All Stories

  1. Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

    Article • Biomolecules, March 2024, MDPI AG

    Prof. Dr. Gustavo Benaim

  2. Molecular, immunological, and physiological evidences of a sphingosine-activated plasma membrane Ca2+-channel in Trypanosoma equiperdum

    Article • Parasitology Research, March 2024, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  3. Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

    Article • February 2024, MDPI AG

    Prof. Dr. Gustavo Benaim

  4. Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

    Article • Pharmaceuticals, December 2023, MDPI AG

    Prof. Dr. Gustavo Benaim

  5. Effects of SQ109 on Trichomonas vaginalis

    Article • Experimental Parasitology, July 2023, Elsevier

    Prof. Dr. Gustavo Benaim

  6. Editorial: Chagas disease novel drug targets and treatments

    Article • Frontiers in Cellular and Infection Microbiology, May 2023, Frontiers

    Prof. Dr. Gustavo Benaim

  7. Synthesis of novel 6-substituted-3-formyl chromone derivatives as anti-leishmanial agents and their possible mechanism of action in Leishmania donovani

    Article • Journal of Molecular Structure, May 2023, Elsevier

    Prof. Dr. Gustavo Benaim

  8. Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites

    Article • ACS Infectious Diseases, January 2023, American Chemical Society (ACS)

    Prof. Dr. Gustavo Benaim, Ioannis P. Papanastasiou

  9. Structural Analysis and Diversity of Calmodulin-Binding Domains in Membrane and Intracellular Ca2+-ATPases

    Article • The Journal of Membrane Biology, December 2022, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  10. Effect of tetrahydroquinoline derivatives on the intracellular Ca2+ homeostasis in breast cancer cells (MCF-7) and its relationship with apoptosis.

    Article • Investigación Clínica, August 2022, Cuestiones Politicas, Universidad del Zulia

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis, Vladimir Kouznetsov

  11. Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis

    Article • Parasitology Research, April 2022, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  12. The role of tryptophan in Chagas disease and other trypanosomatid infections

    Article • January 2022, Elsevier

    Prof. Dr. Gustavo Benaim

  13. Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies

    Article • Frontiers in Cellular and Infection Microbiology, October 2021, Frontiers

    Prof. Dr. Gustavo Benaim

  14. First evidence of the presence of a Store-operated calcium channel (SOCE) in trypanosomatids.

    Article • Molecular and Biochemical Parasitology, July 2021, Elsevier

    Prof. Dr. Gustavo Benaim

  15. Advances in the Molecular Biology of Trypanosomatid Pathogens

    Article • January 2021, Frontiers

    Prof. Dr. Gustavo Benaim

  16. Amiodarone and its Derivatives for the Treatment of Chagas’ Disease and Leishmaniasis

    Article • Current Pharmaceutical Design, September 2020, Bentham Science Publishers

    Prof. Dr. Gustavo Benaim

  17. Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

    Article • Frontiers in Cellular and Infection Microbiology, February 2020, Frontiers

    Prof. Dr. Gustavo Benaim

  18. The anti-tuberculosis drug SQ109 kills Leishmania donovani. Tne mechanism of action is shown

    Article • Parasitology Research, January 2020, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  19. Determination of Intracellular Ca2+ Concentration in the Human Pathogens Trypanosomatids Leishmania mexicana and Trypanosoma cruzi by the Use of the Fluorescent Ca2+ Indicator Fura-2

    Article • BIO-PROTOCOL, January 2020, Bio-Protocol, LLC

    Prof. Dr. Gustavo Benaim

  20. Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs

    Article • Journal of the American Veterinary Medical Association, August 2019, American Veterinary Medical Association (AVMA)

    Prof. Dr. Gustavo Benaim

  21. Identification and Electrophysiological Properties of a Sphingosine‐dependent Plasma Membrane Ca 2+ Channel in Trypanosoma cruzi

