All Stories

  1. Chronic Low-Level IFN-γ Expression Disrupts Mitochondrial Complex I Activity in Renal Macrophages: An Early Mechanistic Driver of Lupus Nephritis Pathogenesis

    Article • International Journal of Molecular Sciences, December 2024, MDPI AG

    Dr Howard A Young

  2. Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production

    Article • EMBO Reports, November 2024, Springer Science + Business Media

    Dr Howard A Young

  3. D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance

    Article • Nutrients, September 2023, MDPI AG

    Dr Howard A Young

  4. IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells

    Article • The Journal of Immunology, September 2023, Oxford University Press (OUP)

    Dr Howard A Young

  5. Dual B-cell targeting therapy ameliorates autoimmune cholangitis

    Article • Journal of Autoimmunity, October 2022, Elsevier

    Dr Howard A Young

  6. Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression

    Article • Cellular and Molecular Immunology, August 2022, Springer Science + Business Media

    Dr Howard A Young

  7. Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?

    Article • Frontiers in Immunology, July 2022, Frontiers

    Dr Howard A Young

  8. Joost J. Oppenheim: 1934–2022

    Article • Journal of Leukocyte Biology, June 2022, Oxford University Press (OUP)

    Dr Howard A Young

  9. Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages

    Article • Cancer Research, December 2021, American Association for Cancer Research (AACR)

    Dr Howard A Young

  10. Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic

    Article • Immunotherapy, November 2021, Future Medicine

    Dr Howard A Young

  11. Using PET imaging to track STING-induced interferon signaling

    Article • Proceedings of the National Academy of Sciences, September 2021, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  12. Cytokines: From Clinical Significance to Quantification

    Article • Advanced Science, June 2021, Wiley

    Dr Howard A Young

  13. Promise and complexity of lupus mouse models

    Article • Nature Immunology, May 2021, Springer Science + Business Media

    Dr Howard A Young

  14. The Experts Speak: A New Feature in the JICR

    Article • Journal of Interferon & Cytokine Research, May 2021, Mary Ann Liebert Inc

    Dr Howard A Young

  15. Lessons learned: new insights on the role of cytokines in COVID-19

    Article • Nature Immunology, March 2021, Springer Science + Business Media

    Dr Howard A Young

  16. Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells

    Article • Journal of Autoimmunity, January 2021, Elsevier

    Dr Howard A Young

  17. IFNγ Is a Key Link between Obesity and Th1-Mediated AutoImmune Diseases

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Dr Howard A Young

  18. Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair–deficient tumors

    Article • Molecular Case Studies, October 2020, Cold Spring Harbor Laboratory Press

    Dr Stephen M Hewitt, Dr Howard A Young

  19. Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

    Article • Journal of Clinical Investigation, September 2020, American Society for Clinical Investigation

    Dr Howard A Young

  20. The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

    Article • Nature Immunology, August 2020, Springer Science + Business Media

    Dr Howard A Young

  21. Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases

    Article • Journal of Autoimmunity, July 2020, Elsevier

    Dr Howard A Young

  22. The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps

    Article • Toxicological Sciences, June 2020, Oxford University Press (OUP)

    Dr Howard A Young

  23. Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin

    Article • Acta Biomaterialia, January 2020, Elsevier

    Dr Howard A Young

  24. Meeting Overview: Interferon Lambda—Disease Impact and Therapeutic Potential

    Article • Journal of Interferon & Cytokine Research, October 2019, Mary Ann Liebert Inc

    Dr Howard A Young

  25. Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study

    Article • Journal of Thoracic Oncology, August 2019, Elsevier

    Dr Stephen M Hewitt, Dr Howard A Young

  26. Ion Gresser 1928–2019

    Article • Nature Immunology, June 2019, Springer Science + Business Media

    Dr Howard A Young

  27. IFN-γ: A cytokine at the right time, is in the right place

    Article • Seminars in Immunology, June 2019, Elsevier

    Dr Howard A Young

  28. Report on the 2018 Cancer, Autoimmunity, and Immunology Conference

    Article • The Journal of Immunology, April 2019, The American Association of Immunologists

    Dr Howard A Young, Colleen Curran

  29. Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development

    Article • PLoS Pathogens, January 2019, PLOS

    Dr Howard A Young

  30. Adaptive <i>in vivo</i> Device for Theranostics of Inflammation by Monitoring of Cytokine Interferon-γ and Its Triggered Aspirin Release

    Article • SSRN Electronic Journal, January 2019, Elsevier

    Dr Howard A Young

  31. Partners in Crime: Fledgling Tumors Hijack Inflammation

    Article • Journal of Interferon & Cytokine Research, January 2019, Mary Ann Liebert Inc

    Dr Howard A Young

  32. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

    Article • OncoImmunology, October 2018, Taylor & Francis

    Dr Howard A Young

  33. Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

    Article • Nature Immunology, July 2018, Springer Science + Business Media

    Dr Howard A Young

  34. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Dr Howard A Young

  35. Interferon-Gamma Impairs Maintenance and Alters Hematopoietic Support of Bone Marrow Mesenchymal Stromal Cells

    Article • Stem Cells and Development, May 2018, Mary Ann Liebert Inc

    Dr Howard A Young

  36. Dr. Luigi (Gigi) Varesio: A memorial

    Article • Journal of Leukocyte Biology, April 2018, Wiley

    Dr Howard A Young

  37. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity

    Article • Hepatology, February 2018, Wiley

    Dr Howard A Young

  38. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

    Article • Cell Reports, February 2018, Elsevier

    Dr Howard A Young

  39. Interferon-Gamma

    Article • January 2018, Springer Science + Business Media

    Dr Howard A Young

  40. Current prospects of type II interferon γ signaling and autoimmunity

    Article • Journal of Biological Chemistry, August 2017, Elsevier

    Dr Howard A Young

  41. Toward solving the etiological mystery of primary biliary cholangitis

    Article • Hepatology Communications, May 2017, Wolters Kluwer Health

    Dr Howard A Young

  42. Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis

    Article • Cell Reports, March 2017, Elsevier

    Dr Howard A Young

  43. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology

    Article • The Journal of Immunology, February 2017, The American Association of Immunologists

    Dr Howard A Young

  44. Therapeutic and immunological interventions in primary biliary cholangitis: from mouse models to humans

    Article • Archives of Medical Science, January 2017, Termedia Sp. z.o.o.

