All Stories

  1. Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
  2. Radiation‑Induced Microglial Turnover Elicits a cGAS‑Mediated Interferon Response
  3. Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics
  4. Rapid and robust isolation of microglia and vascular cells from brain subregions for integrative single-cell analyses
  5. Irradiation and lithium treatment alter the global DNA methylation pattern and gene expression underlying a shift from gliogenesis towards neurogenesis in human neural progenitors
  6. Irradiation and lithium treatment alter the global DNA methylation pattern and gene expression underlying a shift from gliogenesis towards neurogenesis in human neural progenitors
  7. Correction: Dying transplanted neural stem cells mediate survival bystander effects in the injured brain
  8. Dying transplanted neural stem cells mediate survival bystander effects in the injured brain
  9. Post-Compulsory Education in Teenagers and Young Adults Treated for Brain Tumors in Childhood: A Swedish Nationwide Registry-Based Study
  10. A cross‐sectional survey of moral distress and ethical climate – Situations in paediatric oncology care that involve children’s voices
  11. Optical Coherence Tomography Identifies Visual Pathway Involvement Earlier than Visual Function Tests in Children with MRI-Verified Optic Pathway Gliomas
  12. Radiobiological Evaluation of Combined Gamma Knife Radiosurgery and Hyperthermia for Pediatric Neuro-Oncology
  13. Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway
  14. Multifaceted microglia — key players in primary brain tumour heterogeneity
  15. Can National Tests from the Last Year of Compulsory School Be Used to Obtain More Detailed Information about Academic Performance in Children Treated for Brain Tumours? A Nationwide, Population-Based Study from Sweden
  16. Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion
  17. Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis
  18. Nationwide, population-based study of school grades in practical and aesthetic subjects of children treated for brain tumour
  19. Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition
  20. A nationwide, population‐based study of school grades, delayed graduation, and qualification for school years 10‐12, in children with brain tumors in Sweden
  21. Hyperthermia Treatment Planning Including Convective Flow in Cerebrospinal Fluid for Brain Tumour Hyperthermia Treatment Using a Novel Dedicated Paediatric Brain Applicator
  22. The Secretome of Microglia Regulate Neural Stem Cell Function
  23. Language barriers and the use of professional interpreters in pediatric oncology.
  24. Development and evaluation of the Communication over Language Barriers questionnaire (CoLB-q) in paediatric healthcare
  25. A role for endothelial cells in radiation-induced inflammation
  26. A novel mouse model of radiation-induced cancer survivorship diseases of the gut
  27. Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype
  28. Hypothermia after cranial irradiation protects neural progenitor cells in the subventricular zone but not in the hippocampus
  29. Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia
  30. Radiation induces progenitor cell death, microglia activation and blood-brain barrier damage in the juvenile rat cerebellum
  31. Lithium protects hippocampal progenitors, cognitive performance and hypothalamus–pituitary function after irradiation to the juvenile rat brain
  32. Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain
  33. Lithium Accumulates in Neurogenic Brain Regions as Revealed by High Resolution Ion Imaging
  34. Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia
  35. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
  36. Autophagy in acute brain injury
  37. Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice
  38. C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning
  39. Active video gaming improves body coordination in survivors of childhood brain tumours
  40. Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury
  41. Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice
  42. Towards better patient safety in otolaryngology: characteristics of patient injuries and their relationship with items on the WHO Surgical Safety Checklist
  43. Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia
  44. Healthcare professionals' perceptions of the ethical climate in paediatric cancer care
  45. Irradiation of the Juvenile Brain Provokes a Shift from Long-Term Potentiation to Long-Term Depression
  46. Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
  47. Clarifying perspectives
  48. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
  49. Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in Neonatal Rats
  50. Experiences of Ethical Issues When Caring for Children With Cancer
  51. How Patients Experience Antral Irrigation
  52. A template for writing radiotherapy protocols
  53. Transplantation of Enteric Neural Stem/Progenitor Cells into the Irradiated Young Mouse Hippocampus
  54. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
  55. Therapeutic Benefits of Delayed Lithium Administration in the Neonatal Rat after Cerebral Hypoxia-Ischemia
  56. The hippocampal neurovascular niche during normal development and after irradiation to the juvenile mouse brain
  57. Different reactions to irradiation in the juvenile and adult hippocampus
  58. Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3
  59. Delayed, Long-Term Administration of the Caspase Inhibitor Q-VD-OPh Reduced Brain Injury Induced by Neonatal Hypoxia-Ischemia
  60. The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
  61. Lipopolysaccharide sensitized male and female juvenile brains to ionizing radiation
  62. Irradiation to the young mouse brain impaired white matter growth more in females than in males
  63. Loss of hippocampal neurogenesis, increased novelty-induced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain
  64. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
  65. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species
  66. Effect of tonsillectomy on health-related quality of life and costs
  67. Grafting of neural stem and progenitor cells to the hippocampus of young, irradiated mice causes gliosis and disrupts the granule cell layer
  68. Irradiation to the Young Mouse Brain Caused Long-Term, Progressive Depletion of Neurogenesis but did not Disrupt the Neurovascular Niche
  69. Injury and Repair in the Immature Brain
  70. Lipopolysaccharide-Induced Inflammation Aggravates Irradiation-Induced Injury to the Young Mouse Brain
  71. Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury
  72. Decreased oxidative stress during glycolytic inhibition enables maintenance of ATP production and astrocytic survival
  73. Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain
  74. Sex-dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain
  75. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury
  76. Estimated clinical benefit of protecting neurogenesis in the developing brain during radiation therapy for pediatric medulloblastoma
  77. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury
  78. Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles
  79. Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
  80. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia–Ischemia: Cell Signaling
  81. Morphological Assessments of Neonatal Hypoxia–Ischemia: In Situ Cell Degeneration
  82. Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice
  83. Lithium-Mediated Long-Term Neuroprotection in Neonatal Rat Hypoxia–Ischemia is Associated with Antiinflammatory Effects and Enhanced Proliferation and Survival of Neural Stem/Progenitor Cells
  84. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
  85. Unique gene expression patterns indicate microglial contribution to neural stem cell recovery following irradiation
  86. Developmental dysregulation of adult neurogenesis
  87. Learning and Activity after Irradiation of the Young Mouse Brain Analyzed in Adulthood Using Unbiased Monitoring in a Home Cage Environment
  88. Repeated exposure of the developing rat brain to magnetic resonance imaging did not affect neurogenesis, cell death or memory function
  89. Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation
  90. Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia
  91. Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia–ischemia
  92. Erythropoietin: not just about erythropoiesis
  93. Life with or without AIF
  94. The growth hormone secretagogue hexarelin increases cell proliferation in neurogenic regions of the mouse hippocampus
  95. A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2
  96. Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents
  97. Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adult
  98. Decreased cytogenesis in the granule cell layer of the hippocampus and impaired place learning after irradiation of the young mouse brain evaluated using the IntelliCage platform
  99. Stimulatory Effects of Thyroid Hormone on Brain Angiogenesis in vivo and in vitro
  100. NF-κB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein
  101. Erythropoietin Improved Neurologic Outcomes in Newborns With Hypoxic-Ischemic Encephalopathy
  102. Mitochondrial membrane permeabilization in neuronal injury
  103. Reduced Liver Injury and Cytokine Release After Transplantation of Preconditioned Intestines
  104. Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat
  105. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
  106. Differential Recovery of Neural Stem Cells in the Subventricular Zone and Dentate Gyrus After Ionizing Radiation
  107. Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury
  108. Systemic Hypothermia Induced within 10 Hours After Birth Improved Neurological Outcome in Newborns with Hypoxic-Ischemic Encephalopathy
  109. Irradiation-induced loss of microglia in the young brain
  110. Neural stem/progenitor cells transplanted into the hippocampus of young mice survive and normalize behavior changes induced by irradiation
  111. Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury
  112. Differential effects on stem and progenitor cells in the subventricular zone and hippocampus after ionizing radiation
  113. Age-Dependent Regenerative Responses in the Striatum and Cortex after Hypoxia-Ischemia
  114. Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
  115. Regulation of autophagy by cytoplasmic p53
  116. Proliferative and Protective Effects of Growth Hormone Secretagogues on Adult Rat Hippocampal Progenitor Cells
  117. Developing Postmitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy
  118. X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants
  119. X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-κB activation
  120. Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia
  121. Failure to complete apoptosis following neonatal hypoxia–ischemia manifests as “continuum” phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain
  122. Mitochondrial Cell Death Control in Familial Parkinson Disease
  123. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
  124. Donor pretreatment with FK506 reduces reperfusion injury and accelerates intestinal graft recovery in rats
  125. Pathological apoptosis in the developing brain
  126. Antioxidant Status Alters Levels of Fas-Associated Death Domain-Like IL-1B-Converting Enzyme Inhibitory Protein following Neonatal Hypoxia-Ischemia
  127. Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
  128. Less Neurogenesis and Inflammation in the Immature than in the Juvenile Brain after Cerebral Hypoxia-Ischemia
  129. Transplantation of Preconditioned Intestinal Grafts is Associated With Lower Inflammatory Activation and Remote Organ Injury in Rats
  130. Neuroprotective properties of memantine in differentin vitroandin vivomodels of excitotoxicity
  131. Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic–ischemic injury
  132. Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
  133. Free radicals, mitochondria, and hypoxia–ischemia in the developing brain
  134. Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia
  135. Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
  136. Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia
  137. FK506 Donor Pretreatment Improves Intestinal Graft Microcirculation and Morphology by Concurrent Inhibition of Early NF-κB Activation and Augmented HSP72 Synthesis
  138. Role of cathepsins and cystatins in patients with recurrent miscarriage
  139. IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3β?
  140. Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells
  141. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia
  142. The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin
  143. Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition
  144. Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia
  145. X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia–ischemia
  146. The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer
  147. Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia
  148. Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
  149. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia–ischemia
  150. Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival
  151. Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activation
  152. Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia
  153. Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
  154. Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus
  155. Neuroprotection by Selective Nitric Oxide Synthase Inhibition at 24 Hours After Perinatal Hypoxia-Ischemia
  156. Effects of Selective Nitric Oxide Synthase Inhibition on IGF-1, Caspases and Cytokines in a Newborn Piglet Model of Perinatal Hypoxia-Ischaemia
  157. Role of Calpain in Human Sperm Activated by Progesterone for Fertilization
  158. NMDA blockade attenuates caspase-3 activation and DNA fragmentation after neonatal hypoxia–ischemia
  159. Degradation of fodrin and MAP 2 after neonatal cerebral hypoxic-ischemia
  160. Calpain and calpastatin activity in the optic pathway
  161. Developmental changes of calpain and calpastatin in rabbit brain
  162. Cerebral Hypoxia—Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury