All Stories

  1. Inclusion of ΑVβ3 integrin into extracellular vesicles in a caveolin-1 tyrosine-14- phosphorylation dependent manner and subsequent transfer to recipient melanoma cells promotes migration, invasion and metastasis

    Article • Cell Communication and Signaling, March 2025, Springer Science + Business Media

    Manuel Varas

  2. Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells

    Article • Biological Research, October 2024, Springer Science + Business Media

    Manuel Varas

  3. MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution

    Article • Nature Genetics, October 2024, Springer Science + Business Media

    Manuel Varas

  4. Tumor‐derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β‐catenin signaling

    Article • The FASEB Journal, June 2024, Wiley

    Manuel Varas

  5. Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function

    Article • Journal of Extracellular Biology, May 2024, Wiley

    Manuel Varas

  6. Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism

    Article • February 2024, Research Square

    Manuel Varas

  7. GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells

    Article • Cells, February 2024, MDPI AG

    Manuel Varas

  8. Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Manuel Varas

  9. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

    Article • Journal of Extracellular Vesicles, February 2024, Wiley

    Manuel Varas, Dr Ioannis Azoidis, Dr. Asima Bhattacharyya, Dr Mehdi Kabani, Dr Gabriella Pocsfalvi, Andreina Schoeberlein

  10. Membrane vesicles in Acidithiobacillia class extreme acidophiles: influence on collective behaviors of ‘Fervidacidithiobacillus caldus’

    Article • Frontiers in Microbiology, January 2024, Frontiers

    Manuel Varas

  11. Caveolin-1-dependent tenascin C inclusion in extracellular vesicles is required to promote breast cancer cell malignancy

    Article • Nanomedicine, October 2023, Future Medicine

    Manuel Varas

  12. S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis

    Article • September 2023, Springer Science + Business Media

    Manuel Varas

  13. Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer

    Article • OncoImmunology, June 2023, Taylor & Francis

    Manuel Varas

  14. Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Manuel Varas

  15. Cancer Stem Cell and Aggressiveness Traits Are Promoted by Stable Endothelin-Converting Enzyme-1c in Glioblastoma Cells

    Article • Cells, February 2023, MDPI AG

    Manuel Varas

  16. A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

    Article • mBio, August 2022, ASM Journals

    Manuel Varas

  17. Role of the Pro-Inflammatory Tumor Microenvironment in Extracellular Vesicle-Mediated Transfer of Therapy Resistance

    Article • Frontiers in Oncology, May 2022, Frontiers

    Manuel Varas

  18. GIT1 protects against breast cancer growth through negative regulation of Notch

    Article • Nature Communications, March 2022, Springer Science + Business Media

    Manuel Varas

  19. Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

    Article • Frontiers in Cell and Developmental Biology, March 2022, Frontiers

    Manuel Varas

  20. H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus

    Article • Frontiers in Cell and Developmental Biology, January 2022, Frontiers

    Manuel Varas

  21. TNF-α-activated eNOS signaling increases leukocyte adhesion through the S-nitrosylation pathway

    Article • AJP Heart and Circulatory Physiology, December 2021, American Physiological Society

    Manuel Varas

  22. Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Manuel Varas

  23. Selective Surface and Intraluminal Localization of Wnt Ligands on Small Extracellular Vesicles Released by HT-22 Hippocampal Neurons

    Article • Frontiers in Cell and Developmental Biology, October 2021, Frontiers

    Manuel Varas

  24. Overexpression of DAZL, STRA8, and BOULE Genes and Treatment With BMP4 or Retinoic Acid Modulate the Expression of MSC Overexpressing Germ Cell Genes

    Article • Frontiers in Veterinary Science, May 2021, Frontiers

    Manuel Varas

  25. Dietary Fructose Promotes Prostate Cancer Growth

    Article • Cancer Research, March 2021, American Association for Cancer Research (AACR)

    Manuel Varas

  26. The histone variant H3.3 regulates the transcription of the hepatitis B virus

    Article • Annals of Hepatology, March 2021, Elsevier

    Manuel Varas

  27. Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression

    Article • Frontiers in Oncology, February 2021, Frontiers

    Manuel Varas

  28. eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effects

    Article • Cell Death and Disease, January 2021, Springer Science + Business Media

    Manuel Varas

  29. The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

    Article • Scientific Reports, December 2020, Springer Science + Business Media

    Manuel Varas

  30. A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Article • eLife, November 2020, eLife

    Manuel Varas

  31. Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells

    Article • Frontiers in Oncology, July 2020, Frontiers

    Manuel Varas

  32. Srebf1 Controls Midbrain Dopaminergic Neurogenesis

    Article • Cell Reports, May 2020, Elsevier

    Manuel Varas

  33. Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells

    Article • Biomolecules, April 2020, MDPI AG

    Manuel Varas

  34. Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity

    Article • Cells, April 2020, MDPI AG

    Manuel Varas

  35. Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy

    Article • Diagnostics, April 2020, MDPI AG

    Manuel Varas

  36. Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors

    Article • Journal of Nanobiotechnology, January 2020, Springer Science + Business Media

    Manuel Varas

  37. Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Manuel Varas

  38. Convergent Met and voltage-gated Ca2+ channel signaling drives hypermigration of Toxoplasma-infected dendritic cells

    Article • Journal of Cell Science, January 2020, The Company of Biologists

    Manuel Varas

  39. Endothelin‐converting enzyme‐1c promotes stem cell traits and aggressiveness in colorectal cancer cells

    Article • Molecular Oncology, December 2019, Wiley

    Manuel Varas

  40. Vesículas extracelulares como predictores tempranos de diabetes gestacional

    Article • Revista médica de Chile, December 2019, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Manuel Varas