    Dr Howard A Young

  45. Chronic expression of interferon‐gamma leads to murine autoimmune cholangitis with a female predominance

    Article • Hepatology, June 2016, Wolters Kluwer Health

    Dr Howard A Young

  46. CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

    Article • PLoS Pathogens, May 2016, PLOS

    Dr Vitaly V Ganusov, Dr Howard A Young

  47. Aging Converts Innate B1a Cells into Potent CD8+T Cell Inducers

    Article • The Journal of Immunology, March 2016, The American Association of Immunologists

    Dr Howard A Young

  48. Interferon γ: An Overview of Its Functions in Health and Disease

    Article • January 2016, Elsevier

    Dr Howard A Young

  49. Regulation of IFN-γ Expression

    Article • January 2016, Springer Science + Business Media

    Dr Howard A Young

  50. Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications

    Article • Scientific Reports, December 2015, Springer Science + Business Media

    Dr Howard A Young

  51. Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis

    Article • BMC Biotechnology, December 2015, Springer Science + Business Media

    Dr Howard A Young

  52. Short Course in the Microbiome

    Article • Journal of Circulating Biomarkers, July 2015, Aboutscience Srl

    Dr Howard A Young

  53. NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay

    Article • Cancer Research, July 2015, American Association for Cancer Research (AACR)

    Dr Howard A Young

  54. Sera from patients with active systemic lupus erythematosus patients enhance the toll-like receptor 4 response in monocyte subsets

    Article • Journal of Inflammation, May 2015, Springer Science + Business Media

    Prof. Luís Sousa Ines, Dr Howard A Young

  55. Impact of dietary components on NK and Treg cell function for cancer prevention

    Article • Molecular Carcinogenesis, April 2015, Wiley

    Dr Howard A Young

  56. IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation

    Article • Blood, December 2014, American Society of Hematology

    Dr Howard A Young

  57. Does the microbiota play a role in the pathogenesis of autoimmune diseases?

    Article • Gut, November 2014, BMJ

    Dr Howard A Young

  58. IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

    Article • Journal of Autoimmunity, September 2014, Elsevier

    Dr Howard A Young, Dr Philipp Kaldis

  59. IFN-gamma causes aplastic anemia by altering HSC composition and interrupting lineage differentiation

    Article • Experimental Hematology, August 2014, Elsevier

    Dr Howard A Young

  60. Interferons: Success in anti-viral immunotherapy

    Article • Cytokine & Growth Factor Reviews, August 2014, Elsevier

    Dr Howard A Young

  61. Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

    Article • Proceedings of the National Academy of Sciences, April 2014, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  62. Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12

    Article • PLOS One, February 2014, PLOS

    Dr Howard A Young

  63. Impaired HCV Clearance in HIV/HCV Coinfected Subjects Treated with PegIFN and RBV Due to Interference of IFN Signaling by IFNαR2a

    Article • Journal of Interferon & Cytokine Research, January 2014, Mary Ann Liebert Inc

    Dr Howard A Young

  64. Faculty of 1000 evaluation for IL-4 blocks TH1-polarizing/inflammatory cytokine gene expression during monocyte-derived dendritic cell differentiation through histone hypoacetylation.

    Article • October 2013, Faculty of 1000, Ltd.

    Dr Howard A Young

  65. Interferon-β Therapy Prolongs Survival in Rhesus Macaque Models of Ebola and Marburg Hemorrhagic Fever

    Article • The Journal of Infectious Diseases, July 2013, Oxford University Press (OUP)

    Dr Howard A Young

  66. The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

    Article • Cancer Cell, April 2013, Elsevier

    Dr Howard A Young

  67. Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment—Poor Prognosis or New Therapeutic Opportunity

    Article • Clinical Cancer Research, March 2013, American Association for Cancer Research (AACR)

    Dr Howard A Young

  68. The talented interferon-gamma

    Article • Advances in Bioscience and Biotechnology, January 2013, Scientific Research Publishing, Inc,

    Dr Howard A Young

  69. Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling in Sirt6 Mutant Mice

    Article • Journal of Biological Chemistry, December 2012, Elsevier

    Dr Howard A Young

  70. Interleukin-18 in Pulmonary Inflammatory Diseases

    Article • Journal of Interferon & Cytokine Research, October 2012, Mary Ann Liebert Inc

    Dr Howard A Young

  71. MCP‐1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes

    Article • European Journal of Immunology, August 2012, Wiley

    Dr Howard A Young

  72. Scientific Apps are here (and more will be coming)

    Article • Cytokine, July 2012, Elsevier

    Dr Howard A Young

  73. Distinct and overlapping genomic profiles and antiviral effects of Interferon‐λ and ‐α on HCV‐infected and noninfected hepatoma cells

    Article • Journal of Viral Hepatitis, May 2012, Wiley

    Dr Howard A Young

  74. IFN-Gamma

    Article • January 2012, Springer Science + Business Media

    Dr Howard A Young

  75. IFN-γ

    Article • January 2012, Springer Science + Business Media

    Dr Howard A Young

  76. CS13-7. Loss of Ifn-g 3’Untranslated Region Au-rich Element Affects b220+ b Cell and Plasmacytoid Dendritic cell Populations in a Novel Murine Lupus Model

    Article • Cytokine, October 2011, Elsevier

    Dr Howard A Young

  77. Gut microbiota and probiotics in colon tumorigenesis

    Article • Cancer Letters, October 2011, Elsevier

    Dr Howard A Young

  78. Protein delivery using engineered virus-like particles

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  79. Revamping Research Funding

    Article • Genetic Engineering & Biotechnology News, September 2011, Mary Ann Liebert Inc

    Dr Howard A Young

  80. In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

    Article • Hepatology, July 2011, Wolters Kluwer Health

    Dr Howard A Young

  81. Differential microRNA regulation of HLA-C expression and its association with HIV control

    Article • Nature, April 2011, Nature

    Dr Howard A Young

  82. Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

    Article • The Journal of Immunology, April 2011, Oxford University Press (OUP)

    Dr Howard A Young

  83. Editorial: One small molecule: a new way to treat the flu?

    Article • Journal of Leukocyte Biology, March 2011, Oxford University Press (OUP)

    Dr Howard A Young

  84. Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis

    Article • PLOS One, February 2011, PLOS

    Dr Howard A Young

  85. Interferon-γ links ultraviolet radiation to melanomagenesis in mice

    Article • Nature, January 2011, Nature

    Dr Howard A Young, Sean Davis

  86. A novel role for IL-22R1 as a driver of inflammation

    Article • Blood, January 2011, American Society of Hematology

    Dr Howard A Young

  87. Probiotics: From Bench to Market

    Article • Annals of the New York Academy of Sciences, November 2010, Wiley

    Dr Howard A Young

  88. PS3-50 Differential transcriptosome profiles and antiviral effect of interferon-λ and interferon-α on HCV-infected and uninfected hepatoma cells

