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Showing top 100 of 3,884 Stories

  1. Pickering emulsions improve protection and bioaccessibility of curcumin

    The present study aimed to investigate protection and bioaccessibility of curcumin in ovotransferrin (OVT) fibril-stabilized Pickering emulsions. Curcumin protection of OVT fibril-stabilized emulsions against ultraviolet light exposure was studied. OVT fibril-stabilized Pickering emulsion at an ionic strength of 1000 mM provided the best curcumin protection. OVT fibril-stabilized Pickering emulsion at pH 6 provided better curcumin protection than those at pH 2 and 4. Afterwards, digestion of OVT fibril-stabilized curcumin emulsion was investigated in both TNO dynamic digestion model (TIM-1) and pH-stat static digestion model. In terms of TIM-1 result, curcumin bioaccessibility in OVT fibril-stabilized emulsion increased by 129% when compared with that in bulk oil. In pH-stat digestion model, curcumin bioaccessibility increased by 114% after formulated into OVT fibril-stabilized droplets, which was due to higher extent of lipolysis. Interestingly, both TIM-1 and pH-stat digestion models gave almost consistent measurements of improved percentage in curcumin bioaccessibility. Curcumin bioaccessibility of the emulsion in TIM-1 and pH-stat model was 15.3% and 33.8% respectively, indicating bioaccessibility overestimation in pH-stat model. The novel findings in this work could facilitate designing food-grade Pickerinng emulsion with excellent nutraceutical protection and enhanced nutraceutical bioaccessibility.

  2. Sensing Dying Cells in Health and Disease: The Importance of Kidney Injury Molecule-1

    The ability of the body to recognize and remove dying cells is critical to maintain health. The protein Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin (TIM-1) and mucin domain-1, can be found on various cells in the body and helps them to recognize and bind to dead cells to remove them. This article summarizes the role of KIM-1/TIM-1 in health and in diseases such as kidney injury, autoimmunity, transplant rejection, cancer, and viral infections. The potential for enhancing or suppressing KIM-1/TIM-1 function to treat human diseases is also discussed.

  3. Perspectives on the development of social care law in relation to adult safeguarding.

    This interview with Tim Spencer-Lane sheds light on the evolution of the law and policy framework that informs safeguarding practice. It highlights the competing imperatives and tensions for government policymakers in finding the balance between maximising an adult at risk’s autonomy and ensuring adequate protection for those who need it. The findings also suggest the next steps to improve the legal framework that informs safeguarding adults.

  4. Our worldviews shape how we judge antagonistic leaders

    Every individual has an idiosyncratic understanding of how the world “works,” and these beliefs serve as lenses that shape how they perceive and evaluate antagonistic leaders. In particular, people who believe the world is competitive evaluate someone who behaves antagonistically as more competent and more effective as a leader, compared to people who believe the world is cooperative. These judgments are driven by people’s beliefs about the impact of antagonistic behavior. For example, if someone believes being tough gets results, they’re more likely to view a tough leader as smart or effective. Similar effects also play out in reverse: when people evaluate successful CEOs like Apple’s Tim Cook or GM’s Mary Barra, those who think the world is a competitive jungle assume that those leaders must have used confrontational tactics more frequently on their rise to the top, and believe those tactics helped them succeed. People who see the world as competitive are more tolerant of even their own antagonistic bosses. While no one loves having a boss who was a jerk, those who see the world as competitive are more motivated and satisfied with their job under such managers, more likely to choose and stay with such managers, and less likely to leave such managers, compared to those who see the world as cooperative.

  5. Contemporary Scottish Drama in China, 1982–2022

    Who would have thought that as far back as 1982, when the revival of contemporary Scottish theater was just beginning, Chinese scholars had already met John McGrath, a leading figure in Scottish theater, and introduced 7:84 (Scotland) and other early 20th-century Scottish playwrights and theater arts to both scholars and general readers in China? This exchange across cultures and geography not only highlighted the forward-thinking attention of Chinese scholars to global theater but also laid the foundation for dialogue between Chinese and Western theatrical cultures. Entering the new century, works by Scottish playwrights like Anthony Neilson, David Greig, and David Harrower were translated into Chinese and repeatedly staged in theaters in Beijing and Shanghai, bringing Chinese audiences closer to Scottish theater. These works, with their unique storytelling and sharp social critique, captivated audiences and inspired Chinese theater creators. On the academic front, contemporary Scottish writers such as Gregory Burke, Zinnie Harris, Catherine Czerkawska, Rona Munro, and Tim Barrow are reaching more Chinese readers through our research papers and teams. These studies not only enrich China’s theater research but also open a window for the general public to explore Scottish culture.

  6. “Two-Stage” Spirit Reception in the Writings of Paul

    It is often said that the Pauline epistles do not bear witness to a baptism of the Spirit as a (potentially) post-conversion experience. Robert Menzies used 2 Tim 1:6–7 and Rom 1:11 to show that his writings actually do teach such a "two-stage" Spirit reception, as he calls it. This article builds on his work and adds additional Pauline passages to the list of ones that point to such a Spirit reception. Further, the intertextuality of the Lukan and Pauline writings is explored as crucial to a right understanding of this issue. 1 Corinthians 12:13 is examined, since for many this proves Paul does not affirm subsequence. Yet, this passage is shown to be speaking to another issue entirely and is not in conflict with a "two-stage" Spirit reception. The article closes with a series of observations that summarize the findings. The conclusion is that both Paul and Luke speak to a similar Spirit reception, and a definition for this reception needs to be adopted that encompasses both—one that allows for a distinct and dynamic Spirit baptism but with a variety of possible evidences (those found in the Pauline epistles like assurance of God's love and sonship, joy, a pronounced increase of spiritual gifts, etc.) is the one that best meets this criteria.

