All Stories

  1. The “DDVF” motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway

    Article • PLoS Pathogens, March 2025, PLOS

    Thomas Michiels

  2. Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

    Article • PLoS Pathogens, December 2022, PLOS

    Thomas Michiels

  3. A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif

    Article • Proceedings of the National Academy of Sciences, January 2022, Proceedings of the National Academy of Sciences

    Thomas Michiels, Pharmacy Resident Nicolas CAPELLI

  4. Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses

    Article • Viruses, June 2021, MDPI AG

    Thomas Michiels

  5. The Leader Protein of Theiler's Virus Prevents the Activation of PKR

    Article • Journal of Virology, October 2019, ASM Journals

    Thomas Michiels

  6. IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa

    Article • Viruses, August 2019, MDPI AG

    Thomas Michiels

  7. A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L

    Article • PLoS Pathogens, April 2018, PLOS

    Thomas Michiels

  8. Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model

    Article • Antiviral Research, January 2018, Elsevier

    Johan Neyts, Thomas Michiels

  9. Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus

    Article • Journal of Virology, April 2017, ASM Journals

    Professor Fred R. Opperdoes, Thomas Michiels

  10. PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes

    Article • Journal of Neurochemistry, March 2017, Wiley

    Thomas Michiels

  11. Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish

    Article • Cell Host & Microbe, February 2017, Elsevier

    Thomas Michiels

  12. Neurotropism of Saffold virus in a mouse model

    Article • Journal of General Virology, June 2016, Society for General Microbiology

    Thomas Michiels

  13. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

    Article • Gut, March 2016, BMJ

    Lander Foquet, Johan Neyts, Thomas Michiels

  14. Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler’s Virus Replication

    Article • Viruses, March 2016, MDPI AG

    Thomas Michiels

  15. Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

    Article • Journal of Virology, February 2016, ASM Journals

    Thomas Michiels

  16. Inhibition of the OAS/RNase L pathway by viruses

    Article • Current Opinion in Virology, December 2015, Elsevier

    Thomas Michiels

  17. The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler’s Virus Replication

    Article • PLOS One, July 2015, PLOS

    Thomas Michiels

  18. Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus

    Article • Journal of Virology, June 2015, ASM Journals

    Thomas Michiels

  19. Lack of effect of Theiler’s murine encephalomyelitis virus infection on system xc−

    Article • Neuroscience Letters, April 2015, Elsevier

    Thomas Michiels

  20. Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

    Article • PLOS One, January 2014, PLOS

    Thomas Michiels

  21. Inefficient Type I Interferon-Mediated Antiviral Protection of Primary Mouse Neurons Is Associated with the Lack of Apolipoprotein L9 Expression

    Article • Journal of Virology, January 2014, ASM Journals

    Thomas Michiels

  22. Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications

    Article • Journal of Innate Immunity, January 2014, Karger Publishers

    Thomas Michiels

  23. IFN-ε Is Constitutively Expressed by Cells of the Reproductive Tract and Is Inefficiently Secreted by Fibroblasts and Cell Lines

    Article • PLOS One, August 2013, PLOS

    Professor Frederic Clotman, Thomas Michiels

  24. Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

    Article • PLoS Pathogens, June 2013, PLOS

    Thomas Michiels

  25. Antiviral Type I and Type III Interferon Responses in the Central Nervous System

    Article • Viruses, March 2013, MDPI AG

    Thomas Michiels

  26. The Leader Protein of Cardioviruses Inhibits Stress Granule Assembly

    Article • Journal of Virology, July 2011, ASM Journals

    Thomas Michiels

  27. IFN-λ determines the intestinal epithelial antiviral host defense

    Article • Proceedings of the National Academy of Sciences, April 2011, Proceedings of the National Academy of Sciences

    Thomas Michiels

  28. Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane

    Article • Journal of Virology, January 2011, ASM Journals

    Thomas Michiels

  29. What Have We Learned from the IL28 Receptor Knockout Mouse?

    Article • Journal of Interferon & Cytokine Research, August 2010, Mary Ann Liebert Inc

    Thomas Michiels

  30. Type I Interferon Signaling Contributes to Chronic Inflammation in a Murine Model of Silicosis

    Article • Toxicological Sciences, May 2010, Oxford University Press (OUP)

    Thomas Michiels

  31. Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

    Article • Journal of Virology, March 2010, ASM Journals

    Thomas Michiels

  32. Differential IFN-α/β production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus

    Article • Cellular Microbiology, March 2010, Hindawi Publishing Corporation

    Thomas Michiels

  33. Random Mutagenesis Defines a Domain of Theiler's Virus Leader Protein That Is Essential for Antagonism of Nucleocytoplasmic Trafficking and Cytokine Gene Expression

    Article • Journal of Virology, August 2009, ASM Journals

    Thomas Michiels

  34. Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein

    Article • Journal of General Virology, January 2009, Society for General Microbiology

    Thomas Michiels

  35. PCR-Based Simultaneous Analysis of the Interferon-Alpha Family Reveals Distinct Kinetics for Early Interferons

    Article • Journal of Interferon & Cytokine Research, November 2008, Mary Ann Liebert Inc

    Thomas Michiels

  36. TLR Ligand-Induced Type I IFNs Affect Thymopoiesis

    Article • The Journal of Immunology, May 2008, The American Association of Immunologists

    Thomas Michiels

  37. IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

    Article • PLoS Pathogens, March 2008, PLOS

    Thomas Michiels

  38. Anti-IL-17A Autovaccination Prevents Clinical and Histological Manifestations of Experimental Autoimmune Encephalomyelitis