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  89. CS3-5 miRNA interacts with AU-rich elements stabilizing interferon gamma gene

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  90. SS4-4 Ku70 is a novel cytosolic DNA sensor and induces type-III IFN rather than Type-I IFN

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  91. CS1-2 Targeted removal of IFN-gamma 3′untranslated region AU-rich element alters B cell function resulting in lupus-like disease in C57BL6 mice

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  92. Interleukin-26: An IL-10-related cytokine produced by Th17 cells

    Article • Cytokine & Growth Factor Reviews, October 2010, Elsevier

    Dr Howard A Young

  93. PL3-5 A novel role of IL-22R1 as a possible driver of inflammation in ALK+ anaplastic large cell lymphoma

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  94. Interferon Therapy for Malignant Solid Tumors

    Article • Current Drug Therapy, May 2010, Bentham Science Publishers

    Dr Howard A Young

  95. Clinical Use of Interferon-γ

    Article • Annals of the New York Academy of Sciences, December 2009, Wiley

    Dr Howard A Young

  96. Role of Proinflammatory Cytokines IL-18 and IL-1β in Bleomycin-Induced Lung Injury in Humans and Mice

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2009, American Thoracic Society

    Dr Howard A Young

  97. An Overview of Cytokines and Cytokine Antagonists as Therapeutic Agents

    Article • Annals of the New York Academy of Sciences, December 2009, Wiley

    Dr Howard A Young

  98. Lentiviral Gene Transduction in Human and Mouse NK Cell Lines

    Article • November 2009, Springer Science + Business Media

    Dr Howard A Young

  99. Novel gene expression patterns in IFN-gamma 3′untranslated region AU-rich element-deleted mice

    Article • Cytokine, October 2009, Elsevier

    Dr Howard A Young

  100. Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity

    Article • The Journal of Immunology, July 2009, Oxford University Press (OUP)

    Dr Howard A Young

  101. Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias

    Article • Cancer Research, April 2009, American Association for Cancer Research (AACR)

    Dr Howard A Young

  102. Structural conservation of interferon gamma among vertebrates

    Article • Cytokine & Growth Factor Reviews, April 2009, Elsevier

    Dr Howard A Young

  103. Cytokine Multiplex Analysis

    Article • January 2009, Springer Science + Business Media

    Dr Howard A Young

  104. BCL11B enhances TCR/CD28-triggered NF-κB activation through up-regulation of Cot kinase gene expression in T-lymphocytes

    Article • Biochemical Journal, December 2008, Portland Press Ltd.

    Dr Howard A Young

  105. SY-12 The Role of miRNAs in the regulation of interferon-gamma gene expression

    Article • Cytokine, September 2008, Elsevier

    Dr Howard A Young

  106. 293 IFN-γ 3′untranslated region AU-RICH element-deleted mice have altered immune structure and function

    Article • Cytokine, September 2008, Elsevier

    Dr Howard A Young

  107. Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

    Article • Journal of Medicinal Chemistry, August 2008, American Chemical Society (ACS)

    Dr Howard A Young

  108. Protein Kinase R-dependent Regulation of Interleukin-10 in Response to Double-stranded RNA

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams, Dr Howard A Young

  109. In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

    Article • The Journal of Immunology, April 2008, Oxford University Press (OUP)

    Dr Howard A Young

  110. Murine β-defensin 2 promotes TLR-4/MyD88-mediated and NF-κB-dependent atypical death of APCs via activation of TNFR2

    Article • Journal of Leukocyte Biology, January 2008, Oxford University Press (OUP)

    Dr Howard A Young

  111. Marburg Virus Angola Infection of Rhesus Macaques: Pathogenesis and Treatment with Recombinant Nematode Anticoagulant Protein c2

    Article • The Journal of Infectious Diseases, November 2007, Oxford University Press (OUP)

    Dr Howard A Young

  112. A Novel Role of the Interferon-inducible Protein IFI16 as Inducer of Proinflammatory Molecules in Endothelial Cells

    Article • Journal of Biological Chemistry, November 2007, Elsevier

    Dr Howard A Young

  113. Modulation of lymphocyte function with inhibitory CD2: Loss of NK and NKT cells

    Article • Cellular Immunology, September 2007, Elsevier

    Dr Howard A Young

  114. The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever

    Article • Genome Biology, August 2007, Springer Science + Business Media

    Dr Howard A Young

  115. NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye

    Article • The Journal of Immunology, August 2007, Oxford University Press (OUP)

    Dr Howard A Young

  116. 54 Challenging Evolution: Eliminating the IFN-gamma 3 ARE Effects T Cell Homeostasis

    Article • Cytokine, July 2007, Elsevier

    Dr Howard A Young

  117. Pulmonary Inflammation and Emphysema

    Article • American Review of Respiratory Disease, July 2007, American Thoracic Society

    Dr Howard A Young

  118. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

    Article • Journal of Experimental Medicine, June 2007, Rockefeller University Press

    Dr Howard A Young

  119. Post-transcriptional control of the interferon system

    Article • Biochimie, June 2007, Elsevier

    Dr Howard A Young

  120. Hematopoiesis and Thymic Apoptosis Are Not Affected by the Loss of Cdk2

    Article • Molecular and Cellular Biology, May 2007, ASM Journals

    Dr Philipp Kaldis, Dr Howard A Young

  121. NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis

    Article • The Journal of Immunology, November 2006, Oxford University Press (OUP)

    Dr Howard A Young

  122. The Proinflammatory Cytokine Interleukin-18 Alters Multiple Signaling Pathways to Inhibit Natural Killer Cell Death

    Article • Journal of Interferon & Cytokine Research, October 2006, Mary Ann Liebert Inc

    Dr Howard A Young

  123. The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo

    Article • Molecular and Cellular Biology, July 2006, ASM Journals

    Dr Howard A Young

  124. Interferon-γ: Gene and Protein Structure, Transcription Regulation, and Actions

    Article • June 2006, Wiley

    Dr Howard A Young

  125. IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes

    Article • Seminars in Immunology, June 2006, Elsevier

    Dr Howard A Young

  126. TL1A: A mediator of gut inflammation

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  127. An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells

    Article • Genes & Immunity, May 2006, Springer Science + Business Media

    Dr Howard A Young

  128. Unraveling the Pros and Cons of Interferon-γ Gene Regulation

    Article • Immunity, May 2006, Elsevier

    Dr Howard A Young

  129. Peroxisome proliferator activated receptor γ in colonic epithelial cells protects against experimental inflammatory bowel disease

