All Stories

  1. Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus

    Article • mLife, February 2025, Tsinghua University Press

    Hualan Chen

  2. PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

    Article • PLoS Pathogens, April 2022, PLOS

    Hualan Chen

  3. A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis

    Article • PLoS Pathogens, December 2021, PLOS

    Hualan Chen

  4. Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China

    Article • PLoS Pathogens, April 2021, PLOS

    Hualan Chen

  5. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission

    Article • PLoS Pathogens, February 2021, PLOS

    Hualan Chen

  6. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets

    Article • Emerging Microbes & Infections, January 2019, Taylor & Francis

    Yasuo Suzuki, Hualan Chen

  7. A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs

    Article • Journal of Virology, August 2017, ASM Journals

    Hualan Chen

  8. Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response

    Article • Journal of Virology, January 2017, ASM Journals

    Hualan Chen

  9. Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking

    Article • Journal of Virology, October 2016, ASM Journals

    Hualan Chen

  10. Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China

    Article • Journal of Virology, August 2016, ASM Journals

    Hualan Chen

  11. Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice

    Article • Journal of Virology, December 2015, ASM Journals

    Hualan Chen

  12. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China

    Article • Journal of Virology, November 2015, ASM Journals

    Hualan Chen

  13. Rapid Detection of Subtype H10N8 Influenza Virus by One-Step Reverse Transcription–Loop-Mediated Isothermal Amplification Methods

    Article • Journal of Clinical Microbiology, September 2015, ASM Journals

    Hualan Chen

  14. Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China

    Article • Journal of Virology, April 2015, ASM Journals

    Hualan Chen

  15. The vaccine efficacy of recombinant duck enteritis virus expressing secreted E with or without PrM proteins of duck tembusu virus

    Article • Vaccine, September 2014, Elsevier

    Hualan Chen

  16. Avian influenza vaccines against H5N1 ‘bird flu’

    Article • Trends in Biotechnology, March 2014, Elsevier

    Hualan Chen

  17. H6 Influenza Viruses Pose a Potential Threat to Human Health

    Article • Journal of Virology, February 2014, ASM Journals

    Hualan Chen

  18. The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus

    Article • Journal of General Virology, January 2014, Society for General Microbiology

    Hualan Chen

  19. Identification of a linear epitope on the haemagglutinin protein of pandemic A/H1N1 2009 influenza virus using monoclonal antibodies

    Article • Archives of Virology, January 2014, Springer Science + Business Media

    Hualan Chen

  20. Development of a Reverse Transcription Loop-Mediated Isothermal Amplification Method for the Rapid Detection of Subtype H7N9 Avian Influenza Virus

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Hualan Chen

  21. Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice

    Article • Virus Research, December 2013, Elsevier

    Hualan Chen

  22. A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge

    Article • Vaccine, November 2013, Elsevier

    Hualan Chen, Dr Guangliang Liu

  23. H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

    Article • Science, July 2013, American Association for the Advancement of Science

    Hualan Chen

  24. Complex Reassortment of Multiple Subtypes of Avian Influenza Viruses in Domestic Ducks at the Dongting Lake Region of China

    Article • Journal of Virology, June 2013, ASM Journals

    Hualan Chen

  25. Efficacy of Parainfluenza Virus 5 Mutants Expressing Hemagglutinin from H5N1 Influenza A Virus in Mice

    Article • Journal of Virology, June 2013, ASM Journals

    Hualan Chen, Stephen Mark Tompkins

  26. The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

    Article • Nature Genetics, June 2013, Springer Science + Business Media

    Hualan Chen, Dr Jacqueline Smith

  27. Isolation and characterization of H7N9 viruses from live poultry markets — Implication of the source of current H7N9 infection in humans

    Article • Chinese Science Bulletin, April 2013, Springer Science + Business Media

    Hualan Chen

  28. Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection

    Article • Antiviral Research, March 2013, Elsevier

    Hualan Chen

  29. Co-circulation of pandemic 2009 H1N1, classical swine H1N1 and avian-like swine H1N1 influenza viruses in pigs in China

    Article • Infection Genetics and Evolution, January 2013, Elsevier

    Hualan Chen

  30. Protective Efficacy of an H5N1 DNA Vaccine Against Challenge with a Lethal H5N1 Virus in Quail

    Article • Avian Diseases, December 2012, American Association of Avian Pathologists (AAAP)