    Article • Annals of the New York Academy of Sciences, September 2007, Wiley

    Thomas Michiels

  39. The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3

    Article • Cellular Microbiology, July 2007, Hindawi Publishing Corporation

    Thomas Michiels

  40. Type I interferon response in the central nervous system

    Article • Biochimie, June 2007, Elsevier

    Thomas Michiels

  41. La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts

    Article • Journal of Virology, March 2007, ASM Journals

    Friedemann Weber, Thomas Michiels

  42. N-Glycosylation of Murine IFN-βin a Putative Receptor-Binding Region

    Article • Journal of Interferon & Cytokine Research, June 2006, Mary Ann Liebert Inc

    Thomas Michiels

  43. Neurons produce type I interferon during viral encephalitis

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Friedemann Weber, Thomas Michiels

  44. Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness

    Article • Journal of General Virology, May 2006, Society for General Microbiology

    Thomas Michiels

  45. THE GENETICS OF THE PERSISTENT INFECTION AND DEMYELINATING DISEASE CAUSED BY THEILER'S VIRUS

    Article • Annual Review of Microbiology, October 2005, Annual Reviews

    Thomas Michiels

  46. Characterization of the Murine Alpha Interferon Gene Family

    Article • Journal of Virology, August 2004, ASM Journals

    Thomas Michiels

  47. Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-λ1

    Article • Journal of Biological Chemistry, July 2004, Elsevier

    Thomas Michiels

  48. The Leader Protein of Theiler's Virus Interferes with Nucleocytoplasmic Trafficking of Cellular Proteins

    Article • Journal of Virology, April 2004, ASM Journals

    Thomas Michiels

  49. Characterization of Interferon-α 13, a Novel Constitutive Murine Interferon-α Subtype

    Article • Journal of Biological Chemistry, November 2003, Elsevier

    Thomas Michiels

  50. Non-AUG-Initiated Internal Translation of the L* Protein of Theiler's Virus and Importance of This Protein for Viral Persistence

    Article • Journal of Virology, November 2002, ASM Journals

    Thomas Michiels

  51. Mutations That Affect the Tropism of DA and GDVII Strains of Theiler's Virus In Vitro Influence Sialic Acid Binding and Pathogenicity

    Article • Journal of Virology, August 2002, ASM Journals

    Thomas Michiels

  52. The Leader Protein of Theiler's Virus Inhibits Immediate-Early Alpha/Beta Interferon Production

    Article • Journal of Virology, September 2001, ASM Journals

    Thomas Michiels

  53. Influence of the Theiler's Virus L∗ Protein on Macrophage Infection, Viral Persistence, and Neurovirulence

    Article • Journal of Virology, October 2000, ASM Journals

    Thomas Michiels

  54. A coding RNA sequence acts as a replication signal in cardioviruses

    Article • Proceedings of the National Academy of Sciences, September 1999, Proceedings of the National Academy of Sciences

    Thomas Michiels

  55. Adaptation of Theiler's Virus to L929 Cells: Mutations in the Putative Receptor Binding Site on the Capsid Map to Neutralization Sites and Modulate Viral Persistence

    Article • Virology, May 1998, Elsevier

    Thomas Michiels

  56. Analysis of the Leader and Capsid Coding Regions of Persistent and Neurovirulent Strains of Theiler's Virus

    Article • Virology, December 1995, Elsevier

    Thomas Michiels

  57. Individual chaperones required for Yop secretion by Yersinia.

    Article • Proceedings of the National Academy of Sciences, October 1994, Proceedings of the National Academy of Sciences

    Dr Pierre Wattiau, Thomas Michiels

  58. ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions

    Article • Molecular Microbiology, May 1991, Wiley

    Thomas Michiels

  59. Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica.

    Article • Journal of Bacteriology, January 1991, ASM Journals

    Thomas Michiels

  60. Secretion of hybrid proteins by the Yersinia Yop export system.

    Article • Journal of Bacteriology, January 1991, ASM Journals

    Thomas Michiels

  61. The pYV plasmid ofYersiniaencodes a lipoprotein, YlpA, related to TraT

    Article • Molecular Microbiology, September 1990, Wiley

    Thomas Michiels

  62. Secretion of Yop proteins by Yersiniae

    Article • Infection and Immunity, September 1990, ASM Journals

    Thomas Michiels

  63. Site-specific recombinations between direct and inverted res sites of Tn2501

    Article • Plasmid, November 1989, Elsevier

    Thomas Michiels

  64. The Yersinia yop regulon

    Article • Molecular Microbiology, October 1989, Wiley

    Thomas Michiels

  65. Homology between virF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator.

    Article • Journal of Bacteriology, January 1989, ASM Journals

    Thomas Michiels

  66. Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703

    Article • Microbial Pathogenesis, December 1988, Elsevier

    Thomas Michiels

  67. A new method for the physical and genetic mapping of large plasmids: application to the localisation of the virulence determinants on the 90 kb plasmid of Salmonella typhimurium

    Article • Microbial Pathogenesis, August 1987, Elsevier

    Thomas Michiels

  68. Tn2501, a component of the lactose transposon Tn951, is an example of a new category of class II transposable elements.

    Article • Journal of Bacteriology, January 1987, ASM Journals

    Thomas Michiels

  69. Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis

    Article • Gene, January 1986, Elsevier

    Thomas Michiels