  41. Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling

    Article • Stem Cells, November 2019, Wiley

    Manuel Varas

  42. Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells

    Article • International Journal of Molecular Sciences, October 2019, MDPI AG

    Manuel Varas

  43. Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus

    Article • PLOS One, June 2019, PLOS

    Manuel Varas

  44. PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

    Article • Cell Reports, April 2019, Elsevier

    Manuel Varas

  45. Correction: TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63–ITGB1–FAK signaling (doi:10.1242/jcs.225193)

    Article • Journal of Cell Science, February 2019, The Company of Biologists

    Manuel Varas

  46. Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia

    Article • Stem Cells International, January 2019, Hindawi Publishing Corporation

    Dr Roberto Romero, MAroun Khoury, Manuel Varas

  47. CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells

    Article • Cell Death and Disease, January 2019, Springer Science + Business Media

    Manuel Varas

  48. TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63 / ITGB1 / FAK signaling

    Article • Journal of Cell Science, January 2019, The Company of Biologists

    Manuel Varas

  49. HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes

    Article • Aging, December 2018, Impact Journals, LLC

    Manuel Varas

  50. BCG‐induced cytokine release in bladder cancer cells is regulated by Ca 2+ signaling

    Article • Molecular Oncology, December 2018, Wiley

    Manuel Varas

  51. Small Extracellular Vesicles in Rat Serum Contain Astrocyte-Derived Protein Biomarkers of Repetitive Stress

    Article • The International Journal of Neuropsychopharmacology, December 2018, Oxford University Press (OUP)

    Manuel Varas

  52. Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines

    Article • Nanomedicine, October 2018, Future Medicine

    Manuel Varas

  53. Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

    Article • The Journal of Periodontology, August 2018, Wiley

    Manuel Varas

  54. Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia

    Article • Reproductive Sciences, May 2018, SAGE Publications

    Manuel Varas

  55. Effects of earthquake on perinatal outcomes: A Chilean register-based study

    Article • PLOS One, February 2018, PLOS

    Manuel Varas

  56. Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma

    Article • OncoImmunology, February 2018, Taylor & Francis

    Vincenzo Borgna, Manuel Varas

  57. Toxoplasma gondii infection shifts dendritic cells into an amoeboid rapid migration mode encompassing podosome dissolution, secretion of TIMP-1, and reduced proteolysis of extracellular matrix

    Article • Cellular Microbiology, December 2017, Wiley

    Manuel Varas

  58. Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

    Article • PLoS Pathogens, December 2017, PLOS

    Manuel Varas

  59. In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization

    Article • Pigment Cell & Melanoma Research, October 2017, Wiley

    jaime villegas, Manuel Varas

  60. Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures

    Article • Frontiers in Cellular Neuroscience, July 2017, Frontiers

    Manuel Varas

  61. A short hairpin RNA-based adjuvant targeting NF-κB repressor IκBα promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination

    Article • Vaccine, July 2017, Elsevier

    Manuel Varas

  62. Physicochemical characterization of chitosan-hyaluronan-coated solid lipid nanoparticles for the targeted delivery of paclitaxel: a proof-of-concept study in breast cancer cells

    Article • Nanomedicine, March 2017, Future Medicine

    Prof. Dr. Ziyad S. Haidar, Manuel Varas

  63. The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

    Article • Stem Cells International, January 2017, Hindawi Publishing Corporation

    Manuel Varas

  64. Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors

    Article • Oncotarget, September 2016, Impact Journals, LLC

    Manuel Varas

  65. Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species

    Article • Oncotarget, June 2016, Impact Journals, LLC

    Manuel Varas

  66. Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, May 2016, Taylor & Francis

    Manuel Varas

  67. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Manuel Varas

  68. Migratory activation of parasitized dendritic cells by the protozoanToxoplasma gondii14-3-3 protein

    Article • Cellular Microbiology, May 2016, Hindawi Publishing Corporation

    Manuel Varas

  69. Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia

    Article • Prenatal Diagnosis, April 2016, Wiley

    Manuel Varas

  70. Frizzled-1 receptor regulates adult hippocampal neurogenesis

    Article • Molecular Brain, March 2016, Springer Science + Business Media

    Manuel Varas

  71. Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration

    Article • Stem Cells International, January 2016, Hindawi Publishing Corporation

    Manuel Varas

  72. Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Manuel Varas

  73. Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia

    Article • PLOS One, October 2015, PLOS

    Dr Carlos E Irarrazabal, Manuel Varas

  74. Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production

    Article • Molecular and Cellular Neuroscience, September 2015, Elsevier

    Manuel Varas

  75. The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons

    Article • Molecular and Cellular Neuroscience, July 2015, Elsevier

    Manuel Varas

  76. Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker

    Article • The International Journal of Neuropsychopharmacology, March 2015, Oxford University Press (OUP)

    Manuel Varas

  77. Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

    Article • PLOS One, March 2015, PLOS

    Manuel Varas

  78. An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling

    Article • Journal of Molecular and Cellular Cardiology, October 2014, Elsevier

    Manuel Varas

  79. The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment

    Article • Brain Research, July 2013, Elsevier

    Manuel Varas

  80. Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes

    Article • Journal of Biological Chemistry, June 2012, Elsevier

    Manuel Varas

  81. Angiotensin-(1–9) regulates cardiac hypertrophy in vivo and in vitro

    Article • Journal of Hypertension, May 2010, Wolters Kluwer Health

    Manuel Varas

  82. Menores niveles tisulares de la enzima convertidora de angiotensina I homologa (ECA-2) y angiotensina-(1-9) están asociados a mayor remodelamiento de la pared aórtica de ratas hipertensas

    Article • January 2010, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Manuel Varas