    Hualan Chen

  31. Phylogenetic and Pathogenic Analyses of Avian Influenza A H5N1 Viruses Isolated from Poultry in Vietnam

    Article • PLOS One, November 2012, PLOS

    Hualan Chen

  32. Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs

    Article • Virology, October 2012, Elsevier

    Hualan Chen

  33. Characterization of Immune Responses Induced by Immunization with the HA DNA Vaccines of Two Antigenically Distinctive H5N1 HPAIV Isolates

    Article • PLOS One, July 2012, PLOS

    Hualan Chen

  34. Human Infection from Avian-like Influenza A (H1N1) Viruses in Pigs, China

    Article • Emerging Infectious Diseases, July 2012, Centers for Disease Control and Prevention (CDC)

    Hualan Chen

  35. Key Molecular Factors in Hemagglutinin and PB2 Contribute to Efficient Transmission of the 2009 H1N1 Pandemic Influenza Virus

    Article • Journal of Virology, June 2012, ASM Journals

    Hualan Chen

  36. Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses

    Article • PROTEOMICS, June 2012, Wiley

    Hualan Chen

  37. Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice

    Article • Antiviral Research, March 2012, Elsevier

    Hualan Chen

  38. Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of avian influenza virus subtype H7

    Article • Journal of Virological Methods, January 2012, Elsevier

    Hualan Chen

  39. Reassortant H1N1 influenza virus vaccines protect pigs against pandemic H1N1 influenza virus and H1N2 swine influenza virus challenge

    Article • Veterinary Microbiology, September 2011, Elsevier

    Hualan Chen

  40. Newcastle Disease Virus-Vectored Rabies Vaccine Is Safe, Highly Immunogenic, and Provides Long-Lasting Protection in Dogs and Cats

    Article • Journal of Virology, June 2011, ASM Journals

    Hualan Chen

  41. Strategies for improving the efficacy of a H6 subtype avian influenza DNA vaccine in chickens

    Article • Journal of Virological Methods, May 2011, Elsevier

    Hualan Chen

  42. New Avian Influenza Virus (H5N1) in Wild Birds, Qinghai, China

    Article • Emerging Infectious Diseases, February 2011, Centers for Disease Control and Prevention (CDC)

    Hualan Chen

  43. The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks

    Article • Journal of Virology, December 2010, ASM Journals

    Hualan Chen

  44. Dogs are highly susceptible to H5N1 avian influenza virus

    Article • Virology, September 2010, Elsevier

    Hualan Chen

  45. A protein chip designed to differentiate visually antibodies in chickens which were infected by four different viruses

    Article • Journal of Virological Methods, August 2010, Elsevier

    Hualan Chen

  46. Characterization of monoclonal antibodies against Muscovy duck reovirus σB protein

    Article • Virology Journal, June 2010, Springer Science + Business Media

    Hualan Chen

  47. Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic Poultry, and Humans in China from 2004 to 2009

    Article • Journal of Virology, June 2010, ASM Journals

    Hualan Chen

  48. Molecular Basis of Neurovirulence of Flury Rabies Virus Vaccine Strains: Importance of the Polymerase and the Glycoprotein R333Q Mutation

    Article • Journal of Virology, June 2010, ASM Journals

    Hualan Chen

  49. Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity

    Article • Virology, May 2010, Elsevier

    Hualan Chen

  50. Generation and Evaluation of a Newcastle Disease Virus–Based H9 Avian Influenza Live Vaccine

    Article • Avian Diseases, March 2010, American Association of Avian Pathologists (AAAP)

    Hualan Chen

  51. Protective Efficacy of H7 Subtype Avian Influenza DNA Vaccine

    Article • Avian Diseases, March 2010, American Association of Avian Pathologists (AAAP)

    Hualan Chen

  52. Protective Efficacy of the H5 Inactivated Vaccine Against Different Highly Pathogenic H5N1 Avian Influenza Viruses Isolated in China and Vietnam

    Article • Avian Diseases, March 2010, American Association of Avian Pathologists (AAAP)

