All Stories

  1. Identification of potential inflammation markers for outgrowth of cow’s milk allergy

    Article • PLOS One, September 2025, PLOS

    Jan Knol

  2. A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population

    Article • mSystems, July 2025, ASM Journals

    Jan Knol

  3. Targeting the Microbiota Reverses C‐Section‐Induced Effects on Intestinal Permeability, Microbiota Composition, and Amygdala Gene Expression in the Mouse

    Article • Neurogastroenterology & Motility, June 2025, Wiley

    Jan Knol

  4. Aberrant microbiota signatures precede symptom development in infantile colic

    Article • Journal of Pediatric Gastroenterology and Nutrition, June 2025, Wiley

    Jan Knol

  5. Milk phospholipid-coated lipid droplets modulate the infant gut microbiota and metabolome influencing weight gain

    Article • Microbiome, May 2025, Springer Science + Business Media

    Jan Knol

  6. A randomized controlled study protocol of the TOBBI trial: the effect of a 6 weeks intervention with synbiotics on the recovery speed of the gut microbiota after antibiotic treatment in Dutch toddlers

    Article • BMC Pediatrics, February 2025, Springer Science + Business Media

    Jan Knol

  7. Restoration of gut microbiota with a specific synbiotic-containing infant formula in healthy Chinese infants born by cesarean section

    Article • European Journal of Clinical Nutrition, February 2025, Springer Science + Business Media

    Jan Knol

  8. Characterization of Extracellular Vesicles from Streptococcus thermophilus 065 and Their Potential to Modulate the Immune Response

    Article • Probiotics and Antimicrobial Proteins, February 2025, Springer Science + Business Media

    Jan Knol

  9. Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition

    Article • Food Research International, December 2024, Elsevier

    Jan Knol

  10. In vitro gastrointestinal lipid handling and bioaccessibility rate of infant formula with large phospholipid-coated lipid droplets are different from those of standard formula and closer to human milk

    Article • Food Hydrocolloids, November 2024, Elsevier

    Jan Knol

  11. A young child formula supplemented with a synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V improves the gut microbiota and iron status in healthy toddlers

    Article • Frontiers in Pediatrics, October 2024, Frontiers

    Jan Knol

  12. A three-country analysis of the gut microbiome indicates taxon associations with diet vary by location and strain

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Jan Knol

  13. Longitudinal changes in bifidobacterial population during the first two years of life

    Article • Beneficial Microbes, April 2024, De Gruyter

    Jan Knol

  14. Resource sharing of an infant gut microbiota synthetic community in combinations of human milk oligosaccharides

    Article • The ISME Journal, January 2024, Oxford University Press (OUP)

    Jan Knol

  15. Trackability of proteins from probiotic Bifidobacterium spp. in the gut using metaproteomics

    Article • Beneficial Microbes, September 2023, De Gruyter

    Jan Knol

  16. A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge

    Article • Microbiome, August 2023, Springer Science + Business Media

    Jan Knol

  17. Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

    Article • Scientific Reports, July 2023, Springer Science + Business Media

    Jan Knol

  18. Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

    Article • Translational Psychiatry, July 2023, Springer Science + Business Media

    Jan Knol

  19. Quantitative Physiology and Proteome Adaptations of Bifidobacterium breve NRBB57 at Near-Zero Growth Rates

    Article • Microbiology Spectrum, June 2023, ASM Journals

    Jan Knol

  20. The infant gut microbiota: in pursuit of non-protein nitrogen

    Article • Gut Microbes, May 2023, Taylor & Francis

    Jan Knol

  21. Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy

    Article • Cell Death and Disease, May 2023, Springer Science + Business Media

    Jan Knol

  22. Enhanced stress resistance of Bifidobacterium breve NRBB57 by induction of stress proteins at near-zero growth rates

    Article • Beneficial Microbes, March 2023, Wageningen Academic Publishers

    Jan Knol

  23. Prenatal diet, plasma micronutrients/metabolome and inflammatory status influence the development of atopic eczema in early childhood

    Article • Allergy, November 2022, Wiley

    Jan Knol

  24. Proof of principle study replicating microbial clusters in connection to birth mode and diet in the early life intestine

    Article • PLOS One, November 2022, PLOS

    Jan Knol

  25. Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Jan Knol

  26. Altered gut microbiome diversity and function in patients with propionic acidemia

    Article • Molecular Genetics and Metabolism, November 2022, Elsevier

    Jan Knol

  27. Quantitative physiology and proteome adaptations of Bifidobacterium breve NRBB57 at near-zero growth rates

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Jan Knol

  28. The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice

    Article • mSystems, June 2022, ASM Journals

    Jan Knol

  29. Early-life fecal microbiome and metabolome dynamics in response to an intervention with infant formula containing specific prebiotics and postbiotics

