On the mechanism of action of miltefosine in Leishmania spp
What is it about?
We found what we consider the main mechanism of action of miltefosine concerning Lesihmania. The drug is able to open a calcium channel at the plasma membrane which is unique in these parasites, since it is activated by sphingosine. Miltefosine also affect the acidocalcisome function and collapse the lectrochemical mitochondrial potential of the parasite, producing the release of Ca2+ from these compartments
Why is it important?
Because miltefosine is the unique oral approved drug against leishmaniasis and the mechanism of action was only partially elucidated
The following have contributed to this page: Prof. Gustavo Benaim
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