All Stories

  1. Integrating Advanced Metabolomics and Machine Learning for Anti-Doping in Human Athletes

    Article • Metabolites, October 2025, MDPI AG

    Dr Costas G Georgakopoulos

  2. New long‐standing metabolites of 17α‐methyltestosterone are detected in HepG2 cell in vitro metabolic model and in human urine

    Article • Drug Testing and Analysis, October 2023, Wiley

    Dr Costas G Georgakopoulos

  3. Untargeted Metabolomics Identifies a Novel Panel of Markers for Autologous Blood Transfusion

    Article • Metabolites, May 2022, MDPI AG

    Dr Costas G Georgakopoulos, Dr Maryam Al-Nesf

  4. Integrating Whole Blood Transcriptomic Collection Procedures Into the Current Anti-Doping Testing System, Including Long-Term Storage and Re-Testing of Anti-Doping Samples

    Article • Frontiers in Molecular Biosciences, October 2021, Frontiers

    Dr Costas G Georgakopoulos

  5. Olympic anti-doping laboratory: the analytical technological road from 2016 Rio De Janeiro to 2021 Tokyo

    Article • Bioanalysis, October 2021, Future Science

    Dr Costas G Georgakopoulos

  6. Red blood cell derived extracellular vesicles during the process of autologous blood doping

    Article • Drug Testing and Analysis, September 2021, Wiley

    Dr Costas G Georgakopoulos

  7. The use of RNA‐based 5'‐aminolevulinate synthase 2 biomarkers in dried blood spots to detect recombinant human erythropoietin microdoses

    Article • Drug Testing and Analysis, July 2021, Wiley

    Dr Costas G Georgakopoulos

  8. Ultra‐fast retroactive processing by MetAlign of liquid chromatography/high‐resolution full‐scan Orbitrap mass spectrometry data in WADA Human Urine Sample Monitoring Program

    Article • Rapid Communications in Mass Spectrometry, July 2021, Wiley

    Dr Costas G Georgakopoulos

  9. Horseradish‐peroxidase‐conjugated anti‐erythropoietin antibodies for direct recombinant human erythropoietin detection: Proof of concept

    Article • Drug Testing and Analysis, November 2020, Wiley

    Dr Costas G Georgakopoulos

  10. Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances

    Article • Drug Testing and Analysis, November 2020, Wiley

    Dr Costas G Georgakopoulos

  11. Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines

    Article • Frontiers in Physiology, October 2020, Frontiers

    Dr Costas G Georgakopoulos

  12. Alternative markers for Methylnortestosterone misuse in human urine

    Article • Drug Testing and Analysis, July 2020, Wiley

    Dr Costas G Georgakopoulos

  13. Author Correction: Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

    Article • Scientific Reports, June 2020, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  14. Hyperhydration using different hydration agents does not affect the haematological markers of the athlete biological passport in euhydrated volunteers

    Article • Journal of Sports Sciences, June 2020, Taylor & Francis

    Dr Georgia Valsami, Dr Costas G Georgakopoulos

  15. Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism

    Article • Frontiers in Genetics, June 2020, Frontiers

    Dr Costas G Georgakopoulos

  16. Metabolomics and doping analysis: promises and pitfalls

    Article • Bioanalysis, June 2020, Future Science

    Dr Costas G Georgakopoulos

  17. A novel mixed living high training low intervention and the hematological module of the athlete biological passport

    Article • Drug Testing and Analysis, December 2019, Wiley

    Dr Costas G Georgakopoulos

  18. Detecting – the 2004 Athens Olympic Games

    Article • Drug Testing and Analysis, December 2019, Wiley

    Dr Costas G Georgakopoulos

  19. Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  20. Population reference ranges of urinary endogenous sulfate steroids concentrations and ratios as complement to the steroid profile in sports antidoping

    Article • Steroids, December 2019, Elsevier

    Dr Costas G Georgakopoulos

  21. Genome-wide association study reveals novel genetic markers associated with endurance athlete status

    Article • September 2019, Research Square

    Dr Costas G Georgakopoulos

  22. Ultra‐fast retroactive processing of liquid chromatography high‐resolution full‐scan Orbitrap mass spectrometry data in anti‐doping screening of human urine

