All Stories

  1. New Frontiers of Drug Development Through the Use of New Approach Methodologies

    Article • The AAPS Journal, May 2026, Springer Science + Business Media

    Jonathan Paul Mochel

  2. A Comprehensive Mathematical Model of Avidity in Cytokine Signaling

    Article • May 2026, openRxiv

    Jonathan Paul Mochel

  3. Are We Going to the Dogs? Human Disease Phenotypes in Canines

    Article • April 2026, MDPI AG

    Jonathan Paul Mochel

  4. Are We Going to the Dogs? Human Disease Phenotypes in Canines

    Article • April 2026, MDPI AG

    Jonathan Paul Mochel

  5. Gaps and paths forward in cancer pharmacology and translational research

    Article • Frontiers in Pharmacology, April 2026, Frontiers

    Jonathan Paul Mochel

  6. Evidence-Based Medical Therapy for Mitral Regurgitation in Dogs

    Article • Journal of Veterinary Cardiology, April 2026, Elsevier

    Jonathan Paul Mochel

  7. Establishment of a canine urothelial carcinoma‐derived organoid biobank: A platform for comparative and translational research

    Article • Clinical and Translational Medicine, March 2026, Wiley

    Jonathan Paul Mochel

  8. Histologic and immunohistochemical characterization and frequency of rare subtypes of canine invasive urothelial carcinoma

    Article • Veterinary Pathology, March 2026, SAGE Publications

    Jonathan Paul Mochel

  9. Innovative In Vitro-In Silico Platform for Dose–Response Modeling in Canine Bladder Cancer: A 3D Organoid- and Mathematics-Based Approach

    Article • The AAPS Journal, March 2026, Springer Science + Business Media

    Jonathan Paul Mochel

  10. Effect of the sodium glucose transporter-2 inhibitor dapagliflozin on urine and blood biomarkers in dogs with heart disease

    Article • Journal of Veterinary Internal Medicine, March 2026, Oxford University Press (OUP)

    Jonathan Paul Mochel

  11. Prognostic value of plasma cortisol concentration in dogs with congestive heart failure

    Article • Journal of Veterinary Internal Medicine, March 2026, Oxford University Press (OUP)

    Jonathan Paul Mochel

  12. Evidence-Based Medical Therapy for Mitral Regurgitation in Dogs

    Article • January 2026, MDPI AG

    Jonathan Paul Mochel

  13. Leveraging Canine Disease Models in Pharmaceutical Sciences: A One Health Path to Parallel Drug Development

    Article • January 2026, MDPI AG

    Jonathan Paul Mochel

  14. Multicenter Retrospective Evaluation of the Use of Lyophilized Platelets in Dogs

    Article • Journal of Veterinary Emergency and Critical Care, January 2026, Wiley

    Jonathan Paul Mochel

  15. Transmucosal detomidine gel induces emesis in approximately half of cats presenting for dietary indiscretion

    Article • Journal of the American Veterinary Medical Association, January 2026, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  16. Development and characterization of chicken lung organoids for in vitro modeling of avian influenza virus-host cell interaction

    Article • Scientific Reports, January 2026, Springer Science + Business Media

    Jonathan Paul Mochel

  17. Urothelial genotoxicity of household chemicals in healthy canine urinary bladder organoids relative to observed urinary exposures in pet dogs

    Article • Frontiers in Veterinary Science, December 2025, Frontiers

    Jonathan Paul Mochel

  18. Evidence-Based Medical Therapy for Mitral Regurgitation in Dogs

    Article • November 2025, MDPI AG

    Jonathan Paul Mochel

  19. Establishment and transcriptomic characterization of canine organoids from multiple tissues

    Article • Frontiers in Cell and Developmental Biology, November 2025, Frontiers

    Jonathan Paul Mochel

  20. Retrospective Comparison of Outcomes From Septic Peritonitis of Gastrointestinal Versus Non‐Gastrointestinal Etiology in Dogs (2009–2022): 161 Cases

    Article • Journal of Veterinary Emergency and Critical Care, November 2025, Wiley

    Jonathan Paul Mochel

  21. A microfluidic platform for culturing and high-content imaging of adult stem cell-derived organoids

    Article • Scientific Reports, November 2025, Springer Science + Business Media

    Jonathan Paul Mochel

  22. Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson’s disease

    Article • Cell Host & Microbe, November 2025, Elsevier

    Jonathan Paul Mochel

  23. Development of a Time-based Drug Screening Platform for Improved Clinical Translation

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  24. A Roadmap for the Future of Systems Biology in Cancer Research

    Article • Cancer Research, October 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne, Jonathan Paul Mochel

  25. Retrospective Evaluation of Treatment and Survival of Blunt Trauma‐Associated Pneumothorax in Dogs: 89 Cases (2018–2022)

    Article • Journal of Veterinary Emergency and Critical Care, October 2025, Wiley

    Jonathan Paul Mochel

  26. Retrospective Evaluation of the Incidence and Risk Factors Associated With the Development of a Hepatopathy in Xylitol Ingestion: 95 Dogs (2018–2022)

    Article • Journal of Veterinary Emergency and Critical Care, October 2025, Wiley

    Jonathan Paul Mochel

  27. Interdisciplinary research seeks treatments and cures for diseases of animals and humans

    Article • American Journal of Veterinary Research, October 2025, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  28. SUN-056 The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)

    Article • Journal of the Endocrine Society, October 2025, Endocrine Society

    Jonathan Paul Mochel

  29. Establishing a Canine Urothelial Organoid Repository: A Platform for Comparative and Translational Carcinoma Studies

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  30. A comprehensive pharmacodynamic dataset reconciles 50 years of laboratory and clinical knowledge

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  31. Innovative In Vitro-In Silico Platform for Dose-Response Modeling in Canine Bladder Cancer: A 3D Organoid- and Mathematics-Based Approach

    Article • September 2025, Springer Science + Business Media

    Jonathan Paul Mochel

  32. Letter Regarding “Recommendations for a Complete Reporting of Statistical Methods in Veterinary Pharmacology”

    Article • Journal of Veterinary Pharmacology and Therapeutics, August 2025, Wiley

    Jonathan Paul Mochel

  33. Optimizing First‐Line Therapeutics in Non‐Small Cell Lung Cancer: Insights From Joint Modeling and Large‐Scale Data Analysis

