All Stories

  1. New Derivatives of Caracasine Acid with Anti-Leukemic Activity and Limited Effectiveness in Spheroid Cultures

    Article • Pharmaceuticals, July 2025, MDPI AG

    Dr Juan B De Sanctis

  2. Food-Specific IgG Antibodies: Decoding Their Dual Role in Immune Tolerance and Food Intolerance

    Article • Immuno, June 2025, MDPI AG

    Dr Juan B De Sanctis

  3. The response of the Venezuelan population to the sinopharm vaccine

    Article • Biomedicines, June 2025, MDPI AG

    Dr Juan B De Sanctis

  4. Endometriosis: An Immunologist’s Perspective

    Article • International Journal of Molecular Sciences, May 2025, MDPI AG

    Dr Juan B De Sanctis

  5. Specialized Pro-Resolving Lipid Mediators in Pulmonary Diseases: Molecular and Therapeutic Implications

    Article • Molecules, May 2025, MDPI AG

    Dr Juan B De Sanctis

  6. Identification of a novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity

    Article • Bioorganic Chemistry, April 2025, Elsevier

    Dr Juan B De Sanctis

  7. Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis

    Article • Frontiers in Immunology, February 2025, Frontiers

    Dr Juan B De Sanctis

  8. Colchicine for the primary prevention of cardiovascular events

    Article • Cochrane Database of Systematic Reviews, February 2025, Wiley

    Dr Juan B De Sanctis

  9. Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure

    Article • International Journal of Molecular Sciences, February 2025, MDPI AG

    Dr Juan B De Sanctis

  10. Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review

    Article • International Journal of Molecular Sciences, January 2025, MDPI AG

    Dr Juan B De Sanctis

  11. Correction: De Sanctis et al. Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event. Cancers 2024, 16, 2630

    Article • Cancers, December 2024, MDPI AG

    Dr Juan B De Sanctis

  12. Polymer nanotherapeutics with the controlled release of acetylsalicylic acid and its derivatives inhibiting cyclooxygenase isoforms and reducing the production of pro-inflammatory mediators

    Article • International Journal of Pharmaceutics, November 2024, Elsevier

    Dr Juan B De Sanctis

  13. Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era

    Article • International Journal of Molecular Sciences, October 2024, MDPI AG

    Dr Juan B De Sanctis

  14. IgG Antibody Titers Against Ascaris lumbricoides, Strongyloides stercolaris, and Toxocara canis in Venezuelan Patients with Asthma or COPD

    Article • Tropical Medicine and Infectious Disease, October 2024, MDPI AG

    Dr Juan B De Sanctis

  15. PERFIL INMUNOLÓGICO EN INDIVIDUOS ADULTOS VENEZOLANOS CON INFECCIÓN AGUDA POR SARS–CoV-2

    Article • ACTA CIENTIFICA DE LA SOCIEDAD VENEZOLANA DE BIOANALISTAS ESPECIALISTAS, October 2024, Saber CDCH-UCV

    Dr Juan B De Sanctis

  16. Unlocking the Puzzle: Investigating the Role of Interleukin 17 Genetic Polymorphisms, Circulating Lymphocytes, and Serum Levels in Venezuelan Women with Recurrent Pregnancy Loss

    Article • Immuno, September 2024, MDPI AG

    Dr Juan B De Sanctis

  17. Interleukin-receptor antagonist and tumour necrosis factor inhibitors for the primary and secondary prevention of atherosclerotic cardiovascular diseases

    Article • Cochrane Database of Systematic Reviews, September 2024, Wiley

    Dr Juan B De Sanctis

  18. Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

    Article • Microorganisms, August 2024, MDPI AG

    Dr Juan B De Sanctis

  19. Role of Micronutrients in the Response to SARS-CoV-2 Infection in Pediatric Patients

    Article • Immuno, July 2024, MDPI AG

    Dr Juan B De Sanctis

  20. Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

    Article • Cancers, July 2024, MDPI AG

    Dr Juan B De Sanctis

  21. ESTUDIO PILOTO DEL EFECTO DEL TIPO Y CONSERVACION DE LA MUESTRA Y MÉTODO, EN LA MEDICION DE LA CONCENTRACION DE LAS FRACCIONES C3 Y C4 DEL COMPLEMENTO.

