All Stories

  1. High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire

    Article • PLoS Pathogens, November 2022, PLOS

    Dr Jean-Philippe Julien

  2. Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity

    Article • Proceedings of the National Academy of Sciences, January 2022, Proceedings of the National Academy of Sciences

    Dr Jean-Philippe Julien

  3. Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

    Article • PLoS Pathogens, August 2016, PLOS

    Dr Jean-Philippe Julien

  4. The structural basis of modified nucleosome recognition by 53BP1

    Article • Nature, July 2016, Nature

    Dr Jean-Philippe Julien

  5. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

    Article • Science, March 2016, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  6. EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis

    Article • PLoS ONE, March 2016, PLOS

    Dr Jean-Philippe Julien

  7. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

    Article • Cell, December 2015, Elsevier

    Dr Jean-Philippe Julien

  8. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

    Article • Proceedings of the National Academy of Sciences, September 2015, Proceedings of the National Academy of Sciences

    Dr Jean-Philippe Julien

  9. Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody

    Article • EBioMedicine, July 2015, Elsevier

    Dr Jean-Philippe Julien

  10. HIV-1 neutralizing antibodies induced by native-like envelope trimers

    Article • Science, June 2015, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  11. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

    Article • Journal of Clinical Investigation, May 2015, American Society for Clinical Investigation

    Dr James E Crowe, Dr Jean-Philippe Julien

  12. Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer

    Article • PLoS Pathogens, March 2015, PLOS

    Dr Jean-Philippe Julien

  13. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

    Article • Nature Communications, February 2015, Nature

    Dr Jean-Philippe Julien

  14. A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype BenvGene

    Article • Journal of Virology, January 2015, ASM Journals

    Dr Jean-Philippe Julien

  15. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    Dr Jean-Philippe Julien

  16. Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

    Article • Cell, September 2014, Elsevier

    Dr Jean-Philippe Julien

  17. CD4-Induced Activation in a Soluble HIV-1 Env Trimer

    Article • Structure, July 2014, Elsevier

    Dr Jean-Philippe Julien

  18. Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy

    Article • Journal of Virology, June 2014, ASM Journals

    Dr Jean-Philippe Julien

  19. Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

    Article • Science Translational Medicine, May 2014, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  20. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers

    Article • Immunity, May 2014, Elsevier

    Dr Jean-Philippe Julien

  21. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

    Article • Retrovirology, January 2014, Springer Science + Business Media

    Dr Jean-Philippe Julien

  22. The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

    Article • PLoS Pathogens, November 2013, PLOS

    Dr Jean-Philippe Julien

  23. Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

    Article • Science, October 2013, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  24. Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

    Article • Science, October 2013, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  25. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Dr Jean-Philippe Julien

  26. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

    Article • PLoS Pathogens, September 2013, PLOS

    Dr Jean-Philippe Julien

  27. Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

    Article • Journal of Virology, July 2013, ASM Journals

    Erica Ollmann Saphire, Dr Jean-Philippe Julien

  28. Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers

    Article • Journal of Virology, July 2013, ASM Journals

    Dr Jean-Philippe Julien

  29. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein

    Article • Journal of Virology, July 2013, ASM Journals

    Dr Jean-Philippe Julien

  30. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

    Article • Nature Structural & Molecular Biology, May 2013, Nature

    Dr Jean-Philippe Julien

  31. Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

    Article • PLoS Pathogens, May 2013, PLOS

    Dr Jean-Philippe Julien

  32. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

    Article • Science, March 2013, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  33. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Dr Jean-Philippe Julien

  34. Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA

    Article • Immunological Reviews, October 2012, Wiley

    Dr Jean-Philippe Julien

  35. Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

    Article • PLoS Pathogens, September 2012, PLOS

    Erica Ollmann Saphire, Dr Jean-Philippe Julien

  36. Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers

    Article • Journal of Biological Chemistry, May 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jean-Philippe Julien

  37. Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane

    Article • Journal of Virology, January 2012, ASM Journals

    Dr Jean-Philippe Julien

  38. Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope

    Article • Journal of Molecular Biology, January 2012, Elsevier

    Dr Jean-Philippe Julien

  39. Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

    Article • Journal of Molecular Biology, December 2011, Elsevier

    Dr Michael B Zwick, Dr Jean-Philippe Julien

  40. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Article • Nature, November 2011, Nature

    Dr Jean-Philippe Julien

  41. A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

    Article • Science, October 2011, American Association for the Advancement of Science

    Dr Jean-Philippe Julien

  42. Broad neutralization coverage of HIV by multiple highly potent antibodies

    Article • Nature, August 2011, Nature

    Dr Jean-Philippe Julien

  43. Interaction of Anti-HIV Type 1 Antibody 2F5 with Phospholipid Bilayers and Its Relevance for the Mechanism of Virus Neutralization

    Article • AIDS Research and Human Retroviruses, August 2011, Mary Ann Liebert Inc

    Dr Jean-Philippe Julien

  44. Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding

    Article • Journal of Virology, February 2010, ASM Journals

    Dr Jean-Philippe Julien

  45. Structural Constraints Imposed by the Conserved Fusion Peptide on the HIV-1 gp41 Epitope Recognized by the Broadly Neutralizing Antibody 2F5 †

    Article • The Journal of Physical Chemistry, October 2009, American Chemical Society (ACS)

    Dr Jean-Philippe Julien

  46. Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

    Article • Journal of Virology, September 2009, ASM Journals

    Dr Jean-Philippe Julien

  47. Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site

    Article • Journal of Molecular Biology, December 2008, Elsevier

    Dr Jean-Philippe Julien

  48. Crystal Structure of the Complex between the Fab′ Fragment of the Cross-Neutralizing Anti-HIV-1 Antibody 2F5 and the Fab Fragment of Its Anti-idiotypic Antibody 3H6

    Article • Journal of Molecular Biology, October 2008, Elsevier

    Dr Jean-Philippe Julien

  49. Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Vladimir V Lunin, Dr Jean-Philippe Julien, Professor Warren Wakarchuk