All Stories

  1. Mathematical modeling suggests heterogeneous replication ofMycobacterium tuberculosisin rabbits

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  2. Heterogeneity in killing efficacy of individual effector CD8 + T cells against Plasmodium liver stages

    Article • Proceedings of the Royal Society B Biological Sciences, November 2023, Royal Society Publishing

    Dr Vitaly V Ganusov

  3. Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

    Article • F1000Research, October 2023, Faculty of 1000, Ltd.

    Dr Vitaly V Ganusov

  4. Appropriate sampling and long follow-up are required to rigorously evaluate longevity of humoral memory after vaccination

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  5. Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen–Fibrin Gels by Cytolytic and Non-Lytic Mechanisms

    Article • Viruses, June 2023, MDPI AG

    Dr Vitaly V Ganusov

  6. Prioritization of the concepts and skills in quantitative education for graduate students in biomedical science

    Article • PLoS ONE, April 2023, PLOS

    Dr Vitaly V Ganusov

  7. Mathematical modeling suggests cytotoxic T lymphocytes control growth of B16 tumor cells in collagin-fibrin gels by cytolytic and non-lytic mechanisms

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  8. Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

    Article • F1000Research, January 2023, Faculty of 1000, Ltd.

    Dr Vitaly V Ganusov

  9. Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  10. Correlation between speed and turning naturally arises for sparsely sampled cell movements

    Article • Physical Biology, January 2023, Institute of Physics Publishing

    Dr Vitaly V Ganusov

  11. Mathematical Modeling to Guide Experimental Design: T Cell Clustering as a Case Study

    Article • Bulletin of Mathematical Biology, August 2022, Springer Science + Business Media

    Dr Vitaly V Ganusov

  12. Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8+ T Cell Localization in the Murine Liver

    Article • The Journal of Immunology, June 2022, The American Association of Immunologists

    Dr Vitaly V Ganusov

  13. Mathematical modeling suggests that a single Plasmodium-specific CD8 T cell can eliminate a malaria liver stage in mice

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  14. Evaluating impact of experimental design on accuracy of parameter estimation and model selection efficiency: T cell clustering as a case study

    Article • April 2022, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  15. Mathematical Modeling Suggests Cooperation of Plant-Infecting Viruses

    Article • Viruses, March 2022, MDPI AG

    Dr Vitaly V Ganusov

  16. Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells

    Article • The Journal of Immunology, February 2022, The American Association of Immunologists

    Dr Vitaly V Ganusov

  17. Mathematical modeling suggests cooperation of plant-infecting viruses

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  18. Enhancing Quantitative and Data Science Education for Graduate Students in Biomedical Science

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  19. Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  20. Negative correlation between average speed and average turning angle naturally arises for sparsely sampled cell movement data

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  21. A minority of liver-localized CD8 T cells demonstrate difficult-to-detect attraction to Plasmodium-infected hepatocytes

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  22. Impact of oseltamivir treatment on influenza A and B dynamics in human volunteers

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  23. Environment-imposed constraints make Brownian walkers efficient searchers

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  24. Experimental determination of the force of malaria infection reveals a non-linear relationship to mosquito sporozoite loads

    Article • PLoS Pathogens, May 2020, PLOS

    Dr Vitaly V Ganusov

  25. Experimental Determination of the Force of Malaria Infection Reveals a Non-Linear Relationship to Mosquito Sporozoite Loads

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  26. Erratum for Hoft et al., “The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors”

    Article • Infection and Immunity, August 2019, ASM Journals

    Dr Vitaly V Ganusov

  27. Defining Kinetic Properties of HIV-Specific CD8+ T-Cell Responses in Acute Infection

    Article • Microorganisms, March 2019, MDPI AG

    Dr Vitaly V Ganusov

  28. Mathematical modeling suggests that benefits of short or long antibiotic treatment depend on details of infection

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  29. Defining Kinetic Properties of HIV-Specific CD8+ T-cell Responses in Acute Infection

    Article • January 2019, MDPI AG

    Dr Vitaly V Ganusov

  30. Estimating residence times of lymphocytes in ovine lymph nodes: Supplemental Information

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  31. Clustering of activated CD8 T cells around malaria-infected hepatocytes is rapid and is driven by antigen-specific T cells

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  32. Cutting Edge: IL-1R1 Mediates Host Resistance toMycobacterium tuberculosisbyTrans-Protection of Infected Cells

    Article • The Journal of Immunology, August 2018, The American Association of Immunologists

