All Stories

  1. Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles

    Article • Journal of Controlled Release, August 2025, Elsevier

    Dr André Görgens

  2. Sheathless Elasto‐Inertial Focusing of Sub‐25 Nm Particles in Straight Microchannels

    Article • Small, June 2025, Wiley

    Dr André Görgens

  3. Role of extracellular vesicles as promotors for activation of leukemia‑derived dendritic cell‑mediated antileukemic immune response against AML‑blasts

    Article • Oncology Reports, June 2025, Spandidos Publications

    Dr André Görgens

  4. Identification of robust and abundant reference transcripts for EV mRNA cargo normalization

    Article • Extracellular Vesicle, June 2025, Elsevier

    Dr André Görgens

  5. Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

    Article • Nature Communications, April 2025, Springer Science + Business Media

    Dr André Görgens

  6. Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior

    Article • Proceedings of the National Academy of Sciences, April 2025, Proceedings of the National Academy of Sciences

    Apurba Dev, Dr André Görgens

  7. Sheathless elasto-inertial focusing of sub-25 nm particles in straight microchannels

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  8. Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress

    Article • Journal of Extracellular Vesicles, February 2025, Wiley

    Dr André Görgens

  9. Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy

    Article • Nano Letters, January 2025, American Chemical Society (ACS)

    Dr André Görgens

  10. On-chip colorimetric assay for determining serum lithium concentration from whole blood

    Article • Lab on a Chip, January 2025, Royal Society of Chemistry

    Dr André Görgens

  11. Multi-omics analysis of uterine fluid extracellular vesicles reveals a resemblance with endometrial tissue across the menstrual cycle: biological and translational insights

    Article • Human Reproduction Open, January 2025, Oxford University Press (OUP)

    Dr André Görgens

  12. Plasmon-Enhanced Fluorescence of Single Extracellular Vesicles Captured in Arrayed Aluminum Nanoholes

    Article • ACS Omega, December 2024, American Chemical Society (ACS)

    Dr André Görgens

  13. Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification

    Article • Journal of Extracellular Vesicles, October 2024, Wiley

    Dr André Görgens

  14. Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

    Article • Advanced Science, September 2024, Wiley

    Dr André Görgens

  15. Defining the Soluble and Extracellular Vesicle Protein Compartments of Plasma Using In-Depth Mass Spectrometry-Based Proteomics

    Article • Journal of Proteome Research, August 2024, American Chemical Society (ACS)

    Dr André Görgens

  16. Imaging single particle profiler to study nanoscale bioparticles using conventional confocal microscopy

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  17. Inter‐laboratory multiplex bead‐based surface protein profiling of MSC‐derived EV preparations identifies MSC‐EV surface marker signatures

    Article • Journal of Extracellular Vesicles, June 2024, Wiley

    Dr André Görgens

  18. Antibody-displaying extracellular vesicles for targeted cancer therapy

    Article • Nature Biomedical Engineering, May 2024, Springer Science + Business Media

    Dr André Görgens

  19. Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  20. Histones are exosome membrane proteins regulated by cell stress

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  21. Transcriptomic and proteomic profiles of fetal versus adult mesenchymal stromal cells and mesenchymal stromal cell-derived extracellular vesicles

    Article • Stem Cell Research & Therapy, March 2024, Springer Science + Business Media

    Dr André Görgens

  22. Surface adhesion and membrane fluctuations influence the elastic modulus of extracellular vesicles

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  23. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

    Article • Journal of Extracellular Vesicles, February 2024, Wiley

    Manuel Varas, Dr Ioannis Azoidis, Dr. Asima Bhattacharyya, Dr Mehdi Kabani, Dr Gabriella Pocsfalvi, Andreina Schoeberlein, Daniel Bachurski, Dr André Görgens, Dr. Ann M Wehman, Dr Muhammad Nawaz, Maja Kosanovic, Dr Anna Krasnodembskaya

