All Stories

  1. The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease

    Article • Molecular Neurobiology, April 2024, Springer Science + Business Media

    Dr Georgia Valsami

  2. Fabricating hybrid DSPC:DOPC:P(OEGMA-co-LMA) structures: Self-assembly as the milestone of their performance

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, March 2024, Elsevier

    Dr Georgia Valsami

  3. The Complex Mechanisms and the Potential Effects of Statins on Vascular Calcification: A Narrative Review

    Article • Reviews in Cardiovascular Medicine, January 2024, IMR Press

    Dr Georgia Valsami

  4. Fabricating Polymer/Surfactant/Cyclodextrin Hybrid Particles for Possible Nose-to-Brain Delivery of Ropinirole Hydrochloride: In Vitro and Ex Vivo Evaluation

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Dr Georgia Valsami

  5. Nose-to-Heart Approach: Unveiling an Alternative Route of Acute Treatment

    Article • Biomedicines, January 2024, MDPI AG

    Dr Georgia Valsami

  6. The Complementary Effects of Dabigatran Etexilate and Exercise Training on the Development and Stability of the Atherosclerotic Lesions in Diabetic ApoE Knockout Mice

    Article • Pharmaceuticals, October 2023, MDPI AG

    Dr Georgia Valsami

  7. Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles

    Article • Pharmaceutics, July 2023, MDPI AG

    Dr Georgia Valsami

  8. Nose-to-Brain delivery of donepezil hydrochloride following administration of an HPMC-Me-β-CD-PEG400 nasal film in mice

    Article • Journal of Drug Delivery Science and Technology, June 2023, Elsevier

    Dr Georgia Valsami

  9. Donepezil Brain and Blood Pharmacokinetic Modeling after Nasal Film and Oral Solution Administration in Mice

    Article • Pharmaceutics, May 2023, MDPI AG

    Dr Georgia Valsami

  10. Advances in intranasal vaccine delivery: A promising non-invasive route of immunization

    Article • Vaccine, May 2023, Elsevier

    Dr Georgia Valsami

  11. Development of Hybrid DSPC:DOPC:P(OEGMA950-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter

    Article • Polymers, April 2023, MDPI AG

    Dr Georgia Valsami

  12. Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration

    Article • Marine Drugs, April 2023, MDPI AG

    Dr Georgia Valsami

  13. Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin

    Article • Molecules, March 2023, MDPI AG

    Dr Georgia Valsami

  14. Development of a Novel Apigenin Dosage form as a Substitute for the Modern Triple Antithrombotic Regimen

    Article • Molecules, March 2023, MDPI AG

    Dr Georgia Valsami

  15. Intranasal Administration of a Polymeric Biodegradable Film to C57BL/6 Mice

    Article • Journal of the American Association for Laboratory Animal Science, March 2023, American Association for Laboratory Animal Science

    Dr Georgia Valsami

  16. Effects of the Antioxidant Quercetin in an Experimental Model of Ulcerative Colitis in Mice

    Article • Medicina, December 2022, MDPI AG

    Dr Georgia Valsami

  17. Development and Pharmacokinetics of a Novel Acetylsalicylic Acid Dry Powder for Pulmonary Administration

    Article • Pharmaceutics, December 2022, MDPI AG

    Prof stefano giovagnoli, Dr Georgia Valsami

  18. Pharmacokinetic Characteristics of Nebulized Colistimethate Sodium Using Two Different Types of Nebulizers in Critically Ill Patients with Ventilator-Associated Respiratory Infections

    Article • Antibiotics, November 2022, MDPI AG

    Dr Georgia Valsami

  19. Exercise training inhibits atherosclerosis progression and reduces VE-cadherin levels within atherosclerotic plaques in hypercholesterolemic mice

    Article • Biochemical and Biophysical Research Communications, October 2022, Elsevier

    Dr Georgia Valsami

  20. Association of serum levels of osteopontin and osteoprotegerin with adverse outcomes after endovascular revascularisation in peripheral artery disease

    Article • Cardiovascular Diabetology, September 2022, Springer Science + Business Media

    Dr Georgia Valsami

  21. Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin

    Article • Molecules, August 2022, MDPI AG

    Dr Georgia Valsami

  22. Development and In Vitro-Ex Vivo Evaluation of Novel Polymeric Nasal Donepezil Films for Potential Use in Alzheimer’s Disease Using Experimental Design

