All Stories

  1. PPAR-γ dysregulation links NF-κB activation and Nrf2-driven antioxidant responses in axial spondyloarthritis: A pilot study

    Article • Journal of Autoimmunity, June 2026, Elsevier

    Dr Massimo Caruso

  2. Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study

    Article • BMC Cancer, April 2026, Springer Science + Business Media

    Dr Massimo Caruso

  3. Comparative Evaluation of Cigarette Smoke and a Heated Tobacco Product on Corneal Oxidative Stress in an Air/Liquid Interface Model

    Article • Investigative Ophthalmology & Visual Science, April 2025, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Massimo Caruso

  4. Cigarette Smoke and Heated Tobacco Product Exhibit Distinct Biochemical Pathways of Microglial Activation Under Hypoxia-Reoxygenation

    Article • March 2025, MDPI AG

    Dr Massimo Caruso, Dr Ali S Abdelhameed

  5. Evaluating the Risks of Heated Tobacco Products: Toxicological Effects on Two Selected Respiratory Bacteria and Human Lung Cells

    Article • Toxics, January 2025, MDPI AG

    Dr Massimo Caruso

  6. Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study

    Article • American Journal of Respiratory and Critical Care Medicine, November 2024, American Thoracic Society

    Dr Massimo Caruso

  7. Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics

    Article • European Respiratory Journal, October 2024, European Respiratory Society (ERS)

    Lars I. Andersson, Dr Massimo Caruso, Dr Valentyna Yasinska

  8. Comparative evaluation of cigarette smoke and a heated tobacco product on microglial toxicity, oxidative stress and inflammatory response

    Article • Journal of Translational Medicine, September 2024, Springer Science + Business Media

    Professor Nunzio Vicario, Dr Massimo Caruso

  9. Fish Oil Containing Pro-Resolving Mediators Enhances the Antioxidant System and Ameliorates LPS-Induced Inflammation in Human Bronchial Epithelial Cells

    Article • Pharmaceuticals, August 2024, MDPI AG

    Dr Massimo Caruso

  10. Author Correction: Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project

    Article • Scientific Reports, May 2024, Springer Science + Business Media

    Dr Massimo Caruso

  11. Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project

    Article • Scientific Reports, October 2023, Springer Science + Business Media

    Dr Massimo Caruso

  12. Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

    Article • ERJ Open Research, August 2023, European Respiratory Society (ERS)

    Lars I. Andersson, Dr Valentyna Yasinska, Dr Massimo Caruso

  13. Cigarette smoke attenuates mesenchymal stem cell-based suppression of immune cell-driven acute liver failure

    Article • Toxicology Letters, August 2023, Elsevier

    Dr Massimo Caruso

  14. Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk

    Article • American Journal of Respiratory and Critical Care Medicine, July 2023, American Thoracic Society

    Dr Massimo Caruso

  15. The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts

    Article • Brain Behavior and Immunity, July 2023, Elsevier

    Dr Massimo Caruso

  16. Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation

    Article • Allergy, June 2023, Wiley

    Dr Massimo Caruso

  17. Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial

    Article • JMIR Public Health and Surveillance, April 2023, JMIR Publications Inc.

    Prof Marcello Migliore, Dr Massimo Caruso

  18. Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43

    Article • Viruses, March 2023, MDPI AG

    Professor Antonio Rescifina, Dr Massimo Caruso

  19. Comparative assessment of electronic nicotine delivery systems aerosol and cigarette smoke on endothelial cell migration: The Replica Project

    Article • Drug Testing and Analysis, July 2022, Wiley

    Dr Massimo Caruso

  20. Correction to: Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

    Article • Medical Oncology, July 2022, Springer Science + Business Media

    Dr Massimo Caruso

  21. In vitro cytoxicity profile of e‐cigarette liquid samples on primary human bronchial epithelial cells

    Article • Drug Testing and Analysis, April 2022, Wiley

    Dr Massimo Caruso

  22. Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

    Article • Current Pharmaceutical Biotechnology, June 2021, Bentham Science Publishers

    Rosalia Emma, Pio Maria Furneri, Dr Massimo Caruso

  23. Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes

    Article • Harm Reduction Journal, March 2021, Springer Science + Business Media

    Professor Francesco Nocera, Dr Massimo Caruso

  24. Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative tobacco cigarettes

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr Massimo Caruso

  25. Role of Cigarette Smoke on ACE-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model

    Article • October 2020, MDPI AG

    Dr Massimo Caruso

  26. Nicotine dosimetry and stability in Cambridge Filter PADs (CFPs) following different smoking regimen protocols and condition storage

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Massimo Caruso

  27. Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?

