What is it about?

White matter hyperintensities (WMH) are dynamic over time, demonstrating increasing, decreasing, or stable volumes. Prior work has detailed a protocol for assessing such dynamic changes over periods as short as one year. The current study investigated instrumental validation of this biomarker protocol in regard to test-retest, and cross-site inter-rater reliability in the NINDS-funded MarkVCID consortium.

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Why is it important?

The study offered validation for the longitudinal changes in white matter hyperintensity growth and regression. This validation is crucial as it underscores the reliability and reproducibility of the protocol employed. The presented data not only verifies the robustness of the methodology but also illustrates its clinical significance in tracking longitudinal delayed memory performance. This positions the protocol as a promising and potential biomarker for clinical trials addressing vascular cognitive impairment and dementia (VCID).


Collaborating with an exceptional group of investigators across various sites within the MarkVCID consortium has been an immense pleasure. Their collective efforts have significantly propelled this study, which could make a substantial contribution to VCID research. The focus of our investigation was an instrumental validation across-site on unraveling the dynamic nature of white matter hyperintensity, exploring aspects such as growth, regression, and stable volumes. These findings could serve as a pivotal gateway for examining this phenomenon in clinical trials, providing valuable insights into the effects of interventions on degenerative diseases.

Assistant Professor Ahmed A. Bahrani
University of Kentucky

Read the Original

This page is a summary of: Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol, Journal of Alzheimer s Disease, November 2023, IOS Press,
DOI: 10.3233/jad-230629.
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