    Article • AJP Gastrointestinal and Liver Physiology, June 2022, American Physiological Society

    Jan Knol

  30. Effect of antibiotics in the first week of life on faecal microbiota development

    Article • Archives of Disease in Childhood Fetal & Neonatal, May 2022, BMJ

    Jan Knol

  31. Evaluation of Stool Short Chain Fatty Acids Profiles in the First Year of Life With Childhood Atopy-Related Outcomes

    Article • Frontiers in Allergy, April 2022, Frontiers

    Jan Knol

  32. Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea

    Article • Nutrients, March 2022, MDPI AG

    Jan Knol

  33. Tolerance development in cow’s milk–allergic infants receiving amino acid–based formula: A randomized controlled trial

    Article • Journal of Allergy and Clinical Immunology, February 2022, Elsevier

    Jan Knol

  34. The first fungi: mode of delivery determines early life fungal colonization in the intestine of preterm infants

    Article • Microbiome Research Reports, January 2022, OAE Publishing

    Jan Knol

  35. Influence of timing of maternal antibiotic administration during caesarean section on infant microbial colonisation: a randomised controlled trial

    Article • Gut, November 2021, BMJ

    Jan Knol

  36. The role of the gut microbiota in the effects of early-life stress and dietary fatty acids on later-life central and metabolic outcomes in mice

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Jan Knol

  37. Early-Life Respiratory Infections in Infants with Cow’s Milk Allergy: An Expert Opinion on the Available Evidence and Recommendations for Future Research

    Article • Nutrients, October 2021, MDPI AG

    Jan Knol

  38. From Mum to Bum: An Observational Study Protocol to Follow Digestion of Human Milk Oligosaccharides and Glycoproteins from Mother to Preterm Infant

    Article • Nutrients, September 2021, MDPI AG

    Jan Knol

  39. Ligilactobacillus salivarius PS2 Supplementation during Pregnancy and Lactation Prevents Mastitis: A Randomised Controlled Trial

    Article • Microorganisms, September 2021, MDPI AG

    Jan Knol

  40. Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats’ Microbiota and Immunity

    Article • Nutrients, August 2021, MDPI AG

    Jan Knol

  41. Household environmental microbiota influences early‐life eczema development

    Article • Environmental Microbiology, August 2021, Wiley

    Jan Knol

  42. A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants

    Article • BMC Microbiology, June 2021, Springer Science + Business Media

    Jan Knol

  43. A Continuous Battle for Host-Derived Glycans Between a Mucus Specialist and a Glycan Generalist in vitro and in vivo

    Article • Frontiers in Microbiology, June 2021, Frontiers

    Jan Knol

  44. Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Jan Knol

  45. Microbial Glycoside Hydrolases in the First Year of Life: An Analysis Review on Their Presence and Importance in Infant Gut

    Article • Frontiers in Microbiology, May 2021, Frontiers

    Jan Knol

  46. Broad Purpose Vector for Site-Directed Insertional Mutagenesis in Bifidobacterium breve

    Article • Frontiers in Microbiology, March 2021, Frontiers

    Jan Knol

  47. Early life antibiotics and childhood gastrointestinal disorders: a systematic review

    Article • BMJ Paediatrics Open, March 2021, BMJ

    Jan Knol

  48. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants

    Article • Clinical Nutrition, March 2021, Elsevier

    Jan Knol

  49. Cross-feeding betweenBifidobacterium infantisandAnaerostipes caccaeon lactose and human milk oligosaccharides

    Article • Beneficial Microbes, February 2021, Wageningen Academic Publishers

    Jan Knol

  50. Impact of synbiotics on gut microbiota during early life: a randomized, double-blind study

    Article • Scientific Reports, February 2021, Springer Science + Business Media

    Jan Knol

  51. Breast milk urea as a nitrogen source for urease positiveBifidobacterium infantis

    Article • FEMS Microbiology Ecology, February 2021, Oxford University Press (OUP)

    Jan Knol

  52. Bifidobacterium Transformation

    Article • January 2021, Springer Science + Business Media

    Jan Knol

  53. Gut Microbiota of Young Children Living in Four Brazilian Cities

    Article • Frontiers in Pediatrics, December 2020, Frontiers

    Jan Knol

  54. The Bifidogenic Effect Revisited—Ecology and Health Perspectives of Bifidobacterial Colonization in Early Life

    Article • Microorganisms, November 2020, MDPI AG

    Jan Knol

  55. Dietary patterns in childhood and their effect on gut microbiota—an Asian perspective on atopy risk

    Article • Journal of Allergy and Clinical Immunology, November 2020, Elsevier

    Jan Knol

  56. A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

    Article • Gut Microbes, October 2020, Taylor & Francis

    Dr Eric Chun Yong Chan, Jan Knol

  57. Bacteroides thetaiotaomicron Fosters the Growth of Butyrate-Producing Anaerostipes caccae in the Presence of Lactose and Total Human Milk Carbohydrates