  7. Creativity, cognition and material culture: An introduction

    An introduction to the special issue in Pragmatics & Cognition focused on creativity, cognition, and material culture. With contributions from Maurice Bloch, Chris Gosden, Tim Ingold, John Kirsh, Carl Knappett & Sander van der Leeuw, Lambros Malafouris, Frédéric Vallée-Tourangeau, Kevin Warwick, and Tom Wynn and Frederick L. Coolidge.

  8. Creativity, Cognition and Material Culture

    Special issue in Pragmatics & Cognition focused on creativity, cognition, and material culture. With contributions from Maurice Bloch, Chris Gosden, Tim Ingold, John Kirsh, Carl Knappett & Sander van der Leeuw, Lambros Malafouris, Frédéric Vallée-Tourangeau, Kevin Warwick, and Tom Wynn and Frederick L. Coolidge.

  9. East-West flows: Cinematic currents between China and the United States

    Editorial for the special issue of Asian Cinema (29.1) "East-West Flows: Cinematic currents between China and the United States." Includes a brief historical sketch of Asian American filmmaking in the United States. Guest Editors: Tim Gruenewald and George Chun Han Wang

  10. Agnes Varda, memories of place and the artwork as a location

    The article is about Agnes Varda, our memories of place and the creative process. Starting with Varda's exploration of places from her own life in her film The Beaches of Agnes, it goes on to consider the author's own return to her birthplace, the importance of place to the creative process and the artwork itself as a location. It refers to texts by Tim Ingold and Jean Luc Nancy

  11. Role of Sema4A in allergic response in vivo

    Our research has shown that Semaphorin 4A (Sema4A) plays a significant role in modulating allergic responses. Specifically, Sema4A has been found to downregulate the severity of allergic airway inflammation. Key Findings Experimental Models: Studies using Sema4A-deficient (Sema4A⁻/⁻) mice in models of allergen-induced asthma have shown increased eosinophilic airway infiltration and bronchial epithelial cell hyperplasia compared to wild-type mice. Cytokine Production: The absence of Sema4A leads to higher levels of interleukin 13 (IL-13) in bronchoalveolar lavage fluid, which is associated with enhanced airway hyperreactivity. Regulatory T Cells (Tregs): Sema4A⁻/⁻ mice exhibit lower numbers of regulatory T cells, which are crucial for maintaining immune tolerance and controlling inflammation. Th2 Response: Sema4A-deficient CD4⁺ T cells are more effective in transferring a T helper type 2 (Th2) response, which is typically associated with allergic reactions. Mechanism Sema4A interacts with receptors such as Tim-2 on T cells and Plexin D1 on other cell types, influencing various immune responses.

  12. Semaphorins 4A and 4D; their structures, receptors, and functions

    Semaphorins are a family of molecules initially identified for their role in axon guidance within the nervous system. Among them, Semaphorin 4A (Sema4A) and Semaphorin 4D (Sema4D) have been recognized for their significant roles in the immune system, earning them the designation "immune semaphorins". Biology of Sema4A and Sema4D: Sema4A and Sema4D are part of the class IV semaphorins. They are membrane-bound proteins that interact with specific receptors to mediate their effects. Receptors: Sema4A binds to Plexin D1, Plexin B1, and Tim-2, while Sema4D interacts with Plexin B1 and CD72. Functions in the Immune System: Immune Regulation: Both Sema4A and Sema4D play crucial roles in regulating immune responses. They are involved in the activation and migration of immune cells, influencing processes such as inflammation and immune tolerance. Disease Association: These semaphorins are implicated in various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions. For instance, Sema4D has been shown to promote the migration of T cells and dendritic cells, which are essential for immune surveillance and response. Research and Therapeutic Potential: Inflammatory Diseases: Studies have highlighted the potential of targeting Sema4A and Sema4D in treating inflammatory diseases. Their expression is upregulated in conditions like asthma and other allergic inflammations. Cancer: Sema4D, in particular, has been studied for its role in tumor progression and metastasis, making it a potential target for cancer therapy

  13. Personal data markets

    On every ordinary day, BlueKai transacts over 75 million online auctions for personal information.Footnote1 The company, which belongs to Oracle, says it owns 750 million user profiles of people who regularly surf the web, and it processes more than 30,000 attributes about these users. BlueKai claims to run the world’s largest third-party data market place, but it is just one player in a huge web of over a thousand firms that have established themselves in the business that some call “the new oil”: personal data. Personal data markets thrive, driving online companies’ valuation and fueling Internet economics. At the same time this data is not just an ordinary tradable asset. Personal data can be highly sensitive and revealing about a person’s identity; processing it is legally restricted by data protection and privacy laws. In many countries, privacy and the right to information self-determination are recognized as a human right. And even among major high-tech companies, privacy protection now starts to be recognized as essential. While in 1999 Sun founder Scott McNealy claimed that privacy is dead and we should get over it, 2015 saw Apple’s CEO Tim Cook say that “information can make the difference between life and death. If those of us in positions of responsibility fail to do everything in our power to protect the right of privacy, we risk something far more valuable than money; we risk our way of life. Fortunately, technology gives us the tools to avoid these risks and it is my sincere hope that by using them and by working together, we will.”