    Article • Rapid Communications in Mass Spectrometry, August 2019, Wiley

    Dr Costas G Georgakopoulos

  23. Effect of hyperhydration on the pharmacokinetics and detection of orally administered budesonide in doping control analysis

    Article • Scandinavian Journal of Medicine and Science in Sports, July 2019, Wiley

    Dr Georgia Valsami, Dr Costas G Georgakopoulos

  24. Hyperhydration Effect on Pharmacokinetic Parameters and Detection Sensitivity of Recombinant Human Erythropoietin in Urine and Serum Doping Control Analysis of Males

    Article • Journal of Pharmaceutical Sciences, June 2019, Elsevier

    Dr Georgia Valsami, Dr Costas G Georgakopoulos

  25. Metabolic profiling of elite athletes with different cardiovascular demand

    Article • Scandinavian Journal of Medicine and Science in Sports, April 2019, Wiley

    Dr Costas G Georgakopoulos

  26. Hyperhydration-Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes in Doping Control Analysis

    Article • International Journal of Sport Nutrition and Exercise Metabolism, March 2019, Human Kinetics

    Dr Costas G Georgakopoulos, Dr Georgia Valsami

  27. Whole Blood Storage in CPDA1 Blood Bags Alters Erythrocyte Membrane Proteome

    Article • Oxidative Medicine and Cellular Longevity, November 2018, Hindawi Publishing Corporation

    Peter Horvatovich, Dr Costas G Georgakopoulos

  28. Comparison of gas chromatography/quadrupole time-of-flight and quadrupole Orbitrap mass spectrometry in anti-doping analysis: I. Detection of anabolic-androgenic steroids

    Article • Rapid Communications in Mass Spectrometry, November 2018, Wiley

    Dr Costas G Georgakopoulos

  29. The effect of athletes` hyperhydration on the urinary ‘steroid profile’ markers in doping control analysis

    Article • Drug Testing and Analysis, May 2018, Wiley

    Dr Georgia Valsami, Dr Costas G Georgakopoulos

  30. High resolution full scan liquid chromatography mass spectrometry comprehensive screening in sports antidoping urine analysis

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2018, Elsevier

    Dr Costas G Georgakopoulos

  31. A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines

    Article • Sports Medicine - Open, January 2018, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  32. Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption

    Article • Journal of the International Society of Sports Nutrition, January 2018, Taylor & Francis

    Dr Costas G Georgakopoulos

  33. Gas chromatographic quadrupole time-of-flight full scan high resolution mass spectrometric screening of human urine in antidoping analysis

    Article • Journal of Chromatography B, September 2017, Elsevier

    Dr Costas G Georgakopoulos

  34. Analysis of RBC-microparticles in stored whole blood bags - a promising marker to detect blood doping in sports?

    Article • Drug Testing and Analysis, June 2017, Wiley

    Dr Costas G Georgakopoulos

  35. Analytical progresses of the World Anti-Doping Agency Olympic laboratories: a 2016 update from London to Rio

    Article • Bioanalysis, November 2016, Future Science

    Dr Costas G Georgakopoulos

  36. Doping control container for urine stabilization: a pilot study

    Article • Drug Testing and Analysis, September 2016, Wiley

    Dr Costas G Georgakopoulos

  37. Athlome Project Consortium: a concerted effort to discover genomic and other “omic” markers of athletic performance

    Article • Physiological Genomics, December 2015, American Physiological Society

    Dr Costas G Georgakopoulos, Hugh Montgomery, Dr Francesco Sessa, Dr David C Hughes

  38. The effect of fasting during Ramadan on parameters of the haematological and steroidal modules of the athletes biological passport - a pilot study

    Article • Drug Testing and Analysis, December 2015, Wiley

    Dr Costas G Georgakopoulos

  39. Markers of mesterolone abuse in sulfate fraction for doping control in human urine

    Article • Journal of Mass Spectrometry, November 2015, Wiley

    Dr Costas G Georgakopoulos

  40. Comparison of sulfo-conjugated and gluco-conjugated urinary metabolites for detection of methenolone misuse in doping control by LC-HRMS, GC-MS and GC-HRMS