    Article • Microorganisms, October 2020, MDPI AG

    Jan Knol

  58. Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

    Article • Current Biology, October 2020, Elsevier

    Jan Knol

  59. Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro

    Article • Scientific Reports, August 2020, Springer Science + Business Media

    Jan Knol

  60. The Infant-Derived Bifidobacterium bifidum Strain CNCM I-4319 Strengthens Gut Functionality

    Article • Microorganisms, August 2020, MDPI AG

    Jan Knol

  61. Dynamics of the bacterial gut microbiota in preterm and term infants after intravenous amoxicillin/ceftazidime treatment

    Article • BMC Pediatrics, May 2020, Springer Science + Business Media

    Jan Knol

  62. Strain-Specific Probiotic Properties of Bifidobacteria and Lactobacilli for the Prevention of Diarrhea Caused by Rotavirus in a Preclinical Model

    Article • Nutrients, February 2020, MDPI AG

    Jan Knol

  63. The Influence of Timing of Maternal Administration of Antibiotics During Caesarean Section on the Intestinal Microbial Colonization in Infants (MAMI-Trial): A Randomized Controlled Trial

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Jan Knol

  64. Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

    Article • PLOS One, December 2019, PLOS

    Jan Knol

  65. Microbial transmission from mother to child: improving infant intestinal microbiota development by identifying the obstacles

    Article • Critical Reviews in Microbiology, December 2019, Taylor & Francis

    Jan Knol

  66. Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium

    Article • MicrobiologyOpen, September 2019, Wiley

    Dr Janetta Top, Jan Knol

  67. Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond

    Article • International Journal of Molecular Sciences, September 2019, MDPI AG

    Jan Knol

  68. Oligosaccharides Modulate Rotavirus-Associated Dysbiosis and TLR Gene Expression in Neonatal Rats

    Article • Cells, August 2019, MDPI AG

    Jan Knol

  69. Short‐term changes of intestinal microbiota composition in preterm infants after two prophylactic doses of vancomycin

    Article • Acta Paediatrica, July 2019, Wiley

    Jan Knol

  70. Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

    Article • PLOS One, July 2019, PLOS

    Jan Knol

  71. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial

    Article • Clinical and Translational Allergy, May 2019, Wiley

    Jan Knol

  72. Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model

    Article • Allergy, April 2019, Wiley

    Jan Knol

  73. Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses

    Article • Beneficial Microbes, April 2019, Wageningen Academic Publishers

    Jan Knol, Sebastian Tims

  74. The Preterm Gut Microbiota: An Inconspicuous Challenge in Nutritional Neonatal Care

    Article • Frontiers in Cellular and Infection Microbiology, April 2019, Frontiers

    Jan Knol

  75. Metaproteomic and 16S rRNA Gene Sequencing Analysis of the Infant Fecal Microbiome

    Article • International Journal of Molecular Sciences, March 2019, MDPI AG

    Jan Knol

  76. Supplementation of dietary non-digestible oligosaccharides from birth onwards improve social and reduce anxiety-like behaviour in male BALB/c mice

    Article • Nutritional Neuroscience, March 2019, Taylor & Francis

    Jan Knol

  77. Mice co-administrated with partially hydrolysed whey proteins and prebiotic fibre mixtures show allergen-specific tolerance and a modulated gut microbiota

    Article • Beneficial Microbes, March 2019, Wageningen Academic Publishers

    Jan Knol

  78. Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture

    Article • Nutrients, January 2019, MDPI AG

    Jan Knol

  79. A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial

    Article • Clinical and Translational Allergy, January 2019, Springer Science + Business Media

