All Stories

  1. Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

    Article • Advanced Science, March 2026, Wiley

    Dr Cara L Green

  2. Depletion of individual dietary amino acids induce distinct metabolic and chromatin states

    Article • Journal of Biological Chemistry, February 2026, Elsevier

    Dr Cara L Green

  3. A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

    Article • Cell Reports Medicine, December 2025, Elsevier

    Dr Cara L Green

  4. Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice

    Article • Molecular Metabolism, November 2025, Elsevier

    Dr Cara L Green

  5. Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice

    Article • The Journals of Gerontology Series A, September 2025, Oxford University Press (OUP)

    Dr Cara L Green

  6. Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

    Article • September 2025, openRxiv

    Dr Cara L Green

  7. Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

    Article • Nature Communications, August 2025, Springer Science + Business Media

    Dr Cara L Green

  8. Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging

    Article • Nature Aging, November 2024, Springer Science + Business Media

    Dr Cara L Green

  9. Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease

    Article • GeroScience, September 2024, Springer Science + Business Media

    Dr Cara L Green

  10. Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

    Article • Cell Reports, September 2024, Elsevier

    Dr Cara L Green

  11. Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease

    Article • Nature Communications, June 2024, Springer Science + Business Media

    Dr Cara L Green

  12. Protein restriction slows the development and progression of Alzheimer's disease in mice

    Article • April 2024, Springer Science + Business Media

    Dr Cara L Green

  13. Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

    Article • Cell Metabolism, November 2023, Elsevier

    Dr Cara L Green

  14. Biology of Stress Responses in Aging

    Article • June 2023, Aging Biology LLC

    Dr Cara L Green

  15. The Effects of Graded Levels of Calorie Restriction: XX. Impact of Long-Term Graded Calorie Restriction on Survival and Body Mass Dynamics in Male C57BL/6J Mice

    Article • The Journals of Gerontology Series A, June 2023, Oxford University Press (OUP)

    Dr Cara L Green

  16. SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

    Article • Aging Cell, October 2022, Wiley

    Dr Cara L Green

  17. Regulation of metabolic health by dietary histidine in mice

    Article • The Journal of Physiology, September 2022, Wiley

    Dr Cara L Green

  18. Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

    Article • Aging Cell, March 2022, Wiley

    Dr Cara L Green

  19. Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction

    Article • Cell Metabolism, February 2022, Elsevier

    Dr Cara L Green

  20. A food with medicine approach to health

    Article • Cell Metabolism, December 2021, Elsevier

    Dr Cara L Green

  21. Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association

    Article • GeroScience, October 2021, Springer Science + Business Media

    Dr Cara L Green

  22. Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

    Article • Nature Metabolism, October 2021, Springer Science + Business Media

    Dr Cara L Green

  23. We are more than what we eat

    Article • Nature Metabolism, September 2021, Springer Science + Business Media

    Dr Cara L Green

  24. Molecular mechanisms of dietary restriction promoting health and longevity

    Article • Nature Reviews Molecular Cell Biology, September 2021, Springer Science + Business Media

    Dr Cara L Green

  25. The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways

    Article • Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences

    Dr Cara L Green

  26. The Second Annual Symposium of the Midwest Aging Consortium: The Future of Aging Research in the Midwestern United States

    Article • The Journals of Gerontology Series A, July 2021, Oxford University Press (OUP)

    Dr Cara L Green

  27. Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

    Article • Cell Metabolism, June 2021, Elsevier

    Dr Cara L Green

  28. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

    Article • Cell Metabolism, May 2021, Elsevier

    Dr Cara L Green

  29. Of Mice and Men: Impacts of Calorie Restriction on Metabolomics of the Cerebellum

    Article • The Journals of Gerontology Series A, February 2021, Oxford University Press (OUP)

    Dr Cara L Green

  30. Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Dr Cara L Green

  31. The Effects of Graded Levels of Calorie Restriction: XVI. Metabolomic Changes in the Cerebellum Indicate Activation of Hypothalamocerebellar Connections Driven by Hunger Responses

    Article • The Journals of Gerontology Series A, October 2020, Oxford University Press (OUP)

    Dr Cara L Green

  32. Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

    Article • Cell Metabolism, April 2020, Elsevier

    Dr Cara L Green

  33. The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice

    Article • The Journals of Gerontology Series A, April 2019, Oxford University Press (OUP)

    Dr Cara L Green

  34. The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome

    Article • Scientific Reports, January 2019, Springer Science + Business Media

    Dr Cara L Green

  35. Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

    Article • Cell Reports, October 2018, Elsevier

    Dr Cara L Green

  36. Regulation of metabolic health by essential dietary amino acids

    Article • Mechanisms of Ageing and Development, July 2018, Elsevier

    Dr Cara L Green

  37. The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice

    Article • The Journals of Gerontology Series A, April 2018, Oxford University Press (OUP)

    Dr Cara L Green

  38. Energy balance and the sphingosine-1-phosphate/ceramide axis

    Article • Aging, December 2017, Impact Journals, LLC

    Dr Cara L Green

  39. The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

    Article • Aging, July 2017, Impact Journals, LLC

    Dr Cara L Green, Professor John Speakman

  40. The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue

    Article • The Journals of Gerontology Series A, May 2017, Oxford University Press (OUP)

    ms Davina Derous, Dr Cara L Green

  41. The effects of graded levels of calorie restriction: VIII. Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

    Article • Oncotarget, February 2017, Impact Journals, LLC

    ms Davina Derous, Dr Cara L Green

  42. The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

    Article • Aging Cell, January 2017, Wiley

    Dr Cara L Green, ms Davina Derous, Professor John Speakman, Daniel Promislow, Luonan Chen

  43. The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks

    Article • Aging, April 2016, Impact Journals, LLC

    Dr Cara L Green, ms Davina Derous, Professor John Speakman

  44. A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus

    Article • Experimental Gerontology, April 2016, Elsevier

    Dr Cara L Green

  45. The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

    Article • Oncotarget, March 2016, Impact Journals, LLC

    Dr Cara L Green, ms Davina Derous, Professor John Speakman

  46. The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

    Article • Aging, February 2016, Impact Journals, LLC

    Dr Cara L Green, ms Davina Derous, Professor John Speakman

  47. The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

    Article • Scientific Reports, August 2015, Nature

    Dr Cara L Green, ms Davina Derous, Professor John Speakman

  48. The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

    Article • Oncotarget, July 2015, Impact Journals, LLC

    Dr Cara L Green, ms Davina Derous

  49. The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

    Article • Oncotarget, June 2015, Impact Journals, LLC

    Emeritus Professor Richard Aspden, Dr Cara L Green, ms Davina Derous

  50. The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

    Article • Oncotarget, June 2015, Impact Journals, LLC

    Dr Cara L Green, ms Davina Derous