    Article • Gut, March 2006, BMJ

    Dr Howard A Young

  130. Regulation of ITAM-positive receptors: role of IL-12 and IL-18

    Article • Blood, February 2006, American Society of Hematology

    Dr Howard A Young

  131. Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity

    Article • Journal of Leukocyte Biology, February 2006, Oxford University Press (OUP)

    Dr Howard A Young

  132. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells

    Article • BDJ, January 2006, Springer Science + Business Media

    Dr Howard A Young

  133. Interleukin-10 and the immune response against cancer: a counterpoint

    Article • Journal of Leukocyte Biology, October 2005, Oxford University Press (OUP)

    Dr Howard A Young

  134. Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex

    Article • The Journal of Immunology, September 2005, Oxford University Press (OUP)

    Dr Howard A Young

  135. Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma

    Article • Biochemical and Biophysical Research Communications, September 2005, Elsevier

    Dr Howard A Young

  136. Coactivators and Corepressors of NF-κB in IκBα Gene Promoter

    Article • Journal of Biological Chemistry, June 2005, Elsevier

    Dr Howard A Young

  137. Cytokine-driven cell cycling is mediated through Cdc25A

    Article • Journal of Cell Biology, May 2005, Rockefeller University Press

    Dr Howard A Young

  138. Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

    Article • The Journal of Immunology, May 2005, Oxford University Press (OUP)

    Dr Howard A Young

  139. Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe

    Article • Bioorganic & Medicinal Chemistry, April 2005, Elsevier

    Dr Howard A Young

  140. Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression

    Article • The Journal of Immunology, February 2005, The American Association of Immunologists

    Dr Howard A Young

  141. TGF-β and Vitamin D3 Utilize Distinct Pathways to Suppress IL-12 Production and Modulate Rapid Differentiation of Human Monocytes into CD83+ Dendritic Cells

    Article • The Journal of Immunology, February 2005, Oxford University Press (OUP)

    Dr Howard A Young

  142. Mouse Ly49 NK receptors: balancing activation and inhibition

    Article • Molecular Immunology, February 2005, Elsevier

    Dr Howard A Young

  143. Triptolide Attenuates Endotoxin- and Staphylococcal Exotoxin-Induced T-Cell Proliferation and Production of Cytokines and Chemokines

    Article • Immunopharmacology and Immunotoxicology, January 2005, Taylor & Francis

    Dr Howard A Young

  144. Interleukin-10 Induces Uteroglobin-related Protein (UGRP) 1 Gene Expression in Lung Epithelial Cells through Homeodomain Transcription Factor T/EBP/NKX2.1

    Article • Journal of Biological Chemistry, December 2004, Elsevier

    Dr Howard A Young

  145. Enhancer Role of STAT5 in CD2 Activation of IFN-γ Gene Expression

    Article • The Journal of Immunology, November 2004, Oxford University Press (OUP)

    Dr Howard A Young

  146. Peroxisome proliferator-activated receptor-γ and its ligands attenuate biologic functions of human natural killer cells

    Article • Blood, November 2004, American Society of Hematology

    Dr Howard A Young

  147. BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages

    Article • Journal of Biological Chemistry, November 2004, Elsevier

    Dr Howard A Young

  148. Mouse Susceptibility to Anthrax Lethal Toxin Is Influenced by Genetic Factors in Addition to Those Controlling Macrophage Sensitivity

    Article • Infection and Immunity, August 2004, ASM Journals

    Dr Howard A Young

  149. A Distal Region in the Interferon-γ Gene Is a Site of Epigenetic Remodeling and Transcriptional Regulation by Interleukin-2

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Howard A Young

  150. Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members

    Article • Molecular and Cellular Biology, July 2004, ASM Journals

    Dr Howard A Young

  151. Analysis of Murine Natural Killer Cell Microsomal Proteins Using Two-Dimensional Liquid Chromatography Coupled to Tandem Electrospray Ionization Mass Spectrometry

    Article • Journal of Proteome Research, July 2004, American Chemical Society (ACS)

    Dr Howard A Young

  152. Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection

    Article • Journal of Experimental Medicine, July 2004, Rockefeller University Press

    Dr Howard A Young

  153. Proteomic investigation of natural killer cell microsomes using gas-phase fractionation by mass spectrometry

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, April 2004, Elsevier

    Dr Howard A Young

  154. Interleukin 2 plays a central role in Th2 differentiation

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  155. Inactivation of Stat3 in tumor cells

    Article • Cancer Cell, February 2004, Elsevier

    Dr Howard A Young

  156. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells

    Article • Journal of Leukocyte Biology, January 2004, Oxford University Press (OUP)

    Dr Howard A Young

  157. Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides

    Article • The Journal of Immunology, January 2004, Oxford University Press (OUP)

    Dr Howard A Young

  158. Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2

    Article • Experimental Gerontology, January 2004, Elsevier

    Dr Howard A Young

  159. Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines

    Article • Blood, December 2003, American Society of Hematology

    Dr Howard A Young

  160. Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages Is a Key Event

    Article • The Journal of Infectious Diseases, December 2003, Oxford University Press (OUP)

    Dr Howard A Young

  161. Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques

    Article • American Journal Of Pathology, December 2003, Elsevier

    Dr Howard A Young

  162. Pathogenesis of Ebola Hemorrhagic Fever in Primate Models

    Article • American Journal Of Pathology, December 2003, Elsevier

    Dr Howard A Young

  163. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

    Article • The Lancet, December 2003, Elsevier

    Dr Howard A Young

  164. IFN-  Polymorphisms (IFN-  +2109 and IFN-  +3810) Are Associated with Severe Hepatic Fibrosis in Human Hepatic Schistosomiasis (Schistosoma mansoni)

    Article • The Journal of Immunology, November 2003, The American Association of Immunologists

    Dr Howard A Young

  165. Redox-active Protein Thioredoxin Prevents Proinflammatory Cytokine- or Bleomycin-induced Lung Injury

    Article • American Review of Respiratory Disease, November 2003, American Thoracic Society

    Dr Howard A Young

  166. Receptor Glycosylation Regulates Ly-49 Binding to MHC Class I

    Article • The Journal of Immunology, October 2003, Oxford University Press (OUP)

    Dr Howard A Young

  167. Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells

    Article • Blood, September 2003, American Society of Hematology

    Dr Howard A Young

  168. Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

    Article • Journal of Clinical Investigation, September 2003, American Society for Clinical Investigation

    Dr Howard A Young

  169. The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation

    Article • Journal of Experimental Medicine, September 2003, Rockefeller University Press

    Dr Howard A Young

  170. IL-4 synergistically enhances both IL-2– and IL-12–induced IFN-γ expression in murine NK cells

    Article • Blood, July 2003, American Society of Hematology

    Dr Howard A Young

  171. Correction

    Article • The Journal of Immunology, June 2003, Oxford University Press (OUP)

    Dr Howard A Young

  172. CD2 mediates activation of the IFN-γ intronic STAT binding region in mucosal T cells

    Article • European Journal of Immunology, May 2003, Wiley

    Dr Howard A Young

  173. The distinct patterns of T cell IFN-γ promoter responses in LPMC are generated in PBL following IL-2 treatment

    Article • Gastroenterology, April 2003, Elsevier

    Dr Howard A Young

  174. Multiprobe Ribonuclease Protection Assay for Simultaneous Measurement of mRNA Expression

    Article • Current Protocols in Immunology, April 2003, Wiley

    Dr Howard A Young

  175. Characterization of an interleukin-7-dependent thymic cell line derived from a p53−/− mouse

    Article • Journal of Immunological Methods, March 2003, Elsevier

    Dr Howard A Young

  176. Epigenetic Control during Lymphoid Development and Immune Responses

    Article • Annals of the New York Academy of Sciences, March 2003, Wiley

    Dr Howard A Young

  177. Expression of IFN-γ Upon Triggering of Activating Ly49D NK Receptors In Vitro and In Vivo: Costimulation with IL-12 or IL-18 Overrides Inhibitory Receptors

    Article • The Journal of Immunology, February 2003, Oxford University Press (OUP)

    Dr Howard A Young

  178. Interferon-γ

    Article • January 2003, Elsevier

    Dr Howard A Young

  179. Bax Deficiency Partially Corrects Interleukin-7 Receptor α Deficiency

    Article • Immunity, November 2002, Elsevier

    Dr Howard A Young

  180. Redirecting Migration of T Cells to Chemokine Secreted from Tumors by Genetic Modification with CXCR2

    Article • Human Gene Therapy, November 2002, Mary Ann Liebert Inc

    Dr Howard A Young

  181. IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases

    Article • Cellular Signalling, September 2002, Elsevier

    Dr Howard A Young

  182. PPAR and immune system—what do we know?

    Article • International Immunopharmacology, July 2002, Elsevier

    Dr Howard A Young

  183. IL-2 and IL-12 Alter NK Cell Responsiveness to IFN-γ-Inducible Protein 10 by Down-Regulating CXCR3 Expression

    Article • The Journal of Immunology, June 2002, Oxford University Press (OUP)

    Dr Howard A Young

  184. Growth Factor Independent-1 Induced by IL-4 Regulates Th2 Cell Proliferation

    Article • Immunity, May 2002, Elsevier

    Dr Howard A Young

  185. A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription

    Article • Genes & Immunity, May 2002, Springer Science + Business Media

    Dr Howard A Young

  186. Reduced Expression of Nuclear Cyclic Adenosine 5′-Monophospate Response Element-Binding Proteins and IFN-γ Promoter Function in Disease Due to an Intracellular Pathogen

    Article • The Journal of Immunology, April 2002, Oxford University Press (OUP)

    Dr Howard A Young

  187. Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control

    Article • Molecular and Cellular Biology, March 2002, ASM Journals

    Dr Howard A Young

  188. Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily

    Article • Immunology Letters, March 2002, Elsevier

    Dr Howard A Young

  189. Impaired NK Cell Development in an IFN-γ Transgenic Mouse: Aberrantly Expressed IFN-γ Enhances Hematopoietic Stem Cell Apoptosis and Affects NK Cell Differentiation

    Article • The Journal of Immunology, February 2002, Oxford University Press (OUP)

    Dr Howard A Young

  190. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia

    Article • Blood, February 2002, American Society of Hematology

    Dr Howard A Young

  191. Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14+ monocytes cultured under serum-free conditions

    Article • Blood, January 2002, American Society of Hematology

    Dr Howard A Young

  192. Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes

    Article • European Journal of Immunology, January 2002, Wiley

    Dr Howard A Young

  193. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

    Article • Journal of Clinical Investigation, December 2001, American Society for Clinical Investigation

    Dr Howard A Young

  194. Human B Cell Activation by Autologous NK Cells Is Regulated by CD40-CD40 Ligand Interaction: Role of Memory B Cells and CD5+ B Cells

    Article • The Journal of Immunology, December 2001, Oxford University Press (OUP)

    Dr Howard A Young

  195. Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

    Article • Journal of Molecular Endocrinology, August 2001, Bioscientifica

    Dr Howard A Young

  196. Correction: The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer

    Article • Nature, July 2001, Springer Science + Business Media

    Dr Howard A Young

  197. The flavonoid baicalin inhibits superantigen‐induced inflammatory cytokines and chemokines

    Article • FEBS Letters, June 2001, Wiley

    Dr Howard A Young

  198. Cutting Edge: IL-18-Transgenic Mice: In Vivo Evidence of a Broad Role for IL-18 in Modulating Immune Function

    Article • The Journal of Immunology, June 2001, Oxford University Press (OUP)

    Dr Howard A Young

  199. Differential Regulation of Chemokine Gene Expression by 15-Deoxy-Δ12,1412,14 Prostaglandin J2

    Article • The Journal of Immunology, June 2001, Oxford University Press (OUP)

    Dr Howard A Young

  200. Eotaxin (CCL11) Induces In Vivo Angiogenic Responses by Human CCR3+ Endothelial Cells

    Article • The Journal of Immunology, June 2001, Oxford University Press (OUP)

    Dr Howard A Young

  201. Activating Ly-49 NK Receptors: Central Role in Cytokine and Chemokine Production

    Article • The Journal of Immunology, April 2001, Oxford University Press (OUP)

    Dr Howard A Young

  202. Dampened SOCS: An altered balance between STAT activating and SOCS inhibitory signals regulate interferon-γ expression in LPMC

    Article • Gastroenterology, April 2001, Elsevier

    Dr Howard A Young

  203. Interleukin-3 Withdrawal Induces an Early Increase in Mitochondrial Membrane Potential Unrelated to the Bcl-2 Family

    Article • Journal of Biological Chemistry, March 2001, Elsevier

    Dr Howard A Young

  204. Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epi...