    Article • FEBS Journal, June 2019, Wiley

    Prof. Dr. Gustavo Benaim

  22. Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis

    Article • Parasitology International, June 2019, Elsevier

    Prof. Dr. Gustavo Benaim

  23. Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region

    Article • The Lancet Infectious Diseases, May 2019, Elsevier

    Prof. Dr. Gustavo Benaim, Dr. Hernán José Carrasco

  24. Poorly differentiated osteoclast-like giant cell variant of cutaneous squamous cell carcinoma: Uncovering its mutational landscape through massive parallel sequencing

    Article • Pathology - Research and Practice, November 2018, Elsevier

    Prof. Dr. Gustavo Benaim

  25. Phosphorylation-induced conformational changes of photoactivated rhodopsin probed by fluorescent labeling at Cys 140 and Cys 316

    Article • Biochimie, July 2018, Elsevier

    Prof. Dr. Gustavo Benaim

  26. In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption

    Article • Acta Tropica, July 2018, Elsevier

    Prof. Dr. Gustavo Benaim

  27. Anti- Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure

    Article • Experimental Parasitology, June 2018, Elsevier

    Prof. Dr. Gustavo Benaim

  28. Identification and characterization of a calmodulin binding domain in the plasma membrane Ca 2+ -ATPase from Trypanosoma equiperdum

    Article • Molecular and Biochemical Parasitology, June 2018, Elsevier

    Prof. Dr. Gustavo Benaim

  29. On the mechanism of action of miltefosine in Leishmania spp

    Article • Antimicrobial Agents and Chemotherapy, October 2017, ASM Journals

    Prof. Dr. Gustavo Benaim

  30. Evidence of the presence of a calmodulin-sensitive plasma membrane Ca 2+ -ATPase in Trypanosoma equiperdum

    Article • Molecular and Biochemical Parasitology, April 2017, Elsevier

    Prof. Dr. Gustavo Benaim

  31. Tuberculosis Drug SQ109 has potent activity against amastigote of L. mexicana

    Article • Antimicrobial Agents and Chemotherapy, July 2016, ASM Journals

    Prof. Dr. Gustavo Benaim

  32. Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option

    Article • Current Topics in Medicinal Chemistry, May 2016, Bentham Science Publishers

    Prof. Dr. Gustavo Benaim

  33. Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity

    Article • Biochemical and Biophysical Research Communications, April 2016, Elsevier

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis

  34. Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes

    Article • Microbial Cell, January 2016, Shared Science Publishers OG

    Prof. Dr. Gustavo Benaim

  35. The activating role of phospho-(Tyr)-calmodulin on the epidermal growth factor receptor

    Article • Biochemical Journal, November 2015, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  36. Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

    Article • PLoS ONE, June 2015, PLOS

    Prof. Dr. Gustavo Benaim

  37. Characterization of Phospho-(Tyrosine)-Mimetic Calmodulin Mutants

    Article • PLoS ONE, April 2015, PLOS

    Prof. Dr. Gustavo Benaim

  38. Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the question

    Article • Virchows Archiv, January 2015, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  39. SQ109, a New Drug Lead for Chagas Disease

    Article • Antimicrobial Agents and Chemotherapy, January 2015, ASM Journals

    Professor Roberto Docampo, Prof. Dr. Gustavo Benaim

  40. Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing

    Article • Virchows Archiv, July 2014, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  41. Dronedarone maintains the antiproliferative effect of amiodarone , and even improve it.