    Article • CPT Pharmacometrics & Systems Pharmacology, July 2025, Wiley

    Jonathan Paul Mochel

  34. Experimental Methods for Establishing and Maintaining Canine Bladder Cancer Organoids

    Article • July 2025, Taylor & Francis

    Jonathan Paul Mochel

  35. Cancer Detection and Diagnosis

    Article • July 2025, Taylor & Francis

    Jonathan Paul Mochel

  36. Evolving value and validity of animal models in veterinary therapeutic research: Impact of scientific progress

    Article • European Journal of Pharmaceutical Sciences, July 2025, Elsevier

    Jonathan Paul Mochel

  37. Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy

    Article • Antioxidants, June 2025, MDPI AG

    Jonathan Paul Mochel

  38. OrganoidChip+: a Microfluidic Platform for Culturing, Staining, Immobilization, and High-Content Imaging of Adult Stem Cell-Derived Organoids

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  39. Penicillin and Gentamicin Concentrations in the Uterine Fluid of Non‐Pregnant Mares Following a Single Intrauterine Infusion

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2025, Wiley

    Jonathan Paul Mochel

  40. Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  41. Incidence of hypernatremia in dogs treated with multi-dose activated charcoal for acute toxicant ingestion: multi-center retrospective study (2018–2023)

    Article • Frontiers in Veterinary Science, May 2025, Frontiers

    Jonathan Paul Mochel

  42. Pharmacokinetic evaluation and bioavailability of KPT-335 (Verdinexor) in cats

    Article • Frontiers in Veterinary Science, May 2025, Frontiers

    Jonathan Paul Mochel

  43. Su1305: DUODENAL DNA METHYLATION PROFILES IN DOGS WITH CHRONIC INFLAMMATORY ENTEROPATHY TREATED WITH NOVEL SYNBIOTIC

    Article • Gastroenterology, May 2025, Elsevier

    Jonathan Paul Mochel

  44. <span style="mso-bidi-font-weight: bold;">Spontaneous Canine Disease Models in Biomedical Science: A One Health Path to Predictive Drug Development

    Article • April 2025, MDPI AG

    Jonathan Paul Mochel

  45. Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  46. A Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids

    Article • Biology, March 2025, MDPI AG

    Jonathan Paul Mochel

  47. The association between non-depolarizing neuromuscular blockade agents and survival to discharge in dogs undergoing mechanical ventilation: a multi-center retrospective study of 227 dogs (2010–2020)

    Article • Frontiers in Veterinary Science, March 2025, Frontiers

    Jonathan Paul Mochel

  48. Retrospective Evaluation of Complications Associated With Surgically Placed Gastrostomy Tubes in Dogs (2010–2020): 133 Cases

    Article • Journal of Veterinary Emergency and Critical Care, March 2025, Wiley

    Jonathan Paul Mochel

  49. Effects of a Western Diet on Colonic Dysbiosis, Bile Acid Dysmetabolism and Intestinal Inflammation in Clinically Healthy Dogs

    Article • Journal of Veterinary Internal Medicine, March 2025, Wiley

    Jonathan Paul Mochel

  50. Incidence of hypernatremia in dogs treated with single dose activated charcoal for acute toxicant ingestion: multi-center retrospective study (2018–2023)

    Article • Frontiers in Veterinary Science, February 2025, Frontiers

    Jonathan Paul Mochel

  51. A Novel Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids

    Article • January 2025, MDPI AG

    Jonathan Paul Mochel

  52. A preliminary investigation in dogs to evaluate for post-anesthetic lung ultrasound findings suggestive of atelectasis

    Article • Veterinary Anaesthesia and Analgesia, January 2025, Elsevier

    Jonathan Paul Mochel

  53. A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study

    Article • GeroScience, December 2024, Springer Science + Business Media

    Jonathan Paul Mochel

  54. Utilization of peripheral glucose and lactate differences in the diagnosis of feline arterial thromboembolism: a multi-center study

    Article • Frontiers in Veterinary Science, December 2024, Frontiers

    Jonathan Paul Mochel

  55. Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs

    Article • Journal of Veterinary Internal Medicine, November 2024, Wiley

    Jonathan Paul Mochel

  56. Frequency and progression of azotemia during acute and chronic treatment of congestive heart failure in cats

    Article • Journal of Veterinary Internal Medicine, November 2024, Wiley

    Jonathan Paul Mochel

  57. Treatment of Canine Myxomatous Mitral Valve Disease:Current and Future Approaches

    Article • October 2024, MDPI AG

    Jonathan Paul Mochel

  58. University of Georgia College of Veterinary Medicine’s Precision One Health Initiative improves animal and human health by developing alternative models of disease

    Article • American Journal of Veterinary Research, October 2024, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  59. Cisplatin-Induced Metabolic Responses Measured with Raman Spectroscopy in Cancer Cells, Spheroids, and Canine-Derived Organoids

    Article • ACS Applied Materials & Interfaces, September 2024, American Chemical Society (ACS)

    saji uthaman, Jonathan Paul Mochel

  60. Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity

    Article • Scientific Reports, September 2024, Springer Science + Business Media

    Jonathan Paul Mochel

  61. 166 Development of non-model organoids in animal research: A paradigm shift in in vitro models

    Article • Journal of Animal Science, September 2024, Oxford University Press (OUP)

    Jonathan Paul Mochel

  62. Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs

    Article • PLOS One, July 2024, PLOS

    Jonathan Paul Mochel

  63. Evaluating the Bias of Two Point-of-Care Glucometers for Calves and Ewes: Awareness for Ruminant Practitioners

    Article • Ruminants, July 2024, MDPI AG

    Jonathan Paul Mochel

  64. Systemic absorption and gastrointestinal adverse effects from topical ketorolac and diclofenac ophthalmic solutions in healthy dogs

    Article • Journal of the American Veterinary Medical Association, July 2024, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  65. Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health

    Article • June 2024, MDPI AG

    Jonathan Paul Mochel

  66. Population Pharmacokinetics and Absolute Oral Bioavailability of Lasalocid after Single Intravenous and Intracrop Administration in Laying Hens

    Article • Journal of Agricultural and Food Chemistry, June 2024, American Chemical Society (ACS)

