All Stories

  1. Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

    Article • March 2026, openRxiv

    Professor Russell C Rockne

  2. Computational codes from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  3. Supplementary Figure S.1 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  4. Supplementary Figure S.10 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  5. Supplementary Figure S.11 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  6. Supplementary Figure S.12 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  7. Supplementary Figure S.13 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  8. Supplementary Figure S.14 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  9. Supplementary Figure S.15 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  10. Supplementary Figure S.16 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  11. Supplementary Figure S.17 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  12. Supplementary Figure S.18 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  13. Supplementary Figure S.19 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  14. Supplementary Figure S.2 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  15. Supplementary Figure S.20 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  16. Supplementary Figure S.21 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  17. Supplementary Figure S.22 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  18. Supplementary Figure S.23 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  19. Supplementary Figure S.24 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  20. Supplementary Figure S.25 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  21. Supplementary Figure S.26 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  22. Supplementary Figure S.27 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  23. Supplementary Figure S.28 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  24. Supplementary Figure S.29 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  25. Supplementary Figure S.3 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  26. Supplementary Figure S.30 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  27. Supplementary Figure S.31 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  28. Supplementary Figure S.32 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  29. Supplementary Figure S.4 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  30. Supplementary Figure S.5 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  31. Supplementary Figure S.6 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  32. Supplementary Figure S.7 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  33. Supplementary Figure S.8 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  34. Supplementary Figure S.9 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  35. Supplementary Material from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • March 2026, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  36. The future of mathematical oncology in the age of AI

    Article • npj Systems Biology and Applications, January 2026, Springer Science + Business Media

    Professor Russell C Rockne

  37. Mathematical modeling of combinatorial antigen targeting with multiple CAR T-cell products for glioblastoma treatment

    Article • npj Systems Biology and Applications, January 2026, Springer Science + Business Media

    Professor Russell C Rockne

  38. CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma

    Article • Mathematical Biosciences, November 2025, Elsevier

    Professor Russell C Rockne

  39. Single‐Cell Analysis of L‐Myc Expressing Neural Stem Cells and Their Extracellular Vesicles Revealed Distinct Progenitor Populations With Neurogenic Potential

    Article • Journal of Extracellular Biology, November 2025, Wiley

    Professor Russell C Rockne

  40. Ligand discrimination in immune cells: Signal processing insights into immune dysfunction in ER+ breast cancer

    Article • PLoS Computational Biology, October 2025, PLOS

    Professor Russell C Rockne

  41. A Roadmap for the Future of Systems Biology in Cancer Research

    Article • Cancer Research, October 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne, Jonathan Paul Mochel

  42. Interstitial fluid transport dynamics predict glioblastoma invasion and progression

    Article • npj Biomedical Innovations, September 2025, Springer Science + Business Media

    Professor Russell C Rockne

  43. Study of combination CAR T-cell treatment for glioblastoma using mathematical modeling

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  44. Use of AlphaFold 2 to predict stabilizing mutations for the R337H variant in the tetramerization domain of TP53.

    Article • Journal of Clinical Oncology, June 2025, American Society of Clinical Oncology (ASCO)

    Professor Russell C Rockne

  45. Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  46. Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  47. Computational codes from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • April 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  48. Supplementary Material from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • April 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  49. Figure 4 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • April 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  50. Data from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • April 2025, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  51. Interstitial fluid transport dynamics predict glioblastoma invasion and progression

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  52. Ligand Discrimination in Immune Cells: Signal Processing Insights into Immune Dysfunction in ER+ Breast Cancer

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  53. Mathematical Modeling of Neural Stem Cell Migration within Brain using Multi-Fiber Tractography

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  54. Modeling cerebral developmentin vitrowith L-MYC-immortalized human neural stem cell-derived organoids

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  55. Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells

    Article • Journal of Hematology & Oncology, February 2025, Springer Science + Business Media

    Professor Russell C Rockne

  56. miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape

    Article • Nature Communications, February 2025, Springer Science + Business Media

    Professor Russell C Rockne

  57. CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma

    Article • January 2025, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  58. Validation of Clinical Dynamic Contrast-Enhanced Magnetic Resonance Imaging Perfusion Modeling and Neoadjuvant Chemotherapy Response Prediction in Breast Cancer Using 18 FDG and 64 C...

    Article • JCO Clinical Cancer Informatics, January 2025, American Society of Clinical Oncology (ASCO)

    Professor Russell C Rockne

  59. Supplementary Figure S.32 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  60. Supplementary Material from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  61. Supplementary Figure S.9 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  62. Supplementary Figure S.31 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  63. Supplementary Figure S.30 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  64. Supplementary Figure S.20 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  65. Supplementary Figure S.14 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  66. Supplementary Figure S.13 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  67. Figure 3 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  68. Supplementary Figure S.8 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  69. Figure 2 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  70. Supplementary Figure S.26 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  71. Supplementary Figure S.7 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  72. Supplementary Figure S.2 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  73. Supplementary Figure S.19 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  74. Supplementary Figure S.12 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  75. Supplementary Figure S.25 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  76. Supplementary Figure S.24 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  77. Supplementary Figure S.18 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  78. Supplementary Figure S.6 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  79. Figure 1 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  80. Supplementary Figure S.11 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  81. Supplementary Figure S.10 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  82. Supplementary Figure S.5 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  83. Computational codes from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  84. Supplementary Figure S.4 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  85. Supplementary Figure S.23 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  86. Supplementary Figure S.17 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  87. Supplementary Figure S.16 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  88. Supplementary Figure S.3 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  89. Supplementary Figure S.1 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  90. Table 1 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  91. Supplementary Figure S.29 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  92. Figure 5 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  93. Supplementary Figure S.22 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  94. Supplementary Figure S.21 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  95. Supplementary Figure S.15 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  96. Supplementary Figure S.28 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  97. Supplementary Figure S.27 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  98. CNSC-54. CENTRAL AND BOUNDARY-DRIVEN GROWTH PATTERNS DOMINATE RESPECTIVELY IDH WILD-TYPE AND MUTANT GLIOMAS

    Article • Neuro-Oncology, November 2024, Oxford University Press (OUP)

    Professor Russell C Rockne

  99. Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • Cancer Research Communications, November 2024, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  100. Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients’ blood

    Article • npj Systems Biology and Applications, October 2024, Springer Science + Business Media

    Professor Russell C Rockne

  101. Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens

    Article • Clinical and Translational Science, August 2024, Wiley

    Professor Russell C Rockne

  102. Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  103. Structural and practical identifiability of contrast transport models for DCE-MRI

    Article • PLoS Computational Biology, May 2024, PLOS

    Professor Russell C Rockne

  104. Model discovery approach enables noninvasive measurement of intra-tumoral fluid transport in dynamic MRI

    Article • APL Bioengineering, April 2024, American Institute of Physics

    Professor Russell C Rockne

  105. Transcriptome free energy can serve as a dynamic patient-specific biomarker in acute myeloid leukemia

    Article • npj Systems Biology and Applications, March 2024, Springer Science + Business Media

    Professor Russell C Rockne

  106. Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial

    Article • Nature Reports Stem Cells, March 2024, Springer Science + Business Media

    Professor Russell C Rockne

  107. Targeting Wnt signaling for improved glioma immunotherapy

    Article • Frontiers in Immunology, February 2024, Frontiers

    Professor Russell C Rockne

  108. A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens

    Article • Nature Structural & Molecular Biology, February 2024, Springer Science + Business Media

    Professor Russell C Rockne

  109. State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia

    Article • Leukemia, February 2024, Springer Science + Business Media

    Professor Russell C Rockne

  110. Structural and practical identifiability of contrast transport models for DCE-MRI

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  111. Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients’ blood

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  112. Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury

    Article • Scientific Reports, October 2023, Springer Science + Business Media

    Professor Russell C Rockne

  113. State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  114. Enhancing Brain Flow Visualization with Automated 3D Data Processing: A Study on DCE-MRI Data from Mice with Tumors.

