Contact

All Stories

  1. Ιdentification of SQ109 analogs with enhanced antimicrobial activity against methicillin-resistant Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, April 2026, ASM Journals

    Ioannis P. Papanastasiou

  2. Synthesis and evaluation of nitroheterocyclic aromatic adamantane amides with trypanocidal activity. Part II

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Ioannis P. Papanastasiou

  3. New Trypanosoma brucei acting derivatives incorporating 1-(4-phenyl)adamantane and 1-(4-phenoxyphenyl)adamantane

    Article • RSC Medicinal Chemistry, January 2025, Royal Society of Chemistry

    Ioannis P. Papanastasiou

  4. Overview of Small Molecules as Fluorescent Probes of Mycobacterium tuberculosis

    Article • ACS Omega, July 2024, American Chemical Society (ACS)

    Ioannis P. Papanastasiou

  5. Study of SQ109 analogs binding to mycobacterium MmpL3 transporter using MD simulations and alchemical relative binding free energy calculations

    Article • Journal of Computer-Aided Molecular Design, May 2023, Springer Science + Business Media

    Ioannis P. Papanastasiou

  6. Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites

    Article • ACS Infectious Diseases, January 2023, American Chemical Society (ACS)

    Prof. Dr. Gustavo Benaim, Ioannis P. Papanastasiou

  7. Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

    Article • Molbank, May 2022, MDPI AG

    Ioannis P. Papanastasiou

  8. Mapping the Melatonin Receptor. 8. Selective MT2 Agonists Derived from 5,6‐Dihydroindolo[2,1‐ a ]isoquinolines and Related Systems

    Article • ChemMedChem, May 2022, Wiley

    Ioannis P. Papanastasiou

  9. Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity

    Article • Molecules, December 2021, MDPI AG

    Ioannis P. Papanastasiou

  10. Evidence for spontaneous cannabinoid withdrawal in mice

    Article • Behavioural Pharmacology, December 2021, Wolters Kluwer Health

    Ioannis P. Papanastasiou

  11. Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists

    Article • European Journal of Medicinal Chemistry, December 2021, Elsevier

    Ioannis P. Papanastasiou

  12. An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

    Article • Molecules, July 2021, MDPI AG

    Ioannis P. Papanastasiou

  13. Selective MT 2 Melatonin Receptor Antagonist Modulates Circadian Activity via Inhibition of the Endogenous Melatonin Signal in the East Bound Jet Lag Model

    Article • The FASEB Journal, May 2021, Wiley

    Ioannis P. Papanastasiou

  14. Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)

    Article • International Journal of Molecular Medicine, February 2021, Spandidos Publications

    Ioannis P. Papanastasiou

  15. Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels

    Article • ACS Chemical Biology, August 2020, American Chemical Society (ACS)

    Ioannis P. Papanastasiou

  16. Repurposing current therapeutic regimens against SARS-CoV-2 (Review)

    Article • Experimental and Therapeutic Medicine, June 2020, Spandidos Publications

    Ioannis P. Papanastasiou

  17. Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives

    Article • Mini-Reviews in Medicinal Chemistry, May 2020, Bentham Science Publishers

    Ioannis P. Papanastasiou , Professor John K Gallos

  18. Synthetic Melatonin Receptor Agonists and Antagonists

    Article • March 2020, IntechOpen

    Ioannis P. Papanastasiou

  19. Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei

    Article • RSC Medicinal Chemistry, January 2020, Royal Society of Chemistry

    Ioannis P. Papanastasiou

  20. Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

    Article • ChemistrySelect, October 2019, Wiley

    Ioannis P. Papanastasiou

  21. New antitubercular isoniazid-based adamantane derivatives

    Article • Future Medicinal Chemistry, September 2019, Future Science

    Ioannis P. Papanastasiou , Tahsin F Kellici

  22. Synthesis of New Indole and Adamantane Amido Derivatives with Pharmacological Interest

    Article • ChemistrySelect, August 2019, Wiley

    Ioannis P. Papanastasiou

  23. Synthesis and evaluation of new nifurtimox‐adamantane adducts with trypanocidal activity

    Article • ChemMedChem, May 2019, Wiley

    Ioannis P. Papanastasiou

  24. Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

    Article • Bioorganic & Medicinal Chemistry Letters, April 2019, Elsevier

    Ioannis P. Papanastasiou

  25. Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists

    Article • MedChemComm, January 2019, Royal Society of Chemistry

    Ioannis P. Papanastasiou

  26. Synthesis of Pyrrole derivatives-Multicomponent reaction-Microwave assisted

    Article • Current Microwave Chemistry, April 2018, Bentham Science Publishers

    Angeliki Panagiotopoulou, Ioannis P. Papanastasiou , MARILI MARGARITOULI

  27. Insights in Organometallic Synthesis of Various Adamantane Derivatives with Sigma Receptor-Binding Affinity and Antiproliferative/Anticancer Activity