    Jonathan Paul Mochel

  67. Abstract PR002: Sarcomatoid Histological Variants of Canine Muscle-Invasive Bladder Cancer: Transcription Factor Activation Highlights Pathways of Epithelial-Mesenchymal Transformation Similar to Humans

    Article • Clinical Cancer Research, May 2024, American Association for Cancer Research (AACR)

    Jonathan Paul Mochel

  68. Retrospective evaluation of the prevalence and risk factors associated with red blood cell transfusions in cats with urethral obstruction (2009–2019): 575 cases

    Article • Journal of Veterinary Emergency and Critical Care, May 2024, Wiley

    Jonathan Paul Mochel

  69. Tu1739 MICRORNAS AS POTENTIAL BIOMARKERS FOR DIAGNOSIS AND MONITORING CHRONIC INFLAMMATORY ENTEROPATHY IN DOGS

    Article • Gastroenterology, May 2024, Elsevier

    Jonathan Paul Mochel

  70. Randomized comparison between a forced air system and warm water bath for resuscitation of neonatal hypothermic calves with or without oral administration of caffeine

    Article • Journal of Veterinary Internal Medicine, April 2024, Wiley

    Jonathan Paul Mochel

  71. Preclinical Modeling of Metabolic Syndrome to Study the Pleiotropic Effects of Novel Antidiabetic Therapy Independent of Obesity

    Article • April 2024, Springer Science + Business Media

    Jonathan Paul Mochel

  72. Experimental Methods for Establishing and Maintaining Canine Bladder Cancer Organoids

    Article • April 2024, Springer Science + Business Media

    Jonathan Paul Mochel

  73. A machine learning approach for potential Super‐Agers identification using neuronal functional connectivity networks

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, April 2024, Wiley

    Jonathan Paul Mochel

  74. Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model

    Article • Heliyon, April 2024, Elsevier

    Jonathan Paul Mochel

  75. Letter regarding “Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis”

    Article • Journal of Veterinary Internal Medicine, March 2024, Wiley

    Julien Dandrieux, Jonathan Paul Mochel

  76. Comparison of Traditional Didactic Versus Additional Hands-On Simulation Training in the Performance of Basic Life Support in Veterinary Students—A Prospective, Blinded, Randomized Study

    Article • Journal of Veterinary Medical Education, March 2024, University of Toronto Press (UTPress)

    Jonathan Paul Mochel

  77. Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs

    Article • PLOS One, February 2024, PLOS

    Jonathan Paul Mochel

  78. Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations

    Article • Communications Biology, February 2024, Springer Science + Business Media

    Jonathan Paul Mochel

  79. Effect of amlodipine on the circulating renin‐angiotensin‐aldosterone system in healthy cats

    Article • Journal of Veterinary Internal Medicine, February 2024, Wiley

    Jonathan Paul Mochel

  80. Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study

    Article • February 2024, IOS Press

    Jonathan Paul Mochel

  81. Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Jonathan Paul Mochel

  82. Leveraging the predictive power of 3D organoids in dogs to develop new treatments for man and man’s best friend

    Article • BMC Biology, December 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  83. A Preclinical Model of Obesity-Independent Metabolic Syndrome for Studying the Effects of Novel Antidiabetic Therapy Beyond Glycemic Control

    Article • November 2023, Wiley

    Jonathan Paul Mochel

  84. Retrospective evaluation of admission total plasma protein as a predictor of red blood cell transfusion requirement in dogs diagnosed with traumatic and nontraumatic hemoabdomen: 90 dogs (2009–2019)

    Article • Journal of Veterinary Emergency and Critical Care, November 2023, Wiley

    Jonathan Paul Mochel

  85. Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare

    Article • Frontiers in Veterinary Science, November 2023, Frontiers

    Jonathan Paul Mochel

  86. A Preclinical Model of Obesity-Independent Metabolic Syndrome for Studying the Effects of Novel Antidiabetic Therapy Beyond Glycemic Control

    Article • November 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  87. Exploring the Potential Links Between Gut Bacteria-Related Metabolites and the Risk of Cardiovascular Diseases

    Article • November 2023, MDPI AG

    Jonathan Paul Mochel

  88. Role of the tumour microenvironment in bladder cancer pathogenesis and value of the reverse translational approach: a tale of two species

    Article • Clinical and Translational Discovery, September 2023, Wiley

    Jonathan Paul Mochel

  89. Effect of the Probiotic Bacillus subtilis DE-CA9TM on Fecal Scores, Serum Oxidative Stress Markers and Fecal and Serum Metabolome in Healthy Dogs

    Article • Veterinary Sciences, September 2023, MDPI AG

    Jonathan Paul Mochel

  90. Retrospective comparison of outcomes in septic peritonitis with or without closed-suction abdominal drainage in 115 dogs (2009–2019)

    Article • Veterinary and Animal Science, September 2023, Elsevier

    Jonathan Paul Mochel

  91. Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses

    Article • Frontiers in Veterinary Science, August 2023, Frontiers

    Jonathan Paul Mochel

  92. Gene Editing and Gene Therapy in Oncology

    Article • August 2023, CABI Publishing

    Jonathan Paul Mochel

  93. Echocardiographic caudal vena cava measurements in healthy cats and in cats with congestive heart failure and non-cardiac causes of cavitary effusions

    Article • Journal of Veterinary Cardiology, August 2023, Elsevier

    Jonathan Paul Mochel

  94. Blood product usage and factors associated with transfusions in cats with hemoperitoneum: 33 cases (2018–2022)

    Article • Frontiers in Veterinary Science, July 2023, Frontiers

    Jonathan Paul Mochel

  95. OrganoidChip facilitates hydrogel-free immobilization for fast and blur-free imaging of organoids

    Article • Scientific Reports, July 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  96. Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies

    Article • Veterinary Sciences, June 2023, MDPI AG

    Jonathan Paul Mochel

  97. Increased drug concentration and repeated eye drop administration as strategies to optimize topical drug delivery: A fluorophotometric study in healthy dogs

    Article • Veterinary Ophthalmology, June 2023, Wiley

    Jonathan Paul Mochel

  98. O62 | Population pharmacokinetics of sodium salicylate in chickens and turkeys – New insights into the drug's non‐linear elimination

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  99. O89 | A novel biologically relevant canine in vitro model for the study of intestinal inflammation