    Hualan Chen

  53. Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host

    Article • PLoS Pathogens, December 2009, PLOS

    Hualan Chen

  54. H5N1 influenza viruses: outbreaks and biological properties

    Article • BDJ, November 2009, Springer Science + Business Media

    Hualan Chen

  55. Two genotypes of H1N2 swine influenza viruses appeared among pigs in China

    Article • Journal of Clinical Virology, October 2009, Elsevier

    Hualan Chen

  56. The N-Terminal Region of the PA Subunit of the RNA Polymerase of Influenza A/HongKong/156/97 (H5N1) Influences Promoter Binding

    Article • PLOS One, May 2009, PLOS

    Hualan Chen

  57. H5N1 avian influenza in China

    Article • Science in China Series C Life Sciences, May 2009, Springer Science + Business Media

    Hualan Chen

  58. Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

    Article • PLoS Pathogens, May 2009, PLOS

    Hualan Chen

  59. Recombinant fowlpox virus vector-based vaccine completely protects chickens from H5N1 avian influenza virus

    Article • Antiviral Research, March 2009, Elsevier

    Hualan Chen

  60. Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice

    Article • Virology, February 2009, Elsevier

    Hualan Chen

  61. Development and Application of Avian Influenza Vaccines in China

    Article • January 2009, Springer Science + Business Media

    Hualan Chen

  62. Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons

    Article • Archives of Virology, September 2008, Springer Science + Business Media

    Hualan Chen

  63. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens

    Article • Biochemical and Biophysical Research Communications, July 2008, Elsevier

    Hualan Chen

  64. Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody

    Article • Biochemical and Biophysical Research Communications, June 2008, Elsevier

    Hualan Chen

  65. A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in Mice

    Article • Journal of Virology, March 2008, ASM Journals

    Hualan Chen

  66. Epidemiology and Control of H5N1 Avian Influenza in China

    Article • January 2008, Karger Publishers

    Hualan Chen

  67. A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in Mice

    Article • Journal of Virology, November 2007, ASM Journals

    Hualan Chen

  68. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice

    Article • Virus Research, September 2007, Elsevier

    Hualan Chen

  69. Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector

    Article • Antiviral Research, September 2007, Elsevier

    Hualan Chen

  70. Newcastle Disease Virus-Based Live Attenuated Vaccine Completely Protects Chickens and Mice from Lethal Challenge of Homologous and Heterologous H5N1 Avian Influenza Viruses

    Article • Journal of Virology, October 2006, ASM Journals

    Hualan Chen

  71. Efficacy of DNA Immunization with F and G Protein Genes of Nipah Virus

    Article • Annals of the New York Academy of Sciences, October 2006, Wiley

    Hualan Chen

  72. Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China

    Article • Annals of the New York Academy of Sciences, October 2006, Wiley

    Hualan Chen

  73. Generating Vesicular Stomatitis Virus Pseudotype Bearing the Severe Acute Respiratory Syndrome Coronavirus Spike Envelope Glycoprotein for Rapid and Safe Neutralization Test or Cell‐Entry Assay

    Article • Annals of the New York Academy of Sciences, October 2006, Wiley

    Hualan Chen

  74. The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses

    Article • Journal of Virology, September 2006, ASM Journals

    Hualan Chen

  75. Characterization of An Avian Influenza Virus of Subtype H7N2 Isolated from Chickens in Northern China

    Article • Virus Genes, August 2006, Springer Science + Business Media

    Hualan Chen

  76. The first confirmed human case of avian influenza A (H5N1) in Mainland China

    Article • The Lancet, January 2006, Elsevier

    Hualan Chen

  77. Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics

    Article • Virology, October 2005, Elsevier

    Hualan Chen

  78. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China

    Article • Virology, September 2005, Elsevier

    Hualan Chen

  79. Antigenic and genetic analysis of the H9N2 avian influenza viruses isolated in China

    Article • International Congress Series, June 2004, Elsevier

    Hualan Chen

  80. Development and evaluation of candidate influenza a vaccines for pandemic preparedness

    Article • International Congress Series, June 2004, Elsevier

    Hualan Chen

  81. Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate

    Article • Vaccine, October 2003, Elsevier

    Hualan Chen

  82. Evaluation of a Genetically Modified Reassortant H5N1 Influenza A Virus Vaccine Candidate Generated by Plasmid-Based Reverse Genetics

    Article • Virology, January 2003, Elsevier

    Hualan Chen