    Article • The Journal of Immunology, January 2001, Oxford University Press (OUP)

    Dr Howard A Young

  205. Functional Reconstitution and Regulation of IL-18 Activity by the IL-18Rβ Chain

    Article • The Journal of Immunology, January 2001, Oxford University Press (OUP)

    Dr Howard A Young

  206. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

    Article • Proceedings of the National Academy of Sciences, December 2000, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  207. Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes

    Article • The Journal of Immunology, December 2000, Oxford University Press (OUP)

    Dr Howard A Young

  208. Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes

    Article • European Journal of Immunology, November 2000, Wiley

    Dr Howard A Young

  209. In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells

    Article • European Journal of Immunology, July 2000, Wiley

    Dr Howard A Young

  210. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

    Article • Blood, July 2000, American Society of Hematology

    Dr Howard A Young

  211. A dual role for the -204 to -172 bp region of the IFN-Γ promoter: An activator of expression in LPL while a silencer of expression in PBL

    Article • Gastroenterology, April 2000, Elsevier

    Dr Howard A Young

  212. CD2-mediated activation of stat: transactivation of the lFN-Г intronic stat cis-element is unique for LPMC and independent of IL-12

    Article • Gastroenterology, April 2000, Elsevier

    Dr Howard A Young

  213. Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

    Article • The Journal of Immunology, April 2000, Oxford University Press (OUP)

    Dr Howard A Young

  214. Interleukin-1 polymorphisms associated with increased risk of gastric cancer

    Article • Nature, March 2000, Springer Science + Business Media

    Dr Howard A Young

  215. The Tryptophan Catabolite Picolinic Acid Selectively Induces the Chemokines Macrophage Inflammatory Protein-1α and -1β in Macrophages

    Article • The Journal of Immunology, March 2000, Oxford University Press (OUP)

    Dr Howard A Young

  216. Mucosa-Specific Targets for Regulation of IFN-γ Expression: Lamina Propria T Cells Use Differentcis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-γ Expression

    Article • The Journal of Immunology, February 2000, Oxford University Press (OUP)

    Dr Howard A Young

  217. Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP

    Article • Proceedings of the National Academy of Sciences, January 2000, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  218. Polymorphisms of the human IFNG gene noncoding regions

    Article • Immunogenetics, January 2000, Springer Science + Business Media

    Dr Howard A Young

  219. IFN-γ-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells

    Article • The Journal of Immunology, January 2000, Oxford University Press (OUP)

    Dr Howard A Young

  220. Induction of STAT and NFκB activation by the antitumor agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line

    Article • Biochemical Pharmacology, October 1999, Elsevier

    Dr Howard A Young

  221. Regulation of a Cell Type-specific Silencer in the Human Interleukin-3 Gene Promoter by the Transcription Factor YY1 and an AP2 Sequence-recognizing Factor

    Article • Journal of Biological Chemistry, September 1999, Elsevier

    Dr Howard A Young

  222. CNS Interleukin-3 (IL-3) Expression and Neurological Syndrome in Antisense-IL-3 Transgenic Mice

    Article • Journal of Neuropathology & Experimental Neurology, May 1999, Oxford University Press (OUP)

    Dr Howard A Young

  223. CCR5 Promoter Alleles and Specific DNA Binding Factors

    Article • Science, April 1999, American Association for the Advancement of Science

    Dr Howard A Young

  224. Divergent effects of dithiocarbamates on AP-1-containing and AP-1-less NFAT sites

    Article • European Journal of Immunology, April 1999, Wiley

    Dr Howard A Young

  225. Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells

    Article • American Journal Of Pathology, April 1999, Elsevier

    Dr Howard A Young

  226. Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.

    Article • Journal of Clinical Investigation, November 1998, American Society for Clinical Investigation

    Dr Howard A Young

  227. Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production

    Article • Molecular and Cellular Biology, September 1998, ASM Journals

    Dr Howard A Young

  228. Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

    Article • Journal of Leukocyte Biology, August 1998, Oxford University Press (OUP)

    Dr Howard A Young

  229. Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro

    Article • International Immunology, August 1998, Oxford University Press (OUP)

    Dr Howard A Young

  230. Identification of both Cd2 enhancer and repressor elements within the interferon-λ promoter which regulate cytokine secretion in lamina propria T-cells

    Article • Gastroenterology, April 1998, Elsevier

    Dr Howard A Young

  231. Interaction of NF-κB and NFAT with the Interferon-γ Promoter

    Article • Journal of Biological Chemistry, November 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli, Dr Howard A Young

  232. Negative regulation of cytokine gene transcription 1

    Article • The FASEB Journal, September 1997, Wiley

    Dr Howard A Young

  233. Osteochondrodysplasia Occurring in Transgenic Mice Expressing Interferon-γ

    Article • Veterinary Pathology, September 1997, SAGE Publications

    Dr Howard A Young

  234. Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene

    Article • European Journal of Immunology, August 1997, Wiley

    Dr. Marco Cippitelli, Dr Howard A Young

  235. Apoptosis of L1210 leukemia cells induced by 3-deazaadenosine analogs: Differential expression of c-myc, NF-kappa B and molecular events

    Article • Journal of Biomedical Science, March 1997, Springer Science + Business Media

    Dr Howard A Young

  236. Characterization of the MouseNktrGene and Promoter

    Article • Genomics, February 1997, Elsevier

    Dr Howard A Young

  237. Bone Marrow and Thymus Expression of Interferon-γ Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies

    Article • Blood, January 1997, American Society of Hematology

    Dr Howard A Young

  238. Molecular Regulation of Cytokine Gene Expression: lnterferon-γ as a Model System

    Article • January 1997, Elsevier

    Dr Howard A Young

  239. Interferon Expression by B Cells

    Article • Methods, January 1997, Elsevier

    Dr Howard A Young

  240. Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-γ Promoter

    Article • Journal of Biological Chemistry, October 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli, Dr Howard A Young

  241. Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.

    Article • Proceedings of the National Academy of Sciences, October 1996, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  242. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element.