    Dr Vitaly V Ganusov

  33. Time Intervals in Sequence Sampling, Not Data Modifications, Have a Major Impact on Estimates of HIV Escape Rates

    Article • Viruses, February 2018, MDPI AG

    Dr Vitaly V Ganusov

  34. Using mathematical modeling to define kinetic properties of HIV-specific CD8 + T-cell responses

    Article • July 2017, Cold Spring Harbor Laboratory Press

    Dr Vitaly V Ganusov

  35. Strong Inference in Mathematical Modeling: A Method for Robust Science in the Twenty-First Century

    Article • Frontiers in Microbiology, July 2016, Frontiers

    Dr Vitaly V Ganusov

  36. Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice

    Article • Frontiers in Microbiology, June 2016, Frontiers

    Dr Vitaly V Ganusov

  37. CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

    Article • PLoS Pathogens, May 2016, PLOS

    Dr Vitaly V Ganusov

  38. Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes

    Article • PLoS Computational Biology, October 2015, PLOS

    Dr Vitaly V Ganusov

  39. Evaluating contribution of the cellular and humoral immune responses to the control of shedding of Mycobacterium avium spp. paratuberculosis in cattle

    Article • Veterinary Research, June 2015, Springer Science + Business Media

    Dr Vitaly V Ganusov

  40. Simple Mathematical Models Do Not Accurately Predict Early SIV Dynamics

    Article • Viruses, March 2015, MDPI AG

    Dr Vitaly V Ganusov

  41. Mathematical modeling provides kinetic details of the human immune response to vaccination

    Article • Frontiers in Cellular and Infection Microbiology, January 2015, Frontiers

    Dr Vitaly V Ganusov

  42. Plasmodium Suppresses Expansion of T Cell Responses to Heterologous Infections

    Article • The Journal of Immunology, December 2014, The American Association of Immunologists

    Dr Vitaly V Ganusov

  43. Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism

    Article • PLoS Computational Biology, May 2014, PLOS

    Dr Vitaly V Ganusov

  44. Competition for Antigen between Th1 and Th2 Responses Determines the Timing of the Immune Response Switch during Mycobaterium avium Subspecies paratuberulosis Infection in Ruminants

    Article • PLoS Computational Biology, January 2014, PLOS

    Dr Vitaly V Ganusov

  45. Classification of T cell movement tracks allows for prediction of cell function

    Article • International Journal of Computational Biology and Drug Design, January 2014, Inderscience Publishers

    Dr Vitaly V Ganusov

  46. In vivo imaging of CD8+T cell-mediated elimination of malaria liver stages

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Dr Vitaly V Ganusov

  47. A mechanistic model for bromodeoxyuridine dilution naturally explains labelling data of self-renewing T cell populations

    Article • Journal of The Royal Society Interface, March 2013, Royal Society Publishing

    Dr Vitaly V Ganusov

  48. Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses

    Article • Journal of Statistical Mechanics Theory and Experiment, January 2013, Institute of Physics Publishing

    Dr Vitaly V Ganusov

  49. Cellular and population plasticity of helper CD4+ T cell responses

    Article • Frontiers in Physiology, January 2013, Frontiers

    Dr Vitaly V Ganusov

  50. Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

    Article • Journal of Clinical Investigation, December 2012, American Society for Clinical Investigation

    Dr Vitaly V Ganusov

  51. A mechanistic model for bromodeoxyuridine dilution naturally explains labelling data of self-renewing T cell populations

    Article • Journal of The Royal Society Interface, October 2012, Royal Society Publishing

    Dr Vitaly V Ganusov

  52. Evolution of viral life-cycle in response to cytotoxic T lymphocyte-mediated immunity

    Article • Journal of Theoretical Biology, October 2012, Elsevier

    Dr Vitaly V Ganusov

  53. Mtb-Specific CD27low CD4 T Cells as Markers of Lung Tissue Destruction during Pulmonary Tuberculosis in Humans

    Article • PLoS ONE, August 2012, PLOS

    Dr Vitaly V Ganusov

  54. Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

    Article • PLoS Pathogens, May 2012, PLOS

    Dr Vitaly V Ganusov

  55. Distinct Kinetics of Gag-Specific CD4+ and CD8+ T Cell Responses during Acute HIV-1 Infection

    Article • The Journal of Immunology, January 2012, The American Association of Immunologists

    Dr Vitaly V Ganusov

  56. Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection

    Article • Journal of Virology, August 2011, ASM Journals

    Dr Vitaly V Ganusov

  57. Killing of Targets by CD8+ T Cells in the Mouse Spleen Follows the Law of Mass Action

    Article • PLoS ONE, January 2011, PLOS

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  58. Stochastic Models of Lymphocyte Proliferation and Death

    Article • PLoS ONE, September 2010, PLOS

    Dr Vitaly V Ganusov

  59. Persistence of viral infection despite similar killing efficacy of antiviral CD8+ T cells during acute and chronic phases of infection

