All Stories

  1. Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption

    Article • PLoS Pathogens, December 2025, PLOS

    Thomas Michiels

  2. Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug design

    Article • December 2025, openRxiv

    Thomas Michiels

  3. The leader proteins of Theiler’s virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex

    Article • Journal of Virology, September 2025, ASM Journals

    Thomas Michiels

  4. A simple workflow to identify novel small linear motif (SLiM)-mediated interactions with AlphaFold

    Article • Briefings in Bioinformatics, August 2025, Oxford University Press (OUP)

    Thomas Michiels

  5. Cardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Thomas Michiels

  6. A simple workflow to identify novel Small Linear Motif (SLiM)-mediated interactions with AlphaFold

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Thomas Michiels

  7. The leader proteins of Theiler’s virus and Boone cardiovirus use a combination of Short Linear Motifs (SLiMs) to target RSK kinases to the nuclear pore complex

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Thomas Michiels

  8. The “DDVF” motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway

    Article • PLoS Pathogens, March 2025, PLOS

    Thomas Michiels

  9. The “DDVF” motif used by viral and bacterial proteins to hijack RSK kinases evolved as a mimic of a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Thomas Michiels

  10. Involvement of paraspeckle components in viral infections

    Article • Nucleus, May 2024, Taylor & Francis

    Thomas Michiels

  11. Identification of RSK substrates using an analog-sensitive kinase approach

    Article • Journal of Biological Chemistry, March 2024, Elsevier

    Dr Philippe P Roux, Thomas Michiels

  12. Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

    Article • PLoS Pathogens, December 2022, PLOS

    Thomas Michiels

  13. Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Thomas Michiels

  14. Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection

    Article • Scientific Reports, February 2022, Springer Science + Business Media

    Thomas Michiels

  15. A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif

    Article • Proceedings of the National Academy of Sciences, January 2022, Proceedings of the National Academy of Sciences

    Thomas Michiels, Pharmacy Resident Nicolas CAPELLI

  16. Inhibition of PKR by Viruses

    Article • Frontiers in Microbiology, October 2021, Frontiers

    Thomas Michiels

  17. Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses

    Article • Viruses, June 2021, MDPI AG

    Thomas Michiels

  18. PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs

    Article • Scientific Reports, April 2021, Springer Science + Business Media

    Thomas Michiels

  19. The importance of naturally attenuated SARS‐CoV‐2in the fight against COVID‐19

    Article • Environmental Microbiology, June 2020, Wiley

    Thomas Michiels

  20. The Leader Protein of Theiler's Virus Prevents the Activation of PKR

    Article • Journal of Virology, October 2019, ASM Journals

    Thomas Michiels

  21. IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa

    Article • Viruses, August 2019, MDPI AG

    Thomas Michiels

  22. A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L

    Article • PLoS Pathogens, April 2018, PLOS

    Thomas Michiels

  23. Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model

    Article • Antiviral Research, January 2018, Elsevier

    Johan Neyts, Thomas Michiels

  24. Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus

    Article • Journal of Virology, April 2017, ASM Journals

    Professor Fred R. Opperdoes, Thomas Michiels

  25. PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes

    Article • Journal of Neurochemistry, March 2017, Wiley

    Thomas Michiels

  26. Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish

    Article • Cell Host & Microbe, February 2017, Elsevier

    Thomas Michiels

  27. Neurotropism of Saffold virus in a mouse model

    Article • Journal of General Virology, June 2016, Society for General Microbiology

    Thomas Michiels

  28. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

    Article • Gut, March 2016, BMJ

    Lander Foquet, Johan Neyts, Thomas Michiels

  29. Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler’s Virus Replication

    Article • Viruses, March 2016, MDPI AG

    Thomas Michiels

  30. Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

    Article • Journal of Virology, February 2016, ASM Journals

    Thomas Michiels

  31. Inhibition of the OAS/RNase L pathway by viruses

    Article • Current Opinion in Virology, December 2015, Elsevier

    Thomas Michiels

  32. The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler’s Virus Replication

    Article • PLOS One, July 2015, PLOS

    Thomas Michiels

  33. Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus

    Article • Journal of Virology, June 2015, ASM Journals

    Thomas Michiels

  34. Lack of effect of Theiler’s murine encephalomyelitis virus infection on system xc−

    Article • Neuroscience Letters, April 2015, Elsevier

    Thomas Michiels

  35. Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

    Article • PLOS One, January 2014, PLOS

    Thomas Michiels

  36. Inefficient Type I Interferon-Mediated Antiviral Protection of Primary Mouse Neurons Is Associated with the Lack of Apolipoprotein L9 Expression