    Jan Knol

  80. The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions

    Article • World Allergy Organization Journal, January 2019, Elsevier

    Jan Knol

  81. Targeting the gut microbiota to influence brain development and function in early life

    Article • Neuroscience & Biobehavioral Reviews, December 2018, Elsevier

    Jan Knol

  82. The potential role of gut microbiota and its modulators in the management of propionic and methylmalonic acidemia

    Article • Expert Opinion on Orphan Drugs, October 2018, Taylor & Francis

    Jan Knol, Sebastian Tims

  83. Sex differences in lipid metabolism are affected by presence of the gut microbiota

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Jan Knol

  84. Comparative genomics and genotype-phenotype associations in Bifidobacterium breve

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Jan Knol

  85. A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children

    Article • Beneficial Microbes, June 2018, Wageningen Academic Publishers

    christophe lay, Jan Knol, Mongkol Lao-araya

  86. Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections

    Article • Frontiers in Immunology, June 2018, Frontiers

    Jan Knol

  87. Cross-feeding between Bifidobacterium infantis and Anaerostipes caccae on lactose and human milk oligosaccharides

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Jan Knol

  88. Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development

    Article • Journal of Allergy and Clinical Immunology, April 2018, Elsevier

    Jan Knol

  89. Specific synbiotics in early life protect against diet-induced obesity in adult mice

    Article • Diabetes Obesity and Metabolism, March 2018, Wiley

    Jan Knol

  90. Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach

    Article • Antonie van Leeuwenhoek, February 2018, Springer Science + Business Media

    Jan Knol

  91. Association between duration of intravenous antibiotic administration and early-life microbiota development in late-preterm infants

    Article • European Journal of Clinical Microbiology & Infectious Diseases, January 2018, Springer Science + Business Media

    Jan Knol

  92. Comparative genome and methylome analysis reveals restriction/modification system diversity in the gut commensal Bifidobacterium breve

    Article • Nucleic Acids Research, December 2017, Oxford University Press (OUP)

    Jan Knol

  93. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

    Article • Pediatric Research, December 2017, Springer Science + Business Media

    Jan Knol

  94. Ratio of Klebsiella/Bifidobacterium in early life correlates with later development of paediatric allergy

    Article • Beneficial Microbes, October 2017, Wageningen Academic Publishers

    christophe lay, Dr Joanna D Holbrook, Dr Eline Marleen van der Beek, Jan Knol

  95. Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B12 Production by Intestinal Symbionts

    Article • mBio, September 2017, ASM Journals

    Dr Bhawani Chamlagain, Jan Knol

  96. P35: AMINO ACID-BASED FORMULA WITH SYNBIOTICS MODIFIES GUT MICROBIOTA IN NON-IGE MEDIATED COW’S MILK ALLERGIC INFANTS

    Article • Internal Medicine Journal, September 2017, Wiley

    Jan Knol

  97. Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants

    Article • Molecular & Cellular Proteomics, July 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jan Knol

  98. Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants

    Article • Journal of Pediatric Gastroenterology and Nutrition, July 2017, Wolters Kluwer Health

    Jan Knol

  99. Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

    Article • Microbiome, June 2017, Springer Science + Business Media

    Jan Knol

  100. Intervention strategies for cesarean section–induced alterations in the microbiota-gut-brain axis

    Article • Nutrition Reviews, April 2017, Oxford University Press (OUP)

    Jan Knol

  101. Early-life origin of intestinal inflammatory disorders

    Article • Nutrition Reviews, March 2017, Oxford University Press (OUP)

    Jan Knol

  102. Gut Microbiota Composition of Non-IgE Mediated Cow's Milk Allergic Infants before and after Dietary Management with a Synbiotics-Supplemented Amino Acid-Based Formula

    Article • Journal of Allergy and Clinical Immunology, February 2017, Elsevier

    Jan Knol

  103. A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis

    Article • British Journal Of Nutrition, January 2017, Cambridge University Press

    Jan Knol

  104. Longitudinal Investigation of Carriage Rates, Counts, and Genotypes of Toxigenic Clostridium difficile in Early Infancy

    Article • Applied and Environmental Microbiology, July 2016, ASM Journals

    Jan Knol

  105. Human gut microbes impact host serum metabolome and insulin sensitivity

    Article • Nature, July 2016, Springer Science + Business Media

    Jan Knol

  106. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota

    Article • PLOS One, June 2016, PLOS

    Jan Knol

  107. The Variable Regions ofLactobacillus rhamnosusGenomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires

    Article • Genome Biology and Evolution, June 2016, Oxford University Press (OUP)

    Jan Knol

  108. A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis

    Article • Zeitschrift für Ernährungswissenschaft, April 2016, Springer Science + Business Media

    Jan Knol

  109. Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood–Adulthood Transition

    Article • Inflammatory Bowel Diseases, February 2016, Oxford University Press (OUP)

    Jan Knol

  110. Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study

    Article • Journal of Nutritional Science, January 2016, Cambridge University Press

    Jan Knol

  111. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

    Article • Nature, December 2015, Springer Science + Business Media

    Jan Knol

  112. The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5

    Article • Microorganisms, October 2015, MDPI AG

    Jan Knol

  113. Multilocus sequence typing of bifidobacterial strains from infant’s faeces and human milk: are bifidobacteria being sustainably shared during breastfeeding?