    Article • Virology, September 2010, Elsevier

    Dr Vitaly V Ganusov

  60. Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

    Article • PLoS ONE, August 2010, PLOS

    Dr Vitaly V Ganusov

  61. In Mice, Tuberculosis Progression Is Associated with Intensive Inflammatory Response and the Accumulation of Gr-1dim Cells in the Lungs

    Article • PLoS ONE, May 2010, PLOS

    Dr Vitaly V Ganusov, Professor Rob J de Boer

  62. Explicit Kinetic Heterogeneity: Mathematical Models for Interpretation of Deuterium Labeling of Heterogeneous Cell Populations

    Article • PLoS Computational Biology, February 2010, PLOS

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  63. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

    Article • The Journal of Experimental Medicine, June 2009, Rockefeller University Press

    Dr Vitaly V Ganusov

  64. Lymphocyte kinetics in health and disease

    Article • Trends in Immunology, April 2009, Elsevier

    Dr Vitaly V Ganusov

  65. Estimating In Vivo Death Rates of Targets due to CD8 T-Cell-Mediated Killing

    Article • Journal of Virology, September 2008, ASM Journals

    Dr Vitaly V Ganusov

  66. Do most lymphocytes in humans really reside in the gut?

    Article • Trends in Immunology, December 2007, Elsevier

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  67. Discriminating between Different Pathways of Memory CD8+ T Cell Differentiation

    Article • The Journal of Immunology, October 2007, The American Association of Immunologists

    Dr Vitaly V Ganusov

  68. Dynamics of CD8+ T Cell Responses during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection

    Article • The Journal of Immunology, August 2007, The American Association of Immunologists

    Dr Vitaly V Ganusov

  69. IL-2 Regulates Expansion of CD4+ T Cell Populations by Affecting Cell Death: Insights from Modeling CFSE Data

    Article • The Journal of Immunology, July 2007, The American Association of Immunologists

    Dr Vitaly V Ganusov

  70. Estimating Lymphocyte Division and Death Rates from CFSE Data

    Article • The Bulletin of Mathematical Biophysics, May 2006, Springer Science + Business Media

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  71. IMPERFECT VACCINES AND THE EVOLUTION OF PATHOGENS CAUSING ACUTE INFECTIONS IN VERTEBRATES

    Article • Evolution, May 2006, Wiley

    Dr Vitaly V Ganusov

  72. Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection

    Article • PLoS Computational Biology, January 2006, PLOS

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  73. How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?

    Article • PLoS Computational Biology, January 2006, PLOS

    Dr Vitaly V Ganusov

  74. Pathology during acute infections: contributions of intracellular pathogens and the CTL response

    Article • Proceedings of the Royal Society B Biological Sciences, May 2005, Royal Society Publishing

    Dr Vitaly V Ganusov

  75. Quantifying cell turnover using CFSE data

    Article • Journal of Immunological Methods, March 2005, Elsevier

    Professor Rob J de Boer, Dr Vitaly V Ganusov

  76. The role of models in understanding CD8+ T-cell memory

    Article • Nature Reviews Immunology, January 2005, Nature

    Dr Vitaly V Ganusov

  77. The rescaling method for quantifying the turnover of cell populations

    Article • Journal of Theoretical Biology, November 2003, Elsevier

    Dr Vitaly V Ganusov

  78. Trade-offs and the evolution of virulence of microparasites: do details matter?

    Article • Theoretical Population Biology, September 2003, Elsevier

    Dr Vitaly V Ganusov

  79. The role of the cytotoxic T-lymphocyte response and virus cytopathogenicity in the virus decline during antiviral therapy

    Article • Proceedings of the Royal Society B Biological Sciences, July 2003, Royal Society Publishing

    Dr Vitaly V Ganusov

  80. Evolution of virulence: adaptive or not?

    Article • Trends in Microbiology, March 2003, Elsevier

    Dr Vitaly V Ganusov

  81. Estimating the Instability Parameters of Plasmid-Bearing Cells. I. Chemostat Culture

    Article • Journal of Theoretical Biology, November 2002, Elsevier

    Dr Vitaly V Ganusov

  82. WITHIN-HOST POPULATION DYNAMICS AND THE EVOLUTION OF MICROPARASITES IN A HETEROGENEOUS HOST POPULATION

    Article • Evolution, February 2002, Wiley

    Dr Vitaly V Ganusov

  83. Computer modeling of the biotic cycle formation in a closed ecological system

    Article • Advances in Space Research, January 2001, Elsevier

    Dr Vitaly V Ganusov

  84. Modelling of genetically engineered microorganisms introduction in closed artificial microcosms

    Article • Advances in Space Research, January 1999, Elsevier

    Dr Vitaly V Ganusov