    Article • ACTA CIENTIFICA DE LA SOCIEDAD VENEZOLANA DE BIOANALISTAS ESPECIALISTAS, July 2024, Saber CDCH-UCV

    Dr Juan B De Sanctis

  22. Inflammation, Autoimmunity and Neurodegenerative Diseases, Therapeutics and Beyond

    Article • Current Neuropharmacology, May 2024, Bentham Science Publishers

    Dr Juan B De Sanctis

  23. Genetic polymorphism in primary, recurrent pregnancy loss

    Article • Current Issues in Molecular Biology, April 2024, MDPI AG

    Dr Juan B De Sanctis

  24. Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

    Article • Medicinal Research Reviews, March 2024, Wiley

    Dr Juan B De Sanctis

  25. Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest

    Article • International Journal of Molecular Sciences, December 2023, MDPI AG

    Dr Juan B De Sanctis

  26. Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

    Article • Pharmaceuticals, December 2023, MDPI AG

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis

  27. CRISPR/Cas9 bioluminescence-based assay for monitoring CFTR trafficking to the plasma membrane

    Article • Life Science Alliance, November 2023, Life Science Alliance, LLC

    Dr Juan B De Sanctis

  28. A Synopsis of Hepatitis C Virus Treatments and Future Perspectives

    Article • Current Issues in Molecular Biology, October 2023, MDPI AG

    Dr Juan B De Sanctis

  29. SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study

    Article • Biomedicines, May 2023, MDPI AG

    Dr Juan B De Sanctis

  30. Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19

    Article • Current Issues in Molecular Biology, December 2022, MDPI AG

    Dr Juan B De Sanctis

  31. Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

    Article • Pharmaceuticals, October 2022, MDPI AG

    Dr Juan B De Sanctis

  32. Innate Immune Response in Hypertension

    Article • Current Pharmaceutical Design, October 2022, Bentham Science Publishers

    Dr Juan B De Sanctis

  33. Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives

    Article • Molecules, August 2022, MDPI AG

    Dr Juan B De Sanctis

  34. Effect of tetrahydroquinoline derivatives on the intracellular Ca2+ homeostasis in breast cancer cells (MCF-7) and its relationship with apoptosis.

    Article • Investigación Clínica, August 2022, Cuestiones Politicas, Universidad del Zulia

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis, Vladimir Kouznetsov

  35. Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches

    Article • Pharmaceutics, June 2022, MDPI AG

    Dr Juan B De Sanctis

  36. Molecular Mechanisms of Chloroquine and Hydroxychloroquine use in Cancer Therapy

    Article • Anti-Cancer Agents in Medicinal Chemistry, May 2022, Bentham Science Publishers

    Dr Juan B De Sanctis

  37. Caracasine, an ent-kaurane diterpene with proapoptotic and pro-differentiator activity in human leukaemia cell lines

    Article • Anti-Cancer Agents in Medicinal Chemistry, April 2022, Bentham Science Publishers

    Dr Juan B De Sanctis

  38. Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

    Article • International Journal of Molecular Sciences, April 2022, MDPI AG

    Dr Juan B De Sanctis

  39. Estudio piloto: análisis y detección de anticuerpos IgM e IgG específicos contra el dominio de unión al receptor de la proteína de la espiga del SARS-CoV-2

    Article • Gaceta Médica de Caracas, March 2022, Saber CDCH-UCV

    Dr Juan B De Sanctis

  40. Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis

    Article • International Journal of Molecular Sciences, March 2022, MDPI AG

    Dr Juan B De Sanctis

  41. One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy

    Article • Pharmaceutics, March 2022, MDPI AG

    Dr Juan B De Sanctis

  42. Effect of Glucocorticosteroids in Diamond-Blackfan Anaemia: Maybe Not as Elusive as It Seems

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Dr Juan B De Sanctis

  43. Overview of Memory NK Cells in Viral Infections: Possible Role in SARS-CoV-2 Infection

    Article • Immuno, January 2022, MDPI AG

    Dr Juan B De Sanctis

  44. Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects

    Article • January 2022, Springer Science + Business Media

    Dr Juan B De Sanctis

  45. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Dr Juan B De Sanctis

  46. Assessment of Inflammatory Response and its Resolution in Viral Infection and Rheumatoid Arthritis

    Article • Current Pharmaceutical Design, November 2021, Bentham Science Publishers

