All Stories

  1. Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their household contacts

    Article • Microbiology Spectrum, December 2023, ASM Journals

    Dr Janetta Top

  2. The population-level impact of Enterococcus faecalis genetics on intestinal colonization and extraintestinal infection

    Article • Microbiology Spectrum, December 2023, ASM Journals

    Dr Janetta Top

  3. Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  4. Detecting co-selection through excess linkage disequilibrium in bacterial genomes

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  5. The population-level impact of Enterococcus faecalis genetics on intestinal colonisation and extraintestinal infection

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  6. Functional characterization of a gene cluster responsible for inositol catabolism associated with hospital-adapted isolates of Enterococcus faecium

    Article • Microbiology, September 2021, Society for General Microbiology

    Dr Janetta Top

  7. Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

    Article • Nature Communications, March 2021, Springer Science + Business Media

    Dr Janetta Top

  8. Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals

    Article • Genome Medicine, January 2021, Springer Science + Business Media

    Dr Janetta Top

  9. Comparative genomics of ESBL-producingEscherichia coli(ESBL-Ec) reveals a similar distribution of the 10 most prevalent ESBL-Ec clones and ESBL genes among human community faecal and extra-intestinal infection isolates in the Netherlands (2014–17)

    Article • Journal of Antimicrobial Chemotherapy, January 2021, Oxford University Press (OUP)

    Dr Janetta Top

  10. Genomic rearrangements uncovered by genome-wide co-evolution analysis of a major nosocomial pathogen, Enterococcus faecium

    Article • Microbial Genomics, December 2020, Society for General Microbiology

    Dr Janetta Top

  11. Whole Genome Sequence Analysis of the First Vancomycin-Resistant Enterococcus faecium Isolates from a Libyan Hospital in Tripoli

    Article • Microbial Drug Resistance, November 2020, Mary Ann Liebert Inc

    Dr Janetta Top

  12. Genomic rearrangements uncovered by genome-wide co-evolution analysis of a major nosocomial pathogen Enterococcus faecium

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  13. Mode and dynamics of vanA-type vancomycin-resistance dissemination in Dutch hospitals

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  14. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

    Article • Nature, February 2020, Springer Science + Business Media

    Dr Janetta Top

  15. Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen Enterococcus faecium

    Article • mBio, February 2020, ASM Journals

    Dr Janetta Top

  16. Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium

    Article • MicrobiologyOpen, September 2019, Wiley

    Dr Janetta Top

  17. In vivo acquisition of fosfomycin resistance in Escherichia coli by fosA transmission from commensal flora

    Article • Journal of Antimicrobial Chemotherapy, September 2019, Oxford University Press (OUP)

    Dr Janetta Top

  18. Genomes of a major nosocomial pathogen Enterococcus faecium are shaped by adaptive evolution of the chromosome and plasmidome

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  19. Corrigendum: mlplasmids: a user-friendly tool to predict plasmid- and chromosome-derived sequences for single species

    Article • Microbial Genomics, January 2019, Society for General Microbiology

    Dr Janetta Top

  20. Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood

    Article • International Journal of Microbiology, December 2018, Hindawi Publishing Corporation

    Dr Rob JL Willems, Dr Janetta Top

  21. mlplasmids: a user-friendly tool to predict plasmid- and chromosome-derived sequences for single species

    Article • Microbial Genomics, November 2018, Society for General Microbiology

    Dr Janetta Top

  22. mlplasmids: a user-friendly tool to predict plasmid- and chromosome-derived sequences for single species

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Janetta Top

  23. Identification of a Novel Genomic Island Associated with vanD -Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates

    Article • Antimicrobial Agents and Chemotherapy, January 2018, ASM Journals

    Dr Janetta Top, Prof dr. John W Rossen

  24. Intestinal carriage of ampicillin- and vancomycin-resistant Enterococcus faecium in humans, dogs and cats in the Netherlands

    Article • Journal of Antimicrobial Chemotherapy, December 2017, Oxford University Press (OUP)

    Dr Janetta Top

  25. Characterization of Enterococcus Isolates Colonizing the Intestinal Tract of Intensive Care Unit Patients Receiving Selective Digestive Decontamination

