All Stories

  1. Angiogenesis Suppression via VEGF–VEGFR2 Inhibition and Stromal–Endothelial Crosstalk Disruption by Myrosinase-Activated Broccoli Extract

    Article • Molecules, March 2026, MDPI AG

    Professor CLAUDIA Di Giacomo

  2. Cynara cardunculus subsp. cardunculus (Wild Artichoke) Extract: Antimicrobial Activity and Cytotoxicity, Apoptosis Induction, and Chemosensitization in Colon Cancer Cells

    Article • Biology, March 2026, MDPI AG

    Professor CLAUDIA Di Giacomo

  3. Origanum majorana Extracts: A Preliminary Comparative Study on Phytochemical Profiles and Bioactive Properties of Valuable Fraction and By-Product

    Article • Plants, July 2025, MDPI AG

    Professor CLAUDIA Di Giacomo

  4. Oxalis pes-caprae L. (Oxalidaceae): From Invasive Concern to Promising Bioresource for Health and Sustainable Applications

    Article • Plants, February 2025, MDPI AG

    Professor CLAUDIA Di Giacomo

  5. Protective Effects of Wild Sulla coronaria (Fabaceae) Flowers Phytocomplex in Human Dermal Fibroblasts Stimulated with Interleukin-1β

    Article • Plants, September 2024, MDPI AG

    Professor CLAUDIA Di Giacomo

  6. Natural Compounds and Glutathione: Beyond Mere Antioxidants

    Article • Antioxidants, July 2023, MDPI AG

    Professor CLAUDIA Di Giacomo

  7. Wild Artichoke (Cynara cardunculus subsp. sylvestris, Asteraceae) Leaf Extract: Phenolic Profile and Oxidative Stress Inhibitory Effects on HepG2 Cells

    Article • Molecules, March 2023, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  8. Biological Investigation and Chemical Study of Brassica villosa subsp. drepanensis (Brassicaeae) Leaves

    Article • Molecules, December 2022, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  9. Vitamin E and Non-Communicable Diseases: A Review

    Article • Biomedicines, October 2022, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  10. Phytocomplex of a Standardized Extract from Red Orange (Citrus sinensis L. Osbeck) against Photoaging

    Article • Cells, April 2022, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  11. Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells

    Article • Biomolecules, October 2021, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  12. A standardized extract of Opuntia ficus‐indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfo...

    Article • Phytotherapy Research, March 2021, Wiley

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  13. Plant-Based Bioactive Molecules in Improving Health and Preventing Lifestyle Diseases

    Article • International Journal of Molecular Sciences, March 2021, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  14. Antioxidant, antimicrobial and anticancer activities of Castanea sativa (Fagaceae) extract: new therapeutic perspectives

    Article • Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, September 2020, Taylor & Francis

    Prof. CARLO GENOVESE, Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  15. The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats

    Article • Antioxidants, September 2020, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  16. Rapha Myr®, a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  17. Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

    Article • ACS Medicinal Chemistry Letters, April 2020, American Chemical Society (ACS)

    Professor Antonio Rescifina, Professor CLAUDIA Di Giacomo

  18. Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes

    Article • Natural Product Research, September 2019, Taylor & Francis

    Professor CLAUDIA Di Giacomo, Giuseppe Antonio Malfa

  19. Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

    Article • International Journal of Molecular Sciences, June 2019, MDPI AG

    Professor CLAUDIA Di Giacomo, Giuseppe Antonio Malfa, Prof. CARLO GENOVESE

  20. Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

    Article • International Journal of Molecular Sciences, May 2019, MDPI AG

    Professor CLAUDIA Di Giacomo

  21. Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

    Article • Current Medicinal Chemistry, January 2019, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  22. Blond and blood juice supplementation in high fat diet fed mice: effect on antioxidant status and DDAH/ADMA pathway

    Article • RSC Advances, January 2019, Royal Society of Chemistry

    Professor CLAUDIA Di Giacomo

  23. Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions

    Article • Current Medicinal Chemistry, May 2018, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  24. Dietary Compounds, Epigenetic Modifications and Metabolic Diseases

    Article • September 2017, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  25. Biological activities of Teucrium flavum L., Teucrium fruticans L., and Teucrium siculum rafin crude extracts

    Article • Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, June 2017, Taylor & Francis

    Prof. CARLO GENOVESE, Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  26. Caffeic Acid Phenethyl Ester Restores Adipocyte Gene Profile Expression Following Lipopolysaccharide Treatment