  24. Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

    Article • Journal of Extracellular Vesicles, January 2024, Wiley

    Dr André Görgens

  25. Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

    Article • October 2023, Springer Science + Business Media

    Dr André Görgens

  26. Role of EVs as promotors for activation of leukemia-derived dendritic cell (DCleu)-mediated antileukemic immune response against AML-blasts

    Article • September 2023, Springer Science + Business Media

    Dr André Görgens

  27. Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

    Article • Cell Reports Medicine, September 2023, Elsevier

    Dr André Görgens

  28. The cellular response to extracellular vesicles is dependent on their cell source and dose

    Article • Science Advances, September 2023, American Association for the Advancement of Science

    Dr André Görgens

  29. Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

    Article • Nature Communications, August 2023, Springer Science + Business Media

    Dr André Görgens

  30. Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts

    Article • Cell Death Discovery, July 2023, Springer Science + Business Media

    Dr André Görgens

  31. Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  32. Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  33. Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  34. Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells

    Article • Haematologica, March 2023, Ferrata Storti Foundation (Haematologica)

    Dr André Görgens

  35. A compendium of single extracellular vesicle flow cytometry

    Article • Journal of Extracellular Vesicles, February 2023, Wiley

    Dr André Görgens

  36. The potential role of serum extracellular vesicle derived small RNAs in AML research as non-invasive biomarker

    Article • Nanoscale Advances, January 2023, Royal Society of Chemistry

    Dr André Görgens

  37. Identification of storage conditions stabilizing extracellular vesicles preparations

    Article • Journal of Extracellular Vesicles, June 2022, Wiley

    Dr André Görgens

  38. Description and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies

    Article • Cancer Gene Therapy, April 2022, Springer Science + Business Media

    Dr André Görgens

  39. Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2022, Elsevier

    Dr André Görgens

  40. MPAPASS software enables stitched multiplex, multidimensional EV repertoire analysis and a standard framework for reporting bead-based assays

    Article • Cell Reports Methods, January 2022, Elsevier

    Dr André Görgens

  41. Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

    Article • Nature Communications, December 2021, Springer Science + Business Media

    Dr André Görgens

  42. Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles

    Article • Advanced Healthcare Materials, November 2021, Wiley

    Dr André Görgens

  43. GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

    Article • Nature Communications, November 2021, Springer Science + Business Media

    Dr André Görgens

  44. Diagnostic and Prognostic Utility of the Extracellular Vesicles Subpopulations Present in Pleural Effusion

    Article • Biomolecules, October 2021, MDPI AG

    Dr André Görgens

  45. Extracellular vesicles are the primary source of blood‐borne tumour‐derived mutant KRAS DNA early in pancreatic cancer

    Article • Journal of Extracellular Vesicles, October 2021, Wiley

    Dr André Görgens

  46. Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

    Article • Nature Biomedical Engineering, September 2021, Springer Science + Business Media

    Dr André Görgens

  47. Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics

    Article • The Journal of Immunology, June 2021, The American Association of Immunologists

    Dr André Görgens

  48. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway

    Article • Frontiers in Cell and Developmental Biology, May 2021, Frontiers

    Dr André Görgens

  49. Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features

    Article • Small, March 2021, Wiley

    Dr André Görgens

  50. Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification

    Article • Neuro-Oncology, January 2021, Oxford University Press (OUP)

    Dr André Görgens

  51. Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  52. Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

    Article • Biomaterials, January 2021, Elsevier

    Dr André Görgens

  53. MPA <sub>PASS</sub> Enables Stitched Multiplex Multi-Dimensional EV Repertoire Analysis

    Article • SSRN Electronic Journal, January 2021, Elsevier

    Dr André Görgens

  54. MIFlowCyt‐EV: The Next Chapter in the Reporting and Reliability of Single Extracellular Vesicle Flow Cytometry Experiments

    Article • Cytometry Part A, November 2020, Wiley

    Dr André Görgens

  55. Human Amnion Epithelial Cells Impair T Cell Proliferation: The Role of HLA-G and HLA-E Molecules

    Article • Cells, September 2020, MDPI AG

    Dr André Görgens

  56. Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging

    Article • Journal of Extracellular Vesicles, August 2020, Wiley

    Dr André Görgens

  57. Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  58. Engineering of extracellular vesicles for display of protein biotherapeutics

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  59. Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  60. Aiming to Compare Apples to Apples: Analysis of Extracellular Vesicles and Other Nanosized Particles by Flow Cytometry

    Article • Cytometry Part A, June 2020, Wiley

    Dr André Görgens

  61. High‐Resolution Imaging Flow Cytometry Reveals Impact of Incubation Temperature on Labeling of Extracellular Vesicles with Antibodies

    Article • Cytometry Part A, May 2020, Wiley

    Dr André Görgens

  62. Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells

    Article • Cancers, May 2020, MDPI AG

    Dr André Görgens

  63. Differential B-cell receptor signaling requirement for adhesion of mantle cell lymphoma cells to stromal cells

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Dr André Görgens

  64. CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo

    Article • PLOS One, February 2020, PLOS

    Dr André Görgens

  65. MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

    Article • Journal of Extracellular Vesicles, January 2020, Taylor & Francis

    Dr André Görgens

  66. Extracellular Vesicles

    Article • January 2020, Springer Science + Business Media

    Dr André Görgens

  67. Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection

    Article • Journal of Extracellular Vesicles, January 2020, Taylor & Francis

    Dr André Görgens

  68. Analysis of individual extracellular vesicles by imaging flow cytometry

    Article • January 2020, Elsevier

    Dr André Görgens

  69. Impacts of alien plant invasions on water resources and yields from the Western Cape Water Supply System (WCWSS)

    Article • Water SA, October 2019, Academy of Science of South Africa

    Dr André Görgens

  70. Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging

    Article • Journal of Extracellular Vesicles, September 2019, Taylor & Francis

    Dr André Görgens

  71. Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Dr André Görgens

  72. Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows

    Article • British Journal of Pharmacology, August 2019, Springer Science + Business Media

    Dr André Görgens

  73. Distinct Spatio-Temporal Dynamics of Tumor-Associated Neutrophils in Small Tumor Lesions

    Article • Frontiers in Immunology, June 2019, Frontiers

    Dr André Görgens

  74. Label-Free Surface Protein Profiling of Extracellular Vesicles by an Electrokinetic Sensor

    Article • ACS Sensors, May 2019, American Chemical Society (ACS)

    Dr André Görgens

  75. Analysis of single extracellular vesicles by imaging flow cytometry

    Article • Journal of Extracellular Vesicles, January 2019, Taylor & Francis

    Dr André Görgens, Joshua Welsh, Dr Chantal M Boulanger, Tobias Tertel

  76. Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours

    Article • Journal of Extracellular Vesicles, January 2019, Taylor & Francis

    Dr André Görgens, Lasse Dührsen

  77. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Article • Journal of Extracellular Vesicles, November 2018, Taylor & Francis

    A. Paula Domínguez Rubio, Dr Muhammad Nawaz, Dr. Kenneth W Witwer, Dr. Ann M Wehman, Dr André Görgens, Daniel Bachurski, Anna C. Beardi, Dr Scott M Langevin, Dr Johnathon D Anderson, Maja Kosanovic, Dr. Andre J van Wijnen

  78. Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression

    Article • Biochemical and Biophysical Research Communications, September 2018, Elsevier

    Dr André Görgens

  79. Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures

    Article • Frontiers in Immunology, June 2018, Frontiers

    Dr André Görgens

  80. Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome

    Article • Haematologica, January 2018, Ferrata Storti Foundation (Haematologica)

    Dr André Görgens

  81. Enforced GFI1 expression impedes human and murine leukemic cell growth

    Article • Scientific Reports, November 2017, Nature

    Dr André Görgens

  82. A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease

    Article • Frontiers in Microbiology, October 2017, Frontiers

    Dr André Görgens

  83. Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

    Article • Scientific Reports, September 2017, Nature

    Dr André Görgens

  84. Dissecting the origin of dendritic cell and macrophage subsets in human hematopoiesis

    Article • Experimental Hematology, September 2017, Elsevier

    Dr André Görgens

  85. In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells

    Article • Stem Cell Reports, April 2017, Elsevier

    Dr André Görgens

  86. Webinar | Analysis of extracellular vesicles including exosomes by imaging flow cytometry

    Article • Science, June 2016, American Association for the Advancement of Science

