The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

What is it about?

Calorie restriction is a well-established non-invasive method that reduces the rate of ageing, increases lifespan and delays the onset of age-associated diseases in a wide range of taxa. These effects may be mediated by hunger-driven mechanisms in the hypothalamus. Here, we look at the changes in the hypothalamic hunger and circadian signalling pathways of mice exposed to short-term calorie restriction.

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Why is it important?

Our results suggested that under calorie restriction modulation of the hunger and circadian signalling pathways, in response to altered levels of circulating hormones, drive some of the key phenotypic outcomes, such as activity and body temperature, that are probably important components of the longevity effects of CR.