    Article • Biomolecules, May 2020, MDPI AG

    Dr Massimo Caruso

  28. Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships?

    Article • Journal of Clinical Medicine, May 2020, MDPI AG

    Dr Massimo Caruso

  29. Non-inferiority trial comparing cigarette consumption, adoption rates, acceptability, tolerability, and tobacco harm reduction potential in smokers switching to Heated Tobacco Products or electronic cigarettes: Study protocol for a randomized controlle...

    Article • Contemporary Clinical Trials Communications, March 2020, Elsevier

    Dr Massimo Caruso

  30. Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells

    Article • Molecular Neurobiology, February 2020, Springer Science + Business Media

    Dr Massimo Caruso

  31. Role of 17β-Estradiol on Cell Proliferation and Mitochondrial Fitness in Glioblastoma Cells

    Article • Journal of Oncology, February 2020, Hindawi Publishing Corporation

    Dr Massimo Caruso

  32. Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

    Article • Respiratory Medicine, January 2020, Elsevier

    Dr Massimo Caruso

  33. IL-17–high asthma with features of a psoriasis immunophenotype

    Article • Journal of Allergy and Clinical Immunology, November 2019, Elsevier

    Professor Marek Sanak, Dr Massimo Caruso

  34. Subtypes of eosinophilic asthma with discrete gene pathway phenotypes

    Article • September 2019, European Respiratory Society (ERS)

    Professor Marek Sanak, Dr Massimo Caruso

  35. The effect of e-cigarette aerosol emissions on respiratory health: a narrative review

    Article • Expert Review of Respiratory Medicine, August 2019, Taylor & Francis

    Dr Massimo Caruso, Rosalia Emma

  36. High nicotine exposure in rodents is unlikely to inform about its toxicity in humans

    Article • European Respiratory Journal, August 2019, European Respiratory Society (ERS)

    Dr Massimo Caruso

  37. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation

    Article • Journal of Bone Oncology, August 2019, Elsevier

    Dr Massimo Caruso

  38. Metabolic Characterization of Supernatants Produced by Lactobacillus spp. With in vitro Anti-Legionella Activity

    Article • Frontiers in Microbiology, June 2019, Frontiers

    Professor Antonio Rescifina, Dr Massimo Caruso

  39. An evaluation of mepolizumab for the treatment of severe asthma

    Article • Expert Opinion on Biological Therapy, May 2019, Taylor & Francis

    Jaymin Morjaria, Dr Massimo Caruso

  40. Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

    Article • Journal of Allergy and Clinical Immunology, May 2019, Elsevier

    Dr Massimo Caruso

  41. Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

    Article • European Respiratory Journal, April 2019, European Respiratory Society (ERS)

    Professor Marek Sanak, Dr Massimo Caruso

  42. Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

    Article • PLOS One, September 2018, PLOS

    Dr Massimo Caruso, Professor Marek Sanak

  43. U-BIOPRED accessible handprint: combining omics platforms to identify stable asthma subphenotypes

    Article • September 2018, European Respiratory Society (ERS)

    Professor Marek Sanak, Dr Massimo Caruso

  44. Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort

    Article • September 2018, European Respiratory Society (ERS)

    Dr Massimo Caruso

  45. Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA

    Article • September 2018, European Respiratory Society (ERS)

    Professor Marek Sanak, Dr Massimo Caruso

  46. Electronic cigarette vapour enhances pneumococcal adherence to airway epithelial cells under abnormal conditions of exposure

    Article • European Respiratory Journal, September 2018, European Respiratory Society (ERS)

    Dr Massimo Caruso

  47. Health effects in COPD smokers who switch to electronic cigarettes: a retrospective-prospective 3-year follow-up

    Article • International Journal of Chronic Obstructive Pulmonary Disease, August 2018, Dove Medical Press

    Jaymin Morjaria, Dr Massimo Caruso

  48. Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis

    Article • International Immunopharmacology, July 2018, Elsevier

    Dr Massimo Caruso

  49. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

    Article • Journal of Allergy and Clinical Immunology, June 2018, Elsevier

    Dr Massimo Caruso

  50. A computational framework for complex disease stratification from multiple large-scale datasets

    Article • BMC Systems Biology, May 2018, Springer Science + Business Media

    Dr Massimo Caruso

  51. Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome

    Article • Journal of Proteome Research, May 2018, American Chemical Society (ACS)

