What is it about?
Crocin exhibited anti-inflammatory properties where NF-kB, among other inflammatory markers, was inhibited. In vitro analysis confirmed crocin effect in HepG2 by arresting the cell cycle at S and G2/M phases, inducing apoptosis and down regulating inflammation. Network analysis identified NF-kB as a potential regulatory hub, and therefore, a candidate therapeutic drug target
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Why is it important?
In summary, this study demonstrated the effects of crocin in chemically-induced HCC animal model and promoting crocin as a potential HCC drug. Crocin inhibited the formation of FAH in DEN-induced HCC models, which was accompanied with reduced oxidative stress and restored levels of antioxidants. Moreover, treatment with crocin decreased the activity of inflammatory markers, COX-2, iNOS, NF-kB, TNF- and its receptor p-TNF-R1; in addition to a reduction in the number of Kupffer cells and macrophages. Crocin exhibited anti-proliferative and pro-apoptotic properties when administrated to DEN-treated rats
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This page is a summary of: Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses, Recent Patents on Anti-Cancer Drug Discovery, February 2016, Bentham Science Publishers, DOI: 10.2174/1574892810666151102110248.
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