    Article • Letters in Drug Design & Discovery, February 2017, Elsevier

    Professor CLAUDIA Di Giacomo

  27. Effects of physical activity on systemic oxidative/DNA status in breast cancer survivors

    Article • Oncology Letters, November 2016, Spandidos Publications

    Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  28. Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures

    Article • Oncology Reports, August 2016, Spandidos Publications

    Prof. CARLO GENOVESE, Giuseppe Antonio Malfa, Professor CLAUDIA Di Giacomo

  29. Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes

    Article • PPAR Research, January 2016, Hindawi Publishing Corporation

    Francesca Romana Pluchinotta, Professor CLAUDIA Di Giacomo

  30. Cyanidin induces apoptosis and differentiation in prostate cancer cells

    Article • International Journal of Oncology, August 2015, Spandidos Publications

    Professor CLAUDIA Di Giacomo

  31. Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines

    Article • European Journal of Medicinal Chemistry, May 2015, Elsevier

    Professor CLAUDIA Di Giacomo

  32. Effects of Tithonia diversifolia (Hemsl.) A. Gray Extract on Adipocyte Differentiation of Human Mesenchymal Stem Cells

    Article • PLOS One, April 2015, PLOS

    Prof. CARLO GENOVESE, Professor CLAUDIA Di Giacomo

  33. Neuroprotective Effects of a Glutathione Depletor in Rat Post-Ischemic Reperfusion Brain Damage

    Article • CNS & Neurological Disorders - Drug Targets, February 2015, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  34. Antioxidant Activity and Phenolic Content of Microwave-AssistedSolanum melongenaExtracts

    Article • The Scientific World JOURNAL, January 2014, Hindawi Publishing Corporation

    Professor CLAUDIA Di Giacomo

  35. Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review

    Article • Toxins, October 2013, MDPI AG

    Professor CLAUDIA Di Giacomo

  36. Apoptotic markers in a prostate cancer cell line: Effect of ellagic acid

    Article • Oncology Reports, September 2013, Spandidos Publications

    Professor CLAUDIA Di Giacomo

  37. Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties

    Article • Bioorganic & Medicinal Chemistry, September 2013, Elsevier

    Professor CLAUDIA Di Giacomo

  38. Effects of Ellagic Acid on Angiogenic Factors in Prostate Cancer Cells

    Article • Cancers, June 2013, MDPI AG

    Professor CLAUDIA Di Giacomo

  39. Antioxidant Activity of Extracts of Momordica Foetida Schumach. et Thonn.

    Article • Molecules, March 2013, MDPI AG

    Prof. CARLO GENOVESE, Professor CLAUDIA Di Giacomo

  40. Ellagic Acid: Cytodifferentiating and Antiproliferative Effects In Human Prostatic Cancer Cell Lines

    Article • Current Pharmaceutical Design, March 2013, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  41. Evaluation of Imidazole-Based Compounds as Heme Oxygenase-1 Inhibitors

    Article • Chemical Biology & Drug Design, October 2012, Wiley

    Professor CLAUDIA Di Giacomo

  42. Biochemical modifications in Pinus pinaster Ait. as a result of environmental pollution

    Article • Environmental Science and Pollution Research, June 2012, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  43. Dimethylarginine Dimethylaminohydrolase/Nitric Oxide Synthase Pathway in Liver and Kidney: Protective Effect of Cyanidin 3-O-β-D-Glucoside on Ochratoxin-A Toxicity

    Article • Toxins, May 2012, MDPI AG

    Professor CLAUDIA Di Giacomo

  44. Antiproliferative effect of oleuropein in prostate cell lines

    Article • International Journal of Oncology, April 2012, Spandidos Publications

    Professor CLAUDIA Di Giacomo

  45. Novel inhibitors of nitric oxide synthase with antioxidant properties

    Article • European Journal of Medicinal Chemistry, March 2012, Elsevier

    Professor CLAUDIA Di Giacomo

  46. Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat Ischemic/Reperfusion Brain Damage

    Article • Evidence-based Complementary and Alternative Medicine, January 2012, Hindawi Publishing Corporation