    Article • Pharmaceutics, August 2022, MDPI AG

    Dr Georgia Valsami

  23. Potential Pharmaceutical Applications of Quercetin in Cardiovascular Diseases

    Article • Pharmaceuticals, August 2022, MDPI AG

    Dr Georgia Valsami

  24. Design of a Personalized Nasal Device (Matrix-Piston Nasal Device, MPD) for Drug Delivery: a 3D-Printing Application

    Article • AAPS PharmSciTech, July 2022, Springer Science + Business Media

    Dr Georgia Valsami

  25. A Comprehensive Review of the Cardiovascular Protective Properties of Silibinin/Silymarin: A New Kid on the Block

    Article • Pharmaceuticals, April 2022, MDPI AG

    Dr Georgia Valsami

  26. Losartan Interactions with 2-Hydroxypropyl-β-CD

    Article • Molecules, April 2022, MDPI AG

    Dr Demeter Tzeli, Dr Georgia Valsami

  27. Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing

    Article • Pharmaceutics, March 2022, MDPI AG

    Dr Georgia Valsami

  28. The Association of Arterial Stiffness With Significant Carotid Atherosclerosis and Carotid Plaque Vulnerability

    Article • Angiology, January 2022, SAGE Publications

    Dr Georgia Valsami

  29. Pro‐inflammatory cytokines/chemokines, TNF‐α, IL‐6 and MCP‐1, as biomarkers for the nephro‐ and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochemistry and qRT‐PCR

    Article • Basic & Clinical Pharmacology & Toxicology, January 2022, Wiley

    Dr Georgia Valsami

  30. Nasal powders of quercetin-β-cyclodextrin derivatives complexes with mannitol/lecithin microparticles for Nose-to-Brain delivery: In vitro and ex vivo evaluation

    Article • International Journal of Pharmaceutics, September 2021, Elsevier

    Dr Georgia Valsami

  31. The cardiovascular‐protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature

    Article • Phytotherapy Research, August 2021, Wiley

    Dr Georgia Valsami

  32. Flurbiprofen sodium microparticles and soft pellets for nose-to-brain delivery: Serum and brain levels in rats after nasal insufflation

    Article • International Journal of Pharmaceutics, August 2021, Elsevier

    Dr Georgia Valsami

  33. Dose individualization of intravenous busulfan in pediatric patients undergoing bone marrow transplantation: impact and in vitro evaluation of infusion lag-time

    Article • Journal of Pharmacy and Pharmacology, July 2021, Oxford University Press (OUP)

    Dr Georgia Valsami

  34. The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR

    Article • Journal of Pharmacy and Pharmacology, April 2021, Oxford University Press (OUP)

    Dr Georgia Valsami

  35. Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them

    Article • Cytokine, February 2021, Elsevier

    Dr Georgia Valsami

  36. Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury in an experimental rat model

    Article • Acta Cirúrgica Brasileira, January 2021, FapUNIFESP (SciELO)

    Dr Georgia Valsami

  37. Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications

    Article • Saudi Journal of Gastroenterology, January 2021, Medknow

    Dr Georgia Valsami

  38. Use of natural anti-oxidants in experimental animal models of hepatic ischemia-reperfusion injury

    Article • Annals of Medicine and Surgery, December 2020, Elsevier

    Dr Georgia Valsami

  39. Silibinin-hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) complex prevents apoptosis in liver and kidney after hepatic ischemia-reperfusion injury

    Article • Food and Chemical Toxicology, November 2020, Elsevier

    Dr Georgia Valsami

  40. Application of Neutralization and Technique for the Preparation of the Beneficial in Drug 2-Hydroxypropyl-β-Cyclodextrin with

    Article • October 2020, Springer Science + Business Media

    Dr Georgia Valsami

  41. Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems

    Article • Molecular Pharmaceutics, September 2020, American Chemical Society (ACS)

    Dr Georgia Valsami

  42. Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?