    Dr Juan B De Sanctis

  47. Potential Role of Bioactive Lipids in Rheumatoid Arthritis

    Article • Current Pharmaceutical Design, November 2021, Bentham Science Publishers

    Dr Juan B De Sanctis, Wheeler Torres, Yosselin Gomez, Valmore Bermudez, manuel velasco

  48. Importancia de la respuesta inmune celular adaptativa en la infección por SARS-CoV-2

    Article • Revista de la Facultad de Farmacia, October 2021, Saber CDCH-UCV

    Dr Juan B De Sanctis

  49. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Dr Juan B De Sanctis

  50. Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies

    Article • Experimental Neurology, September 2021, Elsevier

    Dr Juan B De Sanctis

  51. A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

    Article • Immuno, July 2021, MDPI AG

    Dr Juan B De Sanctis

  52. Editorial: Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases

    Article • Frontiers in Immunology, May 2021, Frontiers

    Dr Juan B De Sanctis

  53. Coronavirus infection: An immunologists' perspective

    Article • Scandinavian Journal of Immunology, April 2021, Wiley

    Dr Juan B De Sanctis

  54. Synthesis and antimalarial and anticancer evaluation of 7‐chlorquinoline‐4‐thiazoleacetic derivatives containing aryl hydrazide moieties

    Article • Archiv der Pharmazie, March 2021, Wiley

    Dr Juan B De Sanctis

  55. POTENCIALES OPCIONES TERAPÉUTICAS PARA INFECCIONES POR SARS-CoV 1 Y 2

    Article • ACTA CIENTIFICA DE LA SOCIEDAD VENEZOLANA DE BIOANALISTAS ESPECIALISTAS, February 2021, Saber CDCH-UCV

    Dr Juan B De Sanctis

  56. CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells

    Article • Frontiers in Physiology, February 2021, Frontiers

    Dr Juan B De Sanctis

  57. Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases

    Article • January 2021, Frontiers

    Dr Juan B De Sanctis

  58. Subpoblaciones linfocitarias de pacientes venezolanos infectados con SARS-CoV-2

    Article • Gaceta Médica de Caracas, December 2020, Saber CDCH-UCV

    Dr Juan B De Sanctis

  59. Importance of miRNA in SARS-CoV2 infection

    Article • Gaceta Médica de Caracas, December 2020, Saber CDCH-UCV

    Dr Juan B De Sanctis

  60. Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults

    Article • Nutrients, November 2020, MDPI AG

    Dr Juan B De Sanctis

  61. Small Natural and Synthetic Molecules for Therapeutic Use

    Article • Current Pharmaceutical Design, October 2020, Bentham Science Publishers

    Dr Juan B De Sanctis

  62. A brief overview of cancer research in the elderly population

    Article • Gaceta Médica de Caracas, August 2020, Saber CDCH-UCV

    Dr. Gricelis Patricia Martinez, Dr Juan B De Sanctis

  63. The role of essential fatty acids in cystic fibrosis and normalizing effect of fenretinide

    Article • Cellular and Molecular Life Sciences, May 2020, Springer Science + Business Media

    Dr Juan B De Sanctis

  64. Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis

    Article • Lung, April 2020, Springer Science + Business Media

    Dr Juan B De Sanctis

  65. Treatment of allergic asthma with Fenretinide formulation (LAU-7b) downregulates Ormdl3 expression and normalizes ceramides imbalance

    Article • Journal of Pharmacology and Experimental Therapeutics, April 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Juan B De Sanctis

  66. Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, February 2020, Elsevier

    Dr Juan B De Sanctis

  67. Synthesis and biological activity of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivatives as antimalarial and cytotoxic agents

    Article • Journal of Chemical Research, January 2020, SAGE Publications

    Dr Juan B De Sanctis

  68. Effect of fenretidine on murine asthma model

    Article • Pharmaceutical Research, January 2020, Springer Science + Business Media

