Prof. Dr. Gustavo Benaim
Instituto de Estudios Avanzados (IDEA)
Professor, Life Sciences
Venezuela
My co-authors include
Dr Juan B De Sanctis
Professor Roberto Docampo
Juan Ernesto Ludert
My Publications
Rationale for Use of Amiodarone and Its Derivatives for Treatment of Chagas’ Disease an...
Current Pharmaceutical Design
September 2020
Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypano...
Frontiers in Cellular and Infection Microbiology
February 2020
The anti-tuberculosis drug SQ109 kills Leishmania donovani. Tne mechanism of action is ...
Parasitology Research
January 2020
Investigation of a combination of amiodarone and itraconazole for treatment of American...
Journal of the American Veterinary Medical Association
August 2019
Identification and Electrophysiological Properties of a Sphingosine‐dependent Plasma Me...
FEBS Journal
June 2019
Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone ...
Parasitology International
June 2019
Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications ...
The Lancet Infectious Diseases
May 2019
Poorly differentiated osteoclast-like giant cell variant of cutaneous squamous cell car...
Pathology - Research and Practice
November 2018
Phosphorylation-induced conformational changes of photoactivated rhodopsin probed by fl...
Biochimie
July 2018
Anti- Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone stru...
Experimental Parasitology
June 2018
Identification and characterization of a calmodulin binding domain in the plasma membra...
Molecular and Biochemical Parasitology
June 2018
On the mechanism of action of miltefosine in Leishmania spp
Antimicrobial Agents and Chemotherapy
October 2017
Evidence of the presence of a calmodulin-sensitive plasma membrane Ca 2+ -ATPase in Try...
Molecular and Biochemical Parasitology
April 2017
Tuberculosis Drug SQ109 has potent activity against amastigote of L. mexicana
Antimicrobial Agents and Chemotherapy
July 2016
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option
Current Topics in Medicinal Chemistry
May 2016
Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity
Biochemical and Biophysical Research Communications
April 2016
Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activit...
PLoS ONE
June 2015
Characterization of Phospho-(Tyrosine)-Mimetic Calmodulin Mutants
PLoS ONE
April 2015
Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the ...
Virchows Archiv
January 2015
Cutaneous carcinosarcoma: further insights into its mutational landscape through massiv...
Virchows Archiv
July 2014
Dronedarone maintains the antiproliferative effect of amiodarone , and even improve it.
Antimicrobial Agents and Chemotherapy
February 2014
Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational patter...
Human Pathology
December 2013
Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishm...
Biochemical and Biophysical Research Communications
January 2013
Sodium-Calcium Exchanger Modulates the L-Glutamate Cai 2+ Signalling in Type-1 Cerebell...
October 2012
The emerging role of amiodarone and dronedarone in Chagas disease
Nature Reviews Cardiology
August 2012
In VitroAnti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative w...
Antimicrobial Agents and Chemotherapy
April 2012
The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and ...
Cancer Chemotherapy and Pharmacology
May 2011
Successful Treatment of Old World Cutaneous Leishmaniasis Caused byLeishmania infantumw...
Antimicrobial Agents and Chemotherapy
January 2011
Trypanosoma cruzi calmodulin: Cloning, expression and characterization
Experimental Parasitology
December 2009
Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Indu...
Antimicrobial Agents and Chemotherapy
October 2009
Diacylglycerol regulates the plasma membrane calcium pump from human erythrocytes by di...
Archives of Biochemistry and Biophysics
September 2009
Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in L...
Antimicrobial Agents and Chemotherapy
January 2009
Anti-VSG antibodies induce an increase in Trypanosoma evansi intracellular Ca2+ concent...
Parasitology
August 2008
The Activity of the Na+/Ca2+ Exchanger Largely Modulates the Ca2+i Signal Induced by Hy...
The Journal of Physiological Sciences
January 2008
The Calcium Pump of Plasma Membranes
September 2007
Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and trigger...
Journal of Neurochemistry
November 2006
The plasma membrane Ca2+-ATPase protein from red blood cells is not modified in preecla...
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
March 2006
Amiodarone Has Intrinsic Anti-TrypanosomacruziActivity and Acts Synergistically with Po...
Journal of Medicinal Chemistry
February 2006
Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 ...
Biochemical and Biophysical Research Communications
October 2005
Characterisation of tyrosine-phosphorylation-defective calmodulin mutants
Protein Expression and Purification
June 2005
Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of cal...
Archives of Biochemistry and Biophysics
April 2005
Evaluation of the Presence of a Thapsigargin-Sensitive Calcium Store in Trypanosomatids...
Journal of Parasitology
October 2004
Phosphorylation of calmodulin
European Journal of Biochemistry
July 2002
A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of...
Molecular and Biochemical Parasitology
April 2002
Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase...
Biochemical Journal
March 2002
Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase...
Biochemical Journal
February 2002
The Effect of Ethanol on the Plasma Membrane Calcium Pump Is Isoform-specific
Journal of Biological Chemistry
November 1998
Comparative phosphorylation of calmodulin from trypanosomatids and bovine brain by calm...
Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology
July 1998
Characterization of mitochondrial electron-transfer in Leishmania mexicana
Molecular and Biochemical Parasitology
December 1997
The role of a H+-ATPase in the regulation of cytoplasmic pH inTrypanosoma cruziepimasti...
Biochemical Journal
August 1996
Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes
Biochemical Journal
August 1996
Ouabain-sensitive Na+,K+-ATPase in the plasma membrane of Leishmania mexicana
Molecular and Biochemical Parasitology
November 1995
Regulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptor
Annals of the New York Academy of Sciences
September 1995
Ethanol stimulates the plasma membrane calcium pump from human erythrocytes
Biochimica et Biophysica Acta (BBA) - Biomembranes
October 1994
Disruption of Ca2+Homeostasis In Trypanosoma Cruzi By Crystal Violet
Journal of Eukaryotic Microbiology
May 1993
Fluorimetric quantification of cell death in monolayer cultures and cell suspensions
Journal of Biochemical and Biophysical Methods
October 1991
A calcium pump in plasma membrane vesicles from Leishmania braziliensis
Biochimica et Biophysica Acta (BBA) - Biomembranes
August 1990
Similarities between the effects of dimethyl sulfoxide and calmodulin on the red blood ...
Biochimica et Biophysica Acta (BBA) - Biomembranes
July 1990
Ca2+ transport in isolated mitochondrial vesicles from Leishmania braziliensis promasti...
Molecular and Biochemical Parasitology
February 1990
Increased calcium permeability is not responsible for the rapid lethal effects of ampho...
FEBS Letters
January 1990
Activation of the purified erythrocyte plasma membrane Ca2+ -ATPase by organic solvents
FEBS Letters
February 1989
ATPase activity and Ca2+ transport by reconstituted tryptic fragments of the Ca2+ pump ...
Cell Calcium
June 1986
The Purified Calcium-Pumping ATPase of Plasma Membrane
January 1985
