What is it about?

Hordenine is an alkaloid with several bioactive and pharmacological properties found in barley and consequently in beer. It was recently identified as a food-derived dopamine receptor D2 (D2R) agonist. In his study we analyzed the transport of hordenine across the intestinal and blood-brain barrier.

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Why is it important?

Hordenine was able to rapidly penetrate the blood-brain barrier in a cell culture model, comparable to CNS active drugs indicating that sufficient levels of hordenine could lead to an interaction with D2R

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This page is a summary of: Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro, PLoS ONE, June 2022, PLOS,
DOI: 10.1371/journal.pone.0269486.
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