    Article • Journal of Mass Spectrometry, April 2015, Wiley

    Dr Costas G Georgakopoulos, ARGYRO FRAGKAKI

  41. Gas chromatographic–mass spectrometric quantitation of busulfan in human plasma for therapeutic drug monitoring: A new on-line derivatization procedure for the conversion of busulfan to 1,4-diiodobutane

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2014, Elsevier

    Dr Costas G Georgakopoulos, Dr Georgia Valsami

  42. Advances in the detection of designer steroids in anti-doping

    Article • Bioanalysis, March 2014, Future Science

    Dr Costas G Georgakopoulos

  43. A generic screening methodology for horse doping control by LC–TOF-MS, GC–HRMS and GC–MS

    Article • Journal of Chromatography B, December 2013, Elsevier

    Dr Costas G Georgakopoulos

  44. A Synopsis of the Adverse Analytical and Atypical Findings Between 2005 and 2011 from the Doping Control Laboratory of Athens in Greece

    Article • Journal of Analytical Toxicology, November 2013, Oxford University Press (OUP)

    Dr Costas G Georgakopoulos

  45. Sports doping: Emerging designer and therapeutic β2-agonists

    Article • Clinica Chimica Acta, October 2013, Elsevier

    Dr Costas G Georgakopoulos

  46. Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis

    Article • TrAC Trends in Analytical Chemistry, January 2013, Elsevier

    Dr Costas G Georgakopoulos

  47. Comparison of multiple linear regression, partial least squares and artificial neural networks for prediction of gas chromatographic relative retention times of trimethylsilylated anabolic androgenic steroids

    Article • Journal of Chromatography A, September 2012, Elsevier

    Dr Costas G Georgakopoulos, Professor Nikolaos S. Thomaidis

  48. Evolving concepts and techniques for anti-doping

    Article • Bioanalysis, July 2012, Future Science

    Dr Costas G Georgakopoulos

  49. Analytical progresses of the International Olympic Committee and World Anti-Doping Agency Olympic laboratories

    Article • Bioanalysis, July 2012, Future Science

    Dr Costas G Georgakopoulos

  50. Examination of the kinetic isotopic effect to the acetylation derivatization for the gas chromatographic-combustion-isotope ratio mass spectrometric doping control analysis of endogenous steroids

    Article • Drug Testing and Analysis, February 2012, Wiley

    Dr Costas G Georgakopoulos

  51. Two-step derivatization procedures for the ionization enhancement of anabolic steroids in LC–ESI-MS for doping control analysis

    Article • Bioanalysis, January 2012, Future Science

    Dr Costas G Georgakopoulos, Professor Nikolaos S. Thomaidis

  52. External calibration in Gas Chromatography–Combustion–Isotope Ratio Mass Spectrometry measurements of endogenous androgenic anabolic steroids in sports doping control

    Article • Journal of Chromatography A, August 2011, Elsevier

    Dr Costas G Georgakopoulos

  53. Stabilization of human urine doping control samples: a current opinion

    Article • Analytical and Bioanalytical Chemistry, April 2011, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  54. Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry

    Article • TrAC Trends in Analytical Chemistry, December 2010, Elsevier

    Dr Costas G Georgakopoulos

  55. Stabilization of human urine doping control samples: IV. Human chorionic gonadotropin

    Article • Analytical and Bioanalytical Chemistry, July 2010, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  56. Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, May 2010, Wiley

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  57. Stabilization of human urine doping control samples: III. Recombinant human erythropoietin

    Article • Clinica Chimica Acta, March 2010, Elsevier

    Dr Costas G Georgakopoulos

  58. Generic sample preparation combined with high-resolution liquid chromatography–time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories

    Article • Analytical and Bioanalytical Chemistry, February 2010, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  59. Estimating measurement uncertainty in quantitative methods not based on chromatography for doping control purposes

    Article • Drug Testing and Analysis, January 2010, Wiley

    Dr Costas G Georgakopoulos

  60. Gas chromatographic quantitative structure–retention relationships of trimethylsilylated anabolic androgenic steroids by multiple linear regression and partial least squares

    Article • Journal of Chromatography A, November 2009, Elsevier

    Dr Costas G Georgakopoulos

  61. Two-step silylation procedure for the unified analysis of 190 doping control substances in human urine samples by GC–MS