    Article • Journal of Pharmacy and Pharmacology, August 2020, Wiley

    Dr Georgia Valsami

  43. Population pharmacokinetics of anidulafungin in ICU patients assessing inter‐ and intrasubject variability

    Article • British Journal of Clinical Pharmacology, July 2020, Wiley

    Dr Georgia Valsami

  44. Comparative pharmacokinetics of the three echinocandins in ICU patients

    Article • Journal of Antimicrobial Chemotherapy, July 2020, Oxford University Press (OUP)

    Dr Georgia Valsami

  45. Antihypertensive activity and molecular interactions of irbesartan in complex with 2‐hydroxypropyl‐β‐cyclodextrin

    Article • Chemical Biology & Drug Design, July 2020, Wiley

    Dr Georgia Valsami

  46. Hyperhydration using different hydration agents does not affect the haematological markers of the athlete biological passport in euhydrated volunteers

    Article • Journal of Sports Sciences, June 2020, Taylor & Francis

    Dr Georgia Valsami, Dr Costas G Georgakopoulos

  47. Charting the structural and thermodynamic determinants in phenolic acid natural product – cyclodextrin encapsulations

    Article • Journal of Biomolecular Structure and Dynamics, April 2020, Taylor & Francis

    Dr Georgia Valsami

  48. Glycoprotein non-metastatic melanoma B expression after hepatic ischemia reperfusion and the effect of silibinin

    Article • Translational Gastroenterology and Hepatology, January 2020, AME Publishing Company

    Dr Georgia Valsami

  49. Effect of hyperhydration on the pharmacokinetics and detection of orally administered budesonide in doping control analysis

    Article • Scandinavian Journal of Medicine and Science in Sports, July 2019, Wiley

    Dr Georgia Valsami

  50. Hyperhydration Effect on Pharmacokinetic Parameters and Detection Sensitivity of Recombinant Human Erythropoietin in Urine and Serum Doping Control Analysis of Males

    Article • Journal of Pharmaceutical Sciences, June 2019, Elsevier

    Dr Georgia Valsami

  51. Statins’ Withdrawal Induces Atherosclerotic Plaque Destabilization in Animal Model—A “Rebound” Stimulation of Inflammation

    Article • Journal of Cardiovascular Pharmacology and Therapeutics, March 2019, SAGE Publications

    Dr Georgia Valsami

  52. Hyperhydration-Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes in Doping Control Analysis

    Article • International Journal of Sport Nutrition and Exercise Metabolism, March 2019, Human Kinetics

    Dr Costas G Georgakopoulos, Dr Georgia Valsami

  53. Host–Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism

    Article • Molecular Pharmaceutics, February 2019, American Chemical Society (ACS)

    Tahsin F Kellici, Dr Georgia Valsami

  54. Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer’s disease

    Article • Journal of Drug Targeting, January 2019, Taylor & Francis

    Francesca BUTTINI, Dr Fabio Sonvico, Dr Georgia Valsami

  55. Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativusL.) aqueous extract to C57/BL6J mice

    Article • Journal of Pharmacy and Pharmacology, December 2018, Oxford University Press (OUP)

    Dr Georgia Valsami

  56. Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 2018, Elsevier

    Dr Georgia Valsami

  57. The effect of athletes` hyperhydration on the urinary ‘steroid profile’ markers in doping control analysis

    Article • Drug Testing and Analysis, May 2018, Wiley

    Dr Georgia Valsami

  58. Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals

    Article • Atherosclerosis, January 2018, Elsevier

    Dr Georgia Valsami

  59. Saffron ( Crocus sativus ) intake provides nutritional preconditioning against myocardial ischemia–reperfusion injury in Wild Type and ApoE (−/−) mice: Involvement of Nrf2 activation

    Article • Nutrition Metabolism and Cardiovascular Diseases, October 2017, Elsevier

    Dr Georgia Valsami

  60. Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury

    Article • Journal of Investigative Surgery, September 2017, Taylor & Francis

    Dr Georgia Valsami,  Nikolaos Kostomitsopoulos

  61. Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, June 2017, Elsevier

    Tahsin F Kellici, Dr Georgia Valsami, Professor Doros N. Theodorou

  62. Silibinin Improves TNF-α and M30 Expression and Histological Parameters in Rat Kidneys After Hepatic Ischemia/Reperfusion

    Article • Journal of Investigative Surgery, April 2017, Taylor & Francis

    Dr Georgia Valsami

  63. Mapping the interactions and bioactivity of quercetin⿿(2-hydroxypropyl)-β-cyclodextrin complex

    Article • International Journal of Pharmaceutics, September 2016, Elsevier

    Ms Maria V Chatziathanasiadou, Tahsin F Kellici, Dr Georgia Valsami

  64. Mother's breast milk supplemented with donor milk reduces hospital and health service usage costs in low-birthweight infants