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  100. O59 | Breakthrough: A first‐in‐class virtual simulator for dose optimization of ACE inhibitors in veterinary cardiology

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  101. O60 | Comparison of intestinal barrier integrity in conventional 2D cell lines and canine duodenal enteroids

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  102. P51 | Evaluation of potential anti‐inflammatory and barrier‐enhancing effects of indoles on the canine duodenum using intestinal organoids

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  103. O90 | Lung organoids as a novel model to study the pathogenesis of swine respiratory diseases

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  104. O88 | Prediction of treatment response using canine urine‐derived bladder cancer organoids

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  105. O63 | Population pharmacokinetics and absolute oral bioavailability of lasalocid ionophore in laying hens

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2023, Wiley

    Jonathan Paul Mochel

  106. Concentrations of penicillin and gentamicin following intrauterine administration of two compounded formulations

    Article • Journal of Equine Veterinary Science, June 2023, Elsevier

    Jonathan Paul Mochel

  107. Leveraging Data from Spontaneous Animal Disease Models to Streamline Pharmaceutical Research: A Tale of Two Species

    Article • May 2023, MDPI AG

    Jonathan Paul Mochel

  108. Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs.

    Article • May 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  109. Sa1767 SYNBIOTIC-IGY THERAPY MODULATES THE MUCOSAL MICROBIOME AND INFLAMMATORY INDICES IN DOGS WITH CHRONIC INFLAMMATORY ENTEROPATHY: A RANDOMIZED, CONTROLLED PILOT TRIAL

    Article • Gastroenterology, May 2023, Elsevier

    Jonathan Paul Mochel

  110. Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study

    Article • Cells, April 2023, MDPI AG

    Jonathan Paul Mochel

  111. Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study

    Article • April 2023, MDPI AG

    Jonathan Paul Mochel

  112. Abstract 2509: Similar variant histology and immune cell infiltration in canine and human muscle-invasive bladder cancer

    Article • Cancer Research, April 2023, American Association for Cancer Research (AACR)

    Jonathan Paul Mochel

  113. Exploring the secrets of super-aging: a UK Biobank study on brain health and cognitive function

    Article • GeroScience, March 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  114. Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance

    Article • Frontiers in Veterinary Science, March 2023, Frontiers

    Jonathan Paul Mochel

  115. Pharmacokinetics of intramuscular maropitant in pigs (Sus scrofa domesticus)

    Article • Journal of Veterinary Pharmacology and Therapeutics, March 2023, Wiley

    Jonathan Paul Mochel

  116. Breakthrough: a first-in-class virtual simulator for dose optimization of ACE inhibitors in translational cardiovascular medicine

    Article • Scientific Reports, February 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  117. Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  118. Dose–response of benazepril on biomarkers of the classical and alternative pathways of the renin–angiotensin–aldosterone system in dogs

    Article • Scientific Reports, February 2023, Springer Science + Business Media

    Jonathan Paul Mochel

  119. Retrospective evaluation of the effect of inhalant anesthesia on complications and recurrence rates in feline urethral obstruction

    Article • Journal of Feline Medicine and Surgery, February 2023, SAGE Publications

    Jonathan Paul Mochel

  120. Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves

    Article • Frontiers in Veterinary Science, January 2023, Frontiers

    Jonathan Paul Mochel

  121. Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

    Article • Poultry Science, January 2023, Elsevier

    Jonathan Paul Mochel

  122. Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer Using Large Database Reveals Potential Benefits of Scheduling Optimization

    Article • January 2023, Elsevier

    Jonathan Paul Mochel

  123. Retrospective Comparison of Outcomes in Septic Peritonitis With or Without Closed-Suction Abdominal Drainage in 115 Dogs (2009-2019)

    Article • January 2023, Elsevier

    Jonathan Paul Mochel

  124. Synbiotic-IgY Therapy Modulates the Mucosal Microbiome and Inflammatory Indices in Dogs with Chronic Inflammatory Enteropathy: A Randomized, Double-Blind, Placebo-Controlled Study

    Article • Veterinary Sciences, December 2022, MDPI AG

    Jonathan Paul Mochel

  125. Pilot safety evaluation of doxorubicin chemotherapy combined with non-specific immunotherapy (Immunocidin®) for canine splenic hemangiosarcoma

    Article • PLOS One, December 2022, PLOS

    Jonathan Paul Mochel

  126. Comparison of the pharmacokinetics of continuous and intermittent infusions of ampicillin-sulbactam in dogs with septic peritonitis

    Article • American Journal of Veterinary Research, December 2022, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  127. Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Translational Cardiovascular Medicine

    Article • November 2022, Springer Science + Business Media

    Jonathan Paul Mochel

  128. Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Veterinary Cardiology

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  129. Linear external skeletal fixation applied in minimally invasive fashion for stabilization of nonarticular tibial fractures in dogs and cats

    Article • Veterinary Surgery, November 2022, Wiley

    Jonathan Paul Mochel

  130. Culture and characterization of canine and feline corneal epithelial organoids: A new tool for the study and treatment of corneal diseases

    Article • Frontiers in Veterinary Science, November 2022, Frontiers

    Jonathan Paul Mochel

  131. Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs

    Article • Journal of Veterinary Internal Medicine, October 2022, Wiley

    Jonathan Paul Mochel

  132. Kinetics and minimal inhibitory concentrations of ceftiofur in tear film following extended-release parenteral administration (Excede®) in dogs

    Article • Frontiers in Veterinary Science, September 2022, Frontiers

    Jonathan Paul Mochel

  133. Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study

    Article • GeroScience, September 2022, Springer Science + Business Media

    Jonathan Paul Mochel

  134. Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials

    Article • Clinical and Translational Medicine, September 2022, Wiley

    Jonathan Paul Mochel

  135. Dose-response of benazepril on biomarkers of the classical and alternative pathways of the renin-angiotensin-aldosterone system in dogs

    Article • July 2022, Research Square

    Jonathan Paul Mochel

  136. Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor

    Article • Cancers, July 2022, MDPI AG

    Jonathan Paul Mochel

  137. A Multi-Tissue Comparison and Molecular Characterization of Canine Organoids

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  138. Letter regarding “Gastrointestinal foreign bodies in pet pigs: 17 cases”