  14. The Dent in the Floor: Ecological Knowing in the Skilful Performance of Work

    This paper draws on a phenomenological perspective to explore how people develop and enact skill in work at through ecological knowing – a sensuous form of knowing in one’s being embedded in and across place and time. In doing so, we abductively interweave the work of Finnish architect Juhani Pallasmaa and British anthropologist Tim Ingold with an empirical study of two industrial museums and two contemporary illustrations of choral conducting and motion capture performance. Our contribution is threefold: first, we expand theories of knowledge and corporeality by theorizing ecological knowing as encompassing emplaced wisdom and embodied skill – thus elevating embedded and embodied human agency in contrast to studies that focus on the body, skill, and knowledge as objects. Secondly, we present an alternative way of understanding how expertise develops and is enacted in work activities. Finally, we offer methodological resources, currently underutilized in management studies, for studying this sensorial form of knowing in a way that is consistent with its underlying phenomenological commitments.

  15. The traditional story of a hero is a model that can be found in different media formats

    Narrative across different cultures and a range of media is a crucial element of curricula in English language teacher education. In the twenty-first century, this ought to be supplemented with learning about multiliteracies and multimodality. In combination, this permits equipping pre-service teachers and their future pupils with essential tools to critically analyse mediatized narratives. Adaptation from one media format to another, a thriving practice in recent years, provides student teachers with a focus to engage with transmedia storytelling. In order to make multiple strands of literacy accessible to students, the template of the hero’s journey has proven to be a useful implement. A pervasive if not comprehensive structure, the quest pattern tends to be dominated by male protagonists and, hence, requires addressing issues of gender and stereotype. In a first step the archetype is introduced by means of picture books and then the scope is widened to cover samples from various media formats. Parallel to this, student teachers require an introduction to the critical analysis of graphic novels and film. Three projects conducted in teacher education in Zurich are presented to exemplify how transmedia storytelling can be explored in the (university) classroom in order to foster multiliteracies: the first involves Philip Pullman’s hybrid “novel-cum-graphic-novel” Spring-Heeled Jack; the second focuses on Tim Winton’s Lockie Leonard trilogy and its adaptation for television; the third makes use of Stormbreaker by Anthony Horowitz, adapted both as a graphic novel and as a motion picture.

  16. Ancient Models for the New Musicians

    On the symbolic role assumed by mythical musicians (esp. Marsyas, Olympus, Orpheus, Thamyris) in the debate on music in the second half of the 5th century BC, with particular attention to them in the fragments of New Musicians (Melanipp. PMG 758 and 766, Tim. PMG 791,221-224, Telest. PMG 805 and 806).

  17. Cooperative and Automated Driving

    The book "Cooperative intelligent transport systems: towards high-level automated driving", aims to provide the most recent results of the development and deployment of Cooperative In-telligent Transport Systems (C-ITS), also called Connected Vehicles, in the domain of connect-ed, cooperative and automated road transport. Especially the role of ICT (Information and Communication Technologies) infrastructure is addressed. It provides comprehensive and up-to-date information by presenting both the main achievements (both theory and practice) and the challenges, in Europe, the US and Asia/Pacific. The book contains six parts and twenty-six chapters. Table of Contents Foreword – Commissioner Bulc Foreword – ITS Associations Preface List of acronyms Part I: Introduction 1 ICT-based cooperative ITS: toward automated road transport by Adrian Zlocki, Dominik Raudszus, Lutz Eckstein and Meng Lu Part II: General aspects of connected, cooperative and automated road transport 2 Deployment of C-ITS: a review of global initiatives by Martin Böhm 3 Architecture of cooperative intelligent transport systems by Glenn N. Havinoviski 4 Business-model innovation in the smart mobility domain by Oktay Turetken, Paul Grefen, Rick Gilsing, Onat Ege Adali and Baris Ozkan 5 Driving automation and its effects on drivers – a human factor perspective by Anna Anund, Ignacio Solis Marcos and Niklas Strand 6 Legal frameworks and strategies of regulatory authorities by Juhani Jääskeläinen Part III: V2X communication for cooperative and automated driving 7 Vehicular communication – a technical overview by Zoltán Jakó Ádám Knapp, Lajos Nagy and András Kovács 8 Connectivity for automated driving: an overview of corresponding R&D activities in Europe by Tim Leinmüller and Prachi Mittal 9 Standards and V2X implementation by Glenn N. Havinoviski 10 Assessment of C-ITS network performance scalability and transferability by Iraklis Stamos, Josep Maria Salanova Grau, Emmanouil Chaniotakis, Georgios Tsaples and Evangelos Mitsakis 11 5G for road safety services by Tiia Ojanperä, Jukka Mäkelä, Timo Sukuvaara, Matti Kutila and Pasi Pyykönen Part IV: ICT infrastructure for automated driving and future traffic management 12 Cooperative system integration by Julian Schindler, Daniel Wesemeyer, Andreas Leich, Michele Rondinone and Thomas Walter 13 ICT infrastructure for automated driving by Robbin Blokpoel and Meng Lu 14 Road infrastructure taxonomy for connected and automated driving by Angelos Amditis, Panagiotis Lytrivis, Evdokia Papanikolaou, Anna Carreras and Xavier Daura 15 Infrastructure-assisted automated driving in transition areas by Julian Schindler, Leonhard Lücken, Anton Wijbenga, Evangelos Mintsis and Sven Maerivoet 16 Connected and automated road transport from the perspective of cities by Suzanne Hoadley, Ondřej Přibyl and Jaap Vreeswijk Part V: Automated driving: market, impacts, roadmap, data quality and driver aspects 17 The evolution towards automated driving – insights from market penetration surveys in Germany by Susanne Schönebeck, Torsten Geißler, Jana Hölscher, Dana Gruschwitz and Alexander Schulz 18 Impact assessment of cooperative and automated vehicles by Luca Studer, Serio Agriesti, Paolo Gandini, Giovanna Marchionni and Marco Ponti 19 Deployment of highly automated driving up to 2040 – case Finland by Risto Kulmala and Seppo Pakarinen 20 A practical approach for defining and assessing data quality in automated driving by Peter Lubrich 21 Dynamic Bayesian networks for driver-intention recognition based on the traffic situation by Mark Eilers, Elham Fathiazar, Stefan Suck and Daniel Twumasi Part VI: R&D and applications of connected, cooperative and automated driving outside Europe 22 Recent advances in cooperative and automated driving in Japan and how we approach these technologies by Chunzhao Guo, Kiyosumi Kidono and Yoshiko Kojima 23 Promoting connected and automated vehicles with cooperative sensing and control technology by Shengbo Eben Li, Long Xin, Chang Liu, Jingliang Duan and Yougang Bian 24 Connected and automated vehicle research and development in the United States by Peng Hao, Guoyuan Wu, Kanok Boriboonsomsin and Matthew Barth 25 Mobility-on-demand using autonomous vehicles: systems, solutions and challenges by Malika Meghjani, Hongliang Guo, Zehui Meng, Hao Sun, Mengdan Feng, Wei Kang Leong, Ketki Chaudhary, Marcelo H. Ang Jr. and Daniela Rus Part VII: Discussion and conclusions 26 Cooperative and automated road transport: ambitions, challenges and key findings by Meng Lu Short biographies of the editor and authors Index