    Article • Journal of Virology, January 2014, ASM Journals

    Thomas Michiels

  37. Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications

    Article • Journal of Innate Immunity, January 2014, Karger Publishers

    Thomas Michiels

  38. IFN-ε Is Constitutively Expressed by Cells of the Reproductive Tract and Is Inefficiently Secreted by Fibroblasts and Cell Lines

    Article • PLOS One, August 2013, PLOS

    Professor Frederic Clotman, Thomas Michiels

  39. Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

    Article • PLoS Pathogens, June 2013, PLOS

    Thomas Michiels

  40. Antiviral Type I and Type III Interferon Responses in the Central Nervous System

    Article • Viruses, March 2013, MDPI AG

    Thomas Michiels

  41. The Leader Protein of Cardioviruses Inhibits Stress Granule Assembly

    Article • Journal of Virology, July 2011, ASM Journals

    Thomas Michiels

  42. IFN-λ determines the intestinal epithelial antiviral host defense

    Article • Proceedings of the National Academy of Sciences, April 2011, Proceedings of the National Academy of Sciences

    Thomas Michiels

  43. Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane

    Article • Journal of Virology, January 2011, ASM Journals

    Thomas Michiels

  44. What Have We Learned from the IL28 Receptor Knockout Mouse?

    Article • Journal of Interferon & Cytokine Research, August 2010, Mary Ann Liebert Inc

    Thomas Michiels

  45. Type I Interferon Signaling Contributes to Chronic Inflammation in a Murine Model of Silicosis

    Article • Toxicological Sciences, May 2010, Oxford University Press (OUP)

    Thomas Michiels

  46. Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

    Article • Journal of Virology, March 2010, ASM Journals

    Thomas Michiels

  47. Differential IFN-α/β production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus

    Article • Cellular Microbiology, March 2010, Hindawi Publishing Corporation

    Thomas Michiels

  48. Random Mutagenesis Defines a Domain of Theiler's Virus Leader Protein That Is Essential for Antagonism of Nucleocytoplasmic Trafficking and Cytokine Gene Expression

    Article • Journal of Virology, August 2009, ASM Journals

    Thomas Michiels

  49. Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein

    Article • Journal of General Virology, January 2009, Society for General Microbiology

    Thomas Michiels

  50. PCR-Based Simultaneous Analysis of the Interferon-Alpha Family Reveals Distinct Kinetics for Early Interferons

    Article • Journal of Interferon & Cytokine Research, November 2008, Mary Ann Liebert Inc

    Thomas Michiels

  51. TLR Ligand-Induced Type I IFNs Affect Thymopoiesis

    Article • The Journal of Immunology, May 2008, The American Association of Immunologists

    Thomas Michiels

  52. IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

    Article • PLoS Pathogens, March 2008, PLOS

    Thomas Michiels

  53. Anti-IL-17A Autovaccination Prevents Clinical and Histological Manifestations of Experimental Autoimmune Encephalomyelitis

    Article • Annals of the New York Academy of Sciences, September 2007, Wiley

    Thomas Michiels

  54. The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3

    Article • Cellular Microbiology, July 2007, Hindawi Publishing Corporation

    Thomas Michiels

  55. Type I interferon response in the central nervous system

    Article • Biochimie, June 2007, Elsevier

    Thomas Michiels

  56. La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts

    Article • Journal of Virology, March 2007, ASM Journals

    Friedemann Weber, Thomas Michiels

  57. N-Glycosylation of Murine IFN-βin a Putative Receptor-Binding Region

    Article • Journal of Interferon & Cytokine Research, June 2006, Mary Ann Liebert Inc

    Thomas Michiels

  58. Neurons produce type I interferon during viral encephalitis

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Friedemann Weber, Thomas Michiels

  59. Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness

    Article • Journal of General Virology, May 2006, Society for General Microbiology