    Article • Beneficial Microbes, August 2015, Wageningen Academic Publishers

    Jan Knol

  114. Similar Occurrence of Febrile Episodes Reported in Non-Atopic Children at Three to Five Years of Age after Prebiotics Supplemented Infant Formula

    Article • PLOS One, June 2015, PLOS

    Jan Knol

  115. Carbohydrate utilization genetic signatures in the species Lactobacillus rhamnosus

    Article • Applied and Environmental Microbiology, June 2015, ASM Journals

    Mrs Corina Diana Ceapa, Jan Knol

  116. Fermented Infant Formula Increases Ileal Protein Digestibility and Reduces Ileal Proteolytic Activity Compared with Standard and Hydrolyzed Infant Formulas in Piglets

    Article • Journal of Nutrition, May 2015, Oxford University Press (OUP)

    Jan Knol

  117. Preweaning modulation of intestinal microbiota by oligosaccharides or amoxicillin can contribute to programming of adult microbiota in rats

    Article • Nutrition, March 2015, Elsevier

    Jan Knol

  118. Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance ofPseudomonas aeruginosaLung Infection in Mice by Modulating Intestinal Microbiota and Immunity

    Article • The Journal of Infectious Diseases, August 2014, Oxford University Press (OUP)

    Jan Knol

  119. An integrated catalog of reference genes in the human gut microbiome

    Article • Nature Biotechnology, July 2014, Springer Science + Business Media

    Professor Julian Parkhill, Jan Knol

  120. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

    Article • Nature Biotechnology, July 2014, Springer Science + Business Media

    Professor Julian Parkhill, Jan Knol

  121. The first thousand days - intestinal microbiology of early life: establishing a symbiosis

    Article • Pediatric Allergy and Immunology, June 2014, Wiley

    Jan Knol

  122. Altered gut microbiota and activity in a murine model of autism spectrum disorders

    Article • Brain Behavior and Immunity, March 2014, Elsevier

    Jan Knol

  123. Mother-to-Infant Transmission of Intestinal Bifidobacterial Strains Has an Impact on the Early Development of Vaginally Delivered Infant's Microbiota

    Article • PLOS One, November 2013, PLOS

    Jan Knol

  124. A novel protein mixture containing vegetable proteins renders enteral nutrition products non-coagulating after in vitro gastric digestion

    Article • Clinical Nutrition, October 2013, Elsevier

    Jan Knol

  125. Richness of human gut microbiome correlates with metabolic markers

    Article • Nature, August 2013, Springer Science + Business Media

    Professor Julian Parkhill, Jan Knol

  126. Relevance of pre- and postnatal nutrition to development and interplay between the microbiota and metabolic and immune systems

    Article • American Journal of Clinical Nutrition, July 2013, Oxford University Press (OUP)

    Jan Knol

  127. Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides

    Article • American Journal of Clinical Nutrition, July 2013, Oxford University Press (OUP)

    Jan Knol

  128. The Immunomodulatory Nutritional Intervention NR100157 Reduced CD4+ T-Cell Decline and Immune Activation: A 1-Year Multicenter Randomized Controlled Double-Blind Trial in HIV-Infected Persons Not Receiving Antiretroviral Therapy (The BITE Study)

    Article • Clinical Infectious Diseases, March 2013, Oxford University Press (OUP)

    Jan Knol, Professor Renger Witkamp

  129. Human milk: a source of more life than we imagine

    Article • Beneficial Microbes, March 2013, Wageningen Academic Publishers

    Jan Knol

  130. Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health

    Article • Best Practice & Research Clinical Gastroenterology, February 2013, Elsevier

    Mrs Corina Diana Ceapa, Jan Knol

  131. Development of the Digestive System—Experimental Challenges and Approaches of Infant Lipid Digestion

    Article • Food Digestion, November 2012, Springer Science + Business Media

    Dr Eline Marleen van der Beek, Jan Knol

  132. The effect of enteral supplementation of specific neutral and acidic oligosaccharides on the faecal microbiota and intestinal microenvironment in preterm infants

    Article • European Journal of Clinical Microbiology & Infectious Diseases, September 2012, Springer Science + Business Media

    Jan Knol

  133. Structure and Catalytic Mechanism of 3-Ketosteroid-Δ4-(5α)-dehydrogenase fromRhodococcus jostiiRHA1 Genome

    Article • Journal of Biological Chemistry, July 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Lubbert Dijkhuizen, Jan Knol

  134. The Early Settlers: Intestinal Microbiology in Early Life

    Article • Annual Review of Food Science and Technology, April 2012, Annual Reviews