  18. Security, Confidentiality and Privacy in Health of Healthcare Data

    Background One of the most important facts that should be considered is confidentiality in order to maintain privacy turning out to be matters of security. Keeping up confidentiality is a crucial factor in any field, as well as health realms. Professionals who have the ingress to approach the patients' communications must keep confidentiality in health. The priority for any human being is privacy to information especially related to health. Security enables us to live peacefully, without anxiety and in full insurance. Methods The interpretive methodology was used in this research as it gives an impression of face to face interactions in healthcare bringing in social reality of what is happening in the health society.Results In consultations on gathering these results for our research, we also realized that the most common threats of loss of data and theft come under certain types of disclosures mainly third parties, routine and inadvertent. Upon this realization, there must be notification to protect security, confidentiality and privacy when security breaches occur mainly to patients. As a result, patients must provide consent about their medical information in electronically form or in writing and the consent must be signed by the patient or family member or trusted entity. The patients must come clear on the nature of the information to be disclosed and where it should be disclosed and also when the consent should expire. At the same time, a health facility must take care of the institution's database and can only disclose to the management of the health institution whose obligation would also be to protect the data, as they might need the information for research purposes, where the researchers have approval from their institution's or to legal representatives.Conclusion The advent of the hype of electronic information technology leads to major inconvenience in the main areas of human life. This manuscript explores issues in maintaining confidentiality and privacy in healthcare and other analysis of its value to individual and society as a whole. "Right to privacy is really important. You pull that brick out and another and pretty soon the house falls. Tim Cook 2016 1 Jomin George | Takura Bhila "Security, Confidentiality and Privacy in Health of Healthcare Data" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23780.pdf

  19. Reality Monitoring (RM) and the discrimination between actual and false statements.

    Participants were instructed to either describe a traffic accident as eyewitness actual role or to describe the accident as a simulated vic-tim. Data were analysed in terms of accuracy and quality, and were represented using high dimensional visualization (HDV). In Experiment 1 (between-participant design), participants made significantly more references to cognitive operations, more self-references and less changes in order when describing the event as simulated victim. In Experiment 2 (within-participants design) participants also made significantly more references to cognitive operations and more self references when describing the event from the simulated victim as well as being less accurate, providing less irrelevant information and more evaluative comments. HDV graphics indicated that false statements differ holistically from actual ones.

  20. Current state of Linked Data in digital libraries

    The Semantic Web encourages institutions, including libraries, to collect, link and share their data across the Web in order to ease its processing by machines to get better queries and results. Linked Data technologies enable us to connect related data on the Web using the principles outlined by Tim Berners-Lee in 2006. Digital libraries have great potential to exchange and disseminate data linked to external resources using Linked Data. In this paper, a study about the current uses of Linked Data in digital libraries, including the most important implementations around the world, is presented. The study focuses on selected vocabularies and ontologies, benefits and problems encountered in implementing Linked Data in digital libraries. In addition, it also identifies and discusses specific challenges that digital libraries face, offering suggestions for ways in which libraries can contribute to the Semantic Web. The study uses an adapted methodology for literature review, to find data available to answer research questions. It is based on the information found in the library websites recommended by W3C Library Linked Data Incubator Group in 2011, and scientific publications from Google Scholar, Scopus, ACM and Springer from the last 5 years. The selected libraries for the study are the National Library of France, the Europeana Library, the Library of Congress of the USA, the British Library and the National Library of Spain. In this paper, we outline the best practices found in each experience and identify gaps and future trends.