    Article • January 2018, Springer Science + Business Media

    Ioannis P. Papanastasiou

  28. Synthesis of Adamantane Aminoethers with Antitubercular Potential

    Article • Medicinal Chemistry, October 2017, Bentham Science Publishers

    Ioannis P. Papanastasiou

  29. Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

    Article • Molecules, August 2017, MDPI AG

    Ioannis P. Papanastasiou

  30. In vitro Controlled Release from Solid Pharmaceutical Formulations

    Article • Drug Research, July 2017, Thieme Publishing Group

    Tahsin F Kellici, Ioannis P. Papanastasiou , Angeliki Siamidi

  31. In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I).

    Article • Drug Research, May 2017, Thieme Publishing Group

    Tahsin F Kellici, Ioannis P. Papanastasiou , Angeliki Siamidi

  32. 4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity

    Article • Letters in Organic Chemistry, February 2016, Bentham Science Publishers

    Ioannis P. Papanastasiou

  33. New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: synthesis and in vitro trypanocidal activity

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Ioannis P. Papanastasiou , Tahsin F Kellici

  34. Synthesis and Cytotoxicity of 4-(2-Adamantyl)phenylalkylamines

    Article • Letters in Organic Chemistry, May 2015, Bentham Science Publishers

    Ioannis P. Papanastasiou

  35. New aminoadamantane derivatives with antiproliferative activity

    Article • Medicinal Chemistry Research, September 2013, Springer Science + Business Media

    Ioannis P. Papanastasiou

  36. Synthesis and trypanocidal action of new adamantane substituted imidazolines

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Ioannis P. Papanastasiou

  37. New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain

    Article • Journal of Medicinal Chemistry, November 2012, American Chemical Society (ACS)

    Ioannis P. Papanastasiou

  38. New Adamantane Derivatives with Sigma Affinity and Antiproliferative Activity

    Article • Medicinal Chemistry, June 2012, Bentham Science Publishers

    Ioannis P. Papanastasiou

  39. Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes

    Article • Bioorganic & Medicinal Chemistry, May 2012, Elsevier

    Ioannis P. Papanastasiou

  40. Novel 1′,1′-Chain Substituted Hexahydrocannabinols: 9β-Hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a Highly Potent Cannabinoid Receptor 1 (CB1) Agonist

    Article • Journal of Medicinal Chemistry, October 2010, American Chemical Society (ACS)

    Ioannis P. Papanastasiou

  41. Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids

    Article • Bioorganic & Medicinal Chemistry Letters, September 2010, Elsevier

    Ioannis P. Papanastasiou

  42. ChemInform Abstract: Microwave-Assisted Synthesis of Sodium Sulfonates: Precursors of Sulfonyl Chlorides and Fluorides.

    Article • ChemInform, March 2010, Wiley

    Ioannis P. Papanastasiou

  43. Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

    Article • Tetrahedron Letters, December 2009, Elsevier

    Ioannis P. Papanastasiou

  44. Design and Synthesis ofTrypanosoma bruceiActive 1-Alkyloxy and 1-Benzyloxyadamantano 2-Guanylhydrazones

    Article • ChemMedChem, July 2009, Wiley

    Ioannis P. Papanastasiou

  45. ChemInform Abstract: Synthesis of Conformationally Constrained Adamantane Imidazolines with Trypanocidal Activity.

    Article • ChemInform, February 2009, Wiley

    Ioannis P. Papanastasiou

  46. ChemInform Abstract: Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest.

    Article • ChemInform, December 2008, Wiley

    Ioannis P. Papanastasiou , Professor Judit Ovádi

  47. Synthesis of conformationally constrained adamantane imidazolines with trypanocidal activity

    Article • Journal of Heterocyclic Chemistry, September 2008, Wiley

    Ioannis P. Papanastasiou

  48. ChemInform Abstract: An Intriguing, Regioselective Synthesis of Novel 2-(1-Adamantylmethyl)tetrahydropyridines.

    Article • ChemInform, May 2008, Wiley

    Ioannis P. Papanastasiou

  49. Design, Synthesis, and Trypanocidal Activity of New Aminoadamantane Derivatives

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Ioannis P. Papanastasiou

  50. Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest

    Article • Heterocycles, January 2008, Japan Institute of Heterocyclic Chemistry

    Ioannis P. Papanastasiou

  51. An Intriguing, Regioselective Synthesis of Novel 2-(1-Adamantylmethyl) tetrahydropyridines

    Article • Letters in Organic Chemistry, January 2008, Bentham Science Publishers

    Ioannis P. Papanastasiou

  52. Heterocyclic rimantadine analogues with antiviral activity

    Article • Bioorganic & Medicinal Chemistry, May 2006, Elsevier

    Ioannis P. Papanastasiou , Johan Neyts

  53. The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin

    Article • Bioorganic & Medicinal Chemistry, April 2005, Elsevier

    Ioannis P. Papanastasiou