    Jan Knol

  135. Improved Detection of Bifidobacteria with Optimised 16S rRNA-Gene Based Pyrosequencing

    Article • PLOS One, March 2012, PLOS

    Dr Ming-Shi Li, Jan Knol

  136. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans

    Article • Allergy, January 2012, Wiley

    Jan Knol

  137. A Fermented Infant Milk Formula Reduces Ileal Proteolytic Activity

    Article • Pediatric Research, November 2011, Springer Science + Business Media

    Jan Knol

  138. Effects of a New Prebiotic Mixture on Faecal Gut Microbiota and the Mucosal Immune System in Healthy Infants

    Article • Pediatric Research, November 2011, Springer Science + Business Media

    Jan Knol

  139. Cloning, overexpression, purification, crystallization and preliminary X-ray analysis of 3-ketosteroid Δ4-(5α)-dehydrogenase fromRhodococcus jostiiRHA1

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2011, International Union of Crystallography

    Professor Lubbert Dijkhuizen, Jan Knol

  140. Analysis of infant isolates of Bifidobacterium breve by comparative genome hybridization indicates the existence of new subspecies with marked infant specificity

    Article • Research in Microbiology, September 2011, Elsevier

    Jan Knol

  141. Transmission of Intestinal Bifidobacterium longum subsp.longumStrains from Mother to Infant, Determined by Multilocus Sequencing Typing and Amplified Fragment Length Polymorphism

    Article • Applied and Environmental Microbiology, August 2011, ASM Journals

    Jan Knol

  142. Bifidobacterium breve– HT-29 cell line interaction: modulation of TNF-α induced gene expression

    Article • Beneficial Microbes, June 2011, Wageningen Academic Publishers

    Jan Knol

  143. Bacterial Translocation Is Reduced by a Specific Nutritional Combination in Mice with Chemotherapy-Induced Neutropenia

    Article • Journal of Nutrition, May 2011, Oxford University Press (OUP)

    Jan Knol, Dr. Ir. Ardy van Helvoort

  144. Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial

    Article • Mucosal Immunology, April 2011, Nature

    Jan Knol

  145. Enterotypes of the human gut microbiome

    Article • Nature, April 2011, Springer Science + Business Media

    Professor Julian Parkhill, Jan Knol, Gabriel Fernandes

  146. Early life: gut microbiota and immune development in infancy

    Article • Beneficial Microbes, November 2010, Wageningen Academic Publishers

    Jan Knol

  147. 89 The Effect of Enteral Supplementation of Neutral and Acidic Oligosaccharides on Intestinal Microbiota, Ph, Scfas and Siga in Preterm Infants

    Article • Pediatric Research, November 2010, Nature

    Jan Knol

  148. Bifidobacterium population analysis in the infant gut by direct mapping of genomic hybridization patterns: potential for monitoring temporal development and effects of dietary regimens

    Article • Microbial Biotechnology, October 2010, Wiley

    Jan Knol

  149. Molecular analysis of faecal and duodenal samples reveals significantly higher prevalence and numbers of Pseudomonas aeruginosa in irritable bowel syndrome

    Article • Journal of Medical Microbiology, October 2010, Society for General Microbiology

    Jan Knol

  150. Metagenomics of the intestinal microbiota: potential applications

    Article • Gastroentérologie Clinique et Biologique, September 2010, Elsevier

    Jan Knol

  151. Tolerance and safety of the potentially probiotic strain Lactobacillus rhamnosus PRSF-L477: a randomised, double-blind placebo-controlled trial in healthy volunteers

    Article • British Journal Of Nutrition, August 2010, Cambridge University Press

    Jan Knol

  152. Effect of multifibre mixture with prebiotic components on bifidobacteria and stool pH in tube-fed children

    Article • British Journal Of Nutrition, August 2010, Cambridge University Press

    Jan Knol

  153. Intestinal microbiota in allergic and nonallergic 1-year-old very low birth weight infants after neonatal glutamine supplementation

    Article • Acta Paediatrica, July 2010, Wiley

    Jan Knol

  154. Specific prebiotic oligosaccharides modulate the early phase of a murine vaccination response

    Article • International Immunopharmacology, May 2010, Elsevier

    Jan Knol

  155. Gut health: predictive biomarkers for preventive medicine and development of functional foods

    Article • British Journal Of Nutrition, April 2010, Cambridge University Press

    Jan Knol

  156. A human gut microbial gene catalogue established by metagenomic sequencing

    Article • Nature, March 2010, Springer Science + Business Media

    Professor Julian Parkhill, Jan Knol

  157. Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized-controlled trial

    Article • Clinical & Experimental Allergy, February 2010, Wiley

    Jan Knol

  158. Exposure of Intestinal Epithelial Cells to UV-Killed Lactobacillus GG but Not Bifidobacterium breve Enhances the Effector Immune Response in vitro