    Article • October 2023, ACM (Association for Computing Machinery)

    Professor Russell C Rockne

  115. Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis

    Article • Nature Communications, September 2023, Springer Science + Business Media

    Professor Russell C Rockne

  116. Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression

    Article • Annals of Clinical and Translational Neurology, August 2023, Wiley

    Professor Russell C Rockne

  117. Model discovery approach enables non-invasive measurement of intra-tumoral fluid transport in dynamic MRI

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  118. Differential Distribution of Brain Metastases from Non-Small Cell Lung Cancer Based on Mutation Status

    Article • Brain Sciences, July 2023, MDPI AG

    Professor Russell C Rockne

  119. Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma

    Article • Medical Oncology, May 2023, Springer Science + Business Media

    Professor Russell C Rockne

  120. Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

    Article • Frontiers in Immunology, May 2023, Frontiers

    Professor Russell C Rockne

  121. Supplementary Methods from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  122. Data from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  123. Supplementary Data Figures S1-S14 from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  124. Supplementary Data Tables S1-S15 from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  125. Data from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  126. Supplementary Data Figures S1-S14 from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  127. Supplementary Data Tables S1-S15 from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  128. Supplementary Methods from State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • March 2023, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  129. Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

    Article • ImmunoInformatics, March 2023, Elsevier

    Professor Russell C Rockne

  130. Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design

    Article • iScience, February 2023, Elsevier

    Professor Russell C Rockne

  131. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Professor Russell C Rockne

  132. Cancer Genomics and Evolution

    Article • October 2022, Wiley

    Professor Russell C Rockne

  133. Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  134. Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma

    Article • Neoplasia, August 2022, Elsevier

    Professor Russell C Rockne

  135. Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

    Article • Nature Communications, April 2022, Springer Science + Business Media

    Professor Russell C Rockne

  136. Dynamic patterns of microRNA expression during acute myeloid leukemia state-transition

    Article • Science Advances, April 2022, American Association for the Advancement of Science

    Professor Russell C Rockne

  137. Roadmap on plasticity and epigenetics in cancer

    Article • Physical Biology, April 2022, Institute of Physics Publishing

    Professor Russell C Rockne

  138. MicroRNA networks in FLT3-ITD acute myeloid leukemia

    Article • Proceedings of the National Academy of Sciences, April 2022, Proceedings of the National Academy of Sciences

    Professor Russell C Rockne

  139. Editorial: Advances in Mathematical and Computational Oncology

    Article • Frontiers in Physiology, April 2022, Frontiers

    Professor Russell C Rockne

  140. Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

    Article • PLoS Computational Biology, January 2022, PLOS

    Professor Russell C Rockne

  141. Mathematical modeling of therapeutic neural stem cell migration in mouse brain with and without brain tumors

    Article • Mathematical Biosciences and Engineering, January 2022, American Institute of Mathematical Sciences (AIMS)

    Professor Russell C Rockne

  142. Comparison of cell state models derived from single-cell RNA sequencing data: graph versus multi-dimensional space

    Article • Mathematical Biosciences and Engineering, January 2022, American Institute of Mathematical Sciences (AIMS)

    Professor Russell C Rockne

  143. Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers

    Article • Drug Delivery and Translational Research, October 2021, Springer Science + Business Media

    Professor Russell C Rockne

  144. Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Professor Russell C Rockne

  145. A Mathematical Modeling Approach for Targeted Radionuclide and Chimeric Antigen Receptor T Cell Combination Therapy

    Article • Cancers, October 2021, MDPI AG

    Professor Russell C Rockne

  146. Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  147. A Mathematical Modeling Approach for Targeted Radionuclide and Chimeric Antigen Receptor-T Cell Combination Therapy

    Article • September 2021, MDPI AG

    Professor Russell C Rockne

  148. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML

    Article • Journal of Hematology & Oncology, August 2021, Springer Science + Business Media

    Professor Russell C Rockne

  149. Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning

    Article • Stem Cells International, May 2021, Wiley

    Professor Russell C Rockne

  150. Effect of chemotherapy on default mode network connectivity in older women with breast cancer

    Article • Brain Imaging and Behavior, May 2021, Springer Science + Business Media