    Article • Frontiers in Microbiology, August 2017, Frontiers

    Dr Janetta Top

  26. Intraluminal Agglutination of E. faecium

    Article • mBio, November 2015, ASM Journals

    Dr Antoni P Hendrickx, Dr Rob JL Willems, Dr Janetta Top

  27. Growth condition-dependent cell surface proteome analysis of Enterococcus faecium

    Article • PROTEOMICS, October 2015, Wiley

    Dr Rob JL Willems, Dr Janetta Top

  28. Molecular epidemiology of Enterococcus faecium

    Article • Journal of Clinical Microbiology, September 2015, ASM Journals

    Dr Rob JL Willems, Prof. Dr. Alexander Mellmann, Dr Janetta Top

  29. Environmental survival of vancomycin-sensitive ampicillin-resistant Enterococcus faecium (AREfm)

    Article • European Journal of Clinical Microbiology & Infectious Diseases, July 2015, Springer Science + Business Media

    Dr Rob JL Willems, Dr Janetta Top

  30. Multiple-Locus Variable Number Tandem Repeat Analysis Typing of Vancomycin-Resistant Enterococcus faecium in Serbia

    Article • Infection Control, December 2013, Cambridge University Press

    Dr Rob JL Willems, Dr Janetta Top

  31. The Enterococcus faecium Enterococcal Biofilm Regulator, EbrB, Regulates the esp Operon and Is Implicated in Biofilm Formation and Intestinal Colonization

    Article • PLoS ONE, May 2013, PLOS

    Dr Rob JL Willems, Dr Janetta Top

  32. Identification of a Genetic Determinant in Clinical Enterococcus faecium Strains That Contributes to Intestinal Colonization During Antibiotic Treatment

    Article • The Journal of Infectious Diseases, February 2013, Oxford University Press (OUP)

    Dr Rob JL Willems, Dr Janetta Top

  33. Functional genomic analysis of bile salt resistance in Enterococcus faecium

    Article • BMC Genomics, January 2013, Springer Science + Business Media

    Dr Rob JL Willems, Dr Janetta Top

  34. Restricted Gene Flow among Hospital Subpopulations of Enterococcus faecium

    Article • mBio, July 2012, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  35. Dynamics of ampicillin-resistant Enterococcus faecium clones colonizing hospitalized patients: Data from a prospective observational study

    Article • BMC Infectious Diseases, January 2012, Springer Science + Business Media

    Dr Rob JL Willems, Dr Janetta Top

  36. Intra- and Interspecies Genomic Transfer of the Enterococcus faecalis Pathogenicity Island

    Article • PLoS ONE, April 2011, PLOS

    Dr Rob JL Willems, Dr Janetta Top

  37. Environmental survival of vancomycin-resistant Enterococcus faecium

    Article • Journal of Hospital Infection, March 2011, Elsevier

    Dr Rob JL Willems, Dr Janetta Top

  38. The Recombinase IntA Is Required for Excision of esp-Containing ICEEfm1 in Enterococcus faecium

    Article • Journal of Bacteriology, December 2010, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  39. Evaluation of the DiversiLab System for Detection of Hospital Outbreaks of Infections by Different Bacterial Species

    Article • Journal of Clinical Microbiology, September 2010, ASM Journals

    Dr Janetta Top

  40. Failure of vancomycin treatment for meningitis caused by vancomycin-susceptible Enterococcus faecium

    Article • Scandinavian Journal of Infectious Diseases, May 2010, Taylor & Francis

    Dr Janetta Top

  41. Frequent occurrence of multidrug-resistant CC17Enterococcus faeciumamong clinical isolates in Sweden

    Article • Journal of Applied Microbiology, May 2010, Oxford University Press (OUP)

    Dr Janetta Top

  42. Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Dr Rob JL Willems, Dr Janetta Top

  43. Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria

    Article • Intensive Care Medicine, November 2009, Springer Science + Business Media

    Dr Rob JL Willems, Dr Janetta Top

  44. Comparison of Two Chromogenic Media for Selective Isolation of Vancomycin-Resistant Enterococci from Stool Specimens

    Article • Journal of Clinical Microbiology, October 2009, ASM Journals

    Dr Janetta Top

  45. Intestinal Colonization with Enterococcus faecium Does Not Influence Pulmonary Defense against Pseudomonas aeruginosa in Mice