    Article • Molecular and Cellular Biology, September 1996, ASM Journals

    Dr. Marco Cippitelli, Dr Howard A Young

  243. Regulation of Interferon-γ Gene Expression

    Article • Journal of Interferon & Cytokine Research, August 1996, Mary Ann Liebert Inc

    Dr Howard A Young

  244. Association of the expression of an SR-cyclophilin with myeloid cell differentiation

    Article • Blood, March 1996, American Society of Hematology

    Dr Howard A Young

  245. Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway

    Article • Journal of Biological Chemistry, March 1996, Elsevier

    Dr Howard A Young

  246. Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth

    Article • JNCI Journal of the National Cancer Institute, October 1995, Oxford University Press (OUP)

    Dr. Marco Cippitelli, Dr Howard A Young

  247. Role of interferon-γ in immune cell regulation

    Article • Journal of Leukocyte Biology, October 1995, Oxford University Press (OUP)

    Dr Howard A Young

  248. Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line

    Article • Journal of Leukocyte Biology, August 1995, Oxford University Press (OUP)

    Dr Howard A Young

  249. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)

    Article • Journal of Experimental Medicine, August 1995, Rockefeller University Press

    Dr Howard A Young

  250. Regulation of NK cells through the 80-kDa TNFR (CD120b)

    Article • Journal of Leukocyte Biology, August 1995, Oxford University Press (OUP)

    Dr Howard A Young

  251. Regulation of interferon-γ gene transcription

    Article • Seminars in Virology, June 1995, Elsevier

    Dr Howard A Young

  252. Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5?-flanking sequences

    Article • Immunogenetics, June 1995, Springer Science + Business Media

    Dr Howard A Young

  253. Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

    Article • Journal of Biological Chemistry, May 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli, Dr Howard A Young

  254. CD8+ and CD45RA+ human peripheral blood lymphocytes are potent sources of macrophage inflammatory protein 1α, interleukin‐8 and RANTES

    Article • European Journal of Immunology, March 1995, Wiley

    Dr Howard A Young

  255. Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes

    Article • European Journal of Immunology, March 1995, Wiley

    Dr Howard A Young

  256. Chromium(VI)-induced nuclear factor-кB activation in intact cells via free radical reactions

    Article • Carcinogenesis, January 1995, Oxford University Press (OUP)

    Dr Howard A Young

  257. Poor transduction efficiency of human hematopoietic progenitor cells by a high-titer amphotropic retrovirus producer cell clone

    Article • Journal of Virology, November 1994, ASM Journals

    Dr Howard A Young

  258. Induction of Multiple Cytokine Gene Expression and IRF-1 mRNA by Flavone Acetic Acid in a Murine Macrophage Cell Line

    Article • Cellular Immunology, August 1994, Elsevier

    Dr Howard A Young

  259. Identification of a DNA binding site for the nuclear factor YY1 in the human GM-CSF core promoter

    Article • Nucleic Acids Research, January 1994, Oxford University Press (OUP)

    Dr Howard A Young

  260. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

    Article • Journal of Experimental Medicine, November 1993, Rockefeller University Press

    Dr Howard A Young

  261. Inhibition of tumor growth and enhancement of metastasis after transfection of the γ-interferon gene

    Article • International Journal of Cancer, September 1993, Wiley

    Dr Howard A Young

  262. Localization of a Novel Natural Killer Triggering Receptor Locus to Human Chromosome 3p23-p21 and Mouse Chromosome 9

    Article • Genomics, May 1993, Elsevier

    Dr Howard A Young

  263. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

    Article • Proceedings of the National Academy of Sciences, March 1993, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  264. A cyclophilin-related protein involved in the function of natural killer cells.

    Article • Proceedings of the National Academy of Sciences, January 1993, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  265. Natural Killer (NK) Cell Lytic Dysfunction and Putative NK Cell Receptor Expression Abnormality in Members of a Family With Chromosome 3p-Linked von Hippel-Lindau Disease

    Article • JNCI Journal of the National Cancer Institute, December 1992, Oxford University Press (OUP)

    Dr Howard A Young

  266. Cytokine Induction and Therapeutic Synergy with Interleukin-2 Against Murine Renal and Colon Cancers by Xanthenone-4-Acetic Acid Derivatives

    Article • Journal of Immunotherapy, November 1992, Wolters Kluwer Health

    Dr Howard A Young

  267. Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

    Article • Molecular and Cellular Biology, September 1992, ASM Journals

    Dr Howard A Young

  268. Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation

    Article • Blood, August 1992, American Society of Hematology

    Dr Howard A Young

  269. Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo

    Article • Blood, August 1992, American Society of Hematology

    Dr Howard A Young

  270. The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

    Article • Proceedings of the National Academy of Sciences, March 1992, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  271. IL-7 regulation of cytotoxic lymphocytes: Pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets

    Article • Cellular Immunology, December 1991, Elsevier

    Dr Howard A Young

  272. Comparative studies of CD3− and CD3+ CD56+ cells: Examination of morphology, functions, T cell receptor rearrangement, and pore-forming protein expression

    Article • Cellular Immunology, September 1991, Elsevier

    Dr Howard A Young

  273. In vivo distribution and cytokine gene expression by enriched mouse LAK effector cells

    Article • Biotherapy, July 1991, Springer Science + Business Media

    Dr Howard A Young

  274. Analysis of rat natural killer cytotoxic factor (NKCF): Mechanism of action and relationship to other cytotoxic/cytostatic factors

    Article • Cellular Immunology, June 1991, Elsevier

    Dr Howard A Young

  275. Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

    Article • Journal of Experimental Medicine, April 1991, Rockefeller University Press

    Dr Howard A Young

  276. Differential regulation of interleukin-1 gene expression in human CD3− large granular lymphocytes

    Article • Cellular Immunology, November 1990, Elsevier

    Dr Howard A Young

  277. Expression of human immunodeficiency virus long terminal repeat in the human promonocyte cell line U937: Effect of endotoxin and cytokines

    Article • Cellular Immunology, September 1990, Elsevier

    Dr Howard A Young

  278. A model of human cytokine regulation based on transfection of gamma interferon gene fragments directly into isolated peripheral blood T lymphocytes.

    Article • Journal of Experimental Medicine, August 1990, Rockefeller University Press

    Dr Howard A Young

  279. Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.

