All Stories

  1. Anti-Parasitics with a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing
  2. The discovery of the Sph-gated plasma membrane Ca2+ channel in trypanosomatids. A difficult path for a surprising kind of L-Type VGCC
  3. Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease
  4. Molecular, immunological, and physiological evidences of a sphingosine-activated plasma membrane Ca2+-channel in Trypanosoma equiperdum
  5. Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease
  6. Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives
  7. Effects of SQ109 on Trichomonas vaginalis
  8. Editorial: Chagas disease novel drug targets and treatments
  9. Synthesis of novel 6-substituted-3-formyl chromone derivatives as anti-leishmanial agents and their possible mechanism of action in Leishmania donovani
  10. Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites
  11. Structural Analysis and Diversity of Calmodulin-Binding Domains in Membrane and Intracellular Ca2+-ATPases
  12. Effect of tetrahydroquinoline derivatives on the intracellular Ca2+ homeostasis in breast cancer cells (MCF-7) and its relationship with apoptosis.
  13. Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis
  14. The role of tryptophan in Chagas disease and other trypanosomatid infections
  15. Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies
  16. First evidence of the presence of a Store-operated calcium channel (SOCE) in trypanosomatids.
  17. Advances in the Molecular Biology of Trypanosomatid Pathogens
  18. Amiodarone and its Derivatives for the Treatment of Chagas’ Disease and Leishmaniasis
  19. Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi
  20. The anti-tuberculosis drug SQ109 kills Leishmania donovani. Tne mechanism of action is shown
  21. Determination of Intracellular Ca2+ Concentration in the Human Pathogens Trypanosomatids Leishmania mexicana and Trypanosoma cruzi by the Use of the Fluorescent Ca2+ Indicator Fura-2
  22. Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs
  23. Identification and Electrophysiological Properties of a Sphingosine‐dependent Plasma Membrane Ca 2+ Channel in Trypanosoma cruzi
  24. Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis
  25. Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region
  26. Poorly differentiated osteoclast-like giant cell variant of cutaneous squamous cell carcinoma: Uncovering its mutational landscape through massive parallel sequencing
  27. Phosphorylation-induced conformational changes of photoactivated rhodopsin probed by fluorescent labeling at Cys 140 and Cys 316
  28. In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption
  29. Anti- Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure
  30. Identification and characterization of a calmodulin binding domain in the plasma membrane Ca 2+ -ATPase from Trypanosoma equiperdum
  31. On the mechanism of action of miltefosine in Leishmania spp
  32. Evidence of the presence of a calmodulin-sensitive plasma membrane Ca 2+ -ATPase in Trypanosoma equiperdum
  33. Tuberculosis Drug SQ109 has potent activity against amastigote of L. mexicana
  34. Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option
  35. Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity
  36. Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes
  37. The activating role of phospho-(Tyr)-calmodulin on the epidermal growth factor receptor
  38. Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src
  39. Characterization of Phospho-(Tyrosine)-Mimetic Calmodulin Mutants
  40. Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the question
  41. SQ109, a New Drug Lead for Chagas Disease
  42. Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing
  43. Dronedarone maintains the antiproliferative effect of amiodarone , and even improve it.
  44. Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing
  45. Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana
  46. Sodium-Calcium Exchanger Modulates the L-Glutamate Cai 2+ Signalling in Type-1 Cerebellar Astrocytes
  47. The emerging role of amiodarone and dronedarone in Chagas disease
  48. In VitroAnti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile
  49. The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
  50. Successful Treatment of Old World Cutaneous Leishmaniasis Caused byLeishmania infantumwith Posaconazole
  51. Trypanosoma cruzi calmodulin: Cloning, expression and characterization
  52. Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis
  53. Diacylglycerol regulates the plasma membrane calcium pump from human erythrocytes by direct interaction
  54. Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana
  55. Anti-VSG antibodies induce an increase inTrypanosoma evansiintracellular Ca2+concentration
  56. The Activity of the Na+/Ca2+ Exchanger Largely Modulates the Ca2+i Signal Induced by Hypo-Osmotic Stress in Rat Cerebellar Astrocytes. The Effect of Osmolarity on Exchange Activity
  57. The Calcium Pump of Plasma Membranes
  58. Na+entry via glutamate transporter activates the reverse Na+/Ca2+exchange and triggers ‐induced Ca2+release in rat cerebellar Type‐1 astrocytes
  59. The plasma membrane Ca2+-ATPase protein from red blood cells is not modified in preeclampsia
  60. Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with Posaconazole
  61. Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel
  62. Characterisation of tyrosine-phosphorylation-defective calmodulin mutants
  63. Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel
  64. Evaluation of the Presence of a Thapsigargin-Sensitive Calcium Store in Trypanosomatids Using Trypanosoma evansi as a Model
  65. Phosphorylation of calmodulin
  66. A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi
  67. Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes
  68. Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes
  69. The Effect of Ethanol on the Plasma Membrane Calcium Pump Is Isoform-specific
  70. Comparative phosphorylation of calmodulin from trypanosomatids and bovine brain by calmodulin-binding protein kinases
  71. Characterization of mitochondrial electron-transfer in Leishmania mexicana
  72. The role of a H+-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes
  73. The role of a H+-ATPase in the regulation of cytoplasmic pH inTrypanosoma cruziepimastigotes
  74. Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes
  75. Ouabain-sensitive Na+,K+-ATPase in the plasma membrane of Leishmania mexicana
  76. Regulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptora
  77. Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi
  78. Ethanol stimulates the plasma membrane calcium pump from human erythrocytes
  79. A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine
  80. Disruption of Ca2+ Homeostasis In Trypanosoma Cruzi By Crystal Violet
  81. A calmodulin-activated (Ca2+-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi
  82. Fluorimetric quantification of cell death in monolayer cultures and cell suspensions
  83. A calcium pump in plasma membrane vesicles from Leishmania braziliensis
  84. Similarities between the effects of dimethyl sulfoxide and calmodulin on the red blood cell Ca2+-ATPase
  85. Ca2+ transport in isolated mitochondrial vesicles from Leishmania braziliensis promastigotes
  86. Increased calcium permeability is not responsible for the rapid lethal effects of amphotericin B on Leishmania sp
  87. Activation of the purified erythrocyte plasma membrane Ca2+‐ATPase by organic solvents
  88. ATPase activity and Ca2+ transport by reconstituted tryptic fragments of the Ca2+ pump of the erythrocyte plasma membrane
  89. The Purified Calcium-Pumping ATPase of Plasma Membrane