    Thomas Michiels

  60. THE GENETICS OF THE PERSISTENT INFECTION AND DEMYELINATING DISEASE CAUSED BY THEILER'S VIRUS

    Article • Annual Review of Microbiology, October 2005, Annual Reviews

    Thomas Michiels

  61. Characterization of the Murine Alpha Interferon Gene Family

    Article • Journal of Virology, August 2004, ASM Journals

    Thomas Michiels

  62. Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-λ1

    Article • Journal of Biological Chemistry, July 2004, Elsevier

    Thomas Michiels

  63. The Leader Protein of Theiler's Virus Interferes with Nucleocytoplasmic Trafficking of Cellular Proteins

    Article • Journal of Virology, April 2004, ASM Journals

    Thomas Michiels

  64. Characterization of Interferon-α 13, a Novel Constitutive Murine Interferon-α Subtype

    Article • Journal of Biological Chemistry, November 2003, Elsevier

    Thomas Michiels

  65. Non-AUG-Initiated Internal Translation of the L* Protein of Theiler's Virus and Importance of This Protein for Viral Persistence

    Article • Journal of Virology, November 2002, ASM Journals

    Thomas Michiels

  66. Mutations That Affect the Tropism of DA and GDVII Strains of Theiler's Virus In Vitro Influence Sialic Acid Binding and Pathogenicity

    Article • Journal of Virology, August 2002, ASM Journals

    Thomas Michiels

  67. The Leader Protein of Theiler's Virus Inhibits Immediate-Early Alpha/Beta Interferon Production

    Article • Journal of Virology, September 2001, ASM Journals

    Thomas Michiels

  68. Influence of the Theiler's Virus L∗ Protein on Macrophage Infection, Viral Persistence, and Neurovirulence

    Article • Journal of Virology, October 2000, ASM Journals

    Thomas Michiels

  69. A coding RNA sequence acts as a replication signal in cardioviruses

    Article • Proceedings of the National Academy of Sciences, September 1999, Proceedings of the National Academy of Sciences

    Thomas Michiels

  70. Adaptation of Theiler's Virus to L929 Cells: Mutations in the Putative Receptor Binding Site on the Capsid Map to Neutralization Sites and Modulate Viral Persistence

    Article • Virology, May 1998, Elsevier

    Thomas Michiels

  71. Analysis of the Leader and Capsid Coding Regions of Persistent and Neurovirulent Strains of Theiler's Virus

    Article • Virology, December 1995, Elsevier

    Thomas Michiels

  72. Individual chaperones required for Yop secretion by Yersinia.

    Article • Proceedings of the National Academy of Sciences, October 1994, Proceedings of the National Academy of Sciences

    Dr Pierre Wattiau, Thomas Michiels

  73. ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions

    Article • Molecular Microbiology, May 1991, Wiley

    Thomas Michiels

  74. Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica.

    Article • Journal of Bacteriology, January 1991, ASM Journals

    Thomas Michiels

  75. Secretion of hybrid proteins by the Yersinia Yop export system.

    Article • Journal of Bacteriology, January 1991, ASM Journals

    Thomas Michiels

  76. The pYV plasmid ofYersiniaencodes a lipoprotein, YlpA, related to TraT

    Article • Molecular Microbiology, September 1990, Wiley

    Thomas Michiels

  77. Secretion of Yop proteins by Yersiniae

    Article • Infection and Immunity, September 1990, ASM Journals

    Thomas Michiels

  78. Site-specific recombinations between direct and inverted res sites of Tn2501

    Article • Plasmid, November 1989, Elsevier

    Thomas Michiels

  79. The Yersinia yop regulon

    Article • Molecular Microbiology, October 1989, Wiley

    Thomas Michiels

  80. Homology between virF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator.

    Article • Journal of Bacteriology, January 1989, ASM Journals

    Thomas Michiels

  81. Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703

    Article • Microbial Pathogenesis, December 1988, Elsevier

    Thomas Michiels

  82. A new method for the physical and genetic mapping of large plasmids: application to the localisation of the virulence determinants on the 90 kb plasmid of Salmonella typhimurium

    Article • Microbial Pathogenesis, August 1987, Elsevier

    Thomas Michiels

  83. Tn2501, a component of the lactose transposon Tn951, is an example of a new category of class II transposable elements.

    Article • Journal of Bacteriology, January 1987, ASM Journals

    Thomas Michiels

  84. Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis

    Article • Gene, January 1986, Elsevier

    Thomas Michiels