    Dr André Görgens

  87. Lost in Transplantation? Unexpected shift from multipotent to late lymphomyeloid hematopoietic stem and progenitor cells in patients 1 year after hematopoietic stem cell transplantation

    Article • British Journal of Pharmacology, May 2016, Nature

    Dr André Görgens

  88. Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML

    Article • Experimental Hematology, May 2016, Elsevier

    Dr André Görgens

  89. Superior therapeutic index in lymphoma therapy: CD30+ CD34+ hematopoietic stem cells resist a chimeric antigen receptor (CAR) T cell attack

    Article • Molecular Therapy, April 2016, Nature

    Dr André Görgens

  90. Circulating Tumor Cell Composition in Renal Cell Carcinoma

    Article • PLOS One, April 2016, PLOS

    Dr André Görgens

  91. GFI1 as a novel prognostic and therapeutic factor for AML/MDS

    Article • Leukemia, February 2016, Nature

    Dr André Görgens, Christian Thiede

  92. Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitor cells

    Article • Cell Cycle, January 2016, Taylor & Francis

    Dr André Görgens

  93. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

    Article • Journal of Extracellular Vesicles, December 2015, Co-Action Publishing

    Dr André Görgens, Dr Lorenzo Fraile, Dr Gabriella Pocsfalvi

  94. From Basic Biology to Engineering and Clinical Translation of Stem Cells: Meeting Report on the 8th International Meeting of the Stem Cell Network North Rhine Westphalia

    Article • Cellular Reprogramming, December 2015, Mary Ann Liebert Inc

    Dr André Görgens

  95. Concise Review: Asymmetric Cell Divisions in Stem Cell Biology

    Article • Symmetry, November 2015, MDPI AG

    Dr André Görgens

  96. CEACAM1-4L Promotes Anchorage-Independent Growth in Melanoma

    Article • Frontiers in Oncology, October 2015, Frontiers

    Dr André Görgens

  97. Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

    Article • Stem Cells Translational Medicine, September 2015, Wiley

    Dr André Görgens

  98. Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3

    Article • Stem Cells and Development, September 2015, Mary Ann Liebert Inc

    Dr André Görgens

  99. Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

    Article • Stem Cell Reports, July 2015, Elsevier

    Dr André Görgens

  100. Wie unser Blut entsteht – neue Erkennt nisse zur Hämatopoese

    Article • BIOspektrum, May 2015, Springer Science + Business Media

    Dr André Görgens

  101. CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants

    Article • British Journal of Haematology, March 2015, Wiley

    Dr André Görgens

  102. Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody

    Article • PLOS One, January 2015, PLOS

    Dr André Görgens

  103. Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages

    Article • Stem Cell Reports, December 2014, Elsevier

    Dr André Görgens

  104. New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells

    Article • Cell Cycle, November 2013, Taylor & Francis

    Dr André Görgens

  105. Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages

    Article • Cell Reports, May 2013, Elsevier

    Dr André Görgens

  106. Abstract 4714: Vemurafenib reverses immunosuppression by myeloid derived suppressor cells.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr André Görgens

  107. Vemurafenib reverses immunosuppression by myeloid derived suppressor cells

    Article • International Journal of Cancer, April 2013, Wiley

    Dr André Görgens

  108. Lipid raft redistribution and morphological cell polarization are separable processes providing a basis for hematopoietic stem and progenitor cell migration

    Article • The International Journal of Biochemistry & Cell Biology, July 2012, Elsevier

    Dr André Görgens

  109. Self-Renewal of Primitive Hematopoietic Cells: A Focus on Asymmetric Cell Division

    Article • December 2010, World Scientific Pub Co Pte Lt

    Dr André Görgens