    Dr Juan B De Sanctis

  69. Pharmacologic Modulation of the Immune Response Against Tumours in the Elderly

    Article • January 2020, Springer Science + Business Media

    Dr Juan B De Sanctis

  70. New structures as anti malarials and anti cancer drugs

    Article • Medicinal Chemistry Research, September 2019, Springer Science + Business Media

    Dr Juan B De Sanctis, Dr. Gricelis Patricia Martinez

  71. Caracasine acid is a seco kaurene purified from Croton caracasana

    Article • European Journal of Pharmacology, August 2019, Elsevier

    Dr Juan B De Sanctis, Dr. Gricelis Patricia Martinez

  72. Reviw on the importance of long chain fatty acids

    Article • Progress in Lipid Research, August 2019, Elsevier

    Dr Juan B De Sanctis

  73. Effects of flavonoids and Its Derivatives on Immune Cell Responses

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, April 2019, Bentham Science Publishers

    Dr Juan B De Sanctis, Dr. Gricelis Patricia Martinez

  74. Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives

    Article • Medicinal Chemistry Research, November 2018, Springer Science + Business Media

    Dr Juan B De Sanctis

  75. Cardiorespiratory responses, nitric oxide production and inflammatory factors in patients with myocardial infarction after rehabilitation

    Article • Nitric Oxide, June 2018, Elsevier

    Dr Juan B De Sanctis

  76. Importance of zona pellucida binding protgein in inflammation

    Article • Mammalian Genome, March 2018, Springer Science + Business Media

    Dr Juan B De Sanctis

  77. Anti malarial and anti cancer compound

    Article • Bioorganic & Medicinal Chemistry, February 2018, Elsevier

    Dr Juan B De Sanctis

  78. Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside

    Article • Journal of Molecular Medicine, July 2017, Springer Science + Business Media

    Dr Juan B De Sanctis

  79. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells

    Article • Journal of Proteomics, June 2017, Elsevier

    Dr Juan B De Sanctis

  80. A Review of Clinical Trials of Belimumab in the Management of Systemic Lupus Erythematosus

    Article • Current Pharmaceutical Design, December 2016, Bentham Science Publishers

    Dr Juan B De Sanctis, Alexis Garcia

  81. Editorial of immunomodulation issue

    Article • Current Pharmaceutical Design, December 2016, Bentham Science Publishers

    Dr Juan B De Sanctis

  82. Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931

    Article • AJP Lung Cellular and Molecular Physiology, September 2016, American Physiological Society

    Dr Tamas Oravecz, Dr Juan B De Sanctis

  83. Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity

    Article • Biochemical and Biophysical Research Communications, April 2016, Elsevier

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis

  84. Inflammatory gene polymorphisms in asthma and chronic obstructive pulmonary disease in Venezuela

    Article • September 2015, European Respiratory Society (ERS)

    Dr Juan B De Sanctis

  85. Peptide Vaccines for Cancer Therapy

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, April 2015, Bentham Science Publishers

    Dr Juan B De Sanctis, Dr. Gricelis Patricia Martinez

  86. Editorial (Thematic Issue: Vaccines)

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, April 2015, Bentham Science Publishers

    Dr Juan B De Sanctis

  87. Vaccine Therapy Update for Pregnant, Immunocompromised, and Chronic Diseases Patients

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, April 2015, Bentham Science Publishers

    Dr Juan B De Sanctis

  88. Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy

    Article • Biomedical Papers, March 2015, Palacky University Olomouc

    Dr Juan B De Sanctis

  89. New treatment for asthma

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2014, American Thoracic Society

    Dr Juan B De Sanctis

  90. An Overview of Hepatitis C Vaccines

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, July 2014, Bentham Science Publishers

    Dr Juan B De Sanctis

  91. This review refers to the different approaches for vaccine therapy in HIV infection

    Article • June 2014, Wiley

    Dr Juan B De Sanctis

  92. Importance in unsaturated fatty acids in zoonotic infection

    Article • Infection and Immunity, February 2014, ASM Journals

    Dr Juan B De Sanctis

  93. Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

    Article • PLOS One, February 2014, PLOS

    Dr Juan B De Sanctis

  94. Metabolic Syndrome and Asthma

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, February 2014, Bentham Science Publishers