    Article • Journal of Veterinary Internal Medicine, July 2022, Wiley

    Jonathan Paul Mochel

  139. Evaluation of the Use of External Skeletal Fixation in Minimally Invasive Fashion for the Treatment of Non-articular Tibial Fractures

    Article • Veterinary and Comparative Orthopaedics and Traumatology, July 2022, Thieme Publishing Group

    Jonathan Paul Mochel

  140. Abstract 3092: Urine-derived urinary carcinoma organoids: A novel tool for providing new insights into human and canine bladder cancer treatment

    Article • Cancer Research, June 2022, American Association for Cancer Research (AACR)

    Jonathan Paul Mochel

  141. Retrospective Evaluation of Clinical Bleeding in Dogs With Anticoagulant Rodenticide Toxicity—A Multi-Center Evaluation of 62 Cases (2010–2020)

    Article • Frontiers in Veterinary Science, May 2022, Frontiers

    Jonathan Paul Mochel

  142. Pharmacokinetic Exposures Associated With Oral Administration of Sorafenib in Dogs With Spontaneous Tumors

    Article • Frontiers in Veterinary Science, May 2022, Frontiers

    Jonathan Paul Mochel

  143. Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study

    Article • Scientific Reports, May 2022, Springer Science + Business Media

    Jonathan Paul Mochel

  144. SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

    Article • April 2022, MDPI AG

    Jonathan Paul Mochel

  145. Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves

    Article • Scientific Reports, March 2022, Springer Science + Business Media

    Jonathan Paul Mochel

  146. Circulating renin‐angiotensin‐aldosterone system activity in cats with systemic hypertension or cardiomyopathy

    Article • Journal of Veterinary Internal Medicine, March 2022, Wiley

    Jonathan Paul Mochel

  147. Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

    Article • Journal of Visualized Experiments, March 2022, MyJove Corporation

    Jonathan Paul Mochel

  148. Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

    Article • Journal of Visualized Experiments, March 2022, MyJove Corporation

    Jonathan Paul Mochel

  149. Computed Tomographic Evaluation of Mid-thoracic Vertebral Corridors in Normal French Bulldogs

    Article • European Journal of Veterinary Medicine, February 2022, European Open Access Publishing (Europa Publishing)

    Jonathan Paul Mochel

  150. Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

    Article • Journal of Visualized Experiments, January 2022, MyJove Corporation

    Jonathan Paul Mochel

  151. Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

    Article • Journal of Visualized Experiments, January 2022, MyJove Corporation

    Jonathan Paul Mochel

  152. Differential Transcriptomic Profiles in Canine Intestinal Organoids Following Lipopolysaccharide Stimulation

    Article • January 2022, Research Square

    Jonathan Paul Mochel

  153. Suspected primary hyperreninism in a cat with malignant renal sarcoma and global renin‐angiotensin‐aldosterone system upregulation

    Article • Journal of Veterinary Internal Medicine, December 2021, Wiley

    Jonathan Paul Mochel

  154. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types

    Article • AJP Gastrointestinal and Liver Physiology, December 2021, American Physiological Society

    Jonathan Paul Mochel

  155. Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology

    Article • Frontiers in Medicine, November 2021, Frontiers

    Jonathan Paul Mochel

  156. Harnessing the Biology of Canine Intestinal Organoids to Heighten Understanding of Inflammatory Bowel Disease Pathogenesis and Accelerate Drug Discovery: A One Health Approach

    Article • Frontiers in Toxicology, November 2021, Frontiers

    Jonathan Paul Mochel

  157. Current diagnostics for chronic enteropathies in dogs

    Article • Veterinary Clinical Pathology, October 2021, Wiley

    Jonathan Paul Mochel

  158. Clinical efficacy of prebiotics and glycosaminoglycans versus placebo In dogs with food responsive enteropathy receiving a hydrolyzed diet: A pilot study

    Article • PLOS One, October 2021, PLOS

    Jonathan Paul Mochel

  159. 109 Diet-induced Clinical Responsiveness of Translational Dog Model for Human Western Diet (WD)-related Disease Research

    Article • Journal of Animal Science, October 2021, Oxford University Press (OUP)

    Jonathan Paul Mochel

  160. Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

    Article • Frontiers in Veterinary Science, September 2021, Frontiers

    Jonathan Paul Mochel

  161. Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni

    Article • PLOS One, August 2021, PLOS

    Jonathan Paul Mochel

  162. CULTURE AND MAINTENANCE OF URINE-DERIVED, 3-DIMENSIONAL CANINE TRANSITIONAL CELL CARCINOMA ORGANOIDS

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  163. Retrospective evaluation of a dose‐dependent effect of angiotensin‐converting enzyme inhibitors on long‐term outcome in dogs with cardiac disease

    Article • Journal of Veterinary Internal Medicine, August 2021, Wiley

    Jonathan Paul Mochel

  164. Computed tomography evaluation of proposed implant corridors in canine thoracic vertebrae

    Article • Veterinary Surgery, July 2021, Wiley

    Jonathan Paul Mochel

  165. Inflammation, negative affect, and amyloid burden in Alzheimer’s disease: Insights from the kynurenine pathway

    Article • Brain Behavior and Immunity, July 2021, Elsevier

    Jonathan Paul Mochel

  166. Focused ultrasound of the caudal vena cava in dogs with cavitary effusions or congestive heart failure: A prospective, observational study

    Article • PLOS One, May 2021, PLOS

    Jonathan Paul Mochel

  167. Corrigendum: Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle

    Article • Frontiers in Veterinary Science, May 2021, Frontiers

    Jonathan Paul Mochel

  168. Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

    Article • May 2021, MDPI AG

    Jonathan Paul Mochel

  169. Radiation exposure associated with percutaneous fluoroscopically guided lag screw fixation for sacroiliac luxation in dogs

    Article • Veterinary Surgery, May 2021, Wiley

    Jonathan Paul Mochel

  170. Short‐term outcomes of 59 dogs treated for ilial body fractures with locking or non‐locking plates

    Article • Veterinary Surgery, May 2021, Wiley

    Jonathan Paul Mochel

  171. Su124 HOMOLOGY DIRECTED REPAIR IN CANINE DUODENAL ENTEROIDS TO MIMIC THE WILD-TYPE P-GLYCOPROTEIN MUTATION

    Article • Gastroenterology, May 2021, Elsevier

    Jonathan Paul Mochel

  172. Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics

    Article • The AAPS Journal, April 2021, Springer Science + Business Media

    Jonathan Paul Mochel

  173. Clinical Efficacy of Prebiotics and Glycosaminoglycans versus Placebo In Dogs with Food Responsive Enteropathy Receiving a Hydrolyzed Diet: A Pilot Study