    Article • Midwifery, September 2016, Elsevier

    Dr Georgia Valsami

  65. The impact of maternal- and neonatal-associated factors on human milk's macronutrients and energy

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, August 2016, Taylor & Francis

    Dr Georgia Valsami

  66. Drug Utilization Patterns and Costs of Erythropoiesis-Stimulating Agents in an Outpatient Setting in Greece

    Article • The Consultant Pharmacist, May 2016, American Society of Consultant Pharmacists

    Dr Georgia Valsami

  67. Human Milk Banking: a bridge between the preterm mother and infant; the experience from a Greek Public Perinatal Center

    Article • Journal of Advanced Nutrition and Human Metabolism, October 2015, Smart Science and Technology, LLC

    Dr Georgia Valsami

  68. Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins

    Article • Antimicrobial Agents and Chemotherapy, October 2015, ASM Journals

    Professor Panagiotis Tsirigotis , Dr Georgia Valsami

  69. Serum and tissue pharmacokinetics of silibinin after per os and i.v. administration to mice as a HP-β-CD lyophilized product

    Article • International Journal of Pharmaceutics, September 2015, Elsevier

    Dr Georgia Valsami

  70. Saffron: a natural product with potential pharmaceutical applications

    Article • Journal of Pharmacy and Pharmacology, August 2015, Wiley

    Dr Georgia Valsami

  71. Improved outcomes of feeding low birth weight infants with predominantly raw human milk versus donor banked milk and formula

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, April 2015, Taylor & Francis

    Dr Georgia Valsami

  72. Investigation of the Interactions of Silibinin with 2-Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational Methods

    Article • Molecular Pharmaceutics, March 2015, American Chemical Society (ACS)

    Ms Maria V Chatziathanasiadou, Tahsin F Kellici, Dr Georgia Valsami

  73. Gas chromatographic–mass spectrometric quantitation of busulfan in human plasma for therapeutic drug monitoring: A new on-line derivatization procedure for the conversion of busulfan to 1,4-diiodobutane

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2014, Elsevier

    Dr Costas G Georgakopoulos, Dr Georgia Valsami

  74. Keeping a Critical Eye on the Science and the Regulation of Oral Drug Absorption: A Review

    Article • Journal of Pharmaceutical Sciences, September 2013, Elsevier

    Dr Georgia Valsami

  75. Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS

    Article • Pharmaceutical Research, July 2012, Springer Science + Business Media

    Dr Georgia Valsami

  76. Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges

    Article • Journal of Antimicrobial Chemotherapy, March 2012, Oxford University Press (OUP)

    Dr Georgia Valsami

  77. Penetration of Intact Blood-Brain Barrier by Doripenem

    Article • Antimicrobial Agents and Chemotherapy, May 2011, ASM Journals

    Dr Georgia Valsami

  78. Robust and Sensitive High-Performance Liquid Chromatographic-UV Detection Technique for the Determination of Tigecycline in Rabbit Plasma

    Article • Journal of AOAC International, May 2011, Oxford University Press (OUP)

    Dr Georgia Valsami

  79. Computational-Regulatory Developments in the Prediction of Oral Drug Absorption

    Article • Molecular Informatics, March 2011, Wiley

    Dr Georgia Valsami

  80. Supersaturated dissolution data and their interpretation: the TPGS-carbamazepine model case

    Article • Journal of Pharmacy and Pharmacology, February 2011, Wiley

    Dr Georgia Valsami

  81. Biopharmaceutical Classification Based on Solubility and Dissolution: A Reappraisal of Criteria for Hypothesis Models in the Light of the Experimental Observations

    Article • Basic & Clinical Pharmacology & Toxicology, March 2010, Wiley

    Dr Georgia Valsami

  82. Effect of Cyclodextrin Complexation on the Aqueous Solubility and Solubility/Dose Ratio of Praziquantel

    Article • AAPS PharmSciTech, December 2009, Springer Science + Business Media

    Dr Georgia Valsami

  83. Effect of pH and water-soluble polymers on the aqueous solubility of nimesulide in the absence and presence of β-cyclodextrin derivatives

    Article • Journal of Pharmacy and Pharmacology, November 2008, Oxford University Press (OUP)