    Dr Juan B De Sanctis

  95. Surfactant Protein D in Chornic Obstructive Pulmonary Disease (COPD)

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, February 2014, Bentham Science Publishers

    Dr Juan B De Sanctis

  96. Fenretinide Corrects the Imbalance between Omega-6 to Omega-3 Polyunsaturated Fatty Acids and Inhibits Macrophage Inflammatory Mediators via the ERK Pathway

    Article • PLOS One, September 2013, PLOS

    Dr Juan B De Sanctis

  97. The review focus on the different adjuvants and delivery systems used for diffetent vaccines

    Article • Apmis, August 2013, Wiley

    Dr Juan B De Sanctis

  98. Recent Patents in Autophagy and Immune Response

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, July 2013, Bentham Science Publishers

    Dr Juan B De Sanctis

  99. Nitric oxide synthase and its relation to PKC activation

    Article • AJP Lung Cellular and Molecular Physiology, July 2013, American Physiological Society

    Dr Juan B De Sanctis

  100. Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses

    Article • PLOS One, July 2013, PLOS

    Dr Juan B De Sanctis

  101. Effect of lycopene administration in cystic fibrosis patients

    Article • Paediatric Respiratory Reviews, July 2013, Elsevier

    Dr Juan B De Sanctis

  102. Biomarkers in Asthma and COPD

    Article • Recent Patents on Biomarkerse, May 2013, Bentham Science Publishers

    Dr Juan B De Sanctis

  103. Lipid profile analysis in spinal trauma patients shows severe distortion of AA/DHA after injury

    Article • Frontiers in Immunology, January 2013, Frontiers

    Dr Juan B De Sanctis

  104. Beta 2 adrenergic receptor polymorphisms, at codons 16 and 27, and bronchodilator responses in adult venezuelan asthmatic patients

    Article • Biomedical Papers, November 2012, Palacky University Olomouc

    Dr Juan B De Sanctis

  105. Cytotoxic effects of fisturalin-3 and 11-deoxyfisturalin-3 on jurkat and u937 cell lines

    Article • Biomedical Papers, October 2012, Palacky University Olomouc

    Dr Juan B De Sanctis, Dr. Gricelis Patricia Martinez

  106. Perspectives of New Therapies for Endometriosis

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, August 2012, Bentham Science Publishers

    Dr Juan B De Sanctis

  107. 336 The Leukotriene C4 Synthase (A-444C) Promoter Polymorphism in Venezuelan Individuals with Asthma

    Article • World Allergy Organization Journal, February 2012, Wolters Kluwer Health

    Dr Juan B De Sanctis

  108. Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, September 2011, Bentham Science Publishers

    Dr Juan B De Sanctis

  109. Inhibitors of Phosphoinositol 3 Kinase and NFκB for the Treatment of Chronic Obstructive Pulmonary Disease

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, September 2011, Bentham Science Publishers

    Dr Juan B De Sanctis

  110. The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)

    Article • Cancer Chemotherapy and Pharmacology, May 2011, Springer Science + Business Media

    Prof. Dr. Gustavo Benaim, Dr Juan B De Sanctis

  111. New pharmacological treatments for patients with chronic obstructive pumonary disease (copd)

    Article • Biomedical Papers, March 2011, Palacky University Olomouc

    Dr Juan B De Sanctis

  112. Specific activation of human neutrophils by scorpion venom: A flow cytometry assessment

    Article • Toxicology in Vitro, February 2011, Elsevier

    Dr. Huub JM Op den Camp, Dr Juan B De Sanctis

  113. Atherosclerosis risk in SLE is not dependent on macrophage uptake of ox-LDL

    Article • Autoimmunity, January 2011, Taylor & Francis

    Dr Juan B De Sanctis

  114. Ceramide in Cystic Fibrosis: A Potential New Target for Therapeutic Intervention

    Article • Journal of Lipids, January 2011, Hindawi Publishing Corporation

    Dr Juan B De Sanctis

  115. Pharmacological Properties of Thalidomide and its Analogues

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, June 2010, Bentham Science Publishers

