Role of Sema4A in allergic response in vivo

What is it about?

Our research has shown that Semaphorin 4A (Sema4A) plays a significant role in modulating allergic responses. Specifically, Sema4A has been found to downregulate the severity of allergic airway inflammation. Key Findings Experimental Models: Studies using Sema4A-deficient (Sema4A⁻/⁻) mice in models of allergen-induced asthma have shown increased eosinophilic airway infiltration and bronchial epithelial cell hyperplasia compared to wild-type mice. Cytokine Production: The absence of Sema4A leads to higher levels of interleukin 13 (IL-13) in bronchoalveolar lavage fluid, which is associated with enhanced airway hyperreactivity. Regulatory T Cells (Tregs): Sema4A⁻/⁻ mice exhibit lower numbers of regulatory T cells, which are crucial for maintaining immune tolerance and controlling inflammation. Th2 Response: Sema4A-deficient CD4⁺ T cells are more effective in transferring a T helper type 2 (Th2) response, which is typically associated with allergic reactions. Mechanism Sema4A interacts with receptors such as Tim-2 on T cells and Plexin D1 on other cell types, influencing various immune responses.

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Why is it important?

Sema4A-mediated pathways play important roles in allergic asthma. By modulating these pathways, Sema4A helps to control the extent of inflammation and allergic reactions.

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