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  174. Effect of prazosin on feline recurrent urethral obstruction

    Article • Journal of Feline Medicine and Surgery, March 2021, SAGE Publications

    Jonathan Paul Mochel

  175. Presentation, Clinical Pathology Abnormalities, and Identification of Gastrointestinal Parasites in Camels (Camelus bactrianus and Camelus dromedarius) Presenting to Two North American Veterinary Teaching Hospitals. A Retrospective Study: 1980–2020

    Article • Frontiers in Veterinary Science, March 2021, Frontiers

    Jonathan Paul Mochel

  176. Influence of Schirmer strip wetness on volume absorbed, volume recovered, and total protein content in canine tears

    Article • Veterinary Ophthalmology, March 2021, Wiley

    Jonathan Paul Mochel

  177. A Multi-Institutional Retrospective Analysis of Toceranib Phosphate for Presumed or Confirmed Canine Aortic Body Chemodectomas

    Article • Frontiers in Veterinary Science, February 2021, Frontiers

    Jonathan Paul Mochel

  178. Letter to the editor regarding “Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial”

    Article • Journal of Veterinary Internal Medicine, January 2021, Wiley

    Jonathan Paul Mochel

  179. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure

    Article • Cancers, January 2021, MDPI AG

    Jonathan Paul Mochel

  180. Comprehensive Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  181. Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration

    Article • Frontiers in Veterinary Science, November 2020, Frontiers

    Jonathan Paul Mochel

  182. Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study

    Article • Journal of Alzheimer’s Disease, November 2020, IOS Press

    Jonathan Paul Mochel

  183. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure

    Article • November 2020, MDPI AG

    Jonathan Paul Mochel

  184. Genetics and Immunopathogenesis of Chronic Inflammatory Enteropathies in Dogs

    Article • Advances in Small Animal Care, November 2020, Elsevier

    Jonathan Paul Mochel

  185. Impact of diurnal variation, sex, tear collection method, and disease state on tear protein levels in dogs

    Article • Veterinary Ophthalmology, October 2020, Wiley

    Jonathan Paul Mochel

  186. Tear Film Pharmacokinetics and Systemic Absorption Following Topical Administration of 1% Prednisolone Acetate Ophthalmic Suspension in Dogs

    Article • Frontiers in Veterinary Science, October 2020, Frontiers

    Jonathan Paul Mochel

  187. Pharmacokinetics of Oral Prednisone at Various Doses in Dogs: Preliminary Findings Using a Naïve Pooled-Data Approach

    Article • Frontiers in Veterinary Science, October 2020, Frontiers

    Jonathan Paul Mochel

  188. Considerations in the extrapolation of drug toxicity between humans and dogs

    Article • Current Opinion in Toxicology, October 2020, Elsevier

    Jonathan Paul Mochel

  189. Evaluation of a Pasteurella multocida Respiratory Disease Induction Model for Goats (Capra aegagrus hircus)

    Article • Comparative Medicine, October 2020, American Association for Laboratory Animal Science

    Jonathan Paul Mochel

  190. Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats

    Article • Frontiers in Veterinary Science, September 2020, Frontiers

    Jonathan Paul Mochel

  191. Determination of the milk pharmacokinetics and depletion of milk residues following intramammary administration of cephapirin sodium in lactating dairy goats

    Article • American Association of Bovine Practitioners Conference Proceedings, September 2020, Texas A&M University Libraries

    Jonathan Paul Mochel

  192. Serum albumin and total protein concentration in the tear film of horses with healthy or diseased eyes

    Article • Veterinary Ophthalmology, September 2020, Wiley

    Jonathan Paul Mochel

  193. Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle

    Article • Frontiers in Veterinary Science, September 2020, Frontiers

    Jonathan Paul Mochel

  194. Pharmacokinetics of Intravenous, Intramuscular, Oral, and Transdermal Administration of Flunixin Meglumine in Pre-wean Piglets

    Article • Frontiers in Veterinary Science, August 2020, Frontiers

    Jonathan Paul Mochel

  195. Neuroinflammation, Depressive Affect, and Amyloid Burden in Alzheimer’s Disease: Insights from the Kynurenine Pathway

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  196. Effects of the estrous cycle and pregnancy status on cardiovascular variables in healthy bitches

    Article • Journal of Veterinary Cardiology, August 2020, Elsevier

    Jonathan Paul Mochel

  197. An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

    Article • Medicinal Research Reviews, July 2020, Wiley

    Jonathan Paul Mochel

  198. Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease

    Article • Frontiers in Veterinary Science, July 2020, Frontiers

    Jonathan Paul Mochel

  199. Impact of acute conjunctivitis on ocular surface homeostasis in dogs

    Article • Veterinary Ophthalmology, July 2020, Wiley

    Jonathan Paul Mochel

  200. Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat—A UK Biobank Study

    Article • Obesity, June 2020, Wiley

    Colleen Pappas, Jonathan Paul Mochel

  201. An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface

    Article • May 2020, MDPI AG

    Jonathan Paul Mochel

  202. Sa1976 POLYPHENOLS REVERSE THE PATHOLOGIC EFFECTS OF PALMITIC ACID AND HIGH FAT DIET IN CANINE ENTEROIDS

    Article • Gastroenterology, May 2020, Elsevier

    Jonathan Paul Mochel

  203. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions

    Article • PLOS One, April 2020, PLOS

    Jonathan Paul Mochel

  204. Evaluation of dose-response effects of short-term oral prednisone administration on clinicopathologic and hemodynamic variables in healthy dogs

    Article • American Journal of Veterinary Research, April 2020, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  205. Harnessing The Biology of Intestinal Organoids To Accelerate Drug Discovery in Inflammatory Bowel Disease: A One Health Approach