    Article • Journal of Experimental Medicine, April 1990, Rockefeller University Press

    Dr Howard A Young

  280. Interferon-γ: Producer cells, activation stimuli, and molecular genetic regulation

    Article • Pharmacology & Therapeutics, January 1990, Elsevier

    Dr Howard A Young

  281. Interleukin 2-induced proliferation of murine natural killer cells in vivo.

    Article • Journal of Experimental Medicine, January 1990, Rockefeller University Press

    Dr Howard A Young

  282. Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

    Article • Science, October 1989, American Association for the Advancement of Science

    Dr Howard A Young

  283. Analysis of isotype switch variants of a Qa-5 specific hybridoma

    Article • Journal of Immunological Methods, October 1989, Elsevier

    Dr Howard A Young

  284. Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation

    Article • European Journal of Immunology, May 1989, Wiley

    Dr Howard A Young

  285. The methylation state of the T cell antigen receptor β chain gene in subpopulations of mouse thymocytes

    Article • European Journal of Immunology, May 1989, Wiley

    Dr Howard A Young

  286. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

    Article • Proceedings of the National Academy of Sciences, February 1989, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  287. Coordinate-Enhanced Expression of Three Adhesion Molecules (LFA-3, CD2, and LFA-1) and Three Other Molecules (4B4, UCHL1, and Pgp-1) Defines a Human T Cell Subset Containing Memory Cells and Characterized by Enhanced γ Interferon Production

    Article • January 1989, Springer Science + Business Media

    Dr Howard A Young

  288. Rearrangement of both immunoglobulin and T-cell receptor genes in a prolymphocytic variant of hairy cell leukemia patient resistant to interferon-alpha [published erratum appears in Blood 1989 Feb;73(2):624]

    Article • Blood, November 1988, American Society of Hematology

    Dr Howard A Young

  289. Immunomodulation of Natural Killer Cell Activity by Flavone Acetic Acid: Occurrence Via Induction of Interferon  /beta

    Article • JNCI Journal of the National Cancer Institute, October 1988, Oxford University Press (OUP)

    Dr Howard A Young

  290. Characterization of Interleukin 2 and Phorbol Myristate Acetate Augmentation of Expression of Transfected Human Interferon-γ Genomic DNA

    Article • Journal of Interferon Research, August 1988, Mary Ann Liebert Inc

    Dr Howard A Young

  291. Evidence that mouse promotion-sensitivity gene pro1 is transcribed by RNA polymerase III

    Article • Gene, August 1988, Elsevier

    Dr Howard A Young

  292. Modification of T cell receptor β chain gene: the J2 region but not the J1 region of the T cell receptor β chain gene is hypomethylated in human B cells and monocytes

    Article • Nucleic Acids Research, January 1988, Oxford University Press (OUP)

    Dr Howard A Young

  293. Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.

    Article • Molecular and Cellular Biology, March 1987, ASM Journals

    Dr Howard A Young

  294. Enhanced Interleukin-1 Production by Human Monocyte Cell Lines Following Treatment With 5-Azacytidine

    Article • Journal of Leukocyte Biology, January 1987, Oxford University Press (OUP)

    Dr Howard A Young

  295. Detection of the intracellular ras p21 oncogene product by flow cytometry

    Article • Analytical Biochemistry, July 1986, Elsevier

    Dr Howard A Young

  296. Posttranscriptional control of human gamma interferon gene expression in transfected mouse fibroblasts.

    Article • Molecular and Cellular Biology, June 1986, ASM Journals

    Dr Howard A Young

  297. Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines.

    Article • Journal of Experimental Medicine, May 1985, Rockefeller University Press

    Dr Howard A Young

  298. Molecular cloning, genomic analysis, and biological properties of rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus

    Article • Journal of Virology, November 1982, ASM Journals

    Dr Howard A Young

  299. Induction of fibrosarcoma by rat sarcoma virus

    Article • Virology, April 1982, Elsevier

    Dr Howard A Young

  300. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

    Article • Nature, August 1981, Springer Science + Business Media

    Dr Howard A Young

  301. Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

    Article • Proceedings of the National Academy of Sciences, June 1981, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  302. Rat sarcoma virus: further analysis of individual viral isolates and the gene product

    Article • Journal of Virology, April 1981, ASM Journals

    Dr Howard A Young

  303. Heteroduplex analysis of cloned rat endogenous replication-defective (30 S) retrovirus and Harvey murine sarcoma virus

    Article • Virology, November 1980, Elsevier

    Dr Howard A Young

  304. Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

    Article • Journal of Virology, November 1980, ASM Journals

    Dr Howard A Young

  305. Inhibition of Spontaneous Transformation of Rat Embryo Cells Releasing Endogenous Type C Virus by Virus-Specific Antiserum23

    Article • JNCI Journal of the National Cancer Institute, September 1979, Oxford University Press (OUP)

    Dr Howard A Young

  306. p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation

    Article • Journal of Virology, August 1979, ASM Journals

    Dr Howard A Young

  307. Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus

    Article • Virology, July 1979, Elsevier

    Dr Howard A Young

  308. Different rat-derived transforming retroviruses code for an immunologically related intracellular phosphoprotein.

    Article • Proceedings of the National Academy of Sciences, July 1979, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  309. Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7,12-Dimethylbenz[a]anthracene2

    Article • JNCI Journal of the National Cancer Institute, November 1978, Oxford University Press (OUP)

    Dr Howard A Young

  310. In vitro transcription of mouse mammary tumor virus RNA into DNA

    Article • Journal of Virology, February 1978, ASM Journals

    Dr Howard A Young

  311. Physical map of the Kirsten sarcoma virus genome as determined by fingerprinting RNase T1-resistant oligonucleotides

    Article • Journal of Virology, January 1978, ASM Journals

    Dr Howard A Young

  312. Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.

    Article • Proceedings of the National Academy of Sciences, October 1977, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  313. In vitro transcription of Moloney leukemia virus genes in infected cell nuclei and chromatin: elongation of chromatin associated ribonucleic acid by Escherichia coli ribonucleic acid polymerase

    Article • Biochemistry, May 1977, American Chemical Society (ACS)

    Dr Howard A Young

  314. Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA

    Article • Journal of Virology, January 1977, ASM Journals

    Dr Howard A Young

  315. Biochemical and physiological mechanisms in glucocorticoid hormone induction of mouse mammary tumor virus

    Article • Virology, January 1976, Elsevier

    Dr Howard A Young

  316. Effect of chemical inactivating agents on glucocorticoid receptor proteins in mouse and hamster cells.

    Article • Proceedings of the National Academy of Sciences, August 1975, Proceedings of the National Academy of Sciences

    Dr Howard A Young

  317. Changes in the levels of DNA-dependent RNA polymerases during the transition of the dimorphic fungus Mucor rouxii from yeast-like to mycelial growth

    Article • Experimental Cell Research, March 1975, Elsevier

    Dr Howard A Young

  318. Complementation of human adenovirus type 5 ts mutants by human adenovirus type 12

    Article • Journal of Virology, March 1975, ASM Journals

    Dr Howard A Young

  319. Some observations on the cofactor requirement for partially purified DNA ligase from Escherichia coli

    Article • FEBS Letters, November 1972, Wiley

    Dr Howard A Young

  320. Faculty of 1000 evaluation for Temporal response of the human virome to immunosuppression and antiviral therapy.

    Article • Faculty of 1000, Ltd.

    Dr Howard A Young

  321. IFN-γ: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications

    Article • Springer Science + Business Media

    Dr Howard A Young