    Article • PLoS ONE, August 2009, PLOS

    Dr Rob JL Willems, Dr Janetta Top

  46. Spread without known selective pressure of a vancomycin-resistant clone of Enterococcus faecium among broilers

    Article • Journal of Antimicrobial Chemotherapy, March 2009, Oxford University Press (OUP)

    Dr Janetta Top

  47. Dogs Are a Reservoir of Ampicillin-Resistant Enterococcus faecium Lineages Associated with Human Infections

    Article • Applied and Environmental Microbiology, February 2009, ASM Journals

    Dr Rob JL Willems, Professor Luca Guardabassi, Dr Janetta Top

  48. High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital

    Article • Journal of Antimicrobial Chemotherapy, September 2008, Oxford University Press (OUP)

    Dr Rob JL Willems, Dr Janetta Top

  49. Emergence of CC17 Enterococcus faecium : from commensal to hospital-adapted pathogen

    Article • FEMS Immunology & Medical Microbiology, April 2008, Oxford University Press (OUP)

    Dr Rob JL Willems, Dr Janetta Top

  50. Comparison of multiple-locus variable-number tandem repeat analysis and pulsed-field gel electrophoresis in a setting of polyclonal endemicity of vancomycin-resistant Enterococcus faecium

    Article • Clinical Microbiology and Infection, April 2008, Elsevier

    Dr Rob JL Willems, Dr Janetta Top

  51. Molecular characterization of vancomycin-resistant Enterococcus spp. clinical isolates from Hungary and Serbia

    Article • Scandinavian Journal of Infectious Diseases, January 2008, Taylor & Francis

    Dr Rob JL Willems, Dr Janetta Top

  52. Emergence of Clonal Complex 17 Enterococcus faecium in The Netherlands

    Article • Journal of Clinical Microbiology, October 2007, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  53. Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium

    Article • Clinical Microbiology and Infection, March 2007, Elsevier

    Dr Rob JL Willems, Dr Janetta Top

  54. Growth Condition-Dependent Esp Expression by Enterococcus faecium Affects Initial Adherence and Biofilm Formation

    Article • Infection and Immunity, November 2006, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  55. Multilocus Sequence Typing Scheme for Enterococcus faecalis Reveals Hospital-Adapted Genetic Complexes in a Background of High Rates of Recombination

    Article • Journal of Clinical Microbiology, June 2006, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  56. Multilocus Sequence Typing of Hospital-Associated Enterococcus faecium from Brazil Reveals Their Unique Evolutionary History

    Article • Microbial Drug Resistance, June 2006, Mary Ann Liebert Inc

    Dr Rob JL Willems, Dr Janetta Top

  57. High-Level Ciprofloxacin Resistance from Point Mutations in gyrA and parC Confined to Global Hospital-Adapted Clonal Lineage CC17 of Enterococcus faecium

    Article • Journal of Clinical Microbiology, March 2006, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  58. Population Structure of Enterococcus faecium Causing Bacteremia in a Spanish University Hospital: Setting the Scene for a Future Increase in Vancomycin Resistance?

    Article • Antimicrobial Agents and Chemotherapy, July 2005, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  59. Unnoticed Spread of Integron-Carrying Enterobacteriaceae in Intensive Care Units

    Article • Clinical Infectious Diseases, July 2005, Oxford University Press (OUP)

    Dr Janetta Top

  60. Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex

    Article • Emerging Infectious Diseases, June 2005, Centers for Disease Control and Prevention (CDC)

    Professor Fernando Baquero, Dr Rob JL Willems, Professor Teresa M. Coque, Dr Janetta Top

  61. Molecular Analysis of Human, Porcine, and Poultry Enterococcus faecium Isolates and Their erm(B) Genes

    Article • Applied and Environmental Microbiology, May 2005, ASM Journals

    Professor Freddy Haesebrouck, Dr Rob JL Willems, Dr Janetta Top

  62. Multiple-Locus Variable-Number Tandem Repeat Analysis, a Novel Typing Scheme To Study the Genetic Relatedness and Epidemiology of Enterococcus faecium Isolates

    Article • Journal of Clinical Microbiology, October 2004, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  63. Multilocus Variable-Number Tandem-Repeat Polymorphism among Brazilian Enterococcus faecalis Strains

    Article • Journal of Clinical Microbiology, October 2004, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  64. Duplex Real-Time PCR Assay for Rapid Detection of Ampicillin-Resistant Enterococcus faecium

    Article • Antimicrobial Agents and Chemotherapy, February 2004, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  65. A Novel Putative Enterococcal Pathogenicity Island Linked to the esp Virulence Gene of Enterococcus faecium and Associated with Epidemicity

    Article • Journal of Bacteriology, February 2004, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  66. Mutations in the DNA Mismatch Repair Proteins MutS and MutL of Oxazolidinone-Resistant or -Susceptible Enterococcus faecium

    Article • Antimicrobial Agents and Chemotherapy, October 2003, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  67. Epidemic and Nonepidemic Multidrug-Resistant Enterococcus faecium

    Article • Emerging Infectious Diseases, September 2003, Centers for Disease Control and Prevention (CDC)

    Dr Rob JL Willems, Dr Janetta Top

  68. Molecular Characterization of Ampicillin-Resistant Enterococcus faecium Isolates from Hospitalized Patients in Norway

    Article • Journal of Clinical Microbiology, June 2003, ASM Journals

    Dr Rob JL Willems, Dr Janetta Top

  69. Antibiotic resistance of faecal enterococci in poultry, poultry farmers and poultry slaughterers

    Article • Journal of Antimicrobial Chemotherapy, March 2002, Oxford University Press (OUP)

    Dr Janetta Top

  70. Molecular Analysis of Tn1546-Like Elements in Vancomycin-Resistant Enterococci Isolated from Patients in Europe Shows Geographic Transposon Type Clustering

    Article • Antimicrobial Agents and Chemotherapy, March 2001, ASM Journals

    Dr Janetta Top

  71. Variant esp gene as a marker of a distinct genetic lineage of vancomycinresistant Enterococcus faecium spreading in hospitals

    Article • The Lancet, March 2001, Elsevier

    Dr Rob JL Willems, Dr Janetta Top

  72. Host Specificity of Vancomycin‐Resistant Enterococcus faecium

    Article • The Journal of Infectious Diseases, September 2000, Oxford University Press (OUP)

    Dr Rob JL Willems, Dr Janetta Top

  73. Enterococci with Glycopeptide Resistance in Turkeys, Turkey Farmers, Turkey Slaughterers, and (Sub)Urban Residents in the South of The Netherlands: Evidence for Transmission of Vancomycin Resistance from Animals to Humans?

    Article • Antimicrobial Agents and Chemotherapy, September 1999, ASM Journals

    Dr Janetta Top

  74. Molecular Diversity and Evolutionary Relationships of Tn1546-Like Elements in Enterococci from Humans and Animals

    Article • Antimicrobial Agents and Chemotherapy, March 1999, ASM Journals

    Dr Janetta Top

  75. The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model

    Article • Vaccine, February 1998, Elsevier

    Dr Rob JL Willems, Dr Janetta Top

  76. A Novel Pathogenic Taxon of the Mycobacterium tuberculosis Complex, Canetti: Characterization of an Exceptional Isolate from Africa

    Article • International Journal of Systematic Bacteriology, October 1997, Society for General Microbiology

    Dr Janetta Top

  77. Role of the Bordetella pertussis minor fimbrial subunit, FimD, in colonization of the mouse respiratory tract

    Article • Infection and Immunity, October 1997, ASM Journals

    Dr Janetta Top

  78. Rapid typing of group A streptococci by the use of DNA amplification and non-radioactive allele-specific oligonucleotide probes

    Article • FEMS Microbiology Letters, June 1994, Oxford University Press (OUP)

    Dr Janetta Top

  79. Development and evaluation of a monoclonal antibody inhibition enzyme linked immunosorbent assay to diagnose syphilis.

    Article • Sexually Transmitted Infections, October 1989, BMJ

    Dr Janetta Top

  80. Sensitivity and specificity of an enzyme-linked immunosorbent assay using the recombinant DNA-derived Treponema pallidum protein TmpA for serodiagnosis of syphilis and the potential use of TmpA for assessing the effect of antibiotic therapy

    Article • Journal of Clinical Microbiology, January 1989, ASM Journals

    Dr Janetta Top