All Stories

  1. The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress

    Article • Cancers, June 2019, MDPI AG

    Dr. Marco Cippitelli

  2. Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms

    Article • The FASEB Journal, May 2019, Federation of American Societies For Experimental Biology (FASEB)

    Maria Teresa Bilotta , Dr. Marco Cippitelli, Tina Garofalo, Gianluca Scarno

  3. The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors

    Article • Cell Death and Disease, April 2019, Springer Science + Business Media

    Dr. Marco Cippitelli

  4. The Ubiquitin‐proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing

    Article • European Journal of Immunology, March 2019, Wiley

    Dr. Marco Cippitelli

  5. Key Role of the CD56lowCD16low Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells

    Article • Cancers, November 2018, MDPI AG

    Dr. Marco Cippitelli

  6. Translating the anti-myeloma activity of Natural Killer cells into clinical application

    Article • Cancer Treatment Reviews, November 2018, Elsevier

    Dr. Marco Cippitelli

  7. MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma

    Article • Frontiers in Immunology, May 2018, Frontiers

    Dr. Marco Cippitelli

  8. Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans -Presentation

    Article • Cancer Immunology Research, April 2018, American Association for Cancer Research (AACR)

    Dr. Marco Cippitelli

  9. NKG2D and Its Ligands: “One for All, All for One”

    Article • Frontiers in Immunology, March 2018, Frontiers

    Dr. Marco Cippitelli

  10. Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance

    Article • Frontiers in Immunology, September 2017, Frontiers

    Dr. Marco Cippitelli

  11. Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells

    Article • Scientific Reports, September 2017, Springer Science + Business Media

    Dr. Marco Cippitelli

  12. Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

    Article • OncoImmunology, January 2017, Taylor & Francis

    Dr. Marco Cippitelli

  13. Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

    Article • Journal of Hematology & Oncology, December 2016, Springer Science + Business Media

    Dr. Marco Cippitelli

  14. Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression

    Article • The Journal of Immunology, October 2016, The American Association of Immunologists

    Dr. Marco Cippitelli

  15. Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer

    Article • Current Medicinal Chemistry, August 2016, Bentham Science Publishers

    Dr. Marco Cippitelli

  16. Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy

    Article • Critical Reviews in Immunology, January 2016, Begell House

    Dr. Marco Cippitelli

  17. Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

    Article • Science Signaling, October 2015, American Association for the Advancement of Science

    Dr. Marco Cippitelli

  18. The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

    Article • Oncotarget, June 2015, Impact Journals, LLC

    Dr. Marco Cippitelli

  19. Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells

    Article • The Journal of Immunology, June 2015, The American Association of Immunologists

    Dr. Marco Cippitelli

  20. Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation

    Article • BMC Cancer, January 2015, Springer Science + Business Media

    Dr. Marco Cippitelli

  21. NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Dr. Marco Cippitelli

  22. Reactive Oxygen Species– and DNA Damage Response–Dependent NK Cell Activating Ligand Upregulation Occurs at Transcriptional Levels and Requires the Transcriptional Factor E2F1

    Article • The Journal of Immunology, June 2014, The American Association of Immunologists

    Dr. Marco Cippitelli

  23. HLA and Killer Cell Immunoglobulin-like Receptors Influence the Natural Course of CMV Infection

    Article • The Journal of Infectious Diseases, April 2014, Oxford University Press (OUP)

    Dr. Marco Cippitelli

  24. The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells

    Article • Frontiers in Immunology, January 2014, Frontiers

    Dr. Marco Cippitelli

  25. Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma

    Article • OncoImmunology, December 2013, Taylor & Francis

    Dr. Marco Cippitelli

  26. Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell–Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3

    Article • The Journal of Immunology, May 2013, The American Association of Immunologists

    Dr. Marco Cippitelli

  27. IL-15 inhibits IL-7Rα expression by memory-phenotype CD8+T cells in the bone marrow

    Article • European Journal of Immunology, April 2012, Wiley

    Dr. Marco Cippitelli

  28. Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

    Article • The Journal of Gene Medicine, November 2009, Wiley

    Dr. Marco Cippitelli

  29. Heat Shock Protein-90 Inhibitors Increase MHC Class I-Related Chain A and B Ligand Expression on Multiple Myeloma Cells and Their Ability to Trigger NK Cell Degranulation

    Article • The Journal of Immunology, September 2009, The American Association of Immunologists

    Dr. Marco Cippitelli

  30. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

    Article • Blood, December 2008, American Society of Hematology

    Dr. Marco Cippitelli

  31. Inhibition of Trail Gene Expression by Cyclopentenonic Prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T Lymphocytes

    Article • Molecular Pharmacology, August 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Marco Cippitelli

  32. Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

    Article • Blood, March 2007, American Society of Hematology

    Dr. Marco Cippitelli

  33. Oxidative stress inhibits IFN-α-induced antiviral gene expression by blocking the JAK–STAT pathway

    Article • Journal of Hepatology, August 2006, Elsevier

    Dr. Marco Cippitelli

  34. Hyperthermia Enhances CD95-Ligand Gene Expression in T Lymphocytes

    Article • The Journal of Immunology, December 2004, The American Association of Immunologists

    Dr. Marco Cippitelli

  35. Negative Regulation of CD95 Ligand Gene Expression by Vitamin D3 in T Lymphocytes

    Article • The Journal of Immunology, February 2002, The American Association of Immunologists

    Dr. Marco Cippitelli

  36. Integrin-mediated Ras–Extracellular Regulated Kinase (ERK) Signaling Regulates Interferon γ Production in Human Natural Killer Cells

    Article • The Journal of Experimental Medicine, October 1998, Rockefeller University Press

    Dr. Marco Cippitelli

  37. Interaction of NF-κB and NFAT with the Interferon-γ Promoter

    Article • Journal of Biological Chemistry, November 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli

  38. Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene

    Article • European Journal of Immunology, August 1997, Wiley

    Dr. Marco Cippitelli

  39. Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-γ Promoter

    Article • Journal of Biological Chemistry, October 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli

  40. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element.

    Article • Molecular and Cellular Biology, September 1996, ASM Journals

    Dr. Marco Cippitelli

  41. Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth

    Article • JNCI Journal of the National Cancer Institute, October 1995, Oxford University Press (OUP)

    Dr. Marco Cippitelli

  42. Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun

    Article • Journal of Biological Chemistry, May 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marco Cippitelli

  43. Soluble and cell-associated IL-2 receptor (IL-2R) after local immunotherapy with recombinant interleukin-2 (rIL-2)

    Article • Pharmacological Research, September 1992, Elsevier

    Dr. Marco Cippitelli