    Dr Juan B De Sanctis

  116. Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

    Article • Journal of Neuroscience, March 2010, Society for Neuroscience

    Dr Juan B De Sanctis

  117. CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells

    Article • Cellular Immunology, January 2010, Elsevier

    Dr Juan B De Sanctis

  118. Increased lipid peroxidation and abnormal fatty acid profiles in seminal and blood plasma of normozoospermic males from infertile couples

    Article • Human Reproduction, November 2009, Oxford University Press (OUP)

    Dr Juan B De Sanctis

  119. Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2009, American Thoracic Society

    Dr Juan B De Sanctis

  120. Pharmacological Modulation of Th17

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, June 2009, Bentham Science Publishers

    Dr Juan B De Sanctis

  121. Serum adipokine levels in patients with systemic lupus erythematosus

    Article • Autoimmunity, January 2009, Taylor & Francis

    Dr Juan B De Sanctis

  122. Total and biologically active CD154 in patients with SLE

    Article • Autoimmunity, January 2009, Taylor & Francis

    Dr Juan B De Sanctis

  123. Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus

    Article • Autoimmunity, January 2009, Taylor & Francis

    Dr Juan B De Sanctis

  124. Fenretinide prevents the development of osteoporosis in Cftr-KO mice

    Article • Journal of Cystic Fibrosis, May 2008, Elsevier

    Dr Juan B De Sanctis

  125. Abnalysis of the effect of smoking in muscle

    Article • CHEST Journal, January 2008, Elsevier

    Dr Juan B De Sanctis

  126. Possible role of NFĸB in the embryonic vascular remodeling and the endothelial-mesenchymal transition process

    Article • Cell Adhesion & Migration, January 2008, Taylor & Francis

    Dr Juan B De Sanctis

  127. Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2008, American Thoracic Society

    Dr Juan B De Sanctis, Stan Kubow

  128. Nitric Oxide Metabolites and Nitrotyrosine in Asthma and COPD

    Article • Clinical Immunology, January 2007, Elsevier

    Dr Juan B De Sanctis

  129. Toll-Like Receptors, Cytokines and the Immunotherapeutics of Asthma

    Article • Current Pharmaceutical Design, July 2006, Bentham Science Publishers

    Dr Juan B De Sanctis

  130. New Frontiers in the Therapeutic Management of Transplant Rejection

    Article • Current Pharmaceutical Design, July 2006, Bentham Science Publishers

    Dr Juan B De Sanctis

  131. Role of SLC11A1 (formerly NRAMP1) in regulation of signal transduction induced by Toll-like receptor 7 ligands

    Article • FEMS Immunology & Medical Microbiology, June 2006, Oxford University Press (OUP)

    Dr Juan B De Sanctis

  132. F.23. Polymorphisms of Toll-Like Receptor 2 and 4 Genes in Asthma and COPD

    Article • Clinical Immunology, January 2006, Elsevier

    Dr Juan B De Sanctis

  133. Skeletal muscle inflammation and nitric oxide in patients with COPD

    Article • European Respiratory Journal, September 2005, European Respiratory Society (ERS)

    Dr Juan B De Sanctis

  134. Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients

    Article • Journal of Endocrinology, June 2004, Bioscientifica

    Dr Juan B De Sanctis

  135. Interaction of immune complexes isolated from hepatitis C virus-infected individuals with human cell lines

    Article • Medical Microbiology and Immunology, February 2004, Springer Science + Business Media

    Dr Juan B De Sanctis

  136. Lipoprotein lipase protects bovine endothelial cells from human NK cytotoxic activity

    Article • Cellular Immunology, January 2004, Elsevier

    Dr Juan B De Sanctis

  137. Expression of CD40/CD40L is important is chicken embryo aorta transdifferentiation

    Article • The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology, September 2003, Wiley

    Dr Juan B De Sanctis

  138. Leptin and leptin receptors during malaria infection in mice

    Article • Folia Parasitologica, December 2002, Biology Centre, AS CR

    Dr Juan B De Sanctis

  139. Activity profile in multiple sclerosis: an integrative approach A preliminary report

    Article • Multiple Sclerosis Journal, August 2002, SAGE Publications

    Dr Juan B De Sanctis

  140. Expression of surface molecules on eosinophils from patients with persistent allergic rhinitis (PAR), before and after treatment

