What is it about?

During tumor development, substantial changes in tissue oxygen, glucose and pH take place, which modify the processes responsible for obtaining cellular energy in tumor cells. Lactate is secreted by tumor cells as part of their metabolism. This compound was thought to be a waste product, but further research suggested that lactate might be used as a nutrient by cancer cells localized near blood vessels whereas tumor cells localized far from these vessels might consume glucose. This phenomenon would allow tumor cells near and far from the blood vessels to survive. We wanted to know if lactate is consumed by lung cancer cells, even if they have glucose, a condition resembling the environment near to blood vessels.

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Why is it important?

When glucose is present, Tumor cells do not consume lactate, they choose to consume glucose, albeit at a lower rate.

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Heriberto Prado-Garcia
Instituto Nacional de Enfermedades Respiratorias "Ismael Cosio Villegas"

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This page is a summary of: Lactic Acidosis in the Presence of Glucose Diminishes Warburg Effect in Lung Adenocarcinoma Cells, Frontiers in Oncology, June 2020, Frontiers, DOI: 10.3389/fonc.2020.00807.
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