All Stories

  1. Nickel‐Substituted Rubredoxin Undergoes Demetallation Upon Reaction With Nitric Oxide and Nitroxyl

    Article • ChemBioChem, September 2026, Wiley

    Professor Eduardo Henrique Silva Sousa

  2. Ruthenium nitro complex cis-[Ru(phen)2(4-bzpy)NO2]⁺ with promising biological properties

    Article • January 2026, Elsevier

    Professor Eduardo Henrique Silva Sousa

  3. Antibacterial and antibiofilm activity of ruthenium polypyridine complex against Staphylococcus strains

    Article • Biofouling, September 2025, Taylor & Francis

    Professor Eduardo Henrique Silva Sousa

  4. Enhanced antimicrobial and antibiofilm activities of ruthenium complexes with fluorine- and bromine-substituted ligands against staphylococcal strains

    Article • Biofouling, August 2025, Taylor & Francis

    Professor Eduardo Henrique Silva Sousa

  5. Pharmacological evaluation of a new nanoformulation in the erectile tissue of rabbits and humans

    Article • European Journal of Pharmacology, December 2024, Elsevier

    Professor Eduardo Henrique Silva Sousa

  6. Ellman’s Assay on the Surface: Thiol Quantification of Human Cofilin-1 Protein through Surface Plasmon Resonance

    Article • Langmuir, September 2024, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  7. Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria

    Article • Inorganic Chemistry, July 2024, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  8. Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics

    Article • European Journal of Inorganic Chemistry, April 2024, Wiley

    Professor Eduardo Henrique Silva Sousa

  9. Investigating the reactivity and cellular interactions of indazole-based ruthenium(ii) complexes in cancer and leishmania cells

    Article • New Journal of Chemistry, January 2024, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  10. SÍNTESE, FOTORREATIVIDADE E INTERAÇÃO COM DNA DE UM NOVO COMPLEXO DE RUTÊNIO PROTÓTIPO PARA O DESENVOLVIMENTO DE AGENTES FOTOQUIMIOTERAPÊUTICOS

    Article • Química Nova, January 2024, Sociedade Brasileira de Quimica (SBQ)

    Professor Eduardo Henrique Silva Sousa

  11. New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

    Article • Dalton Transactions, January 2023, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  12. Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

    Article • Molecular Pharmaceutics, November 2022, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  13. Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

    Article • BioChem, February 2022, MDPI AG

    Professor Eduardo Henrique Silva Sousa

  14. A binuclear Fe(iii)/quinizarin complex as a structural model for anthracycline drugs binding to iron

    Article • New Journal of Chemistry, January 2022, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  15. Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl

    Article • Chemical Research in Toxicology, July 2021, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  16. Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice

    Article • PLOS One, March 2021, PLOS

    Wesley Ribeiro, Professor Eduardo Henrique Silva Sousa

  17. Nitrate-nitrite fate and oxygen sensing in dormant Mycobacterium tuberculosis: A bioinorganic approach highlighting the importance of transition metals

    Article • Coordination Chemistry Reviews, November 2020, Elsevier

    Professor Eduardo Henrique Silva Sousa

  18. A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity

    Article • Journal of Inorganic Biochemistry, September 2020, Elsevier

    Professor Eduardo Henrique Silva Sousa

  19. Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities

    Article • JBIC Journal of Biological Inorganic Chemistry, July 2020, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  20. Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry

    Article • JBIC Journal of Biological Inorganic Chemistry, July 2020, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  21. Antihypertensive potential of cis-[Ru(bpy)2(ImN)(NO)]3+, a ruthenium-based nitric oxide donor

    Article • Research in Veterinary Science, June 2020, Elsevier

    Professor Eduardo Henrique Silva Sousa

  22. Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities

    Article • Journal of Inorganic Biochemistry, May 2020, Elsevier

    Professor Eduardo Henrique Silva Sousa

  23. Antimicrobial activity and antibiotic synergy of a biphosphinic ruthenium complex against clinically relevant bacteria

    Article • Biofouling, April 2020, Taylor & Francis

    Professor Eduardo Henrique Silva Sousa

  24. An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity

    Article • JBIC Journal of Biological Inorganic Chemistry, March 2020, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  25. Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case

    Article • Inorganic Chemistry Frontiers, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  26. An anthracene-pendant ruthenium(ii) complex conjugated to a biotin anchor, an essential handle for photo-induced anti-cancer activity

    Article • New Journal of Chemistry, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  27. A bioinorganic chemistry perspective on the roles of metals as drugs and targets againstMycobacterium tuberculosis– a journey of opportunities

    Article • Dalton Transactions, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  28. Biphosphinic ruthenium complexes as the promising antimicrobial agents

    Article • New Journal of Chemistry, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  29. Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(ii)–cymene complexes with potentin vitrocytotoxic activity against HeLa and triple-negative breast cancer cells MDA-MB-231

    Article • Dalton Transactions, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  30. Mechanistic insights into the in vitro metal-promoted oxidation of (di)azine hydroxamic acids: evidence of HNO release and N,O-di(di)azinoyl hydroxylamine intermediate

    Article • New Journal of Chemistry, January 2020, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  31. THE FUNDAMENTAL IMPORTANCE OF BASIC SCIENCE: EXAMPLES OF HIGH-IMPACT DISCOVERIES FROM AN INTERNATIONAL CHEMISTRY NETWORK

    Article • Química Nova, January 2020, Sociedade Brasileira de Quimica (SBQ)

    Professor Eduardo Henrique Silva Sousa

  32. A spectroelectrochemical investigation of the heme‐based sensor DevS from Mycobacterium tuberculosis : a redox versus oxygen sensor

    Article • FEBS Journal, July 2019, Wiley

    Professor Eduardo Henrique Silva Sousa

  33. A new water-soluble ruthenium(II) carbonyl complex: cis-[Ru(bpy)2(SO3)(CO)]

    Article • Polyhedron, July 2019, Elsevier

    Professor Eduardo Henrique Silva Sousa

  34. Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

    Article • Molecular Pharmaceutics, May 2019, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  35. In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis

    Article • Acta Tropica, April 2019, Elsevier

    Professor Eduardo Henrique Silva Sousa

  36. Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin

    Article • JBIC Journal of Biological Inorganic Chemistry, January 2019, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  37. Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure

    Article • FEBS Journal, January 2019, Wiley

    Professor Eduardo Henrique Silva Sousa

  38. Ascorbyl and hydroxyl radical generation mediated by a copper complex adsorbed on gold

    Article • Dalton Transactions, January 2019, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa, Professor Ivan Castillo

  39. Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes

    Article • January 2019, Elsevier

    Professor Eduardo Henrique Silva Sousa

  40. Structural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)

    Article • International Journal of Biological Macromolecules, December 2018, Elsevier

    Professor Eduardo Henrique Silva Sousa

  41. Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity

    Article • Journal of Inorganic Biochemistry, May 2018, Elsevier

    Professor Eduardo Henrique Silva Sousa

  42. Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

    Article • Frontiers in Microbiology, May 2018, Frontiers

    Professor Eduardo Henrique Silva Sousa

  43. Antimicrobial activity of cis -[Ru(bpy) 2 (L)(L′)] n + complexes, where L = 4-(4-chlorobenzoyl)pyridine or 4-(benzoyl)pyridine and L′ = Cl − or CO

    Article • Polyhedron, April 2018, Elsevier

    Professor Eduardo Henrique Silva Sousa, Prof. Javier Alcides Ellena

  44. Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy

    Article • Journal of Inorganic Biochemistry, February 2018, Elsevier

    Professor Eduardo Henrique Silva Sousa

  45. A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa, Prof. Javier Alcides Ellena

  46. Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT

    Article • FEBS Journal, October 2017, Wiley

    Professor Eduardo Henrique Silva Sousa

  47. The potent anti-cancer activity of Dioclea lasiocarpa lectin

    Article • Journal of Inorganic Biochemistry, October 2017, Elsevier

    Professor Eduardo Henrique Silva Sousa

  48. Photochemical studies of cis -[Ru(bpy) 2 (4-bzpy)(CO)](PF 6 ) 2 and cis -[Ru(bpy) 2 (4-bzpy)(Cl)](PF 6 ): Blue light-induced nucleobase binding

    Article • Journal of Inorganic Biochemistry, August 2017, Elsevier

    Prof. Javier Alcides Ellena, Professor Eduardo Henrique Silva Sousa

  49. Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding

    Article • Inorganic Chemistry, July 2017, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  50. Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor

    Article • Journal of Inorganic Biochemistry, July 2017, Elsevier

    Professor Eduardo Henrique Silva Sousa

  51. Drug discovery targeting heme-based sensors and their coupled activities

    Article • Journal of Inorganic Biochemistry, February 2017, Elsevier

    Professor Eduardo Henrique Silva Sousa

  52. A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity

    Article • New Journal of Chemistry, January 2017, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  53. A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties

    Article • Journal of the Brazilian Chemical Society, January 2017, Sociedade Brasileira de Quimica (SBQ)

    Prof. Javier Alcides Ellena, Professor Eduardo Henrique Silva Sousa

  54. Haem-Based Sensors of O 2 : Lessons and Perspectives

    Article • January 2017, Elsevier

    Professor Eduardo Henrique Silva Sousa

  55. Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones

    Article • Journal of the Brazilian Chemical Society, January 2017, Sociedade Brasileira de Quimica (SBQ)

    Professor Eduardo Henrique Silva Sousa

  56. The Heme-Based Oxygen Sensor Rhizobium etli FixL: Influence of Auxiliary Ligands on Heme Redox Potential and Implications on the Enzyme Activity

    Article • Journal of Inorganic Biochemistry, November 2016, Elsevier

    Professor Eduardo Henrique Silva Sousa

  57. Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1α Inhibition for Cancer Therapy

    Article • ACS Chemical Biology, July 2016, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  58. Hydroxyl Radical Generation and DNA Nuclease Activity: A Mechanistic Study Based on a Surface-Immobilized Copper Thioether Clip-Phen Derivative

    Article • Chemistry - A European Journal, June 2016, Wiley

    Professor Eduardo Henrique Silva Sousa

  59. The application of low angle light scattering to evaluate qualitatively and quantitatively the dynamics of formation of oligomers in heme protein sensors

    Article • March 2016, SPIE

    Professor Eduardo Henrique Silva Sousa

  60. Ruthenium(II) bipyridine complexes with pendant anthracenyl and naphthyl moieties: A strategy for a ROS generator with DNA binding selectivity

    Article • Inorganica Chimica Acta, January 2016, Elsevier

    Professor Eduardo Henrique Silva Sousa

  61. Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action

    Article • International Journal of Impotence Research, October 2015, Nature

    Professor Eduardo Henrique Silva Sousa

  62. The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice – Involvement of the soluble guanylate cyclase/KATP pathway

    Article • Nitric Oxide, February 2015, Elsevier

    Professor Eduardo Henrique Silva Sousa

  63. Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  64. Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)nComplexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents

    Article • Journal of the Brazilian Chemical Society, January 2015, Sociedade Brasileira de Quimica (SBQ)

    Professor Eduardo Henrique Silva Sousa

  65. KinChem: A Computational Resource for Teaching and Learning Chemical Kinetics

    Article • Journal of Chemical Education, December 2014, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  66. [Fe(CN)5(isoniazid)]3−: An iron isoniazid complex with redox behavior implicated in tuberculosis therapy

    Article • Journal of Inorganic Biochemistry, November 2014, Elsevier

    Professor Eduardo Henrique Silva Sousa

  67. On the incorporation of Rhodamine B and 2′,7′-dichlorofluorescein dyes in silica: Synthesis of fluorescent nanoparticles

    Article • Optical Materials, May 2014, Elsevier

    Professor Eduardo Henrique Silva Sousa

  68. Nitric Oxide Donors with Therapeutic Strategic in Experimental Schistossomiasis Mansoni

    Article • American Journal of Immunology, April 2014, Science Publications

    Professor Eduardo Henrique Silva Sousa

  69. Electrochemistry, Surface Plasmon Resonance, and Quartz Crystal Microbalance: An Associative Study on Cytochrome c Adsorption on Pyridine Tail-Group Monolayers on Gold

    Article • The Journal of Physical Chemistry B, July 2013, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  70. The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: Involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

    Article • Pharmacology Biochemistry and Behavior, April 2013, Elsevier

    Professor Eduardo Henrique Silva Sousa

  71. Signal Transduction and Phosphoryl Transfer by a FixL Hybrid Kinase with Low Oxygen Affinity: Importance of the Vicinal PAS Domain and Receiver Aspartate

    Article • Biochemistry, January 2013, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  72. Synthesis of bifunctional mesoporous silica spheres as potential adsorbent for ions in solution

    Article • Chemical Engineering Journal, January 2013, Elsevier

    Professor Eduardo Henrique Silva Sousa

  73. Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

    Article • International Journal of Antimicrobial Agents, August 2012, Elsevier

    Professor Eduardo Henrique Silva Sousa

  74. Using Supramolecular Chemistry Strategy for Mapping Electrochemical Phenomena on the Nanoscale

    Article • August 2012, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  75. Preparation, characterization and structure of ruthenium phosphine complexes containing non-innocent ligands

    Article • Polyhedron, January 2012, Elsevier

    Prof. Javier Alcides Ellena, Professor Eduardo Henrique Silva Sousa

  76. Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design

    Article • JBIC Journal of Biological Inorganic Chemistry, September 2011, Springer Science + Business Media

    Professor Eduardo Henrique Silva Sousa

  77. Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

    Article • FEBS Letters, September 2011, Wiley

    Professor Eduardo Henrique Silva Sousa

  78. Asymmetric heterobimetallic mixed-valence complex trans-[(SO3)Co(cyclam)(NCS)Ru(NH3)4(NCS)](BF4): Synthesis and characterization

    Article • Polyhedron, August 2011, Elsevier

    Prof. Javier Alcides Ellena, Professor Eduardo Henrique Silva Sousa

  79. Mechanism and biological implications of the NO release of cis-[Ru(bpy)2L(NO)]n+ complexes: A key role of physiological thiols

    Article • Journal of Inorganic Biochemistry, May 2011, Elsevier

    Professor Eduardo Henrique Silva Sousa

  80. NO donors cis-[Ru(bpy)2(L)NO]3+ and [Fe(CN)4(L)NO]− complexes immobilized on modified mesoporous silica spheres

    Article • Polyhedron, December 2010, Elsevier

    Professor Eduardo Henrique Silva Sousa

  81. On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

    Article • Journal of the Brazilian Chemical Society, January 2010, FapUNIFESP (SciELO)

    Professor Eduardo Henrique Silva Sousa, Dr Gustavo F. S. Andrade

  82. An Oxygen-Sensing Diguanylate Cyclase and Phosphodiesterase Couple for c-di-GMP Control

    Article • Biochemistry, October 2009, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa, Dr Xuehua Wan

  83. Oxygen‐Sensing Histidine‐Protein Kinases: Assays of Ligand Binding and Turnover of Response‐Regulator Substrates

    Article • January 2008, Elsevier

    Professor Eduardo Henrique Silva Sousa

  84. Soluble Guanylyl Cyclase and Its Evolutionary Relatives

    Article • January 2008, Elsevier

    Professor Eduardo Henrique Silva Sousa

  85. DosT and DevS are oxygen-switched kinases inMycobacterium tuberculosis

    Article • Protein Science, August 2007, Wiley

    Professor Eduardo Henrique Silva Sousa

  86. A Memory of Oxygen Binding Explains the Dose Response of the Heme-Based Sensor FixL †

    Article • Biochemistry, May 2007, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  87. Slow-Onset Inhibition of 2-trans-Enoyl-ACP (CoA) Reductase from Mycobacterium tuberculosis by an Inorganic Complex

    Article • Current Pharmaceutical Design, July 2006, Bentham Science Publishers

    Professor Eduardo Henrique Silva Sousa

  88. A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium japonicum FixL Oxygen Sensor

    Article • Journal of Molecular Biology, June 2006, Elsevier

    Professor Eduardo Henrique Silva Sousa, Professor Diana R. Tomchick

  89. Development of a spectrophotometric assay for cyclase activity

    Article • Analytical Biochemistry, January 2006, Elsevier

    Professor Eduardo Henrique Silva Sousa

  90. Oxygen Blocks the Reaction of the FixL−FixJ Complex with ATP but Does Not Influence Binding of FixJ or ATP to FixL†

    Article • Biochemistry, November 2005, American Chemical Society (ACS)

    Professor Eduardo Henrique Silva Sousa

  91. Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs

    Article • Journal of Inorganic Biochemistry, February 2005, Elsevier

    Professor Eduardo Henrique Silva Sousa

  92. An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis

    Article • Chemical Communications, January 2004, Royal Society of Chemistry

    Professor Eduardo Henrique Silva Sousa

  93. Crystal structure, electrochemical and spectroscopic properties of the trans-K{[FeCl(NO0)(cyclam)]·[FeCl(NO+)(cyclam)]2}(PF6)6 complex

    Article • Journal of the Chemical Society Dalton Transactions, April 2002, Royal Society of Chemistry

    Prof. Javier Alcides Ellena, Professor Eduardo Henrique Silva Sousa

  94. Thermal isomerization of cis-[Fe(cyclam)Cl2]Cl·H2O complex in the solid state

    Article • Thermochimica Acta, September 2001, Elsevier

    Professor Eduardo Henrique Silva Sousa