    Article • International Archives of Allergy and Immunology, January 2010, Karger Publishers

    Jan Knol

  159. Oral Treatment with Probiotics Reduces Allergic Symptoms in Ovalbumin-Sensitized Mice: A Bacterial Strain Comparative Study

    Article • International Archives of Allergy and Immunology, January 2010, Karger Publishers

    Jan Knol

  160. Prebiotics and Probiotics in Infant Formulae

    Article • November 2009, Taylor & Francis

    Jan Knol

  161. Cow Milk Allergy Symptoms Are Reduced in Mice Fed Dietary Synbiotics during Oral Sensitization with Whey

    Article • Journal of Nutrition, May 2009, Oxford University Press (OUP)

    Jan Knol

  162. Mixed-Species Genomic Microarray Analysis of Fecal Samples Reveals Differential Transcriptional Responses of Bifidobacteria in Breast- and Formula-Fed Infants

    Article • Applied and Environmental Microbiology, March 2009, ASM Journals

    Jan Knol

  163. Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients

    Article • World Journal of Gastroenterology, January 2009, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Jan Knol

  164. Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides

    Article • Journal of Nutrition, June 2008, Elsevier

    Jan Knol

  165. 3-Keto-5α-steroid Δ1-dehydrogenase fromRhodococcus erythropolisSQ1 and its orthologue inMycobacterium tuberculosisH37Rv are highly specific enzymes that function in cholesterol catabolism

    Article • Biochemical Journal, March 2008, Portland Press Ltd.

    Professor Lubbert Dijkhuizen, Jan Knol

  166. Prebiotic oligosaccharides and the enterohepatic circulation of bile salts in rats

    Article • AJP Gastrointestinal and Liver Physiology, February 2008, American Physiological Society

    Jan Knol

  167. Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project

    Article • Trends in Food Science & Technology, February 2008, Elsevier

    Jan Knol

  168. Carbohydrates in Human Milk and Infant Formulas

    Article • January 2008, Elsevier

    Jan Knol

  169. Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human Immunodeficiency Virus Pathogenesis

    Article • Journal of Clinical Microbiology, December 2007, ASM Journals

    Jan Knol

  170. Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity—a randomized, double-blind, placebo-controlled study

    Article • American Journal of Clinical Nutrition, November 2007, Elsevier

    Jan Knol

  171. The effect of glutamine-enriched enteral nutrition on intestinal microflora in very low birth weight infants: A randomized controlled trial

    Article • Clinical Nutrition, August 2007, Elsevier

    Jan Knol

  172. Dietary supplementation of neutral and acidic oligosaccharides enhances Th1‐dependent vaccination responses in mice

    Article • Pediatric Allergy and Immunology, June 2007, Wiley

    Jan Knol

  173. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants

    Article • Acta Paediatrica, January 2007, Wiley

    Jan Knol

  174. A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model

    Article • International Immunopharmacology, August 2006, Elsevier

    Jan Knol

  175. The intestinal bacterial colonisation in preterm infants: A review of the literature

    Article • Clinical Nutrition, June 2006, Elsevier

    Jan Knol

  176. Transcriptome Analysis Reveals Mechanisms by Which Lactococcus lactis Acquires Nisin Resistance

    Article • Antimicrobial Agents and Chemotherapy, May 2006, ASM Journals

    Jan Knol

  177. Bifidogenic Effects of Solid Weaning Foods With Added Prebiotic Oligosaccharides

    Article • Journal of Pediatric Gastroenterology and Nutrition, May 2006, Wolters Kluwer Health

    Jan Knol

  178. Quantitative Real-Time PCR Analysis of Fecal Lactobacillus Species in Infants Receiving a Prebiotic Infant Formula

    Article • Applied and Environmental Microbiology, April 2006, ASM Journals

    Jan Knol

  179. Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short-chain fatty acids and microbiota

    Article • Clinical Nutrition, February 2006, Elsevier

    Jan Knol

  180. Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life

    Article • British Journal Of Nutrition, November 2005, Cambridge University Press

    Jan Knol

  181. Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review

    Article • Acta Paediatrica, October 2005, Wiley

    Jan Knol

  182. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants

    Article • Acta Paediatrica, October 2005, Wiley

    Jan Knol

  183. Prebiotic carbohydrates in human milk and formulas

    Article • Acta Paediatrica, October 2005, Wiley

    Jan Knol

  184. Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock

    Article • Infection and Immunity, June 2005, ASM Journals

    Jan Knol

  185. Quantitative Real-Time PCR Assays To Identify and Quantify Fecal Bifidobacterium Species in Infants Receiving a Prebiotic Infant Formula