  21. Biomechanical and Histological Analysis of Titanium Versus Zirconia Implant Materials

    The aim of this study was to perform an in vivo histological comparative evaluation of bone formation around of titanium (machined and treated surface) and zirconia implants. For the present study were used 50 commercially pure titanium implants grade IV, being that 25 implants with a machined surface (TiM group), 25 implants with a treated surface (TiT group) and, 25 implants were manufactured in pure zirconia (Zr group).

  22. Medijsko predstavljanje političkih sukoba (Serbian-language publication)

    Izveštavajući o nekim sukobima, a ne o drugima, i predstavljajući ih na određeni način, mediji bitno utiču na dinamiku i rezultate sukoba tokom demokratizacije i tako oblikuju izglede na uspeh sukobljenih strana. Ovaj rad analizira literaturu o medijima i političkim sukobima, naročito onaj deo o medijskom predstavljanju međudržavnih i građanskih ratova, institucionalizovanih sukoba, protesta i društvenih pokreta u demokratijama Zapada, kao i sukoba u nedemokratskim režimima i tokom demokratizacije. Najveći deo literature bavi se načinima na koji Zapadni mediji predstavljaju strane sukobe – oružane i druge – i domaće izborne kampanje i rasprave o javnim politikama, dok je medijsko izveštavanje o domaćim sukobima u nezapadnom okruženju, kao što su oni koji nastaju tokom i posle nedemokratske vladavine, nedovoljno istraženo. Retko se povlače paralele između medijskog izveštavanja o tim, veoma različitim oblicima sukoba. Ovaj rad upravo insistira na upoređivanju nalaza iz ovih srodnih oblasti jer takvo poređenje sugeriše pouke – u vidu argumenata i hipoteza – za empirijsko istraživanje medijskog predstavljanja konfliktne strane savremene demokratizacije. Najznačajniji nalaz ove studije jeste da je politički kontekst ključni činilac koji utiče na predstavljanje različitih oblika političkih sukoba u medijima. Najvažnije dimenzije političkog konteksta iz ovog ugla su oblik političkog režima, međunarodni (spoljni) ili domaći ugao, konsenzus ili sukob elita, oblast javne politike i konsenzus ili neizvesnost oko njihovog donošenja i/ili sadržaja, oblik i nivo institucionalizacije sukoba i etapa demokratizacije. Pored toga, medijsko predstavljanje sukoba značajno utiče na političke ishode i tako podržava ili podriva nove demokratske ustanove.

  23. A guide to transforming the way we teach our children

    A collection of essays about how we educate young people, by a wide range of authors including Jonathan Porritt, Charles Handy, Anita Roddick, Jenny Mosley, Tim Brighouse, Jonathan Sachs, Tamsyn Imison, Ruth Deakin-Crick, Titus Alexander, John Potter and more

  24. Terror in our time, by Ken Booth and Tim Dunne

    A review of the book "Terror in our time" by Ken Booth and Tim Dunne. The authors are well-known scholars in the field of International Relations and the book is their attempt to contribute to the terrorism/counter-terrorism debate. The review highlights the contributions that the book makes to the literature, noting that it broadens the debate on important topics. Despite a few short-comings, the book is a good and informative read.

  25. Christ as mediator

    The article examines the six uses of mesitês (mediator) in the New Testament: Gal 3:19- 20; 1 Tim 2:5; Heb 8:6; 9:15; 12:24. The analysis of the texts brings to light some characteristics of the use of mesitês in the New Testament: unicity (Christ's oneness as mediator is associated to God’s oneness), universality (Christ is the mediator for all humankind), humanity (his mediation is based on his Incarnation and on the offering of his life on the cross), and efficacy (Christ's mediation assures the possibility of a faithful response to God by all men).

  26. The Critique of Certitude in Seventeenth-Century England

    One of the most important developments in early Stuart religious culture was the general decline in “exegetical optimism” that it witnessed, the fading conviction in the simplicity of the bible. Tracing major examples of this development, this chapter compares Lancelot Andrewes’ and Richard Sibbes’ sermons on the “mystery of godliness” (1 Tim. 3:16) with John Calvin’s discussions of the same text. In doing so, Kuchar shows how Herbert’s contemporaries often qualified claims to assurance through faith alone with an emphasis on assurance through love, thereby qualifying strong claims to personal certainty with an emphasis on wonder and mystery. Parallel with this development in biblical hermeneutics was a developing awareness that exaggerated expectations of assurance often inadvertently result in despair.

  27. How Islamic Finance Supports Sustainability: A Study of Research Trends Over Tim

    Islamic finance, which is based on ethical principles from Islamic law, is becoming an important tool for promoting sustainable development around the world. This study looks at the growth of research on Islamic finance and its role in supporting sustainable development from 1995 to 2024. We analyzed many academic papers to find key themes, such as green finance and achieving the United Nations' Sustainable Development Goals (SDGs). We also identified leading researchers and countries, like Malaysia and Indonesia, that are driving this field forward. Our study found that Islamic finance can play a significant role in addressing global challenges, such as climate change and social inequality, by offering financial solutions that are both ethical and environmentally friendly. However, there are still areas that need more research, like using digital technologies to improve Islamic finance and exploring its social and political impacts. The findings can help policymakers, financial institutions, and others understand how to better use Islamic finance to create a fairer, more sustainable world. By highlighting new areas for research and innovation, this study encourages further collaboration and development in this important field.

  28. How buruli ulcer spreads in humans

    Buruli ulcer spreads via mosquito bites and puncture wounds, researchers have found. This infectious disease is spreading in areas near Melbourne, Australia. The University of Melbourne research team is led by Professor Tim Stinear from the Peter Doherty Institute for Infection and Immunity. Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. Possums are carriers, or reservoirs, of the bacteria in the Australian state of Victoria. But how the bacteria spread to humans was not known. The researchers dipped the tails of mice in M. ulcerans and then punctured them with either mosquito bites or a needle. In both instances, the mice contracted Buruli ulcer (two of the 12 mice with mosquito bites, and 21 of the 24 with needle punctures). Mice whose tails were coated in M. ulcerans but not punctured did not develop the disease.

  29. Potential Impact of Biofield Energy Treatment on the Atomic, Physical and Thermal Properties Indium Powder

    Indium has gained significant attention in the semiconductor industries due to its unique thermal and optical properties. The objective of this research was to investigate the influence of the biofield energy treatment on the atomic, physical and thermal properties of the indium. The study was performed in two groups (control and treated). The control group remained as untreated, and treated group received Mr. Trivedi’s biofield energy treatment. Subsequently, the control and treated indium samples were characterized by the X-ray diffraction (XRD), Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), and Fourier transform infrared (FT-IR) spectroscopy. The XRD diffractogram showed the shifting of peaks toward higher Bragg’s angles in the treated indium sample as compared to the control. The crystallite size of treated indium sample were substantially changed from -80% to 150.2% after biofield energy treatment, as compared to control. In addition, the biofield energy treatment has altered the lattice parameter (-0.56%), unit cell volume (-0.23%), density (0.23%), atomic weight (-0.23), and nuclear charge per unit volume (1.69%) of the treated indium sample with respect to the control. The DSC showed an increase in the latent heat of fusion up to 3.23% in the treated indium sample with respect to control. Overall, results suggest that biofield energy treatment has substantially altered the atomic, physical, and thermal properties of treated indium powder. Therefore, the treated indium could be utilized in thermal interface material in semiconductor industries.

  30. Evaluation of data format quality of Open Government Data portals in southern EU countries

    The aim of the study is to evaluate the open data format quality provided by the central government portals for four southern EU countries (Greece, Italy, Spain, and Portugal) according to Tim Berners-Lee five levels evaluation model.

  31. How the Web was told

    Web history, Tim Berners-Lee, innovation and media culture

  32. Cleaning and disinfection of dental practice surfaces

    Infection prevention is a critical aspect of dental practice and the effective cleaning of surfaces has a key role in infection control to help prevent microorganisms being transferred to patients and staff. The choice of disinfectant, the delivery format of the disinfectant and the cleaning technique all need to be taken into consideration.

  33. Rapid microbiological methods for cleanroom environments

    To assess the different operational states within a biopharmaceutical grade clean room, using a rapid microbiological method. The method was a novel system, based on spectrometry, designed for sampling, discriminating, and enumerating airborne particles. Central to the study was the aim to determine the microbiological levels as a clean room went from standard use through maintenance and shutdown, disinfection, and then back to standard use. The objective was to evaluate whether a rapid method c

  34. Heinrich von Kleist's “The Earthquake in Chili” - Annotated Dual-Language Version with Commentary

    Heinrich von Kleist’s “The Earthquake in Chili”, first published in 1807, is a tale of the catastrophic outcomes that may spring from transgressive young love, with a tantalising promise of reprieve cruelly undone by a burst of religious fanaticism – plot elements which in the light of today’s increasing societal polarisation resonate as strongly as they ever have. Kleist led a short and frequently troubled life, a displaced aristocrat who at once longed for and resented the more personable trappings of the bourgeoisie. Outside of literature, where he turned to prose after his initial dramatic ambitions met with critical failure, he tried himself at law and later also at publishing, yet he was too restless and had too little business sense to pursue such ventures to lasting success. Kleist’s narrative style in “The Earthquake in Chili” is informed by the tensions of his changing life directions – the poetic eloquence carried over from his dramatic writing is offset by the persuasive, matter-of-fact descriptiveness of the legal style that he learnt during his law studies. While the latter influence becomes more pronounced in later works, the “Earthquake in Chili” bears the most traces of Kleist’s lingering dramatic expressivity, which makes it all the more engaging and intensely tragic.

  35. Heinrich von Kleist's “Marquise von O….” - Annotated Dual-Language Version with Commentary

    Heinrich von Kleist’s “Marquise von O….”, first published in 1808, opens thus: “In M..., an important town in northern Italy, the widowed Marquise von O...., a lady of exemplary reputation and mother to several well-reared children, had the following announced in the newspapers: that she, without her knowledge, had come to be in a delicate condition, that the father, of the child which she would bear, was to declare himself; and that she, out of regard for her family, was resolved to marry him.” As might be expected, much upheaval ensues, and although the story resolves in a seemingly happy end, the conclusions to be drawn from it are rather sober. From a current perspective, “Marquise von O….” can be read as a provocative depiction of systemic bias against victims of sexual transgression, with the echelons of aristocracy in the story mirroring those of today’s power structures. Heinrich von Kleist led a short and frequently troubled life, a displaced aristocrat who at once longed for and resented the more personable trappings of the bourgeoisie. Outside of literature, where he turned to prose after his initial dramatic ambitions met with critical failure, he tried himself at law and later also at publishing, yet he was too restless and had too little business sense to pursue such ventures to lasting success. Kleist’s narrative style in “Marquise von O….” is informed by the tensions of his changing life directions – the poetic eloquence carried over from his dramatic writing is offset by the persuasive, matter-of-fact descriptiveness of the legal style that he learnt during his law studies.

  36. Heinrich von Kleist’s Prose Style - an Introduction

    Heinrich von Kleist (1777 – 1811) led a short and frequently troubled life, a displaced aristocrat who at once longed for and resented the more personable trappings of the bourgeoisie. Outside of literature, where he turned to prose after his initial dramatic ambitions met with critical failure, he tried himself at law, science and economics, and later publishing, yet he was too restless and had too little business sense to pursue such ventures to lasting success. These biographical vagaries deeply inform the tensions within Kleist’s narrative prose style, which is examined here in minute detail. Coming from drama, Kleist’s prose diction is infused with prosodic eloquence, and his narrative threads with action rather than novelistic reflection. Somewhat paradoxically, his urgent diction is also rather dry and factual, which is explained by his formative training as a legal clerk. The resulting syntactic contours are striking – long and complex sentences that are filled with detailed interjecting clauses, which themselves are frequently interjected. Because the interjections are often more interesting to read than their framing sentences, the reading experience is rather disruptive, and the recounted facts and viewpoints constantly need to be revised. This disruptiveness is compounded by the frequent use of Latin and French grammaticisms, and the syntactic references of the sentences often stretch well beyond their ends, which can become rather confusing. At the same time, Kleist’s overexplicating use of conjunctions, another remnant of his legal writing – and as such also evoking his later admirer Franz Kafka – compels the reader to infer a sense of narrative causality even where this is lacking. Indeed, research frequently ascribes an “unreliable narrator” to Kleist; although the narrator’s tone suggests omniscience and impartiality, he frequently slips into adopting figural perspectives instead, and the resulting divergences can be jarring. The following sample sentence, from "The Duel", demonstrates the stylistic complexities that the reader faces in Kleist's prose: "Sir Friedrich von Trota, his chamberlain, most disconcerted at what had happened, took him, with the help of a few other knights, to the palace, where he could barely muster, in the arms of his distraught wife, the strength to read out, to a congregation of Imperial vassals, who, at the latter’s behest, had been gathered in great haste, the Emperor’s deed of legitimation; and after the vassals, not without some lively resistance, since by law the Crown should now fall to his half-brother, Count Jacob Rothbart, had fulfilled this last, unequivocal request, and, on the condition of obtaining approval of this from the Emperor, recognised Count Philipp as heir to the throne, and in turn his mother, since he was still a minor, as custodian and regent: he lay down and died."

  37. Heinrich von Kleist’s “Michael Kohlhaas” - Annotated Dual-Language Version with Commentary

    Heinrich von Kleist’s first major story, published in full in 1810, is one that both in subject matter and length – at 34,000 words – stands on its own among the remainder of his prose works: the purported chronicle of Michael Kohlhaas, “one of the most upright and at the same time most dreadful people of his day”. At its heart a thought experiment of how far a person will go in righting an ultimately trivial wrong, the story not only traces the titular horse-dealer’s changing fortunes but also offers some of the most riveting accounts of small-scale warfare in all of German literature. From today’s perspective, “Michael Kohlhaas” evokes much of the same unsavoury politicking and nepotistic power-play that we have seen in the U.S. in recent years; the violent David-vs.-Goliath rebellion of Kohlhaas also speaks strongly to the emotionally-charged wars and conflicts in Ukraine, Palestine, Lebanon and Sudan. Heinrich von Kleist led a short and frequently troubled life, a displaced aristocrat who at once longed for and resented the more personable trappings of the bourgeoisie. Outside of literature, where he turned to prose after his initial dramatic ambitions met with critical failure, he tried himself at law and later also at publishing, yet he was too restless and had too little business sense to pursue such ventures to lasting success. Kleist’s narrative style in “Michael Kohlhaas” is informed by the tensions of his changing life directions – the poetic eloquence carried over from his dramatic writing is offset by the persuasive, matter-of-fact descriptiveness of the legal style that he learnt during his law studies.

  38. Immune checkpoint inhibitors face competition – Indian research suggests

    Immune checkpoints are protein molecules found on immune cells, designed to prevent the immune system from attacking the body's own cells. However, as cancer cells are abnormal, the immune system identifies them as foreign and attempts to eliminate them. To evade immune destruction, cancer cells can activate these immune checkpoints, thereby suppressing anti-tumor immune responses. As a result, using specific monoclonal antibodies to block these activated immune checkpoints could enable the immune system to effectively target and destroy cancer cells. Immune checkpoint inhibitors are thus being extensively researched for cancer treatment. These include monoclonal antibodies like Ipilimumab for blocking the CTLA-4 immune checkpoint, Pembrolizumab and Nivolumab for inhibiting PD-1, and Atezolizumab, Avelumab, and Durvalumab for targeting PD-L1. In some cases, combinations of more than one inhibitor are employed. Numerous clinical trials are underway to assess the combination of chemotherapy and radiotherapy with immune checkpoint inhibitors. Surprisingly, despite significant interest in immune checkpoint inhibition, the exact mechanisms by which cancer cells activate immune checkpoints remain unclear.