    Article • The FASEB Journal, April 2020, Wiley

    Jonathan Paul Mochel

  206. Serum Vitamin B12, and Related MTRR and Cubilin Genotypes, Predict Neural Outcomes across the AD Spectrum

    Article • British Journal Of Nutrition, March 2020, Cambridge University Press

    Jonathan Paul Mochel

  207. A Retrospective Clinical Investigation of the Safety and Adverse Effects of Pantoprazole in Hospitalized Ruminants

    Article • Frontiers in Veterinary Science, March 2020, Frontiers

    Jonathan Paul Mochel

  208. Investigation of Schirmer tear test-1 for measurement of tear production in cats in various environmental settings and with different test durations

    Article • Journal of the American Veterinary Medical Association, March 2020, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  209. Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

    Article • PLoS Computational Biology, February 2020, PLOS

    Jonathan Paul Mochel

  210. Apparent total tract digestibility, fecal characteristics, and blood parameters of healthy adult dogs fed high-fat diets

    Article • Journal of Animal Science, February 2020, Oxford University Press (OUP)

    Jonathan Paul Mochel

  211. Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs

    Article • Frontiers in Pharmacology, January 2020, Frontiers

    Jonathan Paul Mochel

  212. CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, January 2020, Wiley

    Colleen Pappas, Jonathan Paul Mochel

  213. Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease

    Article • PLOS One, December 2019, PLOS

    Jonathan Paul Mochel

  214. Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter?

    Article • Frontiers in Veterinary Science, December 2019, Frontiers

    Jonathan Paul Mochel

  215. Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os

    Article • Veterinary Ophthalmology, November 2019, Wiley

    Jonathan Paul Mochel

  216. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs

    Article • Frontiers in Veterinary Science, November 2019, Frontiers

    Jonathan Paul Mochel

  217. Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study

    Article • Brain Behavior and Immunity, November 2019, Elsevier

    Jonathan Paul Mochel

  218. Re: “Evaluation of Enrofloxacin for Use in Cryopreservation of Zebu Bull (Bos indicus) Semen” by Ishaq et al. (Biopreserv Biobank 2019;[Epub ahead of print]; DOI: 10.1089/bio.2018.0133)

    Article • Biopreservation and Biobanking, November 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  219. Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs

    Article • Frontiers in Veterinary Science, October 2019, Frontiers

    Jonathan Paul Mochel

  220. Comparative pharmacokinetics of meloxicam between healthy postpartum versus mid-lactation dairy cows

    Article • American Association of Bovine Practitioners Conference Proceedings, September 2019, Texas A&M University Libraries

    Jonathan Paul Mochel

  221. Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats

    Article • Journal of Ocular Pharmacology and Therapeutics, August 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  222. Clinicopathologic, hemodynamic, and echocardiographic effects of short-term oral administration of anti-inflammatory doses of prednisolone to systemically normal cats

    Article • American Journal of Veterinary Research, August 2019, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  223. Nonlinear mixed‐effects pharmacokinetic modeling of the novel COX‐2 selective inhibitor vitacoxib in dogs

    Article • Journal of Veterinary Pharmacology and Therapeutics, August 2019, Wiley

    Jonathan Paul Mochel

  224. Pharmacokinetic Modeling of Ceftiofur Sodium Using Nonlinear Mixed-Effects in Healthy Beagle Dogs

    Article • July 2019, MDPI AG

    Jonathan Paul Mochel

  225. Histamine-Induced Conjunctivitis and Breakdown of Blood–Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics

    Article • Frontiers in Pharmacology, July 2019, Frontiers

    Jonathan Paul Mochel

  226. Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs

    Article • Frontiers in Veterinary Science, June 2019, Frontiers

    Jonathan Paul Mochel

  227. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

    Article • Frontiers in Aging Neuroscience, June 2019, Frontiers

    Jonathan Paul Mochel

  228. A reduced Gompertz model for predicting tumor age using a population approach

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  229. Effects of experimentally induced respiratory disease on the pharmacokinetics and tissue residues of tulathromycin in meat goats

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2019, Wiley

    Jonathan Paul Mochel

  230. Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy

    Article • PLOS One, June 2019, PLOS

    Jonathan Paul Mochel, Edward Hall

  231. Interleukin‐13 and interleukin‐33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy

    Article • Journal of Veterinary Internal Medicine, June 2019, Wiley

    Jonathan Paul Mochel, Edward Hall

  232. Paper spray high-resolution accurate mass spectrometry for quantitation of voriconazole in equine tears

    Article • Fresenius Journal of Analytical Chemistry, May 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  233. Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis

    Article • Journal of Ocular Pharmacology and Therapeutics, May 2019, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  234. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer

    Article • CPT Pharmacometrics & Systems Pharmacology, May 2019, Wiley

    Jonathan Paul Mochel

  235. 449 – High Fat Ketogenic Diet Decreases Serum Lipid Metabolites in Healthy Dogs

    Article • Gastroenterology, May 2019, Elsevier

    Jonathan Paul Mochel

  236. Sa1098 – Molecular Response of Canine Intestinal Organoids to Gastrointestinal Nematode Extracellular Vesicles

    Article • Gastroenterology, May 2019, Elsevier

    Jonathan Paul Mochel

  237. Su1812 – Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Improves Abnormalities in Lipid Metabolism in a Canine Model of Inflammatory Bowel Disease

    Article • Gastroenterology, May 2019, Elsevier

    Jonathan Paul Mochel

  238. Su2043 – A Novel Canine Intestinal Organoid Model to Characterize Dose-Exposure-Response of Chemotherapeutic Drugs

    Article • Gastroenterology, May 2019, Elsevier

    Jonathan Paul Mochel

  239. Derivation of adult canine intestinal organoids for translational research in gastroenterology

    Article • BMC Biology, April 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  240. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

    Article • The AAPS Journal, April 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  241. A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions

    Article • March 2019, MDPI AG

    Jonathan Paul Mochel

  242. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  243. Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation

    Article • European Journal of Pharmaceutical Sciences, February 2019, Elsevier

    Jonathan Paul Mochel

  244. The Role of the Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

    Article • January 2019, MDPI AG

    Jonathan Paul Mochel

  245. Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection

    Article • Comparative Medicine, January 2019, American Association for Laboratory Animal Science

