All Stories

  1. Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions

    Article • Journal of Virology, January 2018, ASM Journals

    Dr Michael B Zwick

  2. Dense Array of Spikes on HIV-1 Virion Particles

    Article • Journal of Virology, April 2017, ASM Journals

    Dr Michael B Zwick

  3. Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes

    Article • Journal of Virology, April 2015, ASM Journals

    Dr Michael B Zwick

  4. Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

    Article • PLoS Pathogens, July 2014, PLOS

    Dr Michael B Zwick

  5. Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers

    Article • Immunity, May 2014, Elsevier

    Dr Michael B Zwick

  6. A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

    Article • PLoS ONE, August 2013, PLOS

    Dr Michael B Zwick

  7. Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution

    Article • PLoS Pathogens, February 2013, PLOS

    Dr Michael B Zwick

  8. Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

    Article • PLoS ONE, January 2013, PLOS

    Dr Michael B Zwick

  9. Purification of chemically fixed HIV-1 spikes for oriented display on nanoparticles

    Article • Retrovirology, September 2012, Springer Science + Business Media

    Dr Michael B Zwick

  10. Analysis of gp41 epitopes in model viral membranes to study HIV-1 neutralization

    Article • Retrovirology, September 2012, Springer Science + Business Media

    Dr Michael B Zwick

  11. Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

    Article • Journal of Molecular Biology, December 2011, Elsevier

    Dr Michael B Zwick, Dr Jean-Philippe Julien

  12. Targeting HIV-1 gp41 in Close Proximity to the Membrane Using Antibody and Other Molecules

    Article • Current Topics in Medicinal Chemistry, December 2011, Bentham Science Publishers

    Dr Michael B Zwick

  13. A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

    Article • PLoS ONE, June 2011, PLOS

    Dr Michael B Zwick

  14. Functional Stability of Unliganded Envelope Glycoprotein Spikes among Isolates of Human Immunodeficiency Virus Type 1 (HIV-1)

    Article • PLoS ONE, June 2011, PLOS

    Dr Michael B Zwick

  15. Synthesis and analysis of the membrane proximal external region epitopes of HIV-1

    Article • Journal of Peptide Science, November 2010, Wiley

    Dr Michael B Zwick

  16. A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

    Article • PLoS Pathogens, August 2010, PLOS

    Dr Michael B Zwick

  17. 4E10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms

    Article • PLoS ONE, March 2010, PLOS

    Dr Michael B Zwick

  18. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

    Article • Proceedings of the National Academy of Sciences, June 2009, Proceedings of the National Academy of Sciences

    Dr Michael B Zwick

  19. S021-05 OA. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

    Article • Retrovirology, January 2009, Springer Science + Business Media

    Dr Michael B Zwick

  20. Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization

    Article • Virology, August 2008, Elsevier

    Dr Michael B Zwick

  21. A welcome burst of human antibodies

    Article • Nature Biotechnology, August 2008, Springer Science + Business Media

    Dr Michael B Zwick

  22. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

    Article • Virology, July 2008, Elsevier

    Dr G. Marius Clore, Dr Michael B Zwick

  23. HIV-1 Neutralization: Mechanisms and Relevance to Vaccine Design

    Article • Current HIV Research, November 2007, Bentham Science Publishers

    Dr Michael B Zwick

  24. Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity

    Article • AIDS, October 2007, Wolters Kluwer Health

    Dr Michael B Zwick

  25. Structure of a High-affinity “Mimotope” Peptide Bound to HIV-1-neutralizing Antibody b12 Explains its Inability to Elicit gp120 Cross-reactive Antibodies

    Article • Journal of Molecular Biology, June 2007, Elsevier

    Erica Ollmann Saphire, Dr Michael B Zwick

  26. Structural Basis of Enhanced Binding of Extended and Helically Constrained Peptide Epitopes of the Broadly Neutralizing HIV-1 Antibody 4E10

    Article • Journal of Molecular Biology, February 2007, Elsevier

    Dr Michael B Zwick

  27. Structural definition of a conserved neutralization epitope on HIV-1 gp120

    Article • Nature, February 2007, Springer Science + Business Media

    Dr Michael B Zwick

  28. Combinatorial Phage Antibody Libraries

    Article • September 2006, Wiley

    Dr Michael B Zwick

  29. Simian Immunodeficiency Virus Engrafted with Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Epitopes: Replication, Neutralization, and Survey of HIV-1-Positive Plasma

    Article • Journal of Virology, March 2006, ASM Journals

    Dr Michael B Zwick

  30. The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring

    Article • AIDS, November 2005, Wolters Kluwer Health

    Dr Michael B Zwick

  31. Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response

    Article • Vaccine, February 2005, Elsevier

    Dr Michael B Zwick

  32. Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41

    Article • Immunity, February 2005, Elsevier

    Dr Michael B Zwick

  33. Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1

    Article • Journal of Virology, January 2005, ASM Journals

    Dr Michael B Zwick

  34. gp41: HIV's shy protein

    Article • Nature Medicine, February 2004, Springer Science + Business Media

    Erica Ollmann Saphire, Dr Michael B Zwick

  35. Improved Breadth and Potency of an HIV-1-Neutralizing Human Single-chain Antibody by Random Mutagenesis and Sequential Antigen Panning

    Article • Journal of Molecular Biology, January 2004, Elsevier

    Dr Michael B Zwick

  36. Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120

    Article • Cell, July 2003, Elsevier

    Dr Michael B Zwick

  37. Crystal Structure of an Intact Human IgG: Antibody Asymmetry, Flexibility, and a Guide for HIV-1 Vaccine Design

    Article • January 2003, Springer Science + Business Media

    Erica Ollmann Saphire, Dr Michael B Zwick

  38. Phage-displayed peptide libraries

    Article • Current Opinion in Biotechnology, August 1998, Elsevier

    Dr Michael B Zwick

  39. Helical Peptide Analogs of gp41 to Develop an HIV Vaccine

    Article • Springer Science + Business Media

    Dr Michael B Zwick