    Article • Bioanalysis, October 2009, Future Science

    Dr Costas G Georgakopoulos, Professor of Analytical Chemistry Antony C. Calokerinos

  62. Direct injection horse urine analysis for the quantification and identification of threshold substances for doping control. III. Determination of salicylic acid by liquid chromatography/quadrupole time-of-flight mass spectrometry

    Article • Analytical and Bioanalytical Chemistry, September 2009, Springer Science + Business Media

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  63. Statistical analysis of fragmentation patterns of electron ionization mass spectra of enolized-trimethylsilylated anabolic androgenic steroids

    Article • International Journal of Mass Spectrometry, August 2009, Elsevier

    Dr Costas G Georgakopoulos

  64. Direct injection horse-urine analysis for the quantification and confirmation of threshold substances for doping control. IV. Determination of 3-methoxytyramine by hydrophilic interaction liquid chromatography/quadrupole time-of-flight mass spectrometry

    Article • Drug Testing and Analysis, August 2009, Wiley

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  65. Searching for in silico predicted metabolites and designer modifications of (cortico)steroids in urine by high-resolution liquid chromatography/time-of-flight mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, July 2009, Wiley

    Dr Costas G Georgakopoulos

  66. Stabilization of human urine doping control samples: II. Microbial degradation of steroids

    Article • Analytical Biochemistry, May 2009, Elsevier

    Dr Costas G Georgakopoulos

  67. Stabilization of human urine doping control samples

    Article • Analytical Biochemistry, May 2009, Elsevier

    Dr Costas G Georgakopoulos

  68. Schemes of metabolic patterns of anabolic androgenic steroids for the estimation of metabolites of designer steroids in human urine

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2009, Elsevier

    Dr Costas G Georgakopoulos

  69. Direct injection liquid chromatography/electrospray ionization mass spectrometric horse urine analysis for the quantification and confirmation of threshold substances for doping control. II. Determination of theobromine

    Article • Rapid Communications in Mass Spectrometry, April 2009, Wiley

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  70. Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities

    Article • Steroids, February 2009, Elsevier

    Dr Costas G Georgakopoulos

  71. Direct injection LC/ESI-MS horse urine analysis for the quantification and identification of threshold substances for doping control. I. Determination of hydrocortisone

    Article • Journal of Mass Spectrometry, September 2008, Wiley

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  72. ISO/IEC 17025 Sysmex R-500 Hematology Reticulocyte Analyzer Validation

    Article • Laboratory Hematology, June 2007, Carden Jennings Publishing Co.

    Dr Costas G Georgakopoulos

  73. Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry

    Article • Analytica Chimica Acta, March 2007, Elsevier

    Dr Costas G Georgakopoulos

  74. Electrophoretic, size-exclusion high-performance liquid chromatography and liquid chromatography–electrospray ionization ion trap mass spectrometric detection of hemoglobin-based oxygen carriers

    Article • Analytica Chimica Acta, February 2007, Elsevier

    Dr Costas G Georgakopoulos

  75. Preventive doping control analysis: liquid and gas chromatography time-of-flight mass spectrometry for detection of designer steroids

    Article • Rapid Communications in Mass Spectrometry, January 2007, Wiley

    Dr Costas G Georgakopoulos, Prof Irene Panderi

  76. Organization of the doping control laboratory in the Athens 2004 Olympic Games: A case study

    Article • Technovation, October 2006, Elsevier

    Dr Costas G Georgakopoulos

  77. Doping control analysis in human urine by liquid chromatography–electrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004: Determination of corticosteroids and quantification of ephedrines, salbutamol and morphine

    Article • Analytica Chimica Acta, July 2006, Elsevier

    Dr Costas G Georgakopoulos

  78. An overview of the doping control analysis during the Olympic Games of 2004 in Athens, Greece

    Article • Analytica Chimica Acta, January 2006, Elsevier

    Dr Costas G Georgakopoulos

  79. Metabolism of isometheptene in human urine and analysis by gas chromatography–mass spectrometry in doping control

    Article • Journal of Chromatography B, December 2005, Elsevier

    Dr Costas G Georgakopoulos

  80. Another designer steroid: discovery, synthesis, and detection of ?madol? in urine

    Article • Rapid Communications in Mass Spectrometry, January 2005, Wiley

    Dr Costas G Georgakopoulos

  81. Quantitative structure–retention relationship study of α-, β1-, and β2-agonists using multiple linear regression and partial least-squares procedures