    Article • Journal of Allergy and Clinical Immunology, January 2002, Elsevier

    Dr Juan B De Sanctis

  141. Clearance of Infection with Mycobacterium bovis BCG in Mice Is Enhanced by Treatment with S28463 (R-848), and Its Efficiency Depends on Expression of Wild-Type Nramp1 (Resistance Allele)

    Article • Antimicrobial Agents and Chemotherapy, November 2001, ASM Journals

    Dr Juan B De Sanctis

  142. Antihypertensive Treatment Decreased Serum Leptin Levels in Severe Preeclampsia during Pregnancy

    Article • Annals of Nutrition and Metabolism, January 2001, Karger Publishers

    Dr Juan B De Sanctis

  143. Endothelial Cells Scraped from the Luminal Surface of Bovine Pulmonary Artery Give Rise to Nonmuscle Cells

    Article • Microvascular Research, July 2000, Elsevier

    Dr Juan B De Sanctis

  144. Increased Peroxide Production by Polymorphonuclear Cells of Chronic Hepatitis C Virus-Infected Patients

    Article • Clinical Immunology and Immunopathology, August 1998, Elsevier

    Dr Juan B De Sanctis

  145. Expression of low‐density lipoprotein receptors in peripheral blood and tonsil B lymphocytes

    Article • Clinical & Experimental Immunology, August 1998, Wiley

    Dr Juan B De Sanctis

  146. Characterization of Local Memory Cells in Stage‐Classified Pulmonary Tuberculosis: Preliminary Observations

    Article • Scandinavian Journal of Immunology, May 1998, Wiley

    Dr Juan B De Sanctis

  147. Phenotypic difference between Bcgr and Bcgs macrophages is related to differences in protein-kinase-C-dependent signalling

    Article • FEBS Journal, February 1998, Wiley

    Dr Juan B De Sanctis

  148. Nitric Oxide in Different Types of Hypertension during Pregnancy

    Article • Clinical Science, November 1997, Portland Press Ltd.

    Dr Juan B De Sanctis

  149. Impaired NK cytotoxicity of NK cells of HCV patients

    Article • Clinical & Experimental Immunology, September 1997, Wiley

    Dr Juan B De Sanctis

  150. Secretion of cytokines by natural killer cells primed with interleukin‐2 and stimulated with different lipoproteins

    Article • Immunology, April 1997, Wiley

    Dr Juan B De Sanctis

  151. Low density lipoprotein receptor expression and function in human polymorphonuclear leucocytes

    Article • Clinical & Experimental Immunology, January 1997, Wiley

    Dr Juan B De Sanctis

  152. Expression and Function of Low-Density Lipoprotein Receptors in CD3−CD16+CD56+Cells: Effect of Interleukin 2

    Article • Cellular Immunology, January 1996, Elsevier

    Dr Juan B De Sanctis

  153. Effects of Different Lipoproteins on the Proliferative Response of Interleukin-2-Activated T Lymphocytes and Large Granular Lymphocytes

    Article • Clinical Science, November 1995, Portland Press Ltd.

    Dr Juan B De Sanctis

  154. Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 1993, Wolters Kluwer Health

    Dr Juan B De Sanctis

  155. High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 1993, Wolters Kluwer Health

    Dr Juan B De Sanctis

  156. Kinetics of product inhibition and mechanisms of lipoprotein lipase activation by apolipoprotein C-II

    Article • Biochemistry, June 1987, American Chemical Society (ACS)

    Dr Juan B De Sanctis

  157. The kinetics of heparin inhibition of the esterase and basal lipase activities of lipoprotein lipase

    Article • Archives of Biochemistry and Biophysics, March 1987, Elsevier

    Dr Juan B De Sanctis

  158. The effects of bovine serum albumin and oleic acid on rat pancreatic lipase and bovine milk lipoprotein lipase

    Article • Comparative Biochemistry and Physiology Part B Comparative Biochemistry, January 1987, Elsevier

    Dr Juan B De Sanctis