    Professor CLAUDIA Di Giacomo

  47. Neuroprotective effect of silibinin in diabetic mice

    Article • Neuroscience Letters, October 2011, Elsevier

    Professor CLAUDIA Di Giacomo

  48. The DDAH/NOS pathway in human prostatic cancer cell lines: Antiangiogenic effect of L-NAME

    Article • International Journal of Oncology, June 2011, Spandidos Publications

    Professor CLAUDIA Di Giacomo

  49. Corrigendum: Oxidative Stress in Normal-Weight Obese Syndrome

    Article • Obesity, December 2010, Wiley

    Professor CLAUDIA Di Giacomo

  50. Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach

    Article • The Journal of Nutritional Biochemistry, September 2010, Elsevier

    Professor CLAUDIA Di Giacomo, Dr Massimo Caruso

  51. Oxidative Stress in Normal-Weight Obese Syndrome

    Article • Obesity, March 2010, Wiley

    Professor CLAUDIA Di Giacomo

  52. Beneficial effects of rutin and l-arginine coadministration in a rat model of liver ischemia-reperfusion injury

    Article • AJP Gastrointestinal and Liver Physiology, March 2009, American Physiological Society

    Professor CLAUDIA Di Giacomo

  53. Oxidative and Antioxidant Status in Plasma of Runners: Effect of Oral Supplementation with Natural Antioxidants

    Article • Journal of Medicinal Food, February 2009, Mary Ann Liebert Inc

    Professor CLAUDIA Di Giacomo

  54. Effect of Ischemia–Reperfusion on Renal Expression and Activity of NG-NG-Dimethylarginine Dimethylaminohydrolases

    Article • Anesthesiology, December 2008, Wolters Kluwer Health

    Professor CLAUDIA Di Giacomo, Dr Massimo Caruso

  55. Protocatechuic acid: The missing human cyanidins' metabolite

    Article • Molecular Nutrition & Food Research, March 2008, Wiley

    Professor CLAUDIA Di Giacomo

  56. Natural heme oxygenase-1 inducers in hepatobiliary function

    Article • World Journal of Gastroenterology, January 2008, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor CLAUDIA Di Giacomo

  57. Phenolic Compounds and Antioxidant Activity of Italian Extra Virgin Olive Oil Monti Iblei

    Article • Journal of Medicinal Food, December 2007, Mary Ann Liebert Inc

    Professor CLAUDIA Di Giacomo

  58. Pharmacological Induction of Heme Oxygenase-1 Inhibits iNOS and Oxidative Stress in Renal Ischemia-Reperfusion Injury

    Article • Transplantation Proceedings, December 2007, Elsevier

    Professor CLAUDIA Di Giacomo

  59. Inhibition of Human Leucocyte Elastase by Novel Thieno-1,3-oxazin-4-ones and Thieno-1,3-thioxazin-4-ones

    Article • Letters in Drug Design & Discovery, September 2007, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  60. Protective effect of cyanidin 3-O-β-d-glucoside on ochratoxin A-mediated damage in the rat

    Article • British Journal Of Nutrition, June 2007, Cambridge University Press

    Professor CLAUDIA Di Giacomo

  61. Heme oxygenase induction by cyanidin-3-O-β-glucoside in cultured human endothelial cells

    Article • Molecular Nutrition & Food Research, May 2007, Wiley

    Professor CLAUDIA Di Giacomo

  62. Cereals consumption and risk for renal cell carcinoma: Can be hypothesized a role of mycotoxins?

    Article • International Journal of Cancer, January 2007, Wiley

    Professor CLAUDIA Di Giacomo

  63. Rutin in rat liver ischemia/reperfusion injury: Effect on DDAH/NOS pathway

    Article • Microsurgery, January 2007, Wiley

    Professor CLAUDIA Di Giacomo

  64. Role of Carbon Monoxide and Biliverdin in Renal Ischemia/Reperfusion Injury

    Article • Nephron Experimental Nephrology, August 2006, Karger Publishers

    Professor CLAUDIA Di Giacomo

  65. High Glucose-Mediated Imbalance of Nitric Oxide Synthase and Dimethylarginine Dimethylaminohydrolase Expression in Endothelial Cells

    Article • Current Neurovascular Research, February 2006, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  66. Imidazole derivatives as antioxidants and selective inhibitors of nNOS

    Article • Nitric Oxide, February 2006, Elsevier

    Professor CLAUDIA Di Giacomo

  67. Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L-Arginine

    Article • Microsurgery, January 2006, Wiley

    Professor CLAUDIA Di Giacomo

  68. Effects of Norepinephrine Depletion in Rats During Cerebral Post-ischemic Reperfusion

    Article • NeuroToxicology, September 2004, Elsevier

    Professor CLAUDIA Di Giacomo

  69. Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling

    Article • Bioorganic & Medicinal Chemistry, June 2004, Elsevier

    Professor CLAUDIA Di Giacomo

  70. Progress in the Development of Selective Nitric Oxide Synthase (NOS) Inhibitors

    Article • Current Pharmaceutical Design, February 2002, Bentham Science Publishers

    Professor CLAUDIA Di Giacomo

  71. Expression of bone morphogenetic protein-6 and transforming growth factor-β1 in the rat brain after a mild and reversible ischemic damage

    Article • Brain Research, March 2001, Elsevier

    Professor CLAUDIA Di Giacomo

  72. Inhibition of Neuronal Nitric Oxide Synthase by N-Phenacyl Imidazoles

    Article • Nitric Oxide, February 2001, Elsevier

    Professor CLAUDIA Di Giacomo

  73. Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro antitumor activity

    Article • Drug Development Research, January 2001, Wiley

    Professor CLAUDIA Di Giacomo

  74. Fibroblast growth factor-2 and transforming growth factor-?1 immunostaining in rat brain after cerebral postischemic reperfusion

    Article • Journal of Neuroscience Research, January 2001, Wiley

    Professor CLAUDIA Di Giacomo

  75. Lipophilic methotrexate conjugates with antitumor activity

    Article • European Journal of Pharmaceutical Sciences, May 2000, Elsevier

    Professor CLAUDIA Di Giacomo

  76. Article • Cell Biology and Toxicology, January 2000, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  77. Article • Cell Biology and Toxicology, January 2000, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  78. Article • Neurochemical Research, January 1999, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  79. Gfap, S-100 and vimentin proteins in rat after cerebral post-ischemic reperfusion

    Article • International Journal of Developmental Neuroscience, October 1998, Elsevier

    Professor CLAUDIA Di Giacomo

  80. Article • Neurochemical Research, January 1998, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  81. Enhanced Resistance of Adriamycin-Treated MCR-5 Lung Fibroblasts by Increased Intracellular Glutathione Peroxidase and Extracellular Antioxidants

    Article • Biochemical and Molecular Medicine, October 1997, Elsevier

    Professor CLAUDIA Di Giacomo

  82. Article • Neurochemical Research, January 1997, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  83. Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

    Article • Neurochemical Research, June 1996, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  84. Liposomes as In-vivo Carriers for Citicoline: Effects on Rat Cerebral Post-ischaemic Reperfusion

    Article • Journal of Pharmacy and Pharmacology, December 1994, Oxford University Press (OUP)

    Professor CLAUDIA Di Giacomo

  85. Free radical scavenger depletion in post-ischemic reperfusion brain damage

    Article • Neurochemical Research, December 1993, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  86. Effect of acetyl-l-carnitine on lipid peroxidation and xanthine oxidase activity in rat skeletal muscle

    Article • Neurochemical Research, November 1993, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  87. Impaired Antioxidant Defense Mechanisms in Two Children with Hemolytic—Uremic Syndrome

    Article • Renal Failure, January 1993, Taylor & Francis

    Professor CLAUDIA Di Giacomo

  88. Transglutaminase activity in primary and subcultured rat astroglial cells

    Article • Neurochemical Research, December 1992, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  89. GSH levels in rat cerebral cortex following some antiepileptic drug treatment

    Article • Pharmacological Research, September 1992, Elsevier

    Professor CLAUDIA Di Giacomo

  90. Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age

    Article • Neurochemical Research, June 1992, Springer Science + Business Media

    Professor CLAUDIA Di Giacomo

  91. Lipid peroxidation in rat cerebral cortex during post-ischemic reperfusion: Effect of exogenous antioxidants and Ca++-antagonist drugs

    Article • International Journal of Developmental Neuroscience, February 1992, Elsevier

    Professor CLAUDIA Di Giacomo

  92. Antioxidant enzymatic systems and oxidative stress in erythrocytes with G6PD deficiency: Effect of deferoxamine

    Article • Pharmacological Research, July 1991, Elsevier

    Professor CLAUDIA Di Giacomo

  93. Neurotransmitter amino acid levels in rat thalamus and cerebral cortex after cerebellectomy

    Article • International Journal of Developmental Neuroscience, January 1991, Elsevier

    Professor CLAUDIA Di Giacomo

  94. Superoxide dismutase activity and reduced glutathione content in cataractous lens of patients with glucose-6-phosphate dehydrogenase deficiency

    Article • Ophthalmic Paediatrics and Genetics, January 1987, Taylor & Francis

    Professor CLAUDIA Di Giacomo