    Article • Antimicrobial Agents and Chemotherapy, February 2014, ASM Journals

    Prof. Dr. Gustavo Benaim

  42. Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing

    Article • Human Pathology, December 2013, Elsevier

    Prof. Dr. Gustavo Benaim

  43. Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana

    Article • Biochemical and Biophysical Research Communications, January 2013, Elsevier

    Prof. Dr. Gustavo Benaim

  44. Sodium-Calcium Exchanger Modulates the L-Glutamate Cai 2+ Signalling in Type-1 Cerebellar Astrocytes

    Article • October 2012, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  45. The emerging role of amiodarone and dronedarone in Chagas disease

    Article • Nature Reviews Cardiology, August 2012, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim

  46. In VitroAnti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile

    Article • Antimicrobial Agents and Chemotherapy, April 2012, ASM Journals

    Prof. Dr. Gustavo Benaim

  47. The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)

    Article • Cancer Chemotherapy and Pharmacology, May 2011, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis

  48. Successful Treatment of Old World Cutaneous Leishmaniasis Caused byLeishmania infantumwith Posaconazole

    Article • Antimicrobial Agents and Chemotherapy, January 2011, ASM Journals

    Prof. Dr. Gustavo Benaim

  49. Trypanosoma cruzi calmodulin: Cloning, expression and characterization

    Article • Experimental Parasitology, December 2009, Elsevier

    Prof. Dr. Gustavo Benaim

  50. Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis

    Article • Antimicrobial Agents and Chemotherapy, October 2009, ASM Journals

    Prof. Dr. Gustavo Benaim

  51. Diacylglycerol regulates the plasma membrane calcium pump from human erythrocytes by direct interaction

    Article • Archives of Biochemistry and Biophysics, September 2009, Elsevier

    Prof. Dr. Gustavo Benaim

  52. Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

    Article • Antimicrobial Agents and Chemotherapy, January 2009, ASM Journals

    Prof. Dr. Gustavo Benaim

  53. Anti-VSG antibodies induce an increase inTrypanosoma evansiintracellular Ca2+concentration

    Article • Parasitology, August 2008, Cambridge University Press

    Prof. Dr. Gustavo Benaim

  54. The Activity of the Na+/Ca2+ Exchanger Largely Modulates the Ca2+i Signal Induced by Hypo-Osmotic Stress in Rat Cerebellar Astrocytes. The Effect of Osmolarity on Exchange Activity

    Article • The Journal of Physiological Sciences, January 2008, Physiological Society of Japan

    Prof. Dr. Gustavo Benaim

  55. The Calcium Pump of Plasma Membranes

    Article • September 2007, Wiley

    Prof. Dr. Gustavo Benaim

  56. Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers ‐induced Ca2+ release in rat cerebellar Type‐1 astrocytes

    Article • Journal of Neurochemistry, November 2006, Wiley

    Prof. Dr. Gustavo Benaim

  57. The plasma membrane Ca2+-ATPase protein from red blood cells is not modified in preeclampsia

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, March 2006, Elsevier

    Prof. Dr. Gustavo Benaim, Professor Reinaldo Marín

  58. Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with Posaconazole

    Article • Journal of Medicinal Chemistry, January 2006, American Chemical Society (ACS)

    Prof. Dr. Gustavo Benaim

  59. Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel

    Article • Biochemical and Biophysical Research Communications, October 2005, Elsevier

    Prof. Dr. Gustavo Benaim

  60. Characterisation of tyrosine-phosphorylation-defective calmodulin mutants

    Article • Protein Expression and Purification, June 2005, Elsevier

    Prof. Dr. Gustavo Benaim

  61. Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel

    Article • Archives of Biochemistry and Biophysics, April 2005, Elsevier

    Prof. Dr. Gustavo Benaim

  62. Evaluation of the Presence of a Thapsigargin-Sensitive Calcium Store in Trypanosomatids Using Trypanosoma evansi as a Model

    Article • Journal of Parasitology, October 2004, American Society of Parasitologists

    Prof. Dr. Gustavo Benaim

  63. Phosphorylation of calmodulin

    Article • European Journal of Biochemistry, July 2002, Wiley

    Prof. Dr. Gustavo Benaim

  64. A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, April 2002, Elsevier

    Prof. Dr. Gustavo Benaim, Professor Roberto Docampo

  65. Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes

    Article • Biochemical Journal, March 2002, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  66. Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes

    Article • Biochemical Journal, February 2002, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  67. The Effect of Ethanol on the Plasma Membrane Calcium Pump Is Isoform-specific

    Article • Journal of Biological Chemistry, November 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Dr. Gustavo Benaim

  68. Comparative phosphorylation of calmodulin from trypanosomatids and bovine brain by calmodulin-binding protein kinases

    Article • Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology, July 1998, Elsevier

    Prof. Dr. Gustavo Benaim

  69. Characterization of mitochondrial electron-transfer in Leishmania mexicana

    Article • Molecular and Biochemical Parasitology, December 1997, Elsevier

    Prof. Dr. Gustavo Benaim

  70. The role of a H+-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes

    Article • Biochemical Journal, November 1996, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  71. The role of a H+-ATPase in the regulation of cytoplasmic pH inTrypanosoma cruziepimastigotes

    Article • Biochemical Journal, August 1996, Portland Press Ltd.

    Professor Roberto Docampo, Prof. Dr. Gustavo Benaim

  72. Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes

    Article • Biochemical Journal, August 1996, Portland Press Ltd.

    Professor Roberto Docampo, Prof. Dr. Gustavo Benaim

  73. Ouabain-sensitive Na+,K+-ATPase in the plasma membrane of Leishmania mexicana

    Article • Molecular and Biochemical Parasitology, November 1995, Elsevier

    Prof. Dr. Gustavo Benaim, Professor Reinaldo Marín

  74. Regulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptora

    Article • Annals of the New York Academy of Sciences, September 1995, Wiley

    Prof. Dr. Gustavo Benaim

  75. Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi

    Article • Biochemical Journal, February 1995, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  76. Ethanol stimulates the plasma membrane calcium pump from human erythrocytes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 1994, Elsevier

    Prof. Dr. Gustavo Benaim

  77. A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine

    Article • Biochemical Journal, December 1993, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  78. Disruption of Ca2+ Homeostasis In Trypanosoma Cruzi By Crystal Violet

    Article • Journal of Eukaryotic Microbiology, May 1993, Wiley

    Prof. Dr. Gustavo Benaim

  79. A calmodulin-activated (Ca2+-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi

    Article • Biochemical Journal, December 1991, Portland Press Ltd.

    Prof. Dr. Gustavo Benaim

  80. Fluorimetric quantification of cell death in monolayer cultures and cell suspensions

    Article • Journal of Biochemical and Biophysical Methods, October 1991, Elsevier

    Juan Ernesto Ludert, Prof. Dr. Gustavo Benaim

  81. A calcium pump in plasma membrane vesicles from Leishmania braziliensis

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 1990, Elsevier

    Prof. Dr. Gustavo Benaim

  82. Similarities between the effects of dimethyl sulfoxide and calmodulin on the red blood cell Ca2+-ATPase

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1990, Elsevier

    Prof. Dr. Gustavo Benaim

  83. Ca2+ transport in isolated mitochondrial vesicles from Leishmania braziliensis promastigotes

    Article • Molecular and Biochemical Parasitology, February 1990, Elsevier

    Prof. Dr. Gustavo Benaim

  84. Increased calcium permeability is not responsible for the rapid lethal effects of amphotericin B on Leishmania sp

    Article • FEBS Letters, January 1990, Wiley

    Prof. Dr. Gustavo Benaim

  85. Activation of the purified erythrocyte plasma membrane Ca2+‐ATPase by organic solvents

    Article • FEBS Letters, February 1989, Wiley

    Prof. Dr. Gustavo Benaim

  86. ATPase activity and Ca2+ transport by reconstituted tryptic fragments of the Ca2+ pump of the erythrocyte plasma membrane

    Article • Cell Calcium, June 1986, Elsevier

    Prof. Dr. Gustavo Benaim

  87. The Purified Calcium-Pumping ATPase of Plasma Membrane

    Article • January 1985, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim