All Stories

  1. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Article • eLife, August 2014, eLife

    Dr CHAO ZHANG

  2. A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Dong Wang, Dr CHAO ZHANG

  3. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

    Article • Nature Immunology, December 2013, Springer Science + Business Media

    Dr CHAO ZHANG

  4. Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii

    Article • Journal of Medicinal Chemistry, April 2013, American Chemical Society (ACS)

    Dr CHAO ZHANG

  5. A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

    Article • Molecular Cell, April 2013, Elsevier

    Dr CHAO ZHANG

  6. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development

    Article • Nature Neuroscience, November 2012, Springer Science + Business Media

    Dr CHAO ZHANG

  7. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

    Article • Nature Structural & Molecular Biology, October 2012, Springer Science + Business Media

    Dr CHAO ZHANG

  8. The AMP-activated Protein Kinase Snf1 Regulates Transcription Factor Binding, RNA Polymerase II Activity, and mRNA Stability of Glucose-repressed Genes in Saccharomyces cerevisiae

    Article • Journal of Biological Chemistry, July 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr CHAO ZHANG

  9. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Dr CHAO ZHANG

  10. The In Vivo Response of Stem and Other Undifferentiated Spermatogonia to the Reversible Inhibition of Glial Cell Line‐Derived Neurotrophic Factor Signaling in the Adult

    Article • Stem Cells, March 2012, Oxford University Press (OUP)

    Dr CHAO ZHANG

  11. Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

    Article • Science Signaling, September 2011, American Association for the Advancement of Science

    Dr CHAO ZHANG

  12. TrkB and Protein Kinase M   Regulate Synaptic Localization of PSD-95 in Developing Cortex

    Article • Journal of Neuroscience, August 2011, Society for Neuroscience

    Dr CHAO ZHANG

  13. Structural and functional basis for RNA cleavage by Ire1

    Article • BMC Biology, July 2011, Springer Science + Business Media

    Dr CHAO ZHANG

  14. Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

    Article • Molecular Cell, June 2011, Elsevier

    Professor Andrei Goga, Dr CHAO ZHANG

  15. Sensitizing Plant Protein Kinases to Specific Inhibition by ATP-Competitive Molecules

    Article • January 2011, Springer Science + Business Media

    Dr CHAO ZHANG

  16. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

    Article • The Journal of Cell Biology, July 2010, Rockefeller University Press

    Dr CHAO ZHANG

  17. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

    Article • Nature, May 2010, Springer Science + Business Media

    Dr CHAO ZHANG

  18. Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

    Article • PLoS ONE, April 2010, PLOS

    Dr CHAO ZHANG

  19. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

    Article • Nature, February 2010, Springer Science + Business Media

    Dr CHAO ZHANG

  20. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors

    Article • Molecular BioSystems, January 2010, Royal Society of Chemistry

    Dr CHAO ZHANG

  21. TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

    Article • Molecular and Cellular Biology, August 2009, ASM Journals

    Dr CHAO ZHANG

  22. Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

    Article • PLoS Biology, May 2009, PLOS

    Dr CHAO ZHANG

  23. Inhibitor hijacking of Akt activation

    Article • May 2009, Nature

    Dr CHAO ZHANG

  24. Bypassing Kinase Activity of the Tomato Pto Resistance Protein with Small Molecule Ligands

    Article • Journal of Biological Chemistry, March 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr CHAO ZHANG

  25. Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells

    Article • The Journal of Immunology, January 2009, The American Association of Immunologists

    Dr CHAO ZHANG

  26. The unfolded protein response signals through high-order assembly of Ire1

    Article • Nature, December 2008, Springer Science + Business Media

    Dr CHAO ZHANG

  27. Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells

    Article • Molecular Cell, December 2008, Elsevier

    Dr CHAO ZHANG

  28. Erratum: Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities

    Article • Nature Chemical Biology, October 2008, Springer Science + Business Media

    Professor Corey Nislow, Dr CHAO ZHANG

  29. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value

    Article • European Journal of Neuroscience, September 2008, Wiley

    Dr CHAO ZHANG

  30. An integrated platform of genomic assays reveals small-molecule bioactivities

    Article • Nature Chemical Biology, July 2008, Springer Science + Business Media

    Professor Corey Nislow, Dr CHAO ZHANG

  31. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

    Article • Experimental Cell Research, July 2008, Elsevier

    Dr CHAO ZHANG

  32. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast

    Article • Genes & Development, February 2008, Cold Spring Harbor Laboratory Press

    Dr CHAO ZHANG

  33. IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

    Article • Science, November 2007, American Association for the Advancement of Science

    Dr CHAO ZHANG

  34. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe

    Article • Nature Protocols, November 2007, Springer Science + Business Media

    Dr CHAO ZHANG

  35. A Coupled Chemical-Genetic and Bioinformatic Approach to Polo-like Kinase Pathway Exploration

    Article • Chemistry & Biology, November 2007, Elsevier

    Dr CHAO ZHANG

  36. Protein Kinase C  Regulates  -Aminobutyrate Type A Receptor Sensitivity to Ethanol and Benzodiazepines through Phosphorylation of  2 Subunits

    Article • Journal of Biological Chemistry, September 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr CHAO ZHANG

  37. Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization

    Article • Tetrahedron, June 2007, Elsevier

    Dr CHAO ZHANG

  38. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Dr CHAO ZHANG

  39. Chemical Inactivation of Cdc7 Kinase in Budding Yeast Results in a Reversible Arrest That Allows Efficient Cell Synchronization Prior to Meiotic Recombination

    Article • Genetics, October 2006, Genetics Society of America

    Dr CHAO ZHANG

  40. JNK2 Is a Positive Regulator of the cJun Transcription Factor

    Article • Molecular Cell, September 2006, Elsevier

    Dr CHAO ZHANG

  41. Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK

    Article • Molecular Cell, March 2006, Elsevier

    Dr CHAO ZHANG

  42. Chemical Genetic Engineering of G Protein-coupled Receptor Kinase 2

    Article • Journal of Biological Chemistry, August 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr CHAO ZHANG

  43. A Chemical-Genetic Approach to Studying Neurotrophin Signaling

    Article • Neuron, April 2005, Elsevier

    Dr CHAO ZHANG

  44. Chemical Genetics Reveals a Role for Mps1 Kinase in Kinetochore Attachment during Mitosis

    Article • Current Biology, January 2005, Elsevier

    Dr CHAO ZHANG

  45. Design and Use of Analog‐Sensitive Protein Kinases

    Article • Current Protocols in Molecular Biology, April 2004, Wiley

    Dr CHAO ZHANG

  46. Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors

    Article • January 2003, Elsevier

    Dr CHAO ZHANG

  47. Chemical Genetic Blockade of Transformation Reveals Dependence on Aberrant Oncogenic Signaling

    Article • Current Biology, August 2002, Elsevier

    Dr CHAO ZHANG