All Stories

  1. High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire
  2. Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity
  3. Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
  4. The structural basis of modified nucleosome recognition by 53BP1
  5. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
  6. EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis
  7. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
  8. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens
  9. Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody
  10. HIV-1 neutralizing antibodies induced by native-like envelope trimers
  11. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
  12. Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
  13. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env
  14. A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype BenvGene
  15. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
  16. Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies
  17. CD4-Induced Activation in a Soluble HIV-1 Env Trimer
  18. Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy
  19. Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
  20. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
  21. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
  22. The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
  23. Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
  24. Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
  25. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation
  26. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
  27. Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism
  28. Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
  29. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
  30. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
  31. Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
  32. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
  33. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
  34. Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA
  35. Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism
  36. Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers
  37. Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane
  38. Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
  39. Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
  40. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
  41. A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
  42. Broad neutralization coverage of HIV by multiple highly potent antibodies
  43. Interaction of Anti-HIV Type 1 Antibody 2F5 with Phospholipid Bilayers and Its Relevance for the Mechanism of Virus Neutralization
  44. Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
  45. Structural Constraints Imposed by the Conserved Fusion Peptide on the HIV-1 gp41 Epitope Recognized by the Broadly Neutralizing Antibody 2F5 †
  46. Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications
  47. Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
  48. Crystal Structure of the Complex between the Fab′ Fragment of the Cross-Neutralizing Anti-HIV-1 Antibody 2F5 and the Fab Fragment of Its Anti-idiotypic Antibody 3H6
  49. Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori