All Stories

  1. Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain
  2. Faculty Opinions recommendation of Selection of chromosomal DNA libraries using a multiplex CRISPR system.
  3. The Yeast Deletion Collection: A Decade of Functional Genomics
  4. Sequencing and functional analysis of the genome of a nematode egg-parasitic fungus, Pochonia chlamydosporia
  5. Large-Scale Identification and Analysis of Suppressive Drug Interactions
  6. GC-Rich DNA Elements Enable Replication Origin Activity in the Methylotrophic Yeast Pichia pastoris
  7. CHIP-MYTH: A novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β2-adrenergic receptor
  8. Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection
  9. A genome scale overexpression screen to reveal drug activity in human cells
  10. PITPs as targets for selectively interfering with phosphoinositide signaling in cells
  11. Conserved Substitution Patterns around Nucleosome Footprints in Eukaryotes and Archaea Derive from Frequent Nucleosome Repositioning through Evolution
  12. A unified model for yeast transcript definition
  13. A Novel Small Molecule Methyltransferase Is Important for Virulence in Candida albicans
  14. Whole Genome Duplication and Enrichment of Metal Cation Transporters Revealed by De Novo Genome Sequencing of Extremely Halotolerant Black Yeast Hortaea werneckii
  15. A High-Throughput Yeast Assay Identifies Synergistic Drug Combinations
  16. A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription
  17. DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology
  18. Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations
  19. Faculty Opinions recommendation of Decoupling epigenetic and genetic effects through systematic analysis of gene position.
  20. Chemogenomic Profiling
  21. Chromatin is an ancient innovation conserved between Archaea and Eukarya
  22. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors
  23. Timing of Transcriptional Quiescence during Gametogenesis Is Controlled by Global Histone H3K4 Demethylation
  24. Faculty Opinions recommendation of One-step purification of assembly-competent tubulin from diverse eukaryotic sources.
  25. An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations
  26. Comparative Chemogenomics To Examine the Mechanism of Action of DNA-Targeted Platinum-Acridine Anticancer Agents
  27. Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
  28. Faculty Opinions recommendation of A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.
  29. Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics
  30. Faculty Opinions recommendation of Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast.
  31. Genome Sequence of Shigella flexneri Serotype 5a Strain M90T Sm
  32. Faculty Opinions recommendation of Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.
  33. Faculty Opinions recommendation of A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.
  34. Erratum: Corrigendum: Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans
  35. Faculty Opinions recommendation of Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed.
  36. Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol
  37. A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae
  38. Barcode Sequencing for Understanding Drug–Gene Interactions
  39. A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis
  40. Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pHc in Saccharomyces cerevisiae
  41. Faculty Opinions recommendation of Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution.
  42. Bugs, drugs and chemical genomics
  43. Genomic Approaches for Determining Nucleosome Occupancy in Yeast
  44. Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast
  45. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans
  46. Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
  47. A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis
  48. Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms
  49. Nucleosome-coupled expression differences in closely-related species
  50. Curcumin Inhibits Growth of Saccharomyces cerevisiae through Iron Chelation
  51. New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole
  52. Competitive Genomic Screens of Barcoded Yeast Libraries
  53. Response to “The Reality of Pervasive Transcription”
  54. Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases
  55. Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast
  56. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell
  57. A comprehensive platform for highly multiplexed mammalian functional genetic screens
  58. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4
  59. Systematic exploration of essential yeast gene function with temperature-sensitive mutants
  60. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection
  61. Displaying Chemical Information on a Biological Network Using Cytoscape
  62. Signature-tagged Mutagenesis to Characterize Genes Through Competitive Selection of Bar-coded Genome Libraries
  63. The Automated Cell: Compound and Environment Screening System (ACCESS) for Chemogenomic Screening
  64. The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae
  65. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span
  66. Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection
  67. Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-Wide Analysis of Chromatin Structure
  68. A survey of yeast genomic assays for drug and target discovery
  69. Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation
  70. A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
  71. Most “Dark Matter” Transcripts Are Associated With Known Genes
  72. Recent advances and method development for drug target identification
  73. Exploring Gene Function and Drug Action Using Chemogenomic Dosage Assays
  74. Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action
  75. You too can play with an edge
  76. A comparative analysis of DNA barcode microarray feature size
  77. Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression
  78. Quantitative phenotyping via deep barcode sequencing
  79. Alternative Splicing of PTC7 in Saccharomyces cerevisiae Determines Protein Localization
  80. Self-reporting cells
  81. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
  82. Precise Gene-Dose Alleles for Chemical Genetics
  83. Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae
  84. Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis
  85. Knocking sense into regulatory pathways
  86. Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
  87. Chemogenomic Approaches to Elucidation of Gene Function and Genetic Pathways
  88. A Library of Yeast Transcription Factor Motifs Reveals a Widespread Function for Rsc3 in Targeting Nucleosome Exclusion at Promoters
  89. Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells
  90. Combination chemical genetics
  91. Yeast chemical genomics and drug discovery: an update
  92. Erratum: Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities
  93. Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast
  94. An integrated platform of genomic assays reveals small-molecule bioactivities
  95. Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers
  96. Correction: Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
  97. Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
  98. Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures
  99. A high-resolution atlas of nucleosome occupancy in yeast
  100. Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay
  101. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions
  102. 17 Chemical Genomic Tools for Understanding Gene Function and Drug Action
  103. Chemical Genomic Profiling for Identifying Intracellular Targets of Toxicants Producing Parkinson's Disease
  104. Experimental approaches to identify genetic networks
  105. A unique and universal molecular barcode array
  106. Introns Regulate RNA and Protein Abundance in Yeast
  107. Genome-Wide Requirements for Resistance to Functionally Distinct DNA-Damaging Agents
  108. ‘Chemogenomics: tools for protein families’ and ‘Chemical genomics: chemical and biological integration’
  109. SET1, A Yeast Member of the Trithorax Family, Functions in Transcriptional Silencing and Diverse Cellular Processes
  110. Microtubule Dynamics and Chromosome Movement
  111. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
  112. Molecular components of the mitotic spindle
  113. A monoclonal antibody to a mitotic microtubule-associated protein blocks mitotic progression
  114. Regionalized Cell Division during Sea Urchin Gastrulation Contributes to Archenteron Formation and Is Correlated with the Establishment of Larval Symmetry. (sea urchin/gastrulation/cell division/autoradiography)
  115. The origin of skeleton forming cells in the sea urchin embryo
  116. Chemical-genetic approaches for exploring the mode of action of natural products