    Professor Russell C Rockne

  151. Concepts and Applications of Information Theory to Immuno-Oncology

    Article • Trends in Cancer, April 2021, Elsevier

    Professor Russell C Rockne

  152. Predicting Survival Duration With MRI Radiomics of Brain Metastases From Non-small Cell Lung Cancer

    Article • Frontiers in Oncology, March 2021, Frontiers

    Professor Russell C Rockne

  153. State-Transition Analysis of Time-Sequential microRNA Expression Predicts Development of Acute Myeloid Leukemia

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  154. Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Professor Russell C Rockne

  155. Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia

    Article • Leukemia, February 2021, Springer Science + Business Media

    Professor Russell C Rockne

  156. RAMP2-AS1 Regulates Endothelial Homeostasis and Aging

    Article • Frontiers in Cell and Developmental Biology, February 2021, Frontiers

    Professor Russell C Rockne

  157. Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients

    Article • Pharmaceutics, February 2021, MDPI AG

    Professor Russell C Rockne

  158. Repeatability of tumor perfusion kinetics from dynamic contrast-enhanced MRI in glioblastoma

    Article • Neuro-Oncology Advances, January 2021, Oxford University Press (OUP)

    Professor Russell C Rockne

  159. Interstitial Fluid Flow and Transport in Glioblastoma and Surrounding Parenchyma in Patients

    Article • December 2020, MDPI AG

    Professor Russell C Rockne

  160. Towards integration of 64Cu-DOTA-trastuzumab PET-CT and MRI with mathematical modeling to predict response to neoadjuvant therapy in HER2 + breast cancer

    Article • Scientific Reports, November 2020, Springer Science + Business Media

    Professor Russell C Rockne

  161. Comparison of CD38-Targeted α- Versus β-Radionuclide Therapy of Disseminated Multiple Myeloma in an Animal Model

    Article • Journal of Nuclear Medicine, October 2020, Society of Nuclear Medicine

    Professor Russell C Rockne

  162. Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64–labeled daratumumab

    Article • Blood Advances, October 2020, American Society of Hematology

    Professor Russell C Rockne

  163. The Histone Chaperone CAF-1 Sustains Myeloid Lineage Identity

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  164. Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies

    Article • WIREs Mechanisms of Disease, October 2020, Wiley

    Victoria Seewaldt, Professor Russell C Rockne

  165. State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia

    Article • Cancer Research, August 2020, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  166. TAG-72–Targeted α-Radionuclide Therapy of Ovarian Cancer Using 225Ac-Labeled DOTAylated-huCC49 Antibody

    Article • Journal of Nuclear Medicine, July 2020, Society of Nuclear Medicine

    Professor Russell C Rockne

  167. Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  168. Radiomic prediction of mutation status based on MR imaging of lung cancer brain metastases

    Article • Magnetic Resonance Imaging, June 2020, Elsevier

    Professor Russell C Rockne

  169. Differentiating Peripherally-Located Small Cell Lung Cancer From Non-small Cell Lung Cancer Using a CT Radiomic Approach

    Article • Frontiers in Oncology, April 2020, Frontiers

    Professor Russell C Rockne

  170. P855 High-resolution maps of heterogeneous antigen expression in glioblastoma and implications for immunotherapy

    Article • April 2020, BMJ

    Professor Russell C Rockne

  171. Circulating tumor DNA as an early cancer detection tool

    Article • Pharmacology & Therapeutics, March 2020, Elsevier

    Professor Russell C Rockne

  172. From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response

    Article • PLoS Computational Biology, February 2020, PLOS

    Alexander Anderson, Jill Gallaher, Professor Russell C Rockne

  173. Synthetic Apparent Diffusion Coefficient for High b-Value Diffusion-Weighted MRI in Prostate

    Article • Prostate Cancer, February 2020, Wiley

    Professor Russell C Rockne

  174. Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

    Article • Journal of The Royal Society Interface, January 2020, Royal Society Publishing

    Professor Russell C Rockne

  175. Introduction to Mathematical Oncology

    Article • JCO Clinical Cancer Informatics, December 2019, American Society of Clinical Oncology (ASCO)