    Article • Applied and Environmental Microbiology, May 2005, ASM Journals

    Jan Knol

  186. The gusBC Genes of Escherichia coli Encode a Glucuronide Transport System

    Article • Journal of Bacteriology, April 2005, ASM Journals

    Jan Knol

  187. Colon Microflora in Infants Fed Formula with Galacto- and Fructo-Oligosaccharides: More Like Breast-Fed Infants

    Article • Journal of Pediatric Gastroenterology and Nutrition, January 2005, Wolters Kluwer Health

    Jan Knol

  188. 134 Effect of Colonic Short Chain Fatty Acids, Lactate and PH on The Growth of Common Gut Pathogens

    Article • Pediatric Research, September 2004, Nature

    Jan Knol

  189. Prebiotics in Infant Formulas

    Article • Journal of Clinical Gastroenterology, July 2004, Wolters Kluwer Health

    Jan Knol

  190. Prebiotics and Immune Responses

    Article • Journal of Pediatric Gastroenterology and Nutrition, June 2004, Wolters Kluwer Health

    Jan Knol

  191. Randomized Double-Blind Study of the Nutritional Efficacy and Bifidogenicity of a New Infant Formula Containing Partially Hydrolyzed Protein, a High β-Palmitic Acid Level, and Nondigestible Oligosaccharides

    Article • Journal of Pediatric Gastroenterology and Nutrition, March 2003, Wolters Kluwer Health

    Jan Knol

  192. Development of 16S rRNA-Based Probes for theCoriobacterium Group and the Atopobium Cluster and Their Application for Enumeration of Coriobacteriaceaein Human Feces from Volunteers of Different Age Groups

    Article • Applied and Environmental Microbiology, October 2000, ASM Journals

    Jan Knol

  193. Rotational Mobility and Orientational Stability of a Transport Protein in Lipid Membranes

    Article • Biophysical Journal, August 2000, Elsevier

    Jan Knol

  194. Quaternary Structure of the Lactose Transport Protein ofStreptococcus thermophilusin the Detergent-solubilized and Membrane-reconstituted State

    Article • Journal of Biological Chemistry, July 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jan Knol

  195. Close Approximation of Putative α-Helices II, IV, VII, X, and XI in the Translocation Pathway of the Lactose Transport Protein ofStreptococcus thermophilus

    Article • Journal of Biological Chemistry, May 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jan Knol

  196. Amplified expression and membrane reconstitution of transport proteins

    Article • Biochemical Society Transactions, December 1999, Portland Press Ltd.

    Jan Knol

  197. Detergent-Mediated Reconstitution of Membrane Proteins†

    Article • Biochemistry, November 1998, American Chemical Society (ACS)

    Jan Knol

  198. Amplified Expression, Purification and Functional Reconstitution of the Dipeptide and Tripeptide Transport Protein of Lactococcus Lactis

    Article • FEBS Journal, July 1997, Wiley

    Jan Knol

  199. Unidirectional Reconstitution into Detergent-destabilized Liposomes of the Purified Lactose Transport System ofStreptococcus thermophilus

    Article • Journal of Biological Chemistry, June 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jan Knol

  200. Cation and sugar selectivity determinants in a novel family of transport proteins

    Article • Molecular Microbiology, March 1996, Wiley

    Jan Knol

  201. Purification and Reconstitution of the Glutamate Carrier GltT of the Thermophilic Bacterium Bacillus stearothermophilus

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Dr Juke S Lolkema, Jan Knol

  202. Kinetic Analysis of Lactose and Proton Coupling in Glu379Mutants of the Lactose Transport Protein ofStreptococcus thermophilus

    Article • Journal of Biological Chemistry, June 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jan Knol

  203. Regulation of bacterial sugar-H+ symport by phosphoenolpyruvate-dependent enzyme I/HPr-mediated phosphorylation.

    Article • Proceedings of the National Academy of Sciences, January 1995, Proceedings of the National Academy of Sciences

    Jan Knol

  204. Directed genomic integration, gene replacement, and integrative gene expression in Streptococcus thermophilus

    Article • Journal of Bacteriology, July 1993, ASM Journals

    Jan Knol

  205. A Kdp-like, high-affinity, K+-translocating ATPase is expressed during growth of Rhodobacter sphaeroides in low potassium media

    Article • Archives of Microbiology, October 1992, Springer Science + Business Media

    Jan Knol