    Dr Massimo Caruso, Professor Marek Sanak

  52. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis

    Article • European Respiratory Journal, April 2018, European Respiratory Society (ERS)

    fan Chung, Dr Massimo Caruso

  53. Pathway discovery using transcriptomic profiles in adult-onset severe asthma

    Article • Journal of Allergy and Clinical Immunology, April 2018, Elsevier

    Dr Massimo Caruso

  54. Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma

    Article • Current Allergy and Asthma Reports, March 2018, Springer Science + Business Media

    Dr Massimo Caruso

  55. Lack of Substantial Post-Cessation Weight Increase in Electronic Cigarettes Users

    Article • International Journal of Environmental Research and Public Health, March 2018, MDPI AG

    Dr Massimo Caruso

  56. Assessment of E-cigarette impact on smokers: The importance of experimental conditions relevant to human consumption

    Article • Proceedings of the National Academy of Sciences, March 2018, Proceedings of the National Academy of Sciences

    Dr Massimo Caruso

  57. Mepolizumab in the management of severe eosinophilic asthma in adults: current evidence and practical experience

    Article • Therapeutic Advances in Respiratory Disease, January 2018, SAGE Publications

    Dr Massimo Caruso

  58. Biologic agents for severe asthma patients: clinical perspectives and implications

    Article • Internal and Emergency Medicine, December 2017, Springer Science + Business Media

    Dr Massimo Caruso

  59. Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes

    Article • JAMA Internal Medicine, November 2017, American Medical Association (AMA)

    Dr Massimo Caruso

  60. Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties

    Article • AJP Lung Cellular and Molecular Physiology, November 2017, American Physiological Society

    Dr Massimo Caruso

  61. Late Breaking Abstract - Cluster analysis of treatable traits in the U-BIOPRED adult severe asthma cohort

    Article • September 2017, European Respiratory Society (ERS)

    Dr Massimo Caruso

  62. Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort

    Article • September 2017, European Respiratory Society (ERS)

    Dr Massimo Caruso, Professor Marek Sanak

  63. Urinary metabolomics-based molecular sub-phenotyping of the U-BIOPRED asthma cohort

    Article • September 2017, European Respiratory Society (ERS)

    Professor Marek Sanak, Dr Massimo Caruso

  64. “Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.” Dominick E. Shaw, Ana R. Sousa, Stephen J. Fowler, Louise J. Fleming, Graham Roberts, Julie Corfield, Ioannis Pandis, Aruna T. Bansal, Elisab...

    Article • European Respiratory Journal, June 2017, European Respiratory Society (ERS)

    Dr Massimo Caruso

  65. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

    Article • Journal of Allergy and Clinical Immunology, June 2017, Elsevier

    Dr Massimo Caruso, Professor Marek Sanak

  66. Sugar and mineral enriched fraction from olive mill wastewater for promising cosmeceutical application: characterization,in vitroandin vivostudies

    Article • Food & Function, January 2017, Royal Society of Chemistry

    Dr Massimo Caruso

  67. Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

    Article • December 2016, Springer Science + Business Media

    Dr Massimo Caruso

  68. Lung function and respiratory symptoms in a randomized smoking cessation trial of electronic cigarettes

    Article • Clinical Science, August 2016, Portland Press Ltd.

    Dr Massimo Caruso

  69. Smoking history can influence the epigenetic and gene expression profile

    Article • AJP Lung Cellular and Molecular Physiology, August 2016, American Physiological Society

    Dr Massimo Caruso

  70. Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes

    Article • European Journal of Clinical Investigation, July 2016, Wiley

    Dr Massimo Caruso

  71. Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes

    Article • Internal and Emergency Medicine, January 2016, Springer Science + Business Media

    Konstantinos Farsalinos, Dr Massimo Caruso

  72. Comments on Scheffler et al. Cytotoxic Evaluation of E-Liquid Aerosol using Different Lung Derived Cell Models. Int. J. Environ. Res. Public Health, 2015, 12, 12466-12474

    Article • International Journal of Environmental Research and Public Health, January 2016, MDPI AG

    Dr Massimo Caruso

  73. Evaluation of Post Cessation Weight Gain in a 1-Year Randomized Smoking Cessation Trial of Electronic Cigarettes

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    Dr Massimo Caruso

  74. Acrolein Levels in e-Cigarettes--Letter

    Article • Cancer Prevention Research, November 2015, American Association for Cancer Research (AACR)

