What is it about?

To our knowledge, the importance of microRNAs (miRNAs) in lung squamous cell carcinoma (LUSC), from its emergence to its metastasis and prognosis, has elicited extensive concern. We used TCGA database to obtained LUSC-related miRNA and mRNA samples. The R platform and a series of analytical tools were used to analyze the TCGA data and identify biomarkers with high specificity and sensitivity. Identification of new miRNA markers was performed to predict the prognosis of LUSC.

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Why is it important?

Seven miRNAs and 15 hub genes were found to be closely related to the overall survival of patients with LUSC. Determination of the expression of these miRNAs can help improve the overall survival of LUSC patients. The 15 hub genes correlated with overall survival (OS). The new miRNA markers were identified to predict the prognosis of LUSC. The findings of this study offer novel views on the evolution of precise cancer treatment approaches with high reliability.


Writing this article is a very enjoyable and meaningful thing because through bioinformatics we identified novel miRNA and hub genes to predict the prognostic biomarker.

Prof. Jun Lyu
The First Affiliated Hospital of Jinan University

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This page is a summary of: Identification of miRNA signature for predicting the prognostic biomarker of squamous cell lung carcinoma, PLoS ONE, March 2022, PLOS, DOI: 10.1371/journal.pone.0264645.
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