    Professor Russell C Rockne

  176. Glioblastoma Recurrence and the Role of O6-Methylguanine–DNA Methyltransferase Promoter Methylation

    Article • JCO Clinical Cancer Informatics, December 2019, American Society of Clinical Oncology (ASCO)

    Professor Russell C Rockne

  177. Change in Apparent Diffusion Coefficient Is Associated With Local Failure After Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer: A Prospective Clinical Trial

    Article • International Journal of Radiation Oncology*Biology*Physics, November 2019, Elsevier

    Professor Russell C Rockne

  178. Synthetic apparent diffusion coefficient for high b-value diffusion weighted MRI in Prostate

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  179. Mathematical modeling with single-cell sequencing data

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  180. The 2019 mathematical oncology roadmap

    Article • Physical Biology, June 2019, Institute of Physics Publishing

    Professor Russell C Rockne

  181. Improved model prediction of glioma growth utilizing tissue-specific boundary effects

    Article • Mathematical Biosciences, June 2019, Elsevier

    Professor Paul E Kinahan, Professor Russell C Rockne

  182. From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  183. Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study

    Article • Breast Cancer Research and Treatment, April 2019, Springer Science + Business Media

    Professor Russell C Rockne

  184. Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma

    Article • Frontiers in Oncology, February 2019, Frontiers

    Professor Russell C Rockne

  185. Premature Aging in Young Cancer Survivors

    Article • JNCI Journal of the National Cancer Institute, February 2019, Oxford University Press (OUP)

    Professor Russell C Rockne

  186. New Developments on Computational Methods and Imaging in Biomechanics and Biomedical Engineering

    Article • January 2019, Springer Science + Business Media

    Professor Russell C Rockne

  187. Towards Model-Based Characterization of Biomechanical Tumor Growth Phenotypes

    Article • January 2019, Springer Science + Business Media

    Professor Russell C Rockne

  188. Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: A pilot MRI study

    Article • Magnetic Resonance Imaging, December 2018, Elsevier

    Professor Russell C Rockne

  189. Distinct Phenotypic Clusters of Glioblastoma Growth and Response Kinetics Predict Survival

    Article • JCO Clinical Cancer Informatics, December 2018, American Society of Clinical Oncology (ASCO)

    Professor Russell C Rockne

  190. Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer

    Article • Breast Cancer Research and Treatment, August 2018, Springer Science + Business Media

    Professor Russell C Rockne

  191. Long-term stability and computational analysis of migration patterns of L-MYC immortalized neural stem cells in the brain

    Article • PLOS One, August 2018, PLOS

    Professor Russell C Rockne

  192. MRI analysis to map interstitial flow in the brain tumor microenvironment

    Article • APL Bioengineering, June 2018, American Institute of Physics

    Professor Russell C Rockne

  193. Modelling acute myeloid leukaemia in a continuum of differentiation states

    Article • Letters in Biomathematics, June 2018, Taylor & Francis

    Professor Russell C Rockne

  194. Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study

    Article • Breast Cancer Research, May 2018, Springer Science + Business Media

    Professor Russell C Rockne

  195. Comparative dynamics of microglial and glioma cell motility at the infiltrative margin of brain tumours

    Article • Journal of The Royal Society Interface, February 2018, Royal Society Publishing

    Professor Russell C Rockne

  196. Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival

    Article • Stem Cells International, January 2018, Hindawi Publishing Corporation

    Professor Russell C Rockne

  197. State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Leukemia Development

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  198. Aging in a relativistic biological space-time

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  199. Tumor Uptake of 64Cu-DOTA-Trastuzumab in Patients with Metastatic Breast Cancer

    Article • Journal of Nuclear Medicine, June 2017, Society of Nuclear Medicine

    Professor Russell C Rockne

  200. Exploiting Homeostatic Repopulation to Increase DC Vaccine Efficacy in Multiple Myeloma

    Article • April 2016, Cold Spring Harbor Laboratory Press

    Professor Russell C Rockne

  201. Addendum to ‘A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using18F-FMISO-PET’

    Article • Journal of The Royal Society Interface, November 2015, Royal Society Publishing