    Dr Massimo Caruso

  75. Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability

    Article • PLOS One, October 2015, PLOS

    Dr Massimo Caruso

  76. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

    Article • European Respiratory Journal, September 2015, European Respiratory Society (ERS)

    Dr Massimo Caruso

  77. Unbiased clustering of severe asthma patients based on exhaled breath profiles

    Article • September 2015, European Respiratory Society (ERS)

    Dr Massimo Caruso

  78. Poster Discussion Session PDS 1

    Article • Allergy, September 2015, Wiley

    Dr Massimo Caruso

  79. Impact of air quality on lung health: myth or reality?

    Article • Therapeutic Advances in Chronic Disease, May 2015, SAGE Publications

    Dr Massimo Caruso

  80. Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial

    Article • Trials, December 2014, Springer Science + Business Media

    Dr Massimo Caruso

  81. In vitrocombined treatment with cetuximab and trastuzumab inhibits growth of colon cancer cells

    Article • Cell Proliferation, August 2014, Wiley

    Dr Massimo Caruso

  82. Effect of Smoking Abstinence and Reduction in Asthmatic Smokers Switching to Electronic Cigarettes: Evidence for Harm Reversal

    Article • International Journal of Environmental Research and Public Health, May 2014, MDPI AG

    Dr Massimo Caruso

  83. Airway responsiveness to adenosine after a single dose of fluticasone propionate discriminates asthma from COPD

    Article • Pulmonary Pharmacology & Therapeutics, February 2014, Elsevier

    Dr Massimo Caruso

  84. Preventing Progression of Allergic Rhinitis to Asthma

    Article • Current Allergy and Asthma Reports, January 2014, Springer Science + Business Media

    Dr Massimo Caruso

  85. Correction: EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study

    Article • PLOS One, January 2014, PLOS

    Dr Massimo Caruso

  86. Biologic therapy for atopic asthma and beyond

    Article • Current Opinion in Allergy and Clinical Immunology, December 2013, Wolters Kluwer Health

    Dr Massimo Caruso

  87. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study

    Article • PLOS One, June 2013, PLOS

    Dr Massimo Caruso

  88. Adenosine signaling pathways as potential therapeutic targets in respiratory disease

    Article • Expert Opinion on Therapeutic Targets, May 2013, Informa Healthcare

    Dr Massimo Caruso

  89. Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma

    Article • Expert Opinion on Biological Therapy, January 2013, Informa Healthcare

    Dr Massimo Caruso

  90. Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach

    Article • The Journal of Nutritional Biochemistry, September 2010, Elsevier

    Professor CLAUDIA Di Giacomo, Dr Massimo Caruso

  91. Adenosine and Adenosine Receptors: Their Contribution to Airway Inflammation and Therapeutic Potential in Asthma

    Article • Current Medicinal Chemistry, October 2009, Bentham Science Publishers

    Dr Massimo Caruso

  92. Effect of Ischemia–Reperfusion on Renal Expression and Activity of NG-NG-Dimethylarginine Dimethylaminohydrolases

    Article • Anesthesiology, December 2008, Wolters Kluwer Health

    Professor CLAUDIA Di Giacomo, Dr Massimo Caruso

  93. Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects

    Article • International Immunopharmacology, December 2008, Elsevier

    Dr Massimo Caruso

  94. XXV Conferenza Nazionale di Citometria

    Article • Cytometry Part A, December 2007, Wiley

    Dr Massimo Caruso

  95. Evidence For A Functional Contribution of Adenosine Signalling in Inflammatory Airway Diseases

    Article • Immunology Endocrine & Metabolic Agents - Medicinal Chemistry, August 2007, Bentham Science Publishers

    Dr Massimo Caruso

  96. Adenosine signalling in airways

    Article • Current Opinion in Pharmacology, June 2006, Elsevier

    Dr Massimo Caruso

  97. Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid

    Article • Neurobiology of Aging, April 2006, Elsevier

    Dr Massimo Caruso

  98. Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy

    Article • APOPTOSIS, January 2006, Springer Science + Business Media

    Dr Massimo Caruso

  99. Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor

    Article • Journal of Allergy and Clinical Immunology, December 2005, Elsevier

    Dr Massimo Caruso

  100. Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells

    Article • September 2005, Springer Science + Business Media

    Dr Massimo Caruso

  101. Glia Mediates the Neuroprotective Action of Estradiol on β-Amyloid-Induced Neuronal Death

    Article • Endocrinology, November 2004, Endocrine Society

    Dr Massimo Caruso