subpopulations of Rift Valley Fever Virus Strains ZH548 and MP-12 and Recombinant MP-12 Strains
  89. Detection of Severe Fever with Thrombocytopenia Syndrome Virus by Reverse Transcription-Cross-Priming Amplification Coupled with Vertical Flow Visualization
  90. Recent progress in henipavirus research: Molecular biology, genetic diversity, animal models
  91. Mutational analysis of positively charged amino acid residues of Uukuniemi phlebovirus nucleocapsid protein
  92. The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine
  93. Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse
  94. An Assembly Model of Rift Valley Fever Virus
  95. A Single Sublingual Dose of an Adenovirus-Based Vaccine Protects against Lethal Ebola Challenge in Mice and Guinea Pigs
  96. Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice
  97. Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses
  98. Differential cytokine responses from primary human Kupffer cells following infection with wild-type or vaccine strain yellow fever virus
  99. T-705 (Favipiravir) Inhibition of Arenavirus Replication in Cell Culture
  100. Ubiquitin-Regulated Nuclear-Cytoplasmic Trafficking of the Nipah Virus Matrix Protein Is Important for Viral Budding
  101. A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB
  102. Oligomerization of Uukuniemi virus nucleocapsid protein
  103. A replication-incompetent Rift Valley fever vaccine: Chimeric virus-like particles protect mice and rats against lethal challenge
  104. A broad-spectrum antiviral targeting entry of enveloped viruses
  105. Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection
  106. Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening
  107. Single-particle cryo-electron microscopy of Rift Valley fever virus
  108. Phage Tailspike Proteins withβ-Solenoid Fold as Thermostable Carbohydrate Binding Materials
  109. A catalytically and genetically optimized β-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics
  110. Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus
  111. Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography
  112. An Intersubunit Active Site between Supercoiled Parallel β Helices in the Trimeric Tailspike Endorhamnosidase of Shigella flexneri Phage Sf6
  113. Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA
  114. Folding and Stability of the Leucine-rich Repeat Domain of Internalin B from Listeria monocytogenes
  115. The Tailspike Protein of Shigella Phage Sf6: A STRUCTURAL HOMOLOG OF SALMONELLA PHAGE P22 TAILSPIKE PROTEIN WITHOUT SEQUENCE SIMILARITY IN THE  -HELIX DOMAIN
  116. Stability and Folding of Internalin B - A Biophysical Characterization