  39. Penerapan Teknologi Pirolisis

    Sampah plastik menimbulkan permasalahan serius karena sulitnya terdegradasi oleh alam dan menimbulkan pencemaran pada lingkungan. Kehadiran Bank Sampah Seni Baru yang terletak di Kecamatan Kebayoran Baru, Jakarta Selatan, merupakan salah satu upaya mengurangi pembuangan sampah plastik. Hingga kini, Bank Sampah Seni Baru belum memiliki reaktor pengolahan sampah plastik khususnya reaktor pirolisis. Bank Sampah Seni Baru dalam operasional pengelolaannya melakukan pendekatan daur ulang sampah plastik kepada masyarakat sekitarnya melalui pemanfaatan sampah plastik menjadi bentuk kerajinan tangan dan lainnya. Tentu saja metode daur ulang ini pada suatu waktu akan menghadapi permasalahan yang sama karena hanya mengubah bentuk dari sampah plastik tersebut untuk sementara waktu. Atas dasar permasalahan ini, kegiatan ini bertujuan untuk memperkenalkan teknologi pirolisis sebagai bentuk daur ulang yang dapat mengubah sampah plastik menjadi fraksi cair yang memiliki sifat sebagai bahan bakar. Luaran dari kegiatan ini adalah menghasilkan reaktor pirolisis dan melakukan pelatihan teknis mengenai penggunaan reaktor pirolisis tersebut.

  40. Which kind of rules govern communication?

    Philosophers and linguists often say that language is constituted by its rules. The idea is that our language is what it is because of the rules that regulate it. However, this view is rarely explained, and often it is misunderstood. Examining some competing hypotheses, this paper identifies some common misunderstandings about the nature of linguistic rules, and presents a new framework to explain how language is constituted by rules

  41. Synthesizing Azamacrocycle–Metal Complexes with Diverse Applications

    Azamacrocycles are nitrogen-containing analogues to crown ethers that can form complexes with transition metal ions, and Professor Tim Hubin of Southwestern Oklahoma State University is a chemist who makes use of topological constraint and rigidity factors to synthesize azamacrocyclic ligands that bind transition metal ions very strongly. The resulting complexes are highly stable and have a diverse range of potential applications. Professor Hubin achieves the synthesis of such constrained azamacrocycles with methods that include direct organic synthesis, the use of templates, protection/deprotection chemistry, and various condensation reactions. Professor Hubin completed his Ph.D. in the laboratory of Professor Daryle H. Busch of the University of Kansas, and he credits Professor Busch with being the originator of much of the conceptual knowledge behind his research on azamacrocycle–metal complexes. By applying concepts from Professor Busch’s research, Professor Hubin has successfully synthesized transition metal complexes of ethylene cross-bridged azamacrocycles. Professor Stephen J. Archibald of Hull University is one of Professor Hubin’s key collaborators. Their work together, which focuses on the applications of azamacrocycle–metal complexes in the field of medical imaging, has yielded several papers and patents.

  42. Plato's account of universals in the Timaeus

    This paper tries to clarify how the metaphor of the image and its original resolves the tension between Being and Becoming and therefore also each of the difficulties that were present in the Parmenides. Thus, the Timaeus offers a more coherent alternative to the Presocratics’ mechanistic and the Sophists’ relativist accounts and hence can be read as Plato’s final answer to the problem of universals.

  43. Interaction in qualitative research interviews

    Methodological accounts of research interviews find that how researchers use this tool in their work varies widely: there are many “ways” of interviewing. This edited collection unpacks the interactional dynamics of qualitative research interviews from studies conducted in education, second language acquisition, applied linguistics and disability studies from scholars in the UK, USA, Italy, Portugal, and Korea. These studies explore the interactional details of how the identities of researchers and their participants matter for the generation of interview data, as well as the kinds of discursive resources and social actions that occur in tandem with the production of data for research projects.

  44. domiphen release mechanism in poly L-lactic acid electrospun fibers

    Anti-bacteria cantionic surfactant could be complxed within poly L-lactic acid by solution and emulsion electrospinning, due to which, the release profiles were different, espacially under degradation of proteinase K. The differences between release profiles are based on domiphen exisiting poistion after two different complexing methods. After solution electrospinning, domiphen molecules existed on or near the surface of the fibers, while after emulsion electrospinning, part of domiphen molecules existed on or near the surface of the fibers, and part domiphen molecules existed around the core-sheath surface.

  45. John Calvin on the Merits of Christ

    In several of his writings, John Calvin criticizes Peter Lombard for claiming that Christ merited exaltation for himself, arguing that this was an imposition of a Catholic merit theology on Christ's mission. This paper argues this criticism of Catholic christology indicates Calvin's desire to re-configure the relationship between Christ and the covenant.

  46. Trichoderma

  47. Particle Counting

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