    Jonathan Paul Mochel

  246. Workshop Report: USP Workshop on Exploring the Science of Drug Absorption

    Article • Dissolution Technologies, January 2019, Dissolution Technologies

    Jonathan Paul Mochel

  247. Population Modeling of Tumor Growth Curves, the Reduced Gompertz Model and Prediction of the Age of a Tumor

    Article • January 2019, Springer Science + Business Media

    Jonathan Paul Mochel

  248. Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease

    Article • Veterinary Pathology, December 2018, SAGE Publications

    Jonathan Paul Mochel

  249. CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds against Hematological Malignancies

    Article • November 2018, MDPI AG

    Jonathan Paul Mochel

  250. Relative Oral Bioavailability of Two Amoxicillin–Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study

    Article • Journal of the American Animal Hospital Association, November 2018, American Animal Hospital Association

    Jonathan Paul Mochel

  251. Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)

    Article • Journal of Feline Medicine and Surgery, November 2018, SAGE Publications

    Jonathan Paul Mochel

  252. Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  253. Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs

    Article • Journal of Veterinary Internal Medicine, October 2018, Wiley

    Jonathan Paul Mochel

  254. Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Jonathan Paul Mochel

  255. Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis

    Article • Journal of Veterinary Pharmacology and Therapeutics, July 2018, Wiley

    Jonathan Paul Mochel

  256. Adverse reactions to fentanyl transdermal patches in calves: a preliminary clinical and pharmacokinetic study

    Article • Veterinary Anaesthesia and Analgesia, July 2018, Elsevier

    Jonathan Paul Mochel

  257. Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats

    Article • Journal of Ocular Pharmacology and Therapeutics, July 2018, Mary Ann Liebert Inc

    Jonathan Paul Mochel

  258. Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2018, Wiley

    Marilyn Martinez, Jonathan Paul Mochel

  259. Mo1059 - Comparison of Endoscopically (Egd/Colo) Procured Enteroids and Colonoids from Normal Dogs and Dogs with Naturally Occurring Chronic Enteropathies (IBD)

    Article • Gastroenterology, May 2018, Elsevier

    Jonathan Paul Mochel

  260. Effects of short-term anti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs

    Article • American Journal of Veterinary Research, April 2018, American Veterinary Medical Association (AVMA)

    Jonathan Paul Mochel

  261. Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation

    Article • Journal of Veterinary Pharmacology and Therapeutics, March 2018, Wiley

    Jonathan Paul Mochel

  262. Effect of tear collection on lacrimal total protein content in dogs and cats: a comparison between Schirmer strips and ophthalmic sponges

    Article • BMC Veterinary Research, March 2018, Springer Science + Business Media

    Jonathan Paul Mochel

  263. Comparison of milk and plasma pharmacokinetics of meloxicam in postpartum versus mid-lactation Holstein cows

    Article • Journal of Veterinary Pharmacology and Therapeutics, February 2018, Wiley

    Jonathan Paul Mochel

  264. Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences

    Article • Journal of Veterinary Pharmacology and Therapeutics, December 2017, Wiley

    Jonathan Paul Mochel

  265. Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

    Article • The AAPS Journal, December 2017, American Association of Pharmaceutical Scientists (AAPS)

    Jonathan Paul Mochel

  266. Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics

    Article • Journal of Veterinary Pharmacology and Therapeutics, December 2017, Wiley

    Marilyn Martinez, Jonathan Paul Mochel

  267. Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

    Article • CPT Pharmacometrics & Systems Pharmacology, November 2017, Wiley

    Iñaki F. Troconiz, Jonathan Paul Mochel

  268. Pharmacokinetics and adverse reactions to fentanyl transdermal patches in healthy and hospitalized calves

    Article • American Association of Bovine Practitioners Conference Proceedings, September 2017, Texas A&M University Libraries

    Jonathan Paul Mochel

  269. Tear fluid collection in dogs and cats using ophthalmic sponges

    Article • Veterinary Ophthalmology, August 2017, Wiley

    Jonathan Paul Mochel

  270. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats

    Article • CPT Pharmacometrics & Systems Pharmacology, October 2016, Wiley

    Jonathan Paul Mochel

  271. Position Paper: EUFEPS Network on Veterinary Medicines Initiative

    Article • European Journal of Pharmaceutical Sciences, August 2016, Elsevier

    Jonathan Paul Mochel

  272. Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2016, Wiley

    Dr Bruno Bieth, Jonathan Paul Mochel

  273. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment

    Article • Journal of Veterinary Pharmacology and Therapeutics, April 2016, Wiley

    Jonathan Paul Mochel

  274. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics

    Article • Journal of Veterinary Pharmacology and Therapeutics, November 2015, Wiley

    Jonathan Paul Mochel

  275. Chronobiology and Pharmacologic Modulation of the Renin–Angiotensin–Aldosterone System in Dogs: What Have We Learned?

    Article • January 2015, Springer Science + Business Media

    Jonathan Paul Mochel

  276. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs

    Article • Pharmaceutical Research, December 2014, Springer Science + Business Media

    Jonathan Paul Mochel

  277. FIRST-IN-CLASS ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR LCZ696 MODULATES THE DYNAMICS OF THE RENIN CASCADE AND NATRIURETIC PEPTIDES SYSTEM WITH SIGNIFICANT REDUCTION OF ALDOSTERONE EXPOSURE

    Article • Journal of the American College of Cardiology, April 2014, Elsevier

    Jonathan Paul Mochel

  278. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs

    Article • Chronobiology International, March 2014, Taylor & Francis

    Jonathan Paul Mochel

  279. Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis

    Article • Research in Veterinary Science, October 2013, Elsevier

    Jonathan Paul Mochel

  280. Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology

    Article • Chronobiology International, August 2013, Taylor & Francis

    Jonathan Paul Mochel

  281. Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2013, Wiley

    Jonathan Paul Mochel

  282. Response to letter from Atkinset al. Capturing the dynamics of systemic Renin‐Angiotensin‐Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs

    Article • Journal of Veterinary Pharmacology and Therapeutics, September 2012, Wiley

    Jonathan Paul Mochel

  283. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs

    Article • Journal of Veterinary Pharmacology and Therapeutics, May 2012, Wiley

    Jonathan Paul Mochel

  284. Pharmacokinetics of extravascular maropitant citrate in swine

    Article • American Association of Swine Veterinarians

    Jonathan Paul Mochel