    Article • Analytica Chimica Acta, June 2004, Elsevier

    Dr Costas G Georgakopoulos

  82. Determination of xylazine and its metabolites by GC–MS in equine urine for doping analysis

    Article • Journal of Pharmaceutical and Biomedical Analysis, April 2004, Elsevier

    Dr Costas G Georgakopoulos

  83. Gas Chromatographic ? Mass Spectrometric Cardiotonic Glycosides Detection in Equine Urine Doping Analysis

    Article • Chromatographia, March 2004, Springer Science + Business Media

    Dr Costas G Georgakopoulos

  84. Elimination profiles of flurbiprofen and its metabolites in equine urine for doping analysis

    Article • Talanta, December 2001, Elsevier

    Dr Costas G Georgakopoulos

  85. Determination of ephedrines in urine by gas chromatography–mass spectrometry

    Article • Journal of Chromatography B Biomedical Sciences and Applications, July 2001, Elsevier

    Dr Costas G Georgakopoulos

  86. Study of excretion of ecdysterone in human urine

    Article • Rapid Communications in Mass Spectrometry, January 2001, Wiley

    Dr Costas G Georgakopoulos

  87. Excretion study of the β2-agonist reproterol in human urine

    Article • Journal of Chromatography B Biomedical Sciences and Applications, April 1999, Elsevier

    Dr Costas G Georgakopoulos

  88. Doping control analysis: the 6th World Championships of Athletics, Athens, Greece

    Article • TrAC Trends in Analytical Chemistry, January 1999, Elsevier

    Dr Costas G Georgakopoulos

  89. An expert system for the interpretation of pyrolysis mass spectra of condensation polymers

    Article • Analytica Chimica Acta, February 1998, Elsevier

    Dr Costas G Georgakopoulos

  90. Quantitative structure-retention relationships in doping control

    Article • Journal of Chromatography B Biomedical Sciences and Applications, December 1996, Elsevier

    Dr Costas G Georgakopoulos

  91. Principal component analysis for resolving coeluting substances in gas chromatography-mass spectrometry doping control analysis

    Article • Analytica Chimica Acta, September 1996, Elsevier

    Dr Costas G Georgakopoulos

  92. A method for the interpretation of pyrolysis-mass spectra of polyesters

    Article • Journal of Analytical and Applied Pyrolysis, August 1995, Elsevier

    Dr Costas G Georgakopoulos

  93. HEPHESTUS: An expert system in PROLOG for the interpretation of the pyrolysis-mass spectra of polyesters, polyethers and polyureas using the certainty factor model

    Article • Journal of Analytical and Applied Pyrolysis, June 1995, Elsevier

    Dr Costas G Georgakopoulos

  94. Assessment of the performance of various search systems for mass spectra files of steroids

    Article • Analytica Chimica Acta, July 1993, Elsevier

    Dr Costas G Georgakopoulos

  95. HEPHESTUS: An expert system in PROLOG for the interpretation of pyrolysis mass spectra of polyesters, polyethers and polyureas

    Article • Chemometrics and Intelligent Laboratory Systems, May 1993, Elsevier

    Dr Costas G Georgakopoulos

  96. A method for the interpretation of pyrolysis-mass spectra of polyamides

    Article • Journal of Analytical and Applied Pyrolysis, May 1992, Elsevier

    Dr Costas G Georgakopoulos

  97. Prediction of gas chromatographic relative retention times of anabolic steroids

    Article • Analytical Chemistry, September 1991, American Chemical Society (ACS)

    Dr Costas G Georgakopoulos

  98. Prediction of gas chromatographic relative retention times of stimulants and narcotics

    Article • Analytical Chemistry, September 1991, American Chemical Society (ACS)

    Dr Costas G Georgakopoulos

  99. The interpretation of pyrolysis mass spectra of polymers using a “hybrid” software system based on library searching with heuristics

    Article • Journal of Analytical and Applied Pyrolysis, July 1991, Elsevier

    Dr Costas G Georgakopoulos