    Dr Georgia Valsami

  84. Biopharmaceutics classification systems for new molecular entities (BCS-NMEs) and marketed drugs (BCS-MD): Theoretical basis and practical examples

    Article • International Journal of Pharmaceutics, September 2008, Elsevier

    Dr Georgia Valsami

  85. Development of a reaction-limited model of dissolution: Application to official dissolution tests experiments

    Article • International Journal of Pharmaceutics, May 2008, Elsevier

    Dr Georgia Valsami

  86. Modelling and simulation in drug absorption processes

    Article • Xenobiotica, November 2007, Taylor & Francis

    Dr Georgia Valsami

  87. In-vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion-probe technique

    Article • Journal of Pharmacy and Pharmacology, November 2006, Oxford University Press (OUP)

    Dr Georgia Valsami

  88. Plasma profiles of lycopene after single oral and intravenous administrations in dogs

    Article • Journal of Pharmacy and Pharmacology, September 2006, Wiley

    Dr Georgia Valsami

  89. Solubilization and quantification of lycopene in aqueous media in the form of cyclodextrin binary systems

    Article • International Journal of Pharmaceutics, February 2006, Elsevier

    Dr Georgia Valsami

  90. Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples

    Article • Pharmaceutical Research, September 2004, Springer Science + Business Media

    Dr Georgia Valsami

  91. Quantitative Biopharmaceutics Classification System: The Central Role of Dose/Solubility Ratio

    Article • Pharmaceutical Research, December 2003, Springer Science + Business Media

    Dr Georgia Valsami

  92. The power law can describe the ‘entire’ drug release curve from HPMC-based matrix tablets: a hypothesis

    Article • International Journal of Pharmaceutics, April 2003, Elsevier

    Dr Georgia Valsami

  93. Non-linear regression analysis with errors in both variables: estimation of co-operative binding parameters

    Article • Biopharmaceutics & Drug Disposition, January 2000, Wiley

    Dr Georgia Valsami

  94. A displacement approach for competitive drug–protein binding studies using the potentiometric 1-anilino-8-naphthalene-sulfonate probe technique

    Article • European Journal of Pharmaceutical Sciences, December 1999, Elsevier

    Dr Georgia Valsami

  95. Modeling of supersaturated dissolution data

    Article • International Journal of Pharmaceutics, April 1999, Elsevier

    Dr Georgia Valsami

  96. Studies on the interaction of diflunisal ion with cyclodextrins using ion-selective electrode potentiometry

    Article • European Journal of Pharmaceutical Sciences, March 1999, Elsevier

    Dr Georgia Valsami

  97. Determination of fractal reaction dimension in dissolution studies

    Article • European Journal of Pharmaceutical Sciences, June 1995, Elsevier

    Dr Georgia Valsami

  98. General Treatment of Competitive Binding as Applied to the Potentiometric Ion Probe Technique: Application to the Interaction of Nonsteroidal Anti- Inflammatory Drugs with Bovine Serum Albumin

    Article • Journal of Pharmaceutical Sciences, August 1994, Elsevier

    Dr Georgia Valsami

  99. Automated flow-injection technique for use in dissolution studies of sustained-release formulations: Application to iron(II) formulations

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 1994, Elsevier

    Dr Georgia Valsami

  100. Use of 1-Anilino-8-napthalenesulphonate as an Ion Probe for the Potentiometric Study of the Binding of Sulphonamides to Bovine Serum Albumin and Plasma

    Article • Journal of Pharmacy and Pharmacology, May 1993, Oxford University Press (OUP)

    Dr Georgia Valsami

  101. Article • Pharmaceutical Research, January 1992, Springer Science + Business Media

    Dr Georgia Valsami

  102. Article • Pharmaceutical Research, January 1992, Springer Science + Business Media

    Dr Georgia Valsami

  103. Article • Pharmaceutical Research, January 1991, Springer Science + Business Media

    Dr Georgia Valsami

  104. Binding Studies of Ions with Cyclodextrins Using Ion-Selective Electrodes

    Article • Journal of Pharmaceutical Sciences, December 1990, Elsevier

    Dr Georgia Valsami

  105. Construction of a naproxen ion-selective electrode and its application to pharmaceutical analysis

    Article • The Analyst, January 1989, Royal Society of Chemistry

    Dr Georgia Valsami