    Professor Paul E Kinahan, Professor Russell C Rockne

  202. A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET

    Article • Journal of The Royal Society Interface, December 2014, Royal Society Publishing

    Professor Russell C Rockne, Professor Paul E Kinahan

  203. Patient-Specific Metrics of Invasiveness Reveal Significant Prognostic Benefit of Resection in a Predictable Subset of Gliomas

    Article • PLOS One, October 2014, PLOS

    Professor Russell C Rockne

  204. Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients

    Article • Journal of Clinical Investigation, August 2014, American Society for Clinical Investigation

    Professor Russell C Rockne

  205. Invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status

    Article • Neuro-Oncology, June 2014, Oxford University Press (OUP)

    Professor Russell C Rockne

  206. Toward Patient-Specific, Biologically Optimized Radiation Therapy Plans for the Treatment of Glioblastoma

    Article • PLOS One, November 2013, PLOS

    Professor Russell C Rockne

  207. A digital reference object for the 3D Hoffman brain phantom for characterization of PET neuroimaging quality

    Article • October 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Paul E Kinahan, Professor Russell C Rockne

  208. Response Classification Based on a Minimal Model of Glioblastoma Growth Is Prognostic for Clinical Outcomes and Distinguishes Progression from Pseudoprogression

    Article • Cancer Research, May 2013, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  209. Discriminating Survival Outcomes in Patients with Glioblastoma Using a Simulation-Based, Patient-Specific Response Metric

    Article • PLOS One, January 2013, PLOS

    Professor Russell C Rockne

  210. From Patient-Specific Mathematical Neuro-Oncology to Precision Medicine

    Article • Frontiers in Oncology, January 2013, Frontiers

    Professor Russell C Rockne

  211. Modeling Tumor-Associated Edema in Gliomas during Anti-Angiogenic Therapy and Its Impact on Imageable Tumor

    Article • Frontiers in Oncology, January 2013, Frontiers

    Professor Russell C Rockne

  212. Adaptive IMRT using a multiobjective evolutionary algorithm integrated with a diffusion–invasion model of glioblastoma

    Article • Physics in Medicine and Biology, November 2012, Institute of Physics Publishing

    Professor Russell C Rockne

  213. Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology

    Article • Cancer Research, December 2011, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  214. Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images

    Article • Mathematical Medicine and Biology A Journal of the IMA, May 2011, Oxford University Press (OUP)

    Professor Paul E Kinahan, Professor Russell C Rockne

  215. The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view

    Article • Physical Biology, February 2011, Institute of Physics Publishing

    Professor Russell C Rockne

  216. Magnetic Resonance Imaging Characteristics of Glioblastoma Multiforme: Implications for Understanding Glioma Ontogeny

    Article • Neurosurgery, November 2010, Wolters Kluwer Health

    Professor Russell C Rockne

  217. Predicting the efficacy of radiotherapy in individual glioblastoma patientsin vivo:a mathematical modeling approach

    Article • Physics in Medicine and Biology, May 2010, Institute of Physics Publishing

    Professor Russell C Rockne

  218. Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model

    Article • Cancer Research, November 2009, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  219. Quantitative Metrics of Net Proliferation and Invasion Link Biological Aggressiveness Assessed by MRI with Hypoxia Assessed by FMISO-PET in Newly Diagnosed Glioblastomas

    Article • Cancer Research, May 2009, American Association for Cancer Research (AACR)

    Professor Russell C Rockne

  220. Complementary but Distinct Roles for MRI and18F-Fluoromisonidazole PET in the Assessment of Human Glioblastomas

    Article • Journal of Nuclear Medicine, December 2008, Society of Nuclear Medicine

    Professor Russell C Rockne

  221. A mathematical model for brain tumor response to radiation therapy

    Article • Journal of Mathematical Biology, September 2008, Springer Science + Business Media

    Professor Russell C Rockne

  222. Velocity of Radial Expansion of Contrast-enhancing Gliomas and the Effectiveness of Radiotherapy in Individual Patients: a Proof of Principle

    Article • Clinical